Pyrimidines

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 1211443-61-6, name is 2-Chloro-7-cyclopentyl-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide. This compound has unique chemical properties. The synthetic route is as follows. Recommanded Product: 2-Chloro-7-cyclopentyl-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide

General procedure: To a suspension of 2-chloro-7-cyclopentyl-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide (5) (586 mg, 2 mmol) in 20 mL 1,4-dioxane were added compound 3a-f, 3i-u(2 mmol), Pd(OAc)2 (11 mg, 0.05 mmol), BINAP (62 mg, 0.1 mmol) and Cs2CO3 (978 mg, 3 mmol) and the flask was purged with Ar. Then the flask was sealed and the mixture was heated for 12 h at 100. The reaction was cooled to rt, the solvent was removed under reduced pressure, and the residue was purified by silica gel column chromatography to obtain 4a-f, 4i-o, 4r-u.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 1211443-61-6, 2-Chloro-7-cyclopentyl-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide.

Reference:
Article; Li, Yongtao; Guo, Qingxiang; Zhang, Chao; Huang, Zhi; Wang, Tianqi; Wang, Xin; Wang, Xiang; Xu, Guangwei; Liu, Yanhua; Yang, Shengyong; Fan, Yan; Xiang, Rong; Bioorganic and Medicinal Chemistry Letters; vol. 27; 15; (2017); p. 3231 – 3237;,
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Pyrimidine – Wikipedia

Application of 1240390-28-6, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 1240390-28-6, name is 2,4-Dichloropyrimidine-5-carboxylic acid amide. This compound has unique chemical properties. The synthetic route is as follows.

4-(Bicyclo [1.1.1] pentan-l-ylamino)-2-chloropyrimidine-5-carboxamide : A mixture of 2,4-dichloro-pyrimidine-5-carboxamide (2 g), bicyclo[l.l.l]pentan-l-amine hydrochloride (1.18 g), sodium bicarbonate (1.75 g), and NMP (10 mL) was stirred at 25 C for 24 h. Water (10 mL) was charged maintaining the reaction temperature less than 30 C, and the mixture was stirred at 25 C for 2 h. The suspension was filtered, and washed with NMP: water (1 : 1 10 mL), then water (2X10 mL), and dried in a vacuum oven at 40 C with nitrogen sweep to give 4-(bicyclo[l .l . l]pentan-l-ylamino)-2-chloropyrimidine-5 -carboxamide as a white solid (1.97 g, 83 %yield). 1H NMR (DMSO-d6) delta 2.14 (s, 6H), 2.51-2.53 (m, 1H), 7.76 (br. s., 1H), 8.23 (br. s., 1H), 8.60 (s, 1H), 9.57 (s, 1H).

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 1240390-28-6, 2,4-Dichloropyrimidine-5-carboxylic acid amide.

Reference:
Patent; SIGNAL PHARMACEUTICALS, LLC; FERRETTI, Antonio Christian; MAN, Hon-Wah; MUSLEHIDDINOGLU, Jale; XU, Jean; YONG, Kelvin Hin-yeong; BEAUCHAMPS, Marie Georges; KOTHARE, Mohit Atul; ZHOU, Nanfei; BOERSEN, Nathan Andrew; LI, Ying; HILGRAF, Robert; NAGY, Mark A.; ZOU, Daozhong; HUANG, Lianfeng; WO2015/116755; (2015); A2;,
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Reference of 6299-85-0, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 6299-85-0, name is Methyl 2,6-dichloropyrimidine-4-carboxylate. A new synthetic method of this compound is introduced below.

A suspension of methyl 2,6-dichloropyrimidine-4-carboxylate (1g, 4.87 mmol) in methanol (20 ml) was cooled to -20C, to this 2,4-difluoro benzylamine (0.627mg, 4.39 mmol) and triethylamine (0.98 mg, 9.74 mmol) were added. The reaction mixture was stirred at same temperature for 1 hr then at room temperature for 4 hrs. Methanol was removed under vacuum. The residue was purified by column chromatography to get the title compound. Yield: 45.93% TLC: Pet ether/Ethyl acetate (7/3): Rf: 0.4 LCMS: Mass found (+MS, 314.0) Rt (min): 4.16 Area %: 97.75 (at max), 98.54 (at 254nm) HPLC: > 99% Rt (min): 4.23 Area %: 99.27 (at max), 98.66(at 254nm) 1H NMR (400MHz, DMSO-d6): delta 8.79-8.76 (m, 1 H), 7.47-7.41 (m, 1 H), 7.30-7.24 (m, 1 H), 7.12 (s, 1 H), 7.10-7.05 (m, 1 H), 4.71 (d, J = 5.52 Hz, 2H), 3.83 (s, 3H).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,6299-85-0, its application will become more common.

Reference:
Patent; MERCK PATENT GMBH; HEINRICH, Timo; BRUGGER, Nadia; JOSEPHSON, Kristopher; WO2013/4332; (2013); A1;,
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Electric Literature of 3286-55-3, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.3286-55-3, name is 6-Chloro-2-methoxypyrimidin-4-amine, molecular formula is C5H6ClN3O, molecular weight is 159.57, as common compound, the synthetic route is as follows.

Step 1: 4-(6-amino-2-methoxypyrimidin-4-yl)benzonitrile To a mixture of 6-chloro-2-methoxypyrimidin-4-amine (Ark Pharm, catNo.AK-25131: 1.3 g, 8.0 mmol), (4-cyanophenyl)boronic acid (1.41 g, 9.60 mmol) and sodium carbonate (1.7 g, 16 mmol) in 1,4-dioxane (15 mL) and water (5 mL) was added dichloro(bis{di-tert-butyl[4-(dimethylamino)phenyl]phosphoranyl})palladium (170 mg, 0.24 mmol). The reaction mixture was purged with nitrogen then stirred at 95 C. overnight. The reaction mixture was cooled to room temperature then water (20 mL) was added. The resulting precipitate was collected via filtration then dried to give the desired product (1.7 g, 94%), which was used in the next step without further purification. LC-MS calculated for C12H11N4O (M+H)+: m/z=227.1. found 227.1.

Statistics shows that 3286-55-3 is playing an increasingly important role. we look forward to future research findings about 6-Chloro-2-methoxypyrimidin-4-amine.

Reference:
Patent; Incyte Corporation; He, Chunhong; Li, Zhenwu; Wu, Liangxing; Yao, Wenqing; Zhang, Fenglei; (84 pag.)US2016/289238; (2016); A1;,
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Pyrimidine – Wikipedia

Related Products of 1044767-99-8, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 1044767-99-8, name is 5-Bromo-4-chloropyrimidin-2-amine. A new synthetic method of this compound is introduced below.

Step a: 5-bromo-4-chloropyrimidine-2-amine (2) (370.27 mg, 2.94 mmol), and 2-furancarbohydrazide (3a) (300 mg, 1.44 mmol), dissolved in 10 mL n-butanol At 120 C under nitrogen, the reaction was refluxed for 12 hours, concentrated under reduced pressure to remove the solvent, and subjected to silica gel column chromatography (CH2Cl2: MeOH = 10: 1) to obtain N ‘-(2-amino-5-bromopyrimidin-4-yl ) furan-2-carbohydrazide (4a)

At the same time, in my other blogs, there are other synthetic methods of this type of compound,1044767-99-8, 5-Bromo-4-chloropyrimidin-2-amine, and friends who are interested can also refer to it.

Reference:
Patent; Fudan University; Chang Jun; Wang Meiling; Jin Lin; Zhang Heyanhao; Niu Tong; (9 pag.)CN111018858; (2020); A;,
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Pyrimidine – Wikipedia

Related Products of 287714-35-6, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 287714-35-6, name is Methyl 2-chloropyrimidine-5-carboxylate, molecular formula is C6H5ClN2O2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

Preparation 79: 2-[(3i?,45)-3-feri-Butoxycarbonylamino-4-(2,5-difluoro-phenyl)- pyrrolidin-l-yl]-pyrimidine-5-carbox lic acid methyl esterTo a solution of 2-chloro-pyrimidine-5-carboxylic acid methyl ester (2.1 g, 12mmol) and [(3R,45′)-4-(2,5-difluorophenyl)pyrrolidin-3-yl]carbamic acid tert-butyl ester (Preparation 193, 4.0g, 13mmol) in DCE (l OOmL) was added triethylamine (3.3mL, 23mmol) and the resulting reaction mixture was stirred at r.t. for 16 h. The reaction mixture was diluted with DCM (200mL), washed with water (200mL) and brine (400mL), dried (MgS04), filtered and concentrated in vacuo. The remainder was triturated with MeOH and the solid collected by filtration to afford the title compound: RT = 3.95 min; mlz (ES ) = 435.18 [M+ H]+.

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 287714-35-6, Methyl 2-chloropyrimidine-5-carboxylate.

Reference:
Patent; PROSIDION LIMITED; BARBA, Oscar; BERTRAM, Lisa, Sarah; CARSWELL, Emma Louise; DAVIS, Susan, Helen; FRY, Peter, Timothy; GLEAVE, Robert James; JEEVARATNAM, Revathy, Perpetua; JOHNSTONE, Craig; KEILY, John; PROCTER, Martin, James; SCHOFIELD, Karen, Lesley; STEWART, Alan, John, William; SWAIN, Simon, Andrew; WO2013/26587; (2013); A1;,
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Pyrimidine – Wikipedia

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 1032452-86-0, name is 3-(2-Chloropyrimidin-4-yl)-1-methyl-1H-indole. A new synthetic method of this compound is introduced below., Product Details of 1032452-86-0

3. Synthesis of intermediate 006-5 The intermediates 006-2 (75 mg, 307.8 mmol) and 006-4 (57.4 g, 308.4 mmol), 975 mL of isopropyl alcohol, and p-toluenesulfonic acid (63.7 g, 369.9 mmol) were sequentially added into a 2 L four-necked flask under nitrogen atmosphere, and the reaction was heated and maintained at 105C for 5 h. The reaction mixture was cooled to room temperature and filtered, and the filter cake was washed with 750 mL of isopropanol three times. The filter cake was washed three times with 750 mL of acetonitrile and dried to give 75 g of the intermediate 006-5 (62%) as a yellow solid. LC-MS: 394.1.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 1032452-86-0, 3-(2-Chloropyrimidin-4-yl)-1-methyl-1H-indole.

Reference:
Patent; Shanghai Shaletech Technology Co., Ltd.; JIANG, Yueheng; (143 pag.)EP3216786; (2017); A1;,
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Pyrimidine – Wikipedia

Reference of 3435-25-4 ,Some common heterocyclic compound, 3435-25-4, molecular formula is C5H5ClN2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

c) 8-(3,4-Difluorophenyl)-N-((3S,4R)-3-methoxy-1-(6-methylpyrimidin-4-yl)piperidin-4-yl)-[1,2,4]triazolo[1,5-a]pyridin-2-amine; 8-(3,4-Difluorophenyl)-N-((3S,4R)-3-methoxypiperidin-4-yl)-[1,2,4]triazolo[1,5-a]pyridin-2-amine dihydrochloride (28 mg, 64.8 mumol) was extracted with dichloromethane/2 M NaOH. The organic layers were washed with brine, dried over sodium sulfate and evaporated. The residue was dissolved in dioxane (0.5 mL) and to this solution 4-chloro-6-methylpyrimidine (9.2 mg, 71.2 mumol) and DIPEA (17.0 muL, 97.2 mumol) were added. Argon was bubbled through the solution for 5 minutes, and then heated in the microwave at 130 C. for 2¡Á30 minutes. After evaporation, purification by chromatography (silica gel, 10 g, 0 to 10% methanol in dichloromethane) afforded the title compound (18 mg, 62%) as an off white foam.MS ISP (m/e): 452.3 [(M+H)+].

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 3435-25-4, 4-Chloro-6-methylpyrimidine, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Baumann, Karlheinz; Flohr, Alexander; Goetschi, Erwin; Green, Luke; Jolidon, Synese; Knust, Henner; Limberg, Anja; Luebbers, Thomas; Thomas, Andrew; US2011/201605; (2011); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Adding a certain compound to certain chemical reactions, such as: 13036-57-2, 2-Chloro-4-methylpyrimidine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, COA of Formula: C5H5ClN2, blongs to pyrimidines compound. COA of Formula: C5H5ClN2

Example 4 [00154] The compound is prepared as follows: [00155] The synthetic route to obtain compound 4 started from a chloration of 4-methyl-2- chloropyrimidine. Compound 1 was obtained in 28% yield after purification. The SNAr reactionwas carried out in 52% yield. The Stille reaction was then realised. The product 3 was obtained in 72% yield. The introduction of piperidine was then carried out under microwave conditions. After purification, the final product was obtained in 19% yield.

The synthetic route of 13036-57-2 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; NOGRA PHARMA LIMITED; HOMMES, Daan; VERHAAR, Auke; VAN DEN BRINK, Gijs; VITI, Francesa; WO2013/178816; (2013); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Application of 4270-27-3, Adding some certain compound to certain chemical reactions, such as: 4270-27-3, name is 6-Chloropyrimidine-2,4(1H,3H)-dione,molecular formula is C4H3ClN2O2, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 4270-27-3.

Step – I: Preparation of 2-((6-chloro-2,4-dioxo-3,4-dihydropyrimidin-l(2H)- yl)methyl)benzonitrileTo a 6-chloropyrimidine-2,4(l H,3H)-dione (21 gm) was added N- methylpyrrolidone (80 ml) under stirring and then added diisopropylethylamine (17 ml) slowly for 30 minutes. To the solution was added a solution of 2- (bromomethyl)benzonitrile (20 gm) in toluene (80 ml) slowly for 1 hour and the temperature of the reaction mass was raised to 70 to 80C. The reaction mass was maintained for 4 hours at 70 to 80C and then cooled to 15 to 20C. The reaction mass was quenched with water and maintained for 30 minutes at 15 to 20C. The reaction mass was then cooled to 0 to 5C and stirred for 1 hour. The reaction mass was filtered and washed with water and hexane to obtain a wet solid. To the wet solid thus obtained was added water (200 ml) and pH was adjusted to 9.0 to 10.0 with sodium hydroxide (IN). The reaction mass was stirred for 30 minutes and then added methylene chloride (300 ml) and then the layers were separated. The pH of the aqueous layer was adjusted to 4.0 to 5.0 with hydrochloric acid (IN) and stirred for 30 minutes. The solid obtained was collected by filtration and then dried to obtain 19.3 gm of 2-((6-chloro-2,4-dioxo-3,4- dihydropyrimidin-l(2H)-yl)methyl)benzonitrile.

According to the analysis of related databases, 4270-27-3, the application of this compound in the production field has become more and more popular.

Reference:
Patent; HETERO RESEARCH FOUNDATION; PARTHASARADHI REDDY, Bandi; RATHNAKAR REDDY, Kura; MURALIDHARA REDDY, Dasari; MOHANBABU, Maradolla; VAMSI KRISHNA, Bandi; WO2013/46229; (2013); A1;,
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Pyrimidine – Wikipedia