Pyrimidines

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 31462-54-1, name is 2-Iodopyrimidine. This compound has unique chemical properties. The synthetic route is as follows. name: 2-Iodopyrimidine

To a solution of 2-iodopyrimidine (100 mg, 0.48 mmol, 1 eq) in dioxane (2 mL) and H20 (0.4 mL) were added CS2CO3 (316 mg, 0.97 mmol, 2 eq), Pd(PPh3) (28 mg, 24.2 umol, 0.05 eq) and methyl 3-(4,4,5,5-tetramethyl-l,3,2-dioxaborolan-2-yl)-4-((4- (trifluoromethyl)phenyl)amino)benzoate (245.4 mg, 0.58 mmol, 1.2 eq). The mixture was stirred at 90C for 16 hr. The reaction mixture was concentrated in vacuum and the residue was diluted with EA (20 mL), washed with brine (5 mL), dried over Na2S04, filtered and concentrated in vacuum. The crude product was purified by prep-HPLC to give the title compound (33 mg, 90.9 umol, 18.7% yield). Mass calcd. For CI8HI2F3N302, 359.09 m/z found 359.8 [M+H] +. 1H NMR (400 MHz, DMS0 ) d 12.68 (br s, 1H), 11.64 (s, 1H), 9.15 (d, J= 2.0 Hz, 1H), 9.01 (d, J= 5.0 Hz, 2H), 7.93 (dd, J= 2.0, 8.8 Hz, 1H), 7.70 (d, J= 8.5 Hz, 2H), 7.55 – 7.49 (m, 4H).

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 31462-54-1, 2-Iodopyrimidine.

Reference:
Patent; VIVACE THERAPEUTICS, INC.; KONRADI, Andrei, W.; LIN, Tracy, Tzu-Ling Tang; (238 pag.)WO2019/113236; (2019); A1;,
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In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 26032-72-4, name is 2,4-Dichloro-6-phenylpyrimidine, the common compound, a new synthetic route is introduced below. name: 2,4-Dichloro-6-phenylpyrimidine

To a solution of 2, 4-dichloro-6-phenylpyrimidine (1.52 g, 6.7 mmol) and (+/-) -trans-methyl 3-aminobicyclo [2.2.2] octane-2-carboxylate (1.84 g, 10.0 mmol) in N, N-dimethyl-acetamide (10 mL) was added potassium carbonate (0.92 g, 6.7 mmol) , and the mixture was stirred at rt overnight. To the reaction mixture was added water (50 mL) , and the resulting mixture was extracted with ethyl acetate (40 mL ¡Á 3) . The combined organic layers were washed with saturated brine (80 mL) , dried over anhydrous sodium sulfate and filtered. The filtrate was concentrated in vacuo and the residue was purified by silica gel column chromatography (n-hexane/EtOAc (v/v) = 20/1-10/1) to give the title compound as a white solid (1.65 g, 66%) .[0560]MS (ESI, pos. ion) m/z: 372.2 [M+H]+;[0561]1H NMR (400 MHz, CDCl3) delta (ppm) : 8.04 -7.91 (m, 2H) , 7.51 -7.41 (m, 3H) , 6.78 (s, 1H) , 5.41 (s, 1H) , 4.32 (s, 1H) , 3.73 (s, 3H) , 2.38 (d, J = 5.1 Hz, 1H) , 2.07 (s, 1H) , 1.86 (m, 1H) , 1.73 (m, 1H) , 1.70 -1.60 (m, 4H) , 1.57 (m, 2H) , 1.51 -1.41 (m, 1H) .

The synthetic route of 26032-72-4 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; SUNSHINE LAKE PHARMA CO., LTD.; TANG, Changhua; REN, Qingyun; YIN, Junjun; YI, Kai; LEI, Yibo; WANG, Yejun; ZHANG, Yingjun; (0 pag.)WO2018/157830; (2018); A1;,
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Pyrimidine – Wikipedia

As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 3435-25-4, name is 4-Chloro-6-methylpyrimidine, molecular formula is C5H5ClN2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. SDS of cas: 3435-25-4

A solution of l,4-dioxa-8-azaspiro[4.5]decane (3.04 g, 2.72 mL, 21.2 mmol), 4-chloro-6- methylpyrimidine (3.00 g, 23.4 mmol) and N,N-diisopropylethylamine (4.12 g, 5.56 mL, 31.8 mmol) in dioxane (50 mL) was heated to 140 C in the microwave for 40 minutes. The reaction mixture was concentrated, then directly purified by flash chiOmatography (silica gel, 70 g, 0% to 15% MeOH/NH4OH (9: 1) in dichloromethane). The title compound was obtained as orange oil (4.64 g, 93%).MS ISP (m/e): 236.2 (100) [(M+H)+].1H MR (CDC13, 300 MHz): delta (ppm) = 8.52-8.51 (m, 1H), 6.42 (m, 1H), 4.01 (s, 4H), 3.83-3.79 (m, 4H), 2.45 (s, 3H), 1.79-1.75 (m, 4H).

With the rapid development of chemical substances, we look forward to future research findings about 3435-25-4.

Reference:
Patent; F. HOFFMANN-LA ROCHE AG; BAUMANN, Karlheinz; FLOHR, Alexander; GOETSCHI, Erwin; GREEN, Luke; JOLIDON, Synese; KNUST, Henner; LIMBERG, Anja; LUEBBERS, Thomas; THOMAS, Andrew; WO2011/101304; (2011); A2;,
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Pyrimidine – Wikipedia

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 874-14-6, name is 1,3-Dimethyluracil, the common compound, a new synthetic route is introduced below. category: pyrimidines

General procedure: An 8 mL oven-dried scintillation vial equipped with a magnetic stir bar was charged with a mixture of 4-quinolone or uracil (0.50 mmol, 1.0 equiv), disulfide or thiol (0.75 mmol, 1.5 equiv), molecular iodine (I2) (128 mg, 0.50 mmol, 1.0 equiv), K2S2O8 (1.00-1.50 mmol, 2.0-3.0 equiv), and acetonitrile (CH3CN) (1 mL). The vial was capped, and the reaction mixture was stirred at 60 or 80 C for 12-16 h. Upon completion, saturated Na2S2O3 (5 mL) and distilled deionized H2O (10 mL) was added, and the mixture was extracted with ethyl acetate (3 x 25 mL). The combined organic layer was washed with saturated NaCl, dried over anhydrous Na2SO4, and concentrated in vacuo. The crude product was purified by SiO2 column chromatography to afford the desired thioether products.

The synthetic route of 874-14-6 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Beukeaw, Danupat; Noikham, Medena; Yotphan, Sirilata; Tetrahedron; vol. 75; 39; (2019);,
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Adding a certain compound to certain chemical reactions, such as: 635698-56-5, tert-Butyl 2,4-dichloro-7,8-dihydropyrido[4,3-d]pyrimidine-6(5H)-carboxylate, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Computed Properties of C12H15Cl2N3O2, blongs to pyrimidines compound. Computed Properties of C12H15Cl2N3O2

To a stirred solution of tert-butyl 2,4-dichloro- 7,8-dihydro-5H-pyrido[4,3-d]pyrimidine-6-carboxylate (0.3 g, 0.99 mmol) in i- PrOH (80 ml) were added 3-(aminomethyl)phenol (0.2 g, 1.18 mmol) and TEA (0.3 g, 2.96 mmol). The resulting mixture was stirred at 100 oC for 16 hrs. The reaction mixture was poured into ice-water (50 mL), and then extracted with EtOAc (50 mL x3). The combined organic layer was dried with Na2SO4, and concentrated to give a crude product which was purified by column (3470) chromatography on silica gel (hexane/ethyl acetate) to afford tert-butyl 2-chloro- 4-[(3-hydroxyphenyl)methylamino]-7,8-dihydro-5H-pyrido[4,3-d]pyrimidine-6- carboxylate (0.35 g, 90.8%) as a white solid. LCMS (M+H+) m/z: calcd.391.1; found 391.2.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,635698-56-5, tert-Butyl 2,4-dichloro-7,8-dihydropyrido[4,3-d]pyrimidine-6(5H)-carboxylate, and friends who are interested can also refer to it.

Reference:
Patent; CLEAVE BIOSCIENCES, INC.; ZHOU, Han-Jie; WUSTROW, David; (498 pag.)WO2016/200840; (2016); A1;,
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Adding a certain compound to certain chemical reactions, such as: 62802-38-4, 5-Bromo-2-fluoropyrimidine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Recommanded Product: 62802-38-4, blongs to pyrimidines compound. Recommanded Product: 62802-38-4

As shown in step 6-i of Scheme 6, to a mixture of 5-bromo-2-fluoro-pyrimidine (1 g, 5.651 mmol) in iPrOH (10 mL) was added TEA (1.143 g, 1.574 mL, 11.30 mmol) and trans-4-aminocyclohexan-1-ol (650.8 mg, 5.651 mmol). The mixture was microwaved for 20 min at 150 C., concentrated under reduced pressure, diluted with EtOAc, washed with water, and dried over Na2SO4. After removal of the volatiles under reduced pressure, the residue was purified by medium pressure silica gel chromatography (0-80% EtOAc/hexanes gradient) to provide (trans)-4-((5-bromopyrimidin-2-yl)amino)cyclohexanol (compound 1013, 1.2 g): 1H-NMR (300 MHz, CDCl3) delta 8.28 (s, 2H), 5.03 (d, J=8.1 Hz, 1H), 3.91-3.49 (m, 2H), 2.31-1.90 (m, 4H), 1.56-1.19 (m, 4H).

The synthetic route of 62802-38-4 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; VERTEX PHARMACEUTICALS INCORPORATED; Maxwell, John Patrick; Charifson, Paul S.; Tang, Qing; Ronkin, Steven M.; Jackson, Katrina Lee; Pierce, Albert Charles; Lauffer, David J.; Li, Pan; Giroux, Simon; US2014/275024; (2014); A1;,
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Pyrimidine – Wikipedia

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 6299-85-0, name is Methyl 2,6-dichloropyrimidine-4-carboxylate, the common compound, a new synthetic route is introduced below. Formula: C6H4Cl2N2O2

Reference Example 48: (2-Chloro-6-morpholin-4-yl-pyrimidin-4-vImethyl)- dimethyl-amine.; To a solution of 2,6-dichloro-pyrimidine-4-carboxylic acid methyl ester (5.0 g) in anhydrous methanol (40 mL) was added morpholine (4.20 mL). The reaction mixture was stirred at room temperature for 12 hours, then poured onto ice/water and the white precipitate collected by filtration. The solid was washed with water (30 mL) and dried to give 2-chloro- 6-morpholin-4-yl-pyrimidine-4-carboxylic acid methyl ester (4.94 g).

The synthetic route of 6299-85-0 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; PIRAMED LIMITED; THE INSTITUTE OF CANCER RESEARCH; WO2008/125833; (2008); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Application of 941685-26-3, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 941685-26-3, name is 4-Chloro-7-((2-(trimethylsilyl)ethoxy)methyl)-7H-pyrrolo[2,3-d]pyrimidine. A new synthetic method of this compound is introduced below.

To the quenched reaction mixture, which contains crude 4-chloro-7-[2-(trimethylsilyl)ethoxy]methyl}-7H-pyrrolo[2,3-d]pyrimidine (15, 18.63 g, 65.64 mmol) from previous reaction as described above, was added 1,2-dimethoxyethane (DME, 38 mL), powder potassium carbonate (K2CO3, 23.56 g, 170.5 mmol, 2.6 equiv), 1-(1-ethoxyethyl)-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole (3, 18.60 g, 69.89 mmol, 1.06 equiv) at room temperature. The resulting mixture was degassed four times backfilling with nitrogen gas each time before being treated with tetrakis(triphenylphosphine)palladium(0) (Pd(PPh3)4, 244.2 mg, 0.21 mmol, 0.003 equiv) at room temperature. The resulting reaction mixture was degassed four times backfilling with nitrogen gas each time before being warmed to 80 C. for 4-8 h. When TLC and HPLC showed that the reaction was deemed complete, the reaction mixture was gradually cooled to room temperature and filtered through a short bed of Celite (10 g). The Celite bed was washed with ethyl acetate (EtOAc, 20 mL). The two layers of the filtrate were separated, and the aqueous layer was extracted with ethyl acetate (EtOAc, 2¡Á30 mL). The combined organic extracts were washed with saturated aqueous NaCl solution (20 mL), dried over magnesium sulfate (MgSO4), and concentrated under reduced pressure. The residue, which contains the crude desired Suzuki coupling product (16), was then transferred to a 500 mL round bottom flask with THF (22 mL) for subsequent de-protection reaction without further purification.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,941685-26-3, 4-Chloro-7-((2-(trimethylsilyl)ethoxy)methyl)-7H-pyrrolo[2,3-d]pyrimidine, and friends who are interested can also refer to it.

Reference:
Patent; Zhou, Jiacheng; Liu, Pingli; Lin, Qiyan; Metcalf, Brian W.; Meloni, David; Pan, Yongchun; Xia, Michael; Li, Mei; Yue, Tai-Yuen; Rodgers, James D.; Wang, Haisheng; US2010/190981; (2010); A1;,
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Pyrimidine – Wikipedia

Adding a certain compound to certain chemical reactions, such as: 39876-88-5, 4-Chlorobenzofuro[3,2-d]pyrimidine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, category: pyrimidines, blongs to pyrimidines compound. category: pyrimidines

First of all, 2.42 g of 4-chlorobenzofuran [3, 2-d]pyrimidine, 2.19 g of phenylboronic acid, 1.89 g of sodium carbonate, 0.10 g of bis(triphenylphosphine)palladium chloride(II) (abbreviation: Pd(PPh3)2Cl2), 20 mL of water and 201 mL of acetonitrile were placed in an eggplant type flask equipped with a reflux tube, and the interior of the flask was replaced with argon gas. The reaction vessel was irradiated with microwaves (2.45 GHz, 100 W) for 60 minutes to heat. Then, the obtained residue was filtered with water and washed with hexane. With hexane: The obtained solid was purified by flash column chromatography of ethyl acetate = 2:1 to eluent solvent to give the desired pyrimidine derivative Hpbf pm (white powder, yield 45%). Further, microwaves were irradiated using a microwave synthesizer (manufactured by CEM Corporation, Discover).

The synthetic route of 39876-88-5 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Co., Ltd. Semiconductor Energies Institute; Jing Shangyingzi; Shan Kouzhiye; Lai Weiguangmei; Lai Weizheshi; (69 pag.)CN103450279; (2018); B;,
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Pyrimidine – Wikipedia

Adding a certain compound to certain chemical reactions, such as: 147118-40-9, Rosuvastatin methyl ester, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Recommanded Product: Rosuvastatin methyl ester, blongs to pyrimidines compound. Recommanded Product: Rosuvastatin methyl ester

Add 150 ml of acetonitrile to the 500 ml reaction flask and add 18.0 g of RSM. After completely dissolving, 40 ml of purified water was added and heated to 35 ¡ã C to 40 ¡ã C. 42 ml of 1N sodium hydroxide solution was added dropwise to control the dropping rate Keep the temperature between 35 ~ 40 , the entire drop process takes about 10 ~ 15min, continue to react and then need 2 to 2.5 hours.The reaction was completed at 40 ¡ã C to 50 ¡ã C under reduced pressure to remove the acetonitrile organic solvent and then 30 ml of purified water was added to open the jacketed cooling water to lower the temperature of the contents to 25 ¡ã C to 30 ¡ã C and washed with ether 3 times, each with ether 50 ml, each stirring 10 ~ 15min, static liquid separation, collecting water layer.Then add 3 g of activated carbon in the water layer, heating to maintain the temperature 35 ~ 40 , stirring 50 ~ 60min, filter, filter with 10 ml of purified water filter cake, combined filtrate and lotion, the filtrate was vacuum distillation RSA 19.0 g

At the same time, in my other blogs, there are other synthetic methods of this type of compound,147118-40-9, Rosuvastatin methyl ester, and friends who are interested can also refer to it.

Reference:
Patent; Nanjing Ouxin Pharmaceutical Technology Co., LTD; Chen, Ben Shun; Zhou, Zhang Yue; Chen, Kai; Qi, Chen Chen; (14 pag.)CN104230817; (2016); B;,
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Pyrimidine – Wikipedia