Pyrimidines

Adding a certain compound to certain chemical reactions, such as: 4270-27-3, 6-Chloropyrimidine-2,4(1H,3H)-dione, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 4270-27-3, blongs to pyrimidines compound. Recommanded Product: 6-Chloropyrimidine-2,4(1H,3H)-dione

Reference Example 17. 6-Chloro-1-(2-trimethylsilyl)ethoxymethylpyrimidine-2,4-dione In a similar manner to the procedures described in Reference Example 3, reactions were carried out using 6-chloropyrimidine-2,4-dione, instead of pyrimidine-2,4-dione, and using 2-(trimethylsilyl)ethoxymethyl chloride, instead of benzyloxymethyl chloride, to give the title compound (yield 71%) as a white powder. 1H-Nuclear magnetic resonance spectrum (400 MHz, CDCl3) delta ppm: 9.10 (1H, br.s), 5.93 (1H, s), 5.45 (2H, s), 3.68 (2H, t, J=8Hz), 0.96 (2H, t, J=8Hz), 0.01 (9H, s).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,4270-27-3, its application will become more common.

Reference:
Patent; Sankyo Company Limited; EP1069110; (2001); A1;,
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Pyrimidine – Wikipedia

Related Products of 1197953-49-3, Adding some certain compound to certain chemical reactions, such as: 1197953-49-3, name is (2-((2,5-Dichloropyrimidin-4-yl)amino)phenyl)dimethylphosphine oxide,molecular formula is C12H12Cl2N3OP, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 1197953-49-3.

Add compound 20 (150 mg, 0.6 mmol), compound 5 (189 mg, 0.6 mmol) and ethylene glycol monomethyl ether (3 mL) to a 25 mL single-necked flask equipped with a magnetic stirring and a condensing tube, stir and dissolve, and add hydrogen chloride dropwise. Isopropyl alcohol solution(0.9 mmol, 0.18 mL, 5 M), the temperature was raised to 120 C under a nitrogen atmosphere and the reaction was stirred overnight. Cool to room temperature and add water(10 mL) and saturated sodium bicarbonate (5 mL), dichloromethane (15 mL¡Á3)The combined organic layers were washed with brine, dried over anhydrous sodium sulfateThe residue was passed through a silica gel column to give a white solid160mg,The yield was 50.1%.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 1197953-49-3, (2-((2,5-Dichloropyrimidin-4-yl)amino)phenyl)dimethylphosphine oxide, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Shenzhen Tajirui Bio-pharmaceutical Co., Ltd.; Wang Yihan; Li Huanyin; (67 pag.)CN109369721; (2019); A;,
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Pyrimidine – Wikipedia

Related Products of 36082-45-8, Adding some certain compound to certain chemical reactions, such as: 36082-45-8, name is 2-Amino-5-bromo-4-methoxypyrimidine,molecular formula is C5H6BrN3O, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 36082-45-8.

Method 15; Synthesis of 4-methoxy-5-(4,4,5,5-tetramethyl- (1,3 ,2-dioxaborolan-2-yl))pyrimidine-2-ylamine; [0256] To a dry 200-mL flask was added 5-bromo-4-methoxypyrimidine-2- ylamine (2.88 g, 14.1 mmol), potassium acetate (4.16 g, 42.4 mmol), 4,4,5,5-tetramethyl- 2-(4,4,5,5-tetramethyl-l,3,2-dioxaborolan-2-yl)-l,3,2-dioxaborolane (3.76 g, 14.8 mmol) and dioxane (75 mL). Argon was bubbled through the solution for 15 minutes, at which time 1 , l’-bis(diphenylphosphino)ferrocene palladium(II) chloride dichloromethane adduct (0.58 g, 0.71 mmol). The reaction was refluxed in a 115 0C oil bath for 21 hours under argon. After cooling to room temperature, the dioxane was removed in vacuo. EtOAc (500 mL) was added and the resulting slurry was sonicated and filtered. Additional EtOAc (500 mL) was used to wash the solid. The combined organics were concentrated and the crude material was purified by silica gel chromatography (EtOAc as eluent) yielding 2.4 g of an off white solid. By 1H NMR the material was a 1 :1 mixture of boronate ester and 4-methoxypyrimidine-2-ylamine. The material was used as is in subsequent Suzuki reactions. LCMS (m/z): 170 (MH+ of boronic acid, deriving from in situ product hydrolysis on LC); 1H NMR (CDCl3): delta 8.42 (s, IH), 5.22 (bs, 2H), 3.90 (s, 3H), 1.34 (s, 12H).

According to the analysis of related databases, 36082-45-8, the application of this compound in the production field has become more and more popular.

Reference:
Patent; NOVARTIS VACCINES AND DIAGNOSTICS, INC.; WO2008/98058; (2008); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 22276-95-5, name is 5-Bromo-4-chloro-7H-pyrrolo[2,3-d]pyrimidine. This compound has unique chemical properties. The synthetic route is as follows. SDS of cas: 22276-95-5

N,O-Bis(trimethylsilyl)acetamide (BSA, 0.56 mL, 2.27 mmol) was added to a stirred suspension of 5-bromo-4-chloro-7H-pyrrolo[2,3-d]pyrimidine (480 mg, 2.06 mmol) in dry acetonitrile (15 mL). After stirring at rt for 10 min, 1-O-acetyl-2,3,5-tri-O-benzoyl-beta-d-ribofuranose (1.16 g, 2.31 mmol) was added, followed by the addition of trimethylsilyl trifluoromethanesulfonate (0.41 mL, 2.25 mmol). The reaction mixture was stirred at rt for 15 min, after which the flask was transferred to a preheated 80 C oil bath. After stirring for 1 h at 80 C, the reaction mixture was cooled to rt and diluted with EtOAc (75 mL). The organic phase was sequentially washed with aqueous saturated NaHCO3 solution and brine, dried (Na2SO4), filtered, and concentrated under reduced pressure to afford the crude nucleoside. Purification by flash column chromatography (silica gel, 20-100% EtOAc/hexanes gradient) provided (1) as a colorless foam (870 mg, 63%). TLC (silica gel, hexanes/ethyl acetate 3:1): Rf = 0.45. LRMS (ESI): 677.3, 675.2 and 673.2 [M+H]+.

With the rapid development of chemical substances, we look forward to future research findings about 22276-95-5.

Reference:
Article; Yu, Wenyu; Smil, David; Li, Fengling; Tempel, Wolfram; Fedorov, Oleg; Nguyen, Kong T.; Bolshan, Yuri; Al-Awar, Rima; Knapp, Stefan; Arrowsmith, Cheryl H.; Vedadi, Masoud; Brown, Peter J.; Schapira, Matthieu; Bioorganic and Medicinal Chemistry; vol. 21; 7; (2013); p. 1787 – 1794;,
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Pyrimidine – Wikipedia

Related Products of 39906-04-2, Adding some certain compound to certain chemical reactions, such as: 39906-04-2, name is 4,6-Dichloro-2-methylpyrimidin-5-amine,molecular formula is C5H5Cl2N3, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 39906-04-2.

Preparation 23 4-(5-amino-6-chloro-2-methyl-pyrimidin-4-ylamino)-3-fluoro -phenol; A 10ml flask was charged with EtOH (3ml_). 2-methyl-4,6-dichloro-5-aminopyrimidine was added (140mg, 1.89 mMol) followed by 4-amino-3-fluoro-phenol (100mg, 1.89 mMol) and HCI (2M aq, 0.787ml_, 3.78 mMol). The reaction mixture was heated at 850C under N2 for 6 hours. The reaction mixture was evaporated, partitioned between 10 ml sodium bicarbonate solution and 10 ml ethyl acetate, the aqueous was extracted again twice with 10 ml ethyl acetate, the organics were combined, dried over magnesium sulphate, filtered and evaporated to give a purple gum (416 mg, 82%).LCMS (System 4, acidic run): 2.02 mins m/z (APCI) = 269 [MH+]

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 39906-04-2, 4,6-Dichloro-2-methylpyrimidin-5-amine, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; PFIZER LIMITED; WO2009/144632; (2009); A1;,
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Pyrimidine – Wikipedia

Electric Literature of 2227-98-7, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 2227-98-7, name is 4-Aminopyrrolo[3,2-d]pyrimidine, molecular formula is C6H6N4, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

Example 8.3: (+/-)-frans-4-Butyl-1-[(9-deaza-adenin-9-yl)methyl]-3-hydroxypyrrolidine (1, X = butyl, A = CH, B = NH2, D = H); Formaldehyde (95 mul_, 1.2 mmol, 37 wt% solution in water) followed by 9-deazaadenine (100 mg, 0.7 mmol) are added to a solution of amine 11 (X = butyl) (88 mg, 0.66 mmol) in 1 ,4- dioxane (1.2 ml.) and water (2.5 ml_). The reaction mixture is stirred at room temperature for 66 h, absorbed on to silica and eluted down a silica column using a gradient 10 – 20% (7 N NH3 in MeOH) in CH2CI2. The crude product is collected, concentrated and subject to flash chromatography (5 :4.8 : 0.2, CH2CI2 : MeOH : NH4OH) to afford the title compound 1 (X = butyl, A = CH, B = NH2, D = H) as a pale yellow solid (89 mg, 47%). 13C NMR (125 MHz, CD3OD): delta = 152.1 , 151.0, 147.0, 130.1 , 115.2, 112.4, 77.7, 62.3, 59.69, 49.0, 48.5, 34.0, 31.5, 23.8 and 14.3 ppm; MS (ESI): 290 ([MH]+, 100%); HRMS (ESI): found: 290.1989, C15H24N5O ([MH]+) requires: 290.1981.

According to the analysis of related databases, 2227-98-7, the application of this compound in the production field has become more and more popular.

Reference:
Patent; ALBERT EINSTEIN COLLEGE OF YESHIVA UNIVERSITY; INDUSTRIAL RESEARCH LIMITED; EVANS, Gary Brian; LONGSHAW, Alistair Ian; SCHRAMM, Vern L.; TYLER, Peter, Charles; WO2011/8110; (2011); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 56843-79-9, name is 4-Chloro-2-methylthieno[2,3-d]pyrimidine, the common compound, a new synthetic route is introduced below. Computed Properties of C7H5ClN2S

General conditions1: Chloropyrimidine 5 (0.45 mmol) and aminopyrazole 6 (0.30 mmol) were mixed in 1:1 acetic acid/water solution (1.4 mL) or in glacial acetic acid (1.4 mL) and stirred at 100 C in an oil bath for 1 h (or 50 C for 4 h or 25 C for 18 h). The mixture was neutralized by the addition of ice-cold 5% NaOH solution (10 mL) and extracted with methylene chloride (3 ¡Á 25 mL). Combined organic layers were dried and concentrated. The residue was further purified by normal phase flash chromatography (Biotage, for cPropylphenyl analogs R = C) or reversed phase preparative HPLC (analogs with free amines R = A or B), affording the desired aminopyrimidines (7-30).

The synthetic route of 56843-79-9 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Guo, Chuangxing; Dong, Liming; Marakovits, Joseph; Kephart, Susan; Tetrahedron Letters; vol. 52; 14; (2011); p. 1692 – 1696;,
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Pyrimidine – Wikipedia

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 32779-36-5, name is 5-Bromo-2-chloropyrimidine, the common compound, a new synthetic route is introduced below. Recommanded Product: 5-Bromo-2-chloropyrimidine

5-bromo-2-chloropyrimidine (1g, 5.17mmol) was dissolved in N, N- dimethylformamide (20 mL) was added 4-hydroxypiperidine (522.7mg, 5.17mmol) and triethylamine (1.05 g, 10.34mmol), The reaction was heated to 100C 16 hours, the reaction was complete TLC (PE: EA = 5: 1), water (20 mL), extracted with ethyl acetate (50mL ¡Á 2), the organic phases were combined, washed with water, without over anhydrous sodium sulfate, and concentrated in vacuo to give the title compound (1.3 g of, yield 97.7percent)

The synthetic route of 32779-36-5 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Shandong xuanzhu Pharmaceutical Technology Co., Ltd.; Wu, Yongqian; Tian, Yuwei; (59 pag.)CN106167486; (2016); A;,
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Pyrimidine – Wikipedia

Adding a certain compound to certain chemical reactions, such as: 1439-10-7, 4-Amino-5-bromopyrimidine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, HPLC of Formula: C4H4BrN3, blongs to pyrimidines compound. HPLC of Formula: C4H4BrN3

Preparation 46A: 4-Aminopyrimidin-5-ylboronic acid[00148] To a vial was added 5-bromopyrimidin-4-amine (0.200 g, 1.149 mmol), bis(pinacolato)diboron (0.438 g, 1.724 mmol), and potassium acetate (0.338 g, 3.45 mmol). The vial was capped with a rubber septum and then evacuated and backfilled with N2. Dioxane (volume: 0.120 ml) was added via syringe through the septum. The reaction mixture was sparged with N2, then l, l’-bis(diphenylphosphino)ferrocenedichloropalladium(II) dichloromethane complex (0.042 g, 0.057 mmol) was added. The septum was then replaced with a Teflon screw valve and the vial sealed. The reaction mixture was heated at 105 C in a metal pie block. After 18 h, the reaction mixture was allowed to cool to room temperature. The reaction mixture was filtered through a disposable fritted funnel and the filter cake washed with EtOAc. The filtrate was concentrated to afford a brown solid. The crude material was used without further purification. MS (ESI) : m/z = 140.0 [M+H]+. HPLC Peak tr = 0.24 minutes. HPLC conditions: Column:Luna CI 8 4.6x30mm 3u A: 10:90 H20:ACN NH4OAc/B: 10:90 H20:ACN NH4OAc; 0%-95%B in 2 min; 4mL/min flow.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,1439-10-7, 4-Amino-5-bromopyrimidine, and friends who are interested can also refer to it.

Reference:
Patent; BRISTOL-MYERS SQUIBB COMPANY; HUANG, Audris; WO2012/44537; (2012); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Related Products of 16632-21-6, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 16632-21-6, name is 5-Nitro-6-methyluracil. A new synthetic method of this compound is introduced below.

The raw material 12 (1 eq) was dissolved in 17.54 ml of phosphorus oxychloride, and 2.92 ml of N, N-dimethylaniline (1 eq) was slowly added dropwise at room temperature, and 8.04 ul of DMF (0.00445 eq) 120 under reflux reaction 8h, after the completion of the reaction of raw materials, vacuum distillation of phosphorus oxychloride, adding ice water, adding ethyl acetate extraction, combined organic layer, washed with saturated brine, dried over anhydrous sodium sulfate, spin dry Solvent to give a yellowish brown oil which was dryly chromatographed and finally purified to give a yellow solid 13 (1 g) in 65% yield.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,16632-21-6, its application will become more common.

Reference:
Patent; SICHUAN BAILI PHARMACEUTICAL CO LTD; WU, YONG; ZHU, YI; HAI, LI; WANG, YIXI; LI, JIE; (23 pag.)CN105906621; (2016); A;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia