Pyrimidines

Related Products of 2927-71-1, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.2927-71-1, name is 2,4-Dichloro-5-fluoropyrimidine, molecular formula is C4HCl2FN2, molecular weight is 166.9685, as common compound, the synthetic route is as follows.

A solution of morpholine(870 mg, 10 mmol) in 10 mL EtOH was added slowly to a cooled solution of 18 (1.84g,11 mmol) and K2CO3 (2.76 g, 20 mmol) in EtOH (30 mL), and the mixture wasstirred for about 30 min at 0oC. Stirring was continued for 4h at room temperature andthe reaction was monitored by TLC. The reaction mixture was concertrated, dilutedwith ethyl acetate, washed, intandem, with water and brine. The organic phase wasdried, filtered and concentratedin vacuo to give the title compound (1.87 g) which wasused in the next step without further purification, yield 86%.

The chemical industry reduces the impact on the environment during synthesis 2927-71-1, I believe this compound will play a more active role in future production and life.

Reference:
Article; Wu, Xiaoai; Fang, Zhen; Yang, Bo; Zhong, Lei; Yang, Qiuyuan; Zhang, Chunhui; Huang, Shenzhen; Xiang, Rong; Suzuki, Takayoshi; Li, Lin-Li; Yang, Sheng-Yong; Bioorganic and Medicinal Chemistry Letters; vol. 26; 9; (2016); p. 2284 – 2288;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Application of 659729-09-6, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.659729-09-6, name is 4-Chloro-6-(4-(trifluoromethyl)phenyl)pyrimidine, molecular formula is C11H6ClF3N2, molecular weight is 258.63, as common compound, the synthetic route is as follows.

EXAMPLE 4 N-(5,6,7,8-Tetrahydronaphthalen-1-yl)-6-(4-(trifluoromethyl)phenyl)-pyrimidin-4-amine A mixture of 4-chloro-6-(4-(trifluoromethyl)phenyl) pyrimidine, Example 1(a), (0.26 g, 1.0 mmol) and 1,2,3,4-tetrahydro-1-naphthylamine (0.15 g, 1.0 mmol, Aldrich) in EtOH (1 mL) was heated in a microwave synthesizer at 120 C. for 15 min. The reaction mixture was evaporated under reduced pressure and the residue was dissolved in DCM. The DCM solution was washed with 10% sodium carbonate, dried over sodium sulfate and filtered. The filtrate was evaporated under reduced pressure and the residue purified by silica gel column chromatography (2:1:1 hexane/EtOAc/CHCl3) to give the title compound as an off-white amorphous solid. MS (ESI, pos. ion) m/z: 370.

The chemical industry reduces the impact on the environment during synthesis 659729-09-6, I believe this compound will play a more active role in future production and life.

Reference:
Patent; Doherty, Elizabeth M.; Katon, Jodie; Norman, Mark H.; Retz, Daniel M.; Wang, Xianghong; Bo, Yunxin Y.; Tamayo, Nuria; Nishimura, Nobuko; Liao, Hongyu; US2006/241296; (2006); A1;,
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Pyrimidine – Wikipedia

Application of 149849-94-5, Adding some certain compound to certain chemical reactions, such as: 149849-94-5, name is Methyl 2-chloropyrimidine-4-carboxylate,molecular formula is C6H5ClN2O2, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 149849-94-5.

To a solution of methyl 2-chloropyrimidine-4-carboxylate (30.00 g, 173.84 mmol) in dioxane (300 mL) was added TEA (26.39 g, 260.77 mmol) and ()-1-phenylethanamine(25.28 g, 208.61 mmol). After addition, it was heated at 50C for 4 h. TLC indicated that the reaction was completed. The solvent was removed by concentration in vacuo and residue was dissolved in ethyl acetate (200 mL), washed by water (100 mL x 2) and brine (100 mL). The separated organic layer was dried over sodium sulfate, filtered and concentrated. The crude product was purified by silica gel column chromatography (eluted by DCM : MeOH = 60:1)to give desired product as light yellow solid (38.00 g, yield 85.0%).

According to the analysis of related databases, 149849-94-5, the application of this compound in the production field has become more and more popular.

Reference:
Patent; SHANGHAI METON PHARMACEUTICAL CO., LTD; YANG, Jibin; (67 pag.)WO2018/95344; (2018); A1;,
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Pyrimidine – Wikipedia

Related Products of 767-15-7, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.767-15-7, name is 2-Amino-4,6-dimethylpyrimidine, molecular formula is C6H9N3, molecular weight is 123.16, as common compound, the synthetic route is as follows.

General procedure: To a stirred mixture of 4-methylbenzaldehyde (1 mmol, 0.120 g) and N,N,N’,N’-tetrabromobenzene-1,3-disulfonamide [TBBDA] (0.05 g, 0.09 mmol) or poly(N-bromo-N-ethyl-benzene-1,3-disulfonamide) [PBBS] (0.12 g) at room temperature, was added 2-amino-4,6-dimethylpyrimidin (1 mmol, 0.123 g). Then, indole (1 mmol, 0.12 g) was added to the mixture after 10 min. The progress of the reaction was monitored by TLC (n-hexane/acetone, 17:2). After completion of the reaction, EtOH (5 mL) was added to the reaction mixture and the colorless precipitate was filtered (after evaporation of the ethanol, cool methylene dichloride (2 mL) was added, and the catalyst was recovered), washed with EtOH and dried and purified by recrystallization from ethanol.

Statistics shows that 767-15-7 is playing an increasingly important role. we look forward to future research findings about 2-Amino-4,6-dimethylpyrimidine.

Reference:
Article; Ghorbani-Vaghei, Ramin; Shahbazi, Hajar; Toghraei-Semiromi, Zahra; Comptes Rendus Chimie; vol. 17; 2; (2014); p. 118 – 123;,
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Pyrimidine – Wikipedia

Synthetic Route of 39906-04-2, Adding some certain compound to certain chemical reactions, such as: 39906-04-2, name is 4,6-Dichloro-2-methylpyrimidin-5-amine,molecular formula is C5H5Cl2N3, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 39906-04-2.

4-Chloro-6-(2-fluoro-4-trifluoromethyl-phenyl)-2-methyl-pyhmidin-5-ylamine (Intermediate compound 4) To a solution of commercially available 5-amino-4,6-dichloro-2- methylpyrimidine (2.500 g, 15.2444 mmol) in DME (100 ml) and water (20 ml), 2- fluoro-4-(thfluoromethyl)phenylboronic acid (3.1696 g, 15.2444 mmol) and sodium carbonate (4.847 g, 45.7332 mmol) were added. The reaction mixture was degassed and kept under nitrogen atmosphere during the entire course of the reaction. Palladium (II) (bistriphenylphosphine)dichlohde (0.535 g, 0.7622 mmol) was added and the resulting reaction mixture, heated at 9O0C for 8 hrs, was worked up by addition of water and extraction with AcOEt. The organic phase, dried over anhydrous MgSO4, afforded upon evaporation a dark oily residue (-4.5 g), which was purified by preparative HPLC, to afford 1.21 O g (-26% yield) of the pure title compound.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 39906-04-2, 4,6-Dichloro-2-methylpyrimidin-5-amine, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; NEUROSEARCH A/S; WO2009/112461; (2009); A1;,
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Pyrimidine – Wikipedia

Adding a certain compound to certain chemical reactions, such as: 3438-46-8, 4-Methylpyrimidine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, SDS of cas: 3438-46-8, blongs to pyrimidines compound. SDS of cas: 3438-46-8

A mixture of 4-methylpyrimidine (22) (10 g, 106 mmol), N,Ndimethylformamidedimethylacetal (DMFDMA) (38 g, 319 mmol)and DMF (46.6 g, 637 mmol) was stirred in a sealed-tube at140 C for 24 h. After cooling, the solution was evaporated in vacuoto yield the title compound 23 (15.08 g, 95%). 1H NMR (CDCl3) d:8.73 (br s, 1H), 8.22 (d, J = 5.5 Hz, 1H), 7.77 (d, J = 12.9 Hz, 1H),6.72 (dd, J = 5.5, 12.9 Hz, 1H), 5.00 (d, J = 12.9 Hz, 1H), 2.96 (s, 6H).

The synthetic route of 3438-46-8 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Hasumi, Koichi; Sato, Shuichiro; Saito, Takahisa; Kato, Jun-Ya; Shirota, Kazuhiko; Sato, Jun; Suzuki, Hiroyuki; Ohta, Shuji; Bioorganic and Medicinal Chemistry; vol. 22; 15; (2014); p. 4162 – 4176;,
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Pyrimidine – Wikipedia

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 591-55-9, name is 5-Aminopyrimidine. This compound has unique chemical properties. The synthetic route is as follows. COA of Formula: C4H5N3

(2) 2,2,2-Trichloroethyl pyrimidin-5-ylcarbamate; To a solution of pyrimidine-5-amine (100 mg, 1.05 mmol) and pyridine (0.255 ml, 3.15 mmol) in tetrahydrofuran (3 ml) was added 2,2,2-trichloroethyl chloroformate (0.217 ml, 1.58 mmol) with ice-cooling, the mixture was stirred for 30 minutes with ice-cooling, the reaction mixture was poured into ice-water and the mixture was extracted with ethyl acetate. The extract was washed with water and dried over anhydrous magnesium sulfate and the solvent was distilled off under reduced pressure. The residue was purified by silica gel column chromatography (hexane : ethyl acetate = 1 : 1) to obtain the desired product (100 mg, 35.2%) as a solid. 1H-NMR (CDCl3) delta; 4.87 (2H, s), 7.60 (1H, br s), 8.95 (2H, s), 9.02 (1H, s).

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 591-55-9, 5-Aminopyrimidine.

Reference:
Patent; Takeda Pharmaceutical Company Limited; EP1813606; (2007); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Application of 25940-35-6, Adding some certain compound to certain chemical reactions, such as: 25940-35-6, name is Pyrazolo[1,5-a]pyrimidine-3-carboxylic acid,molecular formula is C7H5N3O2, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 25940-35-6.

PyBOP (298 mg, 572 pmol) was added to a mixture of 8-amino-3-(2-chlorophenyl)-1,3- diazaspiro[4.5]decane-2,4-dione (mixture of cis-/trans-isomers) (140 mg, 477 pmol, Intermediate 36), pyrazolo[1 ,5-a]pyrimidine-3-carboxylic acid (97.2 mg, 596 pmol) and N,Ndiisopropylethylamine (420 p1, 2.4 mmol) in DMF (1.7 ml) and the mixture was stirred overnight at room temperature. For work-up, water was added and the mixture was extracted with ethyl acetate. The combined organic phases were filtered through a silicone filter and concentrated. The residue was purified by preparative HPLC to give the title compound 45.0 mg (21 % yield).[C-MS (Method 2): R = 0.88 mm; MS (ESIneg): m/z = 437 [M-H]1HNMR (400 MHz, DMSO-d6): 6 [ppm] = 9.34-9.31 (m, 1H), 8.93 (5, 1H), 8.82 (dd, 1H), 8.59 (5, 1H), 8.11 (d, 1H), 7.68-7.64 (m, 1H), 7.56-7.45 (m, 3H), 7.29-7.25 (m, 1H), 4.14-4.04 (m, 1 H), 2.23-1.67 (m, 8H)

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 25940-35-6, Pyrazolo[1,5-a]pyrimidine-3-carboxylic acid, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; BAYER PHARMA AKTIENGESELLSCHAFT; BUCHGRABER, Philipp; WAGNER, Sarah; SUeLZLE, Detlev; BENDER, Eckhard; LI, Volkhart, Min-Jian; LIU, Ningshu; SIEGEL, Franziska; LIENAU, Philip; (232 pag.)WO2018/78009; (2018); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.36822-08-9, name is Benzo[4,5]thieno[3,2-d]pyrimidin-4(3H)-one, molecular formula is C10H6N2OS, molecular weight is 202.2324, as common compound, the synthetic route is as follows.Safety of Benzo[4,5]thieno[3,2-d]pyrimidin-4(3H)-one

Benzo[4,5]thieno[3,2-d]pyrimidin-4(3H)-one (10.78 g, 26.7 mmol) was treated with pyridine (2.68 mL, 33.3 mmol) and phosphoryl trichloride (53.4 mL, 573 mmol), then heated to reflux at 110 C. for 1 hr. Excess POC3was removed and cautiously quenched with ice water in an ice bath. The pH was adjusted to 5 with ammonium hydroxide. Solid was collected by filtration washed with water. The solid was dried to give 4-chlorobenzo[4,5]thieno[3,2-d]pyrimidine (10 g, 85% yield).

At the same time, in my other blogs, there are other synthetic methods of this type of compound,36822-08-9, Benzo[4,5]thieno[3,2-d]pyrimidin-4(3H)-one, and friends who are interested can also refer to it.

Reference:
Patent; Universal Display Corporation; Joseph, Scott; Kwang, Raymond; Lee, Chi Hang; Shia, Chuan Jun; Ram, SiV Cheung; (131 pag.)KR2015/9461; (2015); A;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Application of 129872-81-7, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 129872-81-7, name is 2,4-Dichloro-5-methyl-5H-pyrrolo[3,2-d]pyrimidine. This compound has unique chemical properties. The synthetic route is as follows.

General procedure: An oven-dried 15 mL pressure tube cooled under nitrogen, charged with 123 mg (0.61 mmol) of 2,6 dichloro-7-methyl-7H-purine (See US 20110086840 A1 for synthesis) and anhydrous ethanol/ DMF (0.5 mL/0.3 mL, 0.76M). N,N-diisopropylethylamine (0.130 mL,0.73mmol) was added via syringe followed by morpholine (0.064 mL, 0.73 mmol). The pressure tube was flushed with nitrogen and the septa replaced by a Teflon screw cap. The reaction mixture stirred overnight at room temperature. The reaction mixture was poured into 50 % ether/ethyl acetate and washed 1x with 50% brine and 1x with brine.The organic layer was dried (MgSO4), filtered , concentrated to yield 119 mg of crude product (77.6%) which was taken directly into the next step. 1H NMR (400MHz, DMSO d6) d 8.44 (s, 1H), 3.96 (s, 3H), 3.80 – 3.71(m, 4H), 3.53 – 3.44 (m, 4H). LC/MS-m/z FontWeight=”Bold” FontSize=”10″ 254.5 (M+H)+.

According to the analysis of related databases, 129872-81-7, the application of this compound in the production field has become more and more popular.

Reference:
Article; Lee, Wendy; Ortwine, Daniel F.; Bergeron, Philippe; Lau, Kevin; Lin, Lichuan; Malek, Shiva; Nonomiya, Jim; Pei, Zhonghua; Robarge, Kirk D.; Schmidt, Stephen; Sideris, Steve; Lyssikatos, Joseph P.; Bioorganic and Medicinal Chemistry Letters; vol. 23; 18; (2013); p. 5097 – 5104;,
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Pyrimidine – Wikipedia