Zhang, Hongwang; Zhou, Longhu; Amichai, Sarah; Zandi, Keivan; Cox, Bryan; Schinazi, Raymond; Amblard, Franck published the artcile< Novel influenza polymerase PB2 inhibitors for the treatment of influenza A infection>, Application In Synthesis of 18740-39-1, the main research area is pimodivir derivative preparation influenza A infection polymerase PB2 inhibitor; Antiviral; Flu; Influenza A; Virus.
Exploration of the chem. space of known influenza polymerase PB2 inhibitor Pimodivir, was performed by our group. We synthesized and identified compounds I and II, two novel thienopyrimidine derivatives displaying anti-influenza A activity in the single digit nanomolar range in cell culture. Binding of these unique compounds in the influenza polymerase PB2 pocket was also determined using mol. modeling.
Bioorganic & Medicinal Chemistry Letters published new progress about Antiviral agents (anti-influenza A). 18740-39-1 belongs to class pyrimidines, and the molecular formula is C6H2Cl2N2S, Application In Synthesis of 18740-39-1.
Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia