Zengeya, Thomas published the artcileTriple-Helical Recognition of RNA Using 2-Aminopyridine-Modified PNA at Physiologically Relevant Conditions, COA of Formula: C26H26N4O7, the publication is Angewandte Chemie, International Edition (2012), 51(50), 12593-12596, database is CAplus and MEDLINE.
It was recently proposed that biol. relevant double-stranded RNAs (dsRNAs) could be recognized by major groove-binding peptide nucleic acids (PNAs), resulting in triple-helix formation. The present work demonstrates that sequence-selective recognition of duplex RNA can be achieved under physiol. relevant conditions by PNAs containing 2-aminopyridine (M). After preliminary studies that confirmed the binding of M-modified PNAs to RNA hairpin structures, pri-miRNA-215 was selected as an example of a biol. relevant RNA duplex for binding studies with M-modified PNA. Using an RNA hairpin model that contains the purine-rich recognition site present in pri-miRNA-215, it was shown that a PNA containing three M bases recognized the model hairpin with high affinity and 1:1 stoichiometry.
Angewandte Chemie, International Edition published new progress about 169396-92-3. 169396-92-3 belongs to pyrimidines, auxiliary class Pyrimidine,Carboxylic acid,Amine,Amide,Others,PNA, name is 2-(N-(2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)ethyl)-2-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)acetamido)acetic acid, and the molecular formula is C12H10F2Si, COA of Formula: C26H26N4O7.
Referemce:
https://pubchem.ncbi.nlm.nih.gov/compound/Pyrimidine,
Pyrimidine – Wikipedia