Yang, Fan; Su, Huilin; Deng, Ji; Mou, Luohe; Wang, Huali; Li, Rong; Dai, Qing-Qing; Yan, Yu-Hang; Qian, Shan; Wang, Zhouyu; Li, Guo-Bo; Yang, Lingling published an article in 2021. The article was titled 《Discovery of new human Sirtuin 5 inhibitors by mimicking glutaryl-lysine substrates》, and you may find the article in European Journal of Medicinal Chemistry.COA of Formula: C4H2Cl2N2 The information in the text is summarized as follows:
Human sirtuin 5 (SIRT5) plays pivotal roles in metabolic pathways and other biol. processes, and is involved in several human diseases including cancer. Development of new potent and selective SIRT5 inhibitors is currently desirable to provide potential therapeutics for related diseases. Herein, we report a series of new 3-thioureidopropanoic acid derivatives, which were designed to mimic the binding features of SIRT5 glutaryl-lysine substrates. Structure-activity relationship studies revealed several compounds with low micromolar inhibitory activities to SIRT5. Computational and biochem. studies indicated that these compounds exhibited competitive SIRT5 inhibition with respect to the glutaryl-lysine substrate rather than NAD cofactor. Moreover, they showed high selectivity for SIRT5 over SIRT1-3 and 6 and could stabilize SIRT5 proteins as revealed by thermal shift analyses. This work provides an effective substrate-mimicking strategy for future inhibitor design, and offers new inhibitors to investigate their therapeutic potentials in SIRT5-associated disease models. After reading the article, we found that the author used 2,4-Dichloropyrimidine(cas: 3934-20-1COA of Formula: C4H2Cl2N2)
2,4-Dichloropyrimidine(cas: 3934-20-1) is a member of organic chlorides. Organic chloride content in crude oil can be detected through specialized laboratory analysis. Care and attention are essential while sampling and testing.COA of Formula: C4H2Cl2N2
Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia