In 2018,Wu, Chien-Huang; Song, Jen-Shin; Kuan, Hsuan-Hao; Wu, Szu-Huei; Chou, Ming-Chen; Jan, Jiing-Jyh; Tsou, Lun K.; Ke, Yi-Yu; Chen, Chiung-Tong; Yeh, Kai-Chia; Wang, Sing-Yi; Yeh, Teng-Kuang; Tseng, Chen-Tso; Huang, Chen-Lung; Wu, Mine-Hsine; Kuo, Po-Chu; Lee, Chia-Jui; Shia, Kak-Shan published 《Development of Stem-Cell-Mobilizing Agents Targeting CXCR4 Receptor for Peripheral Blood Stem Cell Transplantation and Beyond》.Journal of Medicinal Chemistry published the findings.Related Products of 3764-01-0 The information in the text is summarized as follows:
The function of the CXCR4/CXCL12 axis accounts for many disease indications, including tissue/nerve regeneration, cancer metastasis, and inflammation. Blocking CXCR4 signaling with its antagonists may lead to moving out CXCR4+ cell types from bone marrow to peripheral circulation. We have discovered a novel series of pyrimidine-based CXCR4 antagonists, a representative (i.e., 16) of which was tolerated at a higher dose and showed better HSC-mobilizing ability at the maximal response dose relative to the approved drug 1 (AMD3100), and thus considered a potential drug candidate for PBSCT indication. Docking compound 16 into the X-ray crystal structure of CXCR4 receptor revealed that it adopted a spider-like conformation striding over both major and minor subpockets. This putative binding mode provides a new insight into CXCR4 receptor-ligand interactions for further structural modifications. The experimental process involved the reaction of 2,4,6-Trichloropyrimidine(cas: 3764-01-0Related Products of 3764-01-0)
2,4,6-Trichloropyrimidine(cas: 3764-01-0) is a member of organic chlorides. Almost all organochlorine compounds are synthesized. It is widely used as intermediates, solvents and pesticides of chemical synthetic products.Related Products of 3764-01-0
Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia