On August 26, 2015, Wang, Nenghui; Xu, Rongzhen; Xie, Meiqiang; Gan, Xiaoxian; Xue, Yinghan published a patent.SDS of cas: 63931-21-5 The title of the patent was Pyrimidine derivative as T790 variation inhibitor. And the patent contained the following:
Title compounds I [wherein A and B independently = N and CH; R1 = C1-C8 linear or branched alkyl or substituted C1-C8 linear or branched alkyl; R2 = C1-C8 linear or branched alkyl, C1-C8 linear or branched alkoxy, etc.; R3 = H, F, Cl, Br, I, etc.; R4 = C1-C8 linear or branched alkyl, substituted C1-C8 linear or branched alkyl, etc.], and their pharmaceutically acceptable salts thereof, were prepared as T790 variation inhibitors useful for treating drug-resistant tumor caused by T790M variation. Thus, the invention compound I [A = B = CH; R1 = i-Pr; R2 = CHF2; R3 = F; R4 = C(O)Me]was prepared from 5-bromo-2,4,6-trichloropyrimidine in a multi-step synthesis. The experimental process involved the reaction of 5-Bromo-2,4,6-trichloropyrimidine(cas: 63931-21-5).SDS of cas: 63931-21-5
The Article related to pyrimidine preparation antitumor, Heterocyclic Compounds (More Than One Hetero Atom): Pyrimidines and Quinazolines and other aspects.SDS of cas: 63931-21-5
Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia