On August 26, 2015, Wang, Nenghui; Xu, Rongzhen; Xie, Meiqiang; Gan, Xiaoxian; Xue, Yinghan published a patent.Formula: C4BrCl3N2 The title of the patent was Preparation of pyrimidine derivatives as anaplastic lymphoma kinase inhibitors. And the patent contained the following:
The title pyrimidine derivatives I [wherein W = NH; R1 = (un)substituted C1-C8 linear or branched alkyl; R2 = C1-C8 linear or branched alkyl, alkoxy, etc.; or W and R2 form a ring; R3 = H, F, Cl, Br, I, etc.; R4 = S(O2)R5, S(O)R5R6, or P(O)R5R6; R5 and R6 = independently C1-C8 (un)substituted linear or branched alkyl] or pharmaceutically acceptable salts thereof were prepared as anaplastic lymphoma kinase inhibitors for treating cancer, especially non-small cell lung cancer. For example, II was prepared in a multi-step synthesis. The experimental process involved the reaction of 5-Bromo-2,4,6-trichloropyrimidine(cas: 63931-21-5).Formula: C4BrCl3N2
The Article related to preparation pyrimidine anaplastic lymphoma kinase inhibitor treatment cancer human, Heterocyclic Compounds (More Than One Hetero Atom): Pyrimidines and Quinazolines and other aspects.Formula: C4BrCl3N2
Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia