Electric Literature of 42839-08-7, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.42839-08-7, name is Ethyl pyrimidine-2-carboxylate, molecular formula is C7H8N2O2, molecular weight is 152.15, as common compound, the synthetic route is as follows.
A mixture of ethyl pyrimidin-2-carboxylate (100 gm) and hydrazine hydrate (50 ml in ethanol (500 ml) was stirred at 30 C over a period of 14 h. The suspension was filtered at suction and the wet cake washed with small quantity of ethanol (25 ml) followed by diethyl ether (50 ml) to provide title compound in 80 gm quantity (88%) as a white solid.Mass: m/z: 139.0 (M+l)IH NMR: (400 Mhz, DMSO d6): 4.60 (br s, 2H, exchangeable), 7.64 (t, IH), 8.91 (d, 2H),10.00 (br s, IH, exchangeable)
The chemical industry reduces the impact on the environment during synthesis 42839-08-7, I believe this compound will play a more active role in future production and life.
Reference:
Patent; WOCKHARDT RESEARCH CENTRE; TRIVEDI, Bharat Kalidas; PATEL, Mahesh Vithalbhai; WO2010/136971; (2010); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia