Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 919278-72-1, name is 5-Methyl-3H-pyrrolo[3,2-d]pyrimidin-4(5H)-one. A new synthetic method of this compound is introduced below., Product Details of 919278-72-1
A mixture of 5-methyl-5H-pyrrolo [3, 2-d]pyrimidin-4-ol(489 mg, 3.28 mmol), 1- (bromomethyl) -4-nitrobenzene (1.06 g, 4.92 mmol), potassium carbonate (1.36 g, 9.84 mmol), sodium iodide (98.3 mg, 0.656 mmol) and N,N-dimethylformamide (7 mL) was stirred at 500C for 15 hr. The reaction mixture was diluted with water, and extracted with ethyl acetate (chi3) . The organic layer was washed with saturated brine, dried over anhydrous magnesium sulfate, and filtrated. The filtrate was concentrated under reduced pressure, and the residue was purified by column chromatography (ethyl acetate/hexane=30/70->100/0) to give the title compound (489 mg, 52%) as a yellow solid. 1H-NMR (DMSO-ds, 300 MHz) delta 3.98 (3H, s) , 5.30 (2H, s) , 6.35 -6.36 (IH, m) , 7.41 (IH,- d, J = 2.7 Hz), 7.54 (2H, d, J = 8.9Hz), 8.20 (2H, d, J = 8.9 Hz), 8.29 (IH, s) .
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Reference:
Patent; TAKEDA PHARMACEUTICAL COMPANY LIMITED; WO2007/4749; (2007); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia