The origin of a common compound about 6-Methoxypyrimidine-2,4(1H,3H)-dione

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Adding a certain compound to certain chemical reactions, such as: 29458-38-6, 6-Methoxypyrimidine-2,4(1H,3H)-dione, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Recommanded Product: 6-Methoxypyrimidine-2,4(1H,3H)-dione, blongs to pyrimidines compound. Recommanded Product: 6-Methoxypyrimidine-2,4(1H,3H)-dione

A mixture of 2,4-dihydroxy-6-methoxypyrimidine (15g, 0.106mol) in phosphorus (III) oxychloride (400ml) was heated under reflux for 4 hours to give solution. Excess is phosphorus (III) oxychloride was removed by evaporation, the residue treated with ice/water and extracted with EtOAc. The combined extracts were washed with water, dried (Na2SO4) and the solvent removed by evaporation to give 2,4-dichloro-6-methoxypyrimidine (5.5g, 30%) as an oil. NMR.3.96 (3H, s), 6.63 (IH, s); m/z.179 [MH]+.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,29458-38-6, 6-Methoxypyrimidine-2,4(1H,3H)-dione, and friends who are interested can also refer to it.

Reference:
Patent; ASTRAZENECA AB; ASTRAZENECA UK LIMITED; WO2008/117051; (2008); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia