Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 49845-33-2, name is 2,4-Dichloro-5-nitropyrimidine. This compound has unique chemical properties. The synthetic route is as follows. Computed Properties of C4HCl2N3O2
Dichloro pyrimidine, 1, (0.34 g, 1.75 mmol) is combined with THF (4 mL) and stirred in an ice/salt water bath under N2 atmosphere. Methylamine (2.0 M in THF, 1.4 mL, 2.8 mmol) is added slowly to the stirring solution. After 10 minutes the mixture is diluted with H2O (20 mL) and extracted with EtOAc (2.x.50 mL). The combined organics are dried over MgSO4 and concentrated. The crude residue is purified over silica (0-10percent. EtOAc/hexanes) to afford 150 mg (46percent yield) or the desired product as a yellow oil. 1H NMR (300 MHz, CDCl3) delta 9.06 (s, 1H), 8.43 (br s, 1H), 3.25 (d, J=5.1 Hz, 3H); ESI/MS: 189 (M+H).
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Reference:
Patent; The Procter & Gamble Company; US7256196; (2007); B1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia