The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 2802-62-2, name is 4,6-Difluoropyrimidine. This compound has unique chemical properties. The synthetic route is as follows. Recommanded Product: 4,6-Difluoropyrimidine
b) Preparation of 4-Fluoro-6-[(alpha,alpha,alpha-trifluoro-m-tolyl)oxy]pyrimidine A solution of m-trifluoromethylphenol (74.5 g, 0.46 mol) in tetrahydrofuran (300 mL) is added dropwise to a mixture of 4,6-difluoropyrimidine (53.8 g, 0.46 mol) and potassium carbonate (60 g, 0.43 mol) in tetrahydrofuran (700 mL). The reaction mixture is stirred at room temperature for 3 days and poured into water. The resultant aqueous mixture is washed with 2Nsodium hydroxide solution and extracted with ethyl acetate. The organic extract is dried over anhydrous magnesium sulfate and concentrated in vacuoto obtain a liquid. the liquid is vacuum distilled to give the title product as an oil (87.4 g, 74% yield).
With the rapid development of chemical substances, we look forward to future research findings about 2802-62-2.
Reference:
Patent; American Cyanamid Company; EP794177; (1997); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia