Electric Literature of 2227-98-7, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 2227-98-7, name is 4-Aminopyrrolo[3,2-d]pyrimidine, molecular formula is C6H6N4, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
Example 8.3: (+/-)-frans-4-Butyl-1-[(9-deaza-adenin-9-yl)methyl]-3-hydroxypyrrolidine (1, X = butyl, A = CH, B = NH2, D = H); Formaldehyde (95 mul_, 1.2 mmol, 37 wt% solution in water) followed by 9-deazaadenine (100 mg, 0.7 mmol) are added to a solution of amine 11 (X = butyl) (88 mg, 0.66 mmol) in 1 ,4- dioxane (1.2 ml.) and water (2.5 ml_). The reaction mixture is stirred at room temperature for 66 h, absorbed on to silica and eluted down a silica column using a gradient 10 – 20% (7 N NH3 in MeOH) in CH2CI2. The crude product is collected, concentrated and subject to flash chromatography (5 :4.8 : 0.2, CH2CI2 : MeOH : NH4OH) to afford the title compound 1 (X = butyl, A = CH, B = NH2, D = H) as a pale yellow solid (89 mg, 47%). 13C NMR (125 MHz, CD3OD): delta = 152.1 , 151.0, 147.0, 130.1 , 115.2, 112.4, 77.7, 62.3, 59.69, 49.0, 48.5, 34.0, 31.5, 23.8 and 14.3 ppm; MS (ESI): 290 ([MH]+, 100%); HRMS (ESI): found: 290.1989, C15H24N5O ([MH]+) requires: 290.1981.
According to the analysis of related databases, 2227-98-7, the application of this compound in the production field has become more and more popular.
Reference:
Patent; ALBERT EINSTEIN COLLEGE OF YESHIVA UNIVERSITY; INDUSTRIAL RESEARCH LIMITED; EVANS, Gary Brian; LONGSHAW, Alistair Ian; SCHRAMM, Vern L.; TYLER, Peter, Charles; WO2011/8110; (2011); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia