Synthetic Route of 23906-13-0 ,Some common heterocyclic compound, 23906-13-0, molecular formula is C6H10N4, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.
Step 3: Synthesis of 3-{1-[(4, 6-Dimethyl-pyrimidin-2-yl)-hydrazono]-ethyl}-chromen-2-one: 0.19g of 1 (~1mM) was dissolved in 20ml ethanol and stirred rapidly with mild heating. To it was added 0.14g (~1mM) of 2 in portions along with introduction of a drop of glacial acetic acid. The solution was brought to reflux and continued for 6h, followed by cooling to obtain a bright yellow precipitate which was filtered under suction, washed with cold ethanol and dried under vacuum overnight. The product so obtained was characterized by 1H NMR, 13C NMR, Mass spectrometry and IR analysis. Yield: 68%. IR/cm-1 (ESI, Fig. S1): 3419.82, 1727.32, 1593.99, 1570.18, 1552.36; 1H NMR (ESI, Fig. S2) (300MHz, d6-DMSO, TMS): 10.070 (-NH, s, 1H), 8.130 (Ar-H, s, 1H), 7.850 (Ar-H, d, 1H), 7.618 (Ar-H, s, 1H), 7.428 (Ar-H, d, 1H), 7.366-7.438 ( Ar-H, m, 2H), 6.657 (Py-H, s, 1H), 2.290 (CH3-H, s, 6H), 2.229 (CH3-H, s, 3H); 13C NMR (ESI, Fig. S3) (300MHz, d6-DMSO, TMS): 167.79, 160.63, 160.00, 145.37, 141.06, 132.44, 129.43, 128.00, 125.15, 119.45, 116.41, 112.75, 23.88, 16.13; ESI-MS (ESI, Fig. S4): 309.1299, 331.1117 calculated for M+H+: 309.13 and M+Na+: 331.12.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 23906-13-0, 2-Hydrazinyl-4,6-dimethylpyrimidine, other downstream synthetic routes, hurry up and to see.
Reference:
Article; Bhattacharyya, Arghyadeep; Ghosh, Soumen; Makhal, Subhash Chandra; Guchhait, Nikhil; Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy; vol. 183; (2017); p. 306 – 311;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia