Formula: C8H12ClNO2. The protonation of heteroatoms in aromatic heterocycles can be divided into two categories: lone pairs of electrons are in the aromatic ring conjugated system; and lone pairs of electrons do not participate. Compound: 5-(hydroxymethyl)-2,4-dimethylpyridin-3-ol hydrochloride, is researched, Molecular C8H12ClNO2, CAS is 148-51-6, about Quantitative determination of the biological antivitamin B6 effect of pyridoxol antagonists. Author is Koerner, Wilhelm F.; Nowak, Herbert.
Rats were fed a vitamin B6-free diet for 20 days; however, during the last 10 days the diets were supplemented with 30 γ pyridoxol-HCl. During the next 5 days, the animals were loaded with daily oral doses of 200 mg. L-tryptophan/kg., and during days 26-30 of the experiment 4′-deoxypyridoxol-HCl (0.1-100 mg./kg.) was given i.p. 4′-Deoxypyridoxol-HCl had an antivitamin B6 activity (measured by xanthinuric acid excretion) beginning at the 0.3 mg./kg. dose. The antivitamin B6 activity of pyramin-HCl (10-100 mg./kg.) was 60% that of 4′-deoxypyridoxol-HCl.
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Reference:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia