Related Products of 1374639-77-6 , The common heterocyclic compound, 1374639-77-6, name is (2-Chloro-7-cyclopentyl-7H-pyrrolo[2,3-d]pyrimidin-6-yl)methanol, molecular formula is C12H14ClN3O, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.
To a mixture of (2-chloro-7-cyclopentyl-7H-pyrrolo[2,3-d]pyrimidin-6-yl)methanol (IVa) (4.5 g) and tert-butyl 4-(6-aminopyridin-3-yl)piperazine-l-carboxylate (Va) (4.97 g) in methyl isobutyl ketone (36 mL) was added palladium (II) acetate (0.08 g) and 2,2′- bis(diphenylphosphino)-l, l’-binaphthyl (0.44 g) at 25-30 C. The reaction mass was then heated to 40 C. Cesium carbonate (8.73 g) was added to the above reaction mass portion wise at 40 C. The reaction mass was heated to 100 C and stirred for 3 hours. The reaction mass was cooled to 70 C. Water (36 mL) was added to the above reaction mass at 70 C and again cooled to 50 C. n-Heptane (54 mL) was added to the above reaction mass drop wise at 50 C. The reaction mass was again cooled to 20 C and stirred for 2 hours at the same temperature. Resulting solid compound was then filtered, washed with ^-Heptane (2 chi 10 mL) and dried for 4 hours at 50 C to afford title compound. (0163) Yield: 5 2 g; Purity by HPLC: 97 01 %
The synthetic route of 1374639-77-6 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; DR. REDDY?S LABORATORIES LIMITED; PEDDIREDDY, Subba Reddy; KOTTUR, Mohan Kumar; ORUGANTI, Srinivas; KANDAGATLA, Bhaskar; DAS GUPTA, Shirshendu; (39 pag.)WO2018/51280; (2018); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia