Adding a certain compound to certain chemical reactions, such as: 90905-33-2, 2-Methylpyrimidine-5-carbaldehyde, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, name: 2-Methylpyrimidine-5-carbaldehyde, blongs to pyrimidines compound. name: 2-Methylpyrimidine-5-carbaldehyde
Step-2: 2-Methyl-pyrimidine-5-carbaldehvde oxime:To a mixture of 2-methyl-5-formyl-pyrimidine (180 gm) and hydroxylamine hydrochloride (128 gm) in 50percent v/v aqueous methanol (3600 ml) was added sodium carbonate (94 gm). The reaction mixture was stirred at 30°C for 0.5 h. The resulting suspension was cooled and filtered at -10°C to provide single isomer of title compound in 1 13.5 gm quantity (56percent) as a solid.H’NMR: (DMSO-de) delta 1 1.64 (s, 1H), 8.83 (s, 2H), 8.14 (s, 1H), 2.60 (s, 3H).Further processing of the filtrate such as evaporation and salt removal, provided a mixture of isomers in 51 gm quantity which can be used for the next reaction.
At the same time, in my other blogs, there are other synthetic methods of this type of compound,90905-33-2, 2-Methylpyrimidine-5-carbaldehyde, and friends who are interested can also refer to it.
Reference:
Patent; WOCKHARDT LIMITED; TRIVEDI, Bharat; DESHPANDE, Prasad; TADIPARTHI, Ravikumar; GUPTA, Sunil; DIWAKAR, Santosh; PAWAR, Shivaji; PATIL, Vijay; DEKHANE, Deepak; PATEL, Mahesh; BHAVSAR, Satish; MISHRA, Amit; SOLANKI, Manish; JAFRI, Mohammad; BHAGWAT, Sachin; WO2012/76989; (2012); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia