So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic.Singh, R. P.; Korytnyk, W. researched the compound: 5-(hydroxymethyl)-2,4-dimethylpyridin-3-ol hydrochloride( cas:148-51-6 ).Application In Synthesis of 5-(hydroxymethyl)-2,4-dimethylpyridin-3-ol hydrochloride.They published the article 《Pyridoxine chemistry. VII. Some modifications in the 4-position of pyridoxol》 about this compound( cas:148-51-6 ) in Journal of Medicinal Chemistry. Keywords: ANTIMETABOLITES; CHEMISTRY, PHARMACEUTICAL; EXPERIMENTAL LAB STUDY; PHARMACOLOGY; PYRIDINES; PYRIDOXINE; SACCHAROMYCES. We’ll tell you more about this compound (cas:148-51-6).
cf. preceding abstract Derivatives of I were prepared by treatment of 2,2,8-trimethyl-4H-m-dioxino[4,5-c]pyridine-5-methanol benzoate with HCl. I (R = OH) refluxed with SOCl2 and the residue treated with EtOH produced I (R = Cl). The catalytic (C) hydrogenation of I (R = Cl) afforded I (R = H). I (R = H) refluxed in KOH gave 4-deoxypyridoxine (II). I (R = Cl) stirred with Na2S2O5 produced I (R = SO3H). KCNS refluxed with I (R = Cl) gave I (R = SCN). Similarly, I (R = Cl) stirred with NaHS gave I (R = SH). I (R = H) was as active and I (R = SO3H) one-half as active as II in depressing lymphocyte count in rats fed a pyridoxine deficient diet, while the other reported derivatives were inactive. None of the other compounds inhibited the growth of Saccharomyces carlsbergensis. Cf. Schmidt, and Giesselmann, CA 58, 1429d.
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Reference:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia