Related Products of 874-14-6, Adding some certain compound to certain chemical reactions, such as: 874-14-6, name is 1,3-Dimethyluracil,molecular formula is C6H8N2O2, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 874-14-6.
General procedure: Uracil1 (1 mmol), the arylboronic acid 2 (3 mmol), Pd(OAc)2 (10molpercent) and 1,10-phenanthroline (15 molpercent) were combined in dry DMF (10 ml) under O2 atmosphereand stirred for 5 min (Note: DMF wasdried over calcium hydride). The reaction mixture was stirred at 90oC and monitored by TLC using EtOAc-petroleum ether as the mobilephase. After completion, the reaction mixture was cooled, and water (10 ml) wasadded. The resulting solution was then extracted with EtOAc (3 QUOTE &13;&10;&13;&10;12?”> &13;&10;&13;&10;12?”> 20 ml). TheEtOAc extract was washed with water (5 QUOTE &13;&10;&13;&10;12?”> &13;&10;&13;&10;12?”> 10 ml) and thenbrine (10 ml). The organic layer was dried with Na2SO4.Evaporation of EtOAc furnished the crude product, which was purified by flash chromatography onsilica gel (EtOAc-Petroleum ether).
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 874-14-6, 1,3-Dimethyluracil, other downstream synthetic routes, hurry up and to see.
Reference:
Article; Mondal, Biplab; Hazra, Somjit; Roy; Tetrahedron Letters; vol. 55; 5; (2015); p. 1077 – 1081;,
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