Tag: M.W=400-500

Synthetic Route of 607740-08-9 , The common heterocyclic compound, 607740-08-9, name is 4-(3,5-Dibromophenyl)-2,6-diphenylpyrimidine, molecular formula is C22H14Br2N2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

Under a nitrogen stream3,6-bis (4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl) -9-phenylcarbazole 10.0 gmmol),4- (3,5-Dibromo-phenyl) -2,6-diphenyl-pyrimidine 9.41 g (20.19 mmol) K2CO3 16.7 g,800 ml of toluene,Then, 200 ml of a mixed solution was put into a 2-liter 2-neck round bottom flask, stirred for 30 minutes at room temperature,Pd (PPh3) 4 (70 mg, 0.61 mmol) was added thereto and refluxed for 18 hours.After the reaction was completed, the reaction mixture was extracted with methylene chloride, added with MgSO 4 and filtered.After removal of the solvent of the obtained organic layer, the residue was purified by column chromatography to obtain the target compound Macrocycle-II (4.93 g, yield 22.3%).

The synthetic route of 607740-08-9 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Doosan Co., Ltd; Um Min-sik; Kim Tae-hyeong; Baek Yeong-mi; (20 pag.)KR101847236; (2018); B1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 147118-40-9, name is Rosuvastatin methyl ester. A new synthetic method of this compound is introduced below., Recommanded Product: 147118-40-9

Example 663.0 g (6.0 mmol) of crystalline Form II rosuvastatin methylester are dissolved in 12 cm3 of methanol at 25 °C and while stirring, 5.9 cm3 of 1.0 M aqueous TBA solution are added at the same temperature. Thereafter five times in two-hour periods further 1.2 cm3 of 1.0 M aqueous TBA solution are added to the reaction mixture. The mixture is stirred for further 24 hours, evaporated and by adding 3 x40 cm3 eof ethylacetate, the residual water is removed by repeating azeotropic distillation three times. Into the residue thus obtained 34 cm of ethylacetate and 10 cm3 of distilled water are added. Subsequently 3.7 cm3 of 2.2 M aqueous ZnSO4 solution are added into the biphasic mixture in ten minutes at a temperature between 20 and 25 °C. After one hour stirring, the layers are separated, the organic layer is washed with 2x 10 cm of 2.2 M aqueous ZnSO4 solution and 10 cm of distilled water. The organic layer is evaporated and the remaining water is removed by repeated azeotropic distillation using ethylacetate. The suspension is cooled, filtered, washed with 3 cm of ethylacetate and dried in vacuo. Thus 2.50 g (81 percent) of crude product are obtained, which are stirred in the solutio of 1.2 mg of sodium hydroxide in 12 cm of distilled water in an argon atmosphere for 36 hours at a temperature between 0 and 5 °C. The mixture is filtered, washed with alkaline water having the same composition as described above and dried in vacuo protected from light. Thus 2.25 g (90 percent) of title product are obtained.

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Reference:
Patent; EGIS GYOGYSZERGYAR NYILVANOSAN M?KOeD? RESZVENYTARSASAG; KOVANYINE LAX, Gyoergyi; SIMIG, Gyula; VOLK, Balazs; BARTHA, Ferenc Lorant; KRASZNAI, Gyoergy; RUZSICS, Gyoergy; SIPOS, Eva; NAGY, Kalman; MOROVJAN, Gyoergy; BARKOCZY, Jozsef; KESZTHELYI, Adrienn; IMRE, Janos; BAGYINSZKI, Gabor; WO2012/73055; (2012); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 607740-08-9, name is 4-(3,5-Dibromophenyl)-2,6-diphenylpyrimidine. This compound has unique chemical properties. The synthetic route is as follows. category: pyrimidines

In the argon atmosphere, Intermediate A (4.4 g, 21 mmol) synthesized according to the method described in JP-A-2010180204, Intermediate B (4.7 g, 10 mmol) synthesized according to the method described in International Publication No. 2003/080760, (Dibenzylideneacetone) dipalladium (0.37 g, 0.4 mmol) Tri-t-butylphosphonium tetrafluoroborate (0.46 g, 1.6 mmol)Sodium t-butoxide (2.7 g, 28 mmol) Anhydrous toluene (100 mL), And heated to reflux for 8 hours. After the reaction solution was allowed to cool to room temperature, Separating the organic layer, The organic solvent was distilled off under reduced pressure. The resulting residue was purified by silica gel column chromatography, The title compound GH-4 (3.6 g, yield 50%) was obtained.

With the rapid development of chemical substances, we look forward to future research findings about 607740-08-9.

Reference:
Patent; IDEMITSU KOSAN CO., LTD.; KAWAMURA, MASAHIRO; ITO, HIROKATSU; OGIWARA, TOSHINARI; MIZUKI, YUMIKO; (145 pag.)TWI554499; (2016); B;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Related Products of 147118-40-9, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 147118-40-9, name is Rosuvastatin methyl ester, molecular formula is C23H30FN3O6S, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

Example-5Preparation of Rosuvastatin Sodium Methyl 7-[4-(4-flourophenyl)-6-isopropyl-2-(N-methyl-N-methylsulfonylamino)- pyrimidin-5-yl]-(3R,5S)-dihydroxy -(E)–heptenate (100 g ) was added to ethyl alcohol (900 ml). To this aqueous sodium hydroxide (8.0 g sodium hydroxide dissolved in 500 ml of water) was added at a temperature of 0-5 °C. The reaction mixture was heated to room temperature and maintained for 1-2 hours. After completion of the reaction, the reaction mass was concentrated and ethyl alcohol was added and the reaction mass was distilled off azeotropically. To the obtained residue diisopropyl ether was added and stirred for lhour and filtered. The filtered solid was dried to yield Rosuvastatin sodium.

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 147118-40-9, Rosuvastatin methyl ester.

Reference:
Patent; MATRIX LABORATORIES LIMITED; WO2009/128091; (2009); A2;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Application of 147118-40-9, Adding some certain compound to certain chemical reactions, such as: 147118-40-9, name is Rosuvastatin methyl ester,molecular formula is C23H30FN3O6S, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 147118-40-9.

EXAMPLE 2; PREPARATION OF N,N’-DIBENZYLETHYLENEDIAMINEROSUVASTATIN SALT; Rosuvastatin methyl ester was (1 g) was dissolved in ethanol (15 ml) at 25-300C and cooled to 0-50C and treated with aqueous sodium hydroxide (0.1 N, 20 ml) at 0-50C. The temperature of the reaction mass was raised to 25-300C and stirred for 1 hr. Ethanol was evaporated from the reaction mass under reduced pressure at 40-450C and the resulting aqueous layer was diluted further with 15 ml of DM water. This aqueous layer containing rosuvastatin was washed with 30percent v/v ethyl acetate/toluene (50 ml) at 25-300C and treated with aqueous solution of N,N’- dibenzylethylenediamine diacetate (0.9 g in 5 ml). The resulting suspension was stirred for 1 hr for complete precipitation and the precipitated product was filtered, slurry washed with ethyl acetate (20 ml) and dried under vacuum at 40-450C. Dry wt. 0.68 g; Chromatographic purity (HPLC): 99.28percent, Anti isomer: 0.59percent.; EXAMPLE 3PREPARATION OF N,N’-DIBENZYLETHYLENEDIAMINEROSUVASTATINA solution of rosuvastatin methyl ester (5 g) in ethanol (70 ml) was treated with aqueous sodium hydroxide (0.1N, 88 ml) at 0-50C and the temperature of the reaction was raised to 300C and stirred for 1 h. Ethanol from the reaction mass was evaporated at 40-450C. This aqueous layer was washed with 30 v/v ethyl acetate/toluene (3 x 25 ml) and treated with an aqueous solution of N,N’-dibenzylethylenediamine diacetate(1.8 g in 10 ml water). The resulting mass was further stirred for a period of 2 h, filtered, slurry washed with ethyl acetate (30 ml) and dried under vacuum at 40-450C. Dry Wt. 3.3 g, Chromatographic purity: 99.48 percent, Anti isomer: 0.47percent.

According to the analysis of related databases, 147118-40-9, the application of this compound in the production field has become more and more popular.

Reference:
Patent; AUROBINDO PHARMA LIMITED; WO2008/38132; (2008); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Electric Literature of 607740-08-9, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 607740-08-9, name is 4-(3,5-Dibromophenyl)-2,6-diphenylpyrimidine, molecular formula is C22H14Br2N2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

(3) Synthesis of Compound (A98)Intermediate Compound (K) in an amount of 3.0 g (6 mmoles), 2.3 g (14 mmoles) of carbazole, 0.12 g (0.6 mmoles) of copper iodide and 4.2 g (20 mmoles) of potassium phosphate were suspended into 21 ml of 1,4-dioxane. To the obtained suspension, 0.8 ml (6 mmoles) of trans-1,2-cyclohexanediamine was added. Under the atmosphere of argon, the resultant mixture was heated for 18 hours under the refluxing condition. The reaction solution was then cooled at the room temperature. Methylene chloride and water were added and the resultant mixture was separated into two layers. The organic layer was washed with water and dried with anhydrous sodium sulfate. After the organic solvent was removed by distillation under a reduced pressure, the residue of distillation was suspended into 21 ml of dioxane. To the obtained suspension, 0.12 g (0.6 mmoles) of copper iodide, 2.9 g (14 mmoles) of potassium phosphate and 0.8 ml (6 mmoles) of trans-1,2-cyclohexanediamine were added. Under the atmosphere of argon, the resultant mixture was heated for 18 hours under the refluxing condition. The reaction solution was then cooled at the room temperature. Methylene chloride and water were added and the resultant mixture was separated into two layers. The organic layer was washed with water and dried with anhydrous sodium sulfate. After the organic solvent was removed by distillation under a reduced pressure, 30 ml of ethyl acetate was added. The formed crystals were separated by filtration and washed with ethyl acetate and 3.3 g (the yield: 80%) of yellowish white crystals were obtained. It was confirmed by 90 MHz 1H-NMR and FD-MS that the obtained crystals were the target substance (A98). The result of the measurement by FD-MS is shown in the following:FD-MS calcd. for C46H30N4=638; found: m/z=638 (M+, 100)

According to the analysis of related databases, 607740-08-9, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Idemitsu Kosan Co., Ltd.; US2012/319099; (2012); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 147118-40-9, name is Rosuvastatin methyl ester, molecular formula is C23H30FN3O6S, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. Application In Synthesis of Rosuvastatin methyl ester

In a round bottom flask 2000 ml Tetrahydrofuran (THF) was added under the nitrogen atmosphere and cooled to -90¡ãC then 1Og sodium borohydride was added followed by 230ml diethylmethoxyborane (1 M solution in THF) in 90-120mins. In this reaction mass, mixture of lOOg of Methyl -7-[4-(4-fiourophenyl)-6-isopropyl-2-(N-methyl-N- methylsulfonylaniino)-pyrimidin-5-yl]-(3R)-3-hydroxy-5-oxo-(E)-6-heptenate5 700 ml THF and 700 ml methanol was added for a duration of 90-120min then stirred for 2 hrs at -90 to -80¡ãC. After the completion of reaction, 124 ml acetic acid was added and stirred for 30-60 min at same temperature. Above reaction mass was diluted with 1500ml ethyl acetate and washed with brine solution. To the organic layer, 500 ml DM water was added and pH was adjusted to neutral by ~ 500 ml 6 percent sodium bicarbonate solution. Both the layers were separated Sc the organic layer was dried over sodium sulphate. The organic layer was concentrated at 40-450C. Above concentrated mass was diluted with 900ml ethyl alcohol and then cooled to 0¡ãC. Sodium hydroxide solution was added in 60- 90 min. The reaction mass was stirred for 30 min at room temperature and the pH was adjusted to 11.5-12.0 by using ~ 4 percent sodium hydroxide solution. In this reaction mass, 1Og activated carbon was added and stirred for 20 min. The reaction mass was filtered and washed with ethanol/DM water mixture. The reaction mass was concentrated up to thick residue at 40-45¡ãC. To this concentrated mass, 500 ml DM water was added followed by 1000ml ethyl acetate and the pH was adjusted to 3.5- 4.0 with 1:4 aqueous hydrochloric acid. Both the layers were separated and the organic layer was washed with brine solution.The organic layer was dried over sodium sulphate and concentrated till dryness at 40-45¡ãC. To the above concentrated mass, 1000 ml acetonitrile was added stirred at room temperature for half an hour. Slowly 20.5 g (S)-2-amino-3, 3 -dimethyl butane was added and stirred for almost 2 hrs. The solid was filtered and washed with acetonitrile and diisopropyl ether. Finally the solid was dried for 6-9 hrs at 40-45¡ãC.Above obtained (S)-2-amino-3, 3 -dimethyl butane salt of rosuvastatin was suspended in 1000 ml isopropanol followed by 100 ml methanol. This reaction mass was heated for half an hour at 60-80¡ãC then stirred for 3-4 hrs at 5-1O0C. The solid was filtered washed with isopropanol and diisopropyl ether. 95 gms of (S)-2-amino-3, 3 -dimethyl butane salt of rosuvastatin was obtained.

With the rapid development of chemical substances, we look forward to future research findings about 147118-40-9.

Reference:
Patent; MATRIX LABORATORIES LTD; SETHI, Madhuresh, Kumar; MAHAJAN, Sanjay; MARA, Bhairaiah; AYYARAN, Laxmi, Karthikeyan; DATTA, Debashish; WO2010/35284; (2010); A2;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Let’s face it, organic chemistry can seem difficult to learn. Especially from a beginner’s point of view. Like 139756-22-2, Name is 4-Ethoxy-3-(1-methyl-7-oxo-3-propyl-6,7-dihydro-1H-pyrazolo[4,3-d]pyrimidin-5-yl)benzene-1-sulfonyl chloride. In a document, author is Kamimura, Seiichiro, introducing its new discovery. Product Details of 139756-22-2.

Effects of narrow-band UVB on nasal symptom and upregulation of histamine H-1 receptor mRNA in allergic rhinitis model rats

Background Phototherapy with narrow-band ultraviolet B (narrow-band UVB) is clinically effective treatment for atopic dermatitis. In the present study, we examined the effects of intranasal irradiation with narrow-band UVB on nasal symptom, upregulation of histamine H-1 receptor (H1R) gene expression and induction of DNA damage in the nasal mucosa of allergic rhinitis (AR) model rat. Methods AR model rats were intranasally irradiated with 310 nm of narrow-band UVB. Nasal mucosal levels of H1R mRNA were measured using real-time quantitative reverse transcriptase (RT)-PCR. DNA damage was evaluated using cyclobutane pyrimidine dimer (CPD) immunostaining. Results In toluene 2,4-diisocyanate (TDI)-sensitized rats, TDI provoked sneezes and H1R gene expression in the nasal mucosa. Intranasal pre-irradiation with 310 nm narrow-band UVB at doses of 600 and 1400, but not 200 mJ/cm(2) significantly inhibited the number of sneezes and upregulation of H1R gene expression provoked by TDI. CPD-positive cells appeared in the nasal mucosa after intranasal narrow-band UVB irradiation at a dose of 1400, but not 200 and 600 mJ/cm(2). The suppression of TDI-provoked sneezes and upregulation of H1R gene expression lasted 24 hours, but not 48 hours, after narrow-band UVB irradiation with a dose of 600 mJ/cm(2). Conclusions Intranasal pre-irradiation with narrow-band UVB dose-dependently inhibited sneezes and upregulation of H1R gene expression of the nasal mucosa in AR model rats, suggesting that the inhibition of nasal upregulation of H1R gene expression suppressed nasal symptom. The suppression after narrow-band UVB irradiation at a dose of 600 mJ/cm(2) was reversible without induction of DNA damage. These findings indicated that low-dose narrow-band UVB phototherapy could be effectively and safely used for AR treatment in a clinical setting. Level of Evidence NA.

I hope this article can help some friends in scientific research. I am very proud of our efforts over the past few months and hope to 139756-22-2 help many people in the next few years. Product Details of 139756-22-2.

Reference:
Pyrimidine | C4H4N2 – PubChem,
,Pyrimidine – Wikipedia

Let’s face it, organic chemistry can seem difficult to learn. Especially from a beginner’s point of view. Like 139756-22-2, Name is 4-Ethoxy-3-(1-methyl-7-oxo-3-propyl-6,7-dihydro-1H-pyrazolo[4,3-d]pyrimidin-5-yl)benzene-1-sulfonyl chloride. In a document, author is Saha, Urmila, introducing its new discovery. COA of Formula: C17H19ClN4O4S.

Targeting nucleic acid with a bioactive fluorophore: Insights from spectroscopic and calorimetric studies

The Schiff base (H(2)SALNN) (N,N’-bis(4-methoxy-salicylaldehyde)azine) has been designed to develop a DNA targeted fluorescent probe. The H(2)SALNN was synthesized and geometry optimized by DFT/B3LYP. The interaction of H(2)SALNN with Calf thymus DNA (CT-DNA) was studied by spectroscopic and calorimetric techniques. The compound was found to bind with CT-DNA through groove binding mode. From isothermal calorimetry (ITC) titration experiment, the binding constant between the compound and DNA was estimated to be (1.52 +/- 0.03) x 10(5 )M(-1). The negative Delta G(0) and positive Delta S-0 values obtained from the calorimetric study confirmed the spontaneity of the binding of H(2)SALNN with DNA. Analysis of thermodynamic parameters indicated that the process of interaction of H(2)SALNN with DNA is entropy driven. (C) 2020 Elsevier B.V. All rights reserved.

I hope this article can help some friends in scientific research. I am very proud of our efforts over the past few months and hope to 139756-22-2 help many people in the next few years. COA of Formula: C17H19ClN4O4S.

Reference:
Pyrimidine | C4H4N2 – PubChem,
,Pyrimidine – Wikipedia

A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. 139756-22-2, Name is 4-Ethoxy-3-(1-methyl-7-oxo-3-propyl-6,7-dihydro-1H-pyrazolo[4,3-d]pyrimidin-5-yl)benzene-1-sulfonyl chloride, molecular formula is C17H19ClN4O4S. In an article, author is Han, Jianyang,once mentioned of 139756-22-2, COA of Formula: C17H19ClN4O4S.

An AZT Analog with Strongly Pairing Ethynylpyridone Nucleobase and Its Antiviral Activity against HSV1

Challenges resulting from novel viruses or new strains of known viruses call for new antiviral agents. Nucleoside analogs that act as inhibitors of viral polymerases are an attractive class of antivirals. For nucleosides containing thymine, base pairing is weak, making it desirable to identify nucleobase analogs that pair more strongly with adenine, in order to compete successfully with the natural substrate. We have recently described a new class of strongly binding thymidine analogs that contain an ethynylmethylpyridone as base and a C-nucleosidic linkage to the deoxyribose. Here we report the synthesis of the 3 ‘-azido-2 ‘,3 ‘-deoxyribose derivative of this compound, dubbed AZW, both as free nucleoside and as ProTide phosphoramidate. As a proof of principle, we studied the activity against Herpes simplex virus type 1 (HSV1). Whereas the ProTide phosphoramidate suffered from low solubility, the free nucleoside showed a stronger inhibitory effect than that of AZT in a plaque reduction assay. This suggests that strongly pairing C-nucleoside analogs of pyrimidines have the potential to become active pharmaceutical ingredients with antiviral activity.

Interested yet? Keep reading other articles of 139756-22-2, you can contact me at any time and look forward to more communication. COA of Formula: C17H19ClN4O4S.

Reference:
Pyrimidine | C4H4N2 – PubChem,
,Pyrimidine – Wikipedia