Tag: M.W=300-400

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 862730-04-9, name is 3-Iodo-1-isopropyl-1H-pyrazolo[3,4-d]pyrimidin-4-amine. This compound has unique chemical properties. The synthetic route is as follows. Product Details of 862730-04-9

Synthesis of 1-isopropyl-3-(pyridin-3-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine (BA52); A solution of 3-Pyridinylboronic acid (15 mg, 0.14 mmol) in EtOH (3.3 ml) was added to a solution of 3-iodo-1-isopropyl-1H-pyrazolo[3,4-d]pyrimidin-4-amine (40 mg, 0.13 mmol) in DME (12 ml). Pd(PPh3)4 (15 mg, 0.015 mmol) and saturated Na2CO3 (1.9 ml) were added and the reaction was heated to 80 C. under an argon atmosphere overnight. After cooling, the reaction was extracted with saturated NaCl and CH2Cl2. Organic phases were combined, concentrated in vacuo and purified by RP-HPLC (MeCN:H2O) to yield BA52. ESI-MS (M+H)+ m/z calcd 255.1, found 255.0.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 862730-04-9, 3-Iodo-1-isopropyl-1H-pyrazolo[3,4-d]pyrimidin-4-amine.

Reference:
Patent; Regents of the University of California; US2007/293516; (2007); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Application of 332133-92-3, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.332133-92-3, name is 4-(Tributylstannyl)pyrimidine, molecular formula is C16H30N2Sn, molecular weight is 369.1328, as common compound, the synthetic route is as follows.

A solution of compound 5 (175 mg, 0.19 mmol), compound 51 (103 mg, 0.28 mmol), Pd(PPh3)4 (22 mg, 0.02 mmol) in 1,4-dioxane (4 mL) was microwaved at 100 C for 40 minutes, LC-MS showed that the start materials was consumed up, stopped the reaction, poured into a mixture of DCM (60 mL) and H20 (50 mL), filtered through a pad of celite, the organic layer was separated, washed with brine, dried over anhydrous Na2S04, concentrate in vacuo, the residue was purified by column (DCM/MeOH 100/1 to 40/1) to give compound 52 (9 mg, 11% yield) as a white solid. MS (ESI) (M/Z): [M+H]+ =402.1

The chemical industry reduces the impact on the environment during synthesis 332133-92-3, I believe this compound will play a more active role in future production and life.

Reference:
Patent; ZHANG, Hai-Jun; (63 pag.)WO2018/217439; (2018); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Related Products of 1231930-42-9 ,Some common heterocyclic compound, 1231930-42-9, molecular formula is C15H13ClF2N4, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

Compound A1Sf (66 mg, 0.301 mmol), B1Sa (80 mg, 0.248 mmol), Pd(OAc)2 (20 mg), BINAP (20 mg) and Cs2CO3 (294 mg, 0.903 mmol) were added to 1,4-dioxane (3 mL), the air in reaction system was exchanged with N2, then the mixture was heat to 120 C. and reacted for 2 hours in seal. he LCMS indicated the reaction was complete, the reaction mixture was filtered, the filtrate was concentrated in vacuo, the residue was purified via column chromatography (DCM/MeOH=30:125:1) to afford yellow solid compound B1S (32 mg, yield 25%, >99% ee). 1H NMR (CD3OD, 400 MHz) delta 8.39-8.36 (m, 2H), 7.78 (dd, J=12.0 Hz, 0.8 Hz, 1H), 7.35 (d, J=2.4 Hz, 1H), 7.07 (dd, J=8.8 Hz, 2.8 Hz, 1H), 6.83 (d, J=9.2 Hz, 1H), 4.94-4.89 (m, 1H), 4.24 (dd, J=10.4 Hz, 2.8 Hz, 1H), 3.99 (dd, J=10.8 Hz, 9.2 Hz, 1H), 3.77-3.72 (m, 1H), 3.13-3.07 (m, 1H), 3.00 (d, J=11.2 Hz, 1H), 2.93-2.87 (m, 1H), 2.78-2.70 (m, 1H), 2.69 (s, 3H), 2.38 (s, 3H), 2.37-2.27 (m, 1H), 1.91 (dd, J=11.2 Hz, 10.8 Hz, 1H), 1.72 (d, J=6.8 Hz, 6H); MS m/z 506.3 [M+H]+.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 1231930-42-9, 6-(2-Chloro-5-fluoropyrimidin-4-yl)-4-fluoro-1-isopropyl-2-methyl-1H-benzo[d]imidazole, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Hangzhou Innogate Pharma Co., Ltd.; ZHANG, Hancheng; LIU, Shifeng; YE, Xiangyang; (92 pag.)US2019/308993; (2019); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Application of 332133-92-3, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.332133-92-3, name is 4-(Tributylstannyl)pyrimidine, molecular formula is C16H30N2Sn, molecular weight is 369.1328, as common compound, the synthetic route is as follows.

A solution of compound 5 (175 mg, 0.19 mmol), compound 51 (103 mg, 0.28 mmol), Pd(PPh3)4 (22 mg, 0.02 mmol) in 1,4-dioxane (4 mL) was microwaved at 100 C for 40 minutes, LC-MS showed that the start materials was consumed up, stopped the reaction, poured into a mixture of DCM (60 mL) and H20 (50 mL), filtered through a pad of celite, the organic layer was separated, washed with brine, dried over anhydrous Na2S04, concentrate in vacuo, the residue was purified by column (DCM/MeOH 100/1 to 40/1) to give compound 52 (9 mg, 11% yield) as a white solid. MS (ESI) (M/Z): [M+H]+ =402.1

The chemical industry reduces the impact on the environment during synthesis 332133-92-3, I believe this compound will play a more active role in future production and life.

Reference:
Patent; ZHANG, Hai-Jun; (63 pag.)WO2018/217439; (2018); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Related Products of 1231930-42-9 ,Some common heterocyclic compound, 1231930-42-9, molecular formula is C15H13ClF2N4, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

Compound A1Sf (66 mg, 0.301 mmol), B1Sa (80 mg, 0.248 mmol), Pd(OAc)2 (20 mg), BINAP (20 mg) and Cs2CO3 (294 mg, 0.903 mmol) were added to 1,4-dioxane (3 mL), the air in reaction system was exchanged with N2, then the mixture was heat to 120 C. and reacted for 2 hours in seal. he LCMS indicated the reaction was complete, the reaction mixture was filtered, the filtrate was concentrated in vacuo, the residue was purified via column chromatography (DCM/MeOH=30:125:1) to afford yellow solid compound B1S (32 mg, yield 25%, >99% ee). 1H NMR (CD3OD, 400 MHz) delta 8.39-8.36 (m, 2H), 7.78 (dd, J=12.0 Hz, 0.8 Hz, 1H), 7.35 (d, J=2.4 Hz, 1H), 7.07 (dd, J=8.8 Hz, 2.8 Hz, 1H), 6.83 (d, J=9.2 Hz, 1H), 4.94-4.89 (m, 1H), 4.24 (dd, J=10.4 Hz, 2.8 Hz, 1H), 3.99 (dd, J=10.8 Hz, 9.2 Hz, 1H), 3.77-3.72 (m, 1H), 3.13-3.07 (m, 1H), 3.00 (d, J=11.2 Hz, 1H), 2.93-2.87 (m, 1H), 2.78-2.70 (m, 1H), 2.69 (s, 3H), 2.38 (s, 3H), 2.37-2.27 (m, 1H), 1.91 (dd, J=11.2 Hz, 10.8 Hz, 1H), 1.72 (d, J=6.8 Hz, 6H); MS m/z 506.3 [M+H]+.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 1231930-42-9, 6-(2-Chloro-5-fluoropyrimidin-4-yl)-4-fluoro-1-isopropyl-2-methyl-1H-benzo[d]imidazole, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Hangzhou Innogate Pharma Co., Ltd.; ZHANG, Hancheng; LIU, Shifeng; YE, Xiangyang; (92 pag.)US2019/308993; (2019); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Electric Literature of 1421372-94-2, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.1421372-94-2, name is N-(4-Fluoro-2-methoxy-5-nitrophenyl)-4-(1-methyl-1H-indol-3-yl)pyrimidin-2-amine, molecular formula is C20H16FN5O3, molecular weight is 393.3712, as common compound, the synthetic route is as follows.

1-Methylpiperazine (89 mg, 0.89 mmol), N-(4-fluoro-2-methoxy-5-nitrophenyl)-4-(1-methylindol-3-yl)pyrimidin-2-amine (Intermediate 129 (which may be prepared by the method described for Intermediate 87), 350 mg, 0.89 mmol) and DIPEA (0.186 mL, 1.07 mmol) were suspended in DMA (6 mL) and sealed into a microwave tube. The reaction was heated to 140C for1h in a microwave and then cooled to r.t. CH3OH was added and an orange solid precipitated from solution. The solid was collected by filtration and was washed with CH3OH and then diethyl ether. The solid was then dried to give the title compound (339 mg, 80%) as an orange solid; 1H NMR: 2.26 (3H, s), 3.06-3.11 (4H, m), 3.88 (3H, s), 3.99 (3H, s), 6.86 (1H, s), 7.13 (1H, t), 7.23-7.29 (2H, m), 7.53 (1H, d), 8.10 (1H, s), 8.32-8.38 (3H, m), 8.81 (1H, s); (signals for 4 protons were not observed and are likely to be obscured under the DMSO peak); m/z: ES+ MH+ 474.56.

The chemical industry reduces the impact on the environment during synthesis 1421372-94-2, I believe this compound will play a more active role in future production and life.

Reference:
Patent; ASTRAZENECA AB; ASTRAZENECA UK LIMITED; BUTTERWORTH, Sam; FINLAY, Maurice, Raymond, Verschoyle; WARD, Richard, Andrew; KADAMBAR, Vasantha, Krishna; CHANDRASHEKAR, Reddy, C.; MURUGAN, Andiappan; REDFEARN, Heather, Marie; WO2013/14448; (2013); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Reference of 1197953-49-3, Adding some certain compound to certain chemical reactions, such as: 1197953-49-3, name is (2-((2,5-Dichloropyrimidin-4-yl)amino)phenyl)dimethylphosphine oxide,molecular formula is C12H12Cl2N3OP, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 1197953-49-3.

General procedure: To a solution of 2,5-dichloro-N-(2-(dimethylphosphoryl)phenyl)pyrimidin-4-amine (2g, 6.3mmol) in DMF (30mL) were added s-2a (2.4g, 7.8mmol)Pd(OAc)2 (176mg, 0.78mmol)Xantphos (810mg, 1.4mmol) and Cs2CO3(6.4g, 19.6mmol) in microwave tube, the solution was purged and refilled with nitrogen three times. Then the mixture was stirred at 110C for 2h in the microwave. After the starting material was consumed, the reaction mixture was filtered through a pad of silica gel and most of the solvent of the filtrate was removed under the reduced pressure. Then the mixture was quenched with water, extracted with ethyl acetate, washed with water and brine, dried over anhydrous Na2SO4. The solvent was evaporated under the reduced pressure and the residue was purified by reverse phase ISCO (C18) to give the title compound s-3a as a brown solid.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 1197953-49-3, (2-((2,5-Dichloropyrimidin-4-yl)amino)phenyl)dimethylphosphine oxide, other downstream synthetic routes, hurry up and to see.

Reference:
Article; Sun, Ning; Ren, Chaowei; Kong, Ying; Zhong, Hui; Chen, Jinju; Li, Yan; Zhang, Jianshui; Zhou, Yuedong; Qiu, Xing; Lin, Haifan; Song, Xiaoling; Yang, Xiaobao; Jiang, Biao; European Journal of Medicinal Chemistry; vol. 193; (2020);,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 330786-24-8, name is 3-(4-Phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine, the common compound, a new synthetic route is introduced below. Computed Properties of C17H13N5O

1L three bottles to join4-amino-3- (4-phenoxyphenyl) -1H-pyrazolo [3,4-d] pyrimidine 20 g (66 mmol)S-1-tert-butoxycarbonyl-3-hydroxypiperidine (26.6 g, 132 mmol); triphenylphosphine (51.9 g, 198 mmol) was added to dry tetrahydrofuran (400 mL) and cooled to 5-10 C.Under nitrogen, 40 g (198 mmol) of diisopropyl azodicarboxylate was slowly added dropwise to the flask and the reaction was carried out at 30 C for 12 hours. The reaction solution was cooled to 0 to 10 C, and 20 g of 36% hydrochloric acid was added dropwise(198 mmol), and the temperature was raised to 40 C for 1 hour.Water was added, stirred, extracted three times with dichloromethane, and the aqueous phase was collected and washed with hydrogenSodium hydroxide solution to adjust the water phase into alkaline (pH> 10), precipitate solid, filter, collect solid, blast 50 baking 12 hours(4-phenoxyphenyl) -1- (piperidin-3-yl) -1H-pyrazolo (3,4-d) pyrimidin-4-amine (V) 22.4 g, molar yield 87.9%. (HPLC purity 99.6%; optical purity ?99.8%).

The synthetic route of 330786-24-8 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Biocompounds Pharmaceutical Inc.; Yang, Shiqiong; Li, Qian; Kang, Litao; (14 pag.)CN106008526; (2016); A;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Adding a certain compound to certain chemical reactions, such as: 1197953-49-3, (2-((2,5-Dichloropyrimidin-4-yl)amino)phenyl)dimethylphosphine oxide, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Formula: C12H12Cl2N3OP, blongs to pyrimidines compound. Formula: C12H12Cl2N3OP

A suspension of 2(1.27g, 4.0 mmol), 3-Boc-amino-5-methoxyaniline(965mg, 4.0mmol), palladium acetate(133mg, 0.59mmol), XantPhos(352mg, 0.61 mmol) and potassium phosphate(1.4g, 6.6mmol) in anhydrous DMF(35 mL) was heated at 120 C overnight. After the reaction was cooling to room temperature, ethyl acetate was added to dilute the reaction and the content was filtered through celite. Solvent was removed under vacuum. The residue was purified by flash column chromatography on silica gel to give pure product 1.3g (yield 62%) as a tan solid.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,1197953-49-3, (2-((2,5-Dichloropyrimidin-4-yl)amino)phenyl)dimethylphosphine oxide, and friends who are interested can also refer to it.

Reference:
Patent; ARIAD PHARMACEUTICALS, INC.; ZHU, Xiaotian; WANG, Yihan; SHAKESPEARE, William, C.; HUANG, Wei-Sheng; DALGARNO, David, C.; WO2013/169401; (2013); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 862730-04-9, name is 3-Iodo-1-isopropyl-1H-pyrazolo[3,4-d]pyrimidin-4-amine. This compound has unique chemical properties. The synthetic route is as follows. Recommanded Product: 3-Iodo-1-isopropyl-1H-pyrazolo[3,4-d]pyrimidin-4-amine

Synthesis of 1-isopropyl-3-(4-methoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine (BA48); A solution of (4-Methoxyphenylboronic acid (17 mg, 0.11 mmol) in EtOH (3.3 ml) was added to a solution of 3-iodo-1-isopropyl-1H-pyrazolo[3,4-d]pyrimidin-4-amine (30 mg, 0.10 mmol) in DME (12 ml). Pd(PPh3)4 (30 mg, 0.03 mmol) and saturated Na2CO3 (1.9 ml) were added and the reaction was heated to 80 C. under an argon atmosphere overnight. After cooling, the reaction was extracted with saturated NaCl and CH2Cl2. Organic phases were combined, concentrated in vacuo and purified by RP-HPLC (MeCN:H2O:0.1% TFA) to yield BA48 (4.5 mg, 16% yield). ESI-MS (M+H)+ m/z calcd 284.1, found 284.1.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 862730-04-9, 3-Iodo-1-isopropyl-1H-pyrazolo[3,4-d]pyrimidin-4-amine.

Reference:
Patent; Regents of the University of California; US2007/293516; (2007); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia