Tag: M.W=300-400

As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 1197953-49-3, name is (2-((2,5-Dichloropyrimidin-4-yl)amino)phenyl)dimethylphosphine oxide, molecular formula is C12H12Cl2N3OP, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. Product Details of 1197953-49-3

Compound c24-10 (200 mg, 0.58 mmol) was dissolved in 18 ml of ethylene glycol monobutyl ether, then compound b3-1 (237 mg, 0.75 mmol) was added with stirring at room temperature.0.36 ml of a hydrochloric acid solution in ethanol(5.6 M) was reacted at 120 C overnight.TLC showed that the reaction was completed, diluted with water and ethyl acetate.Concentrated to give crude product by column chromatography to give c-24,20mg.

With the rapid development of chemical substances, we look forward to future research findings about 1197953-49-3.

Reference:
Patent; Zhejiang Tongyuankang Pharmaceutical Co., Ltd.; Wu Yusheng; Zhi Wubin; Wang Xin; Wu Shiyong; Li Jingya; Guo Ruiyun; Zheng Maolin; Liang Apeng; Wang Guohui; Chen Mingtao; Ma Jie; Niu Chengshan; (65 pag.)CN108689994; (2018); A;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.635698-56-5, name is tert-Butyl 2,4-dichloro-7,8-dihydropyrido[4,3-d]pyrimidine-6(5H)-carboxylate, molecular formula is C12H15Cl2N3O2, molecular weight is 304.17, as common compound, the synthetic route is as follows.name: tert-Butyl 2,4-dichloro-7,8-dihydropyrido[4,3-d]pyrimidine-6(5H)-carboxylate

To the mixture of tert-butyl 2,4-dichloro-7, 8-dihydropyrido[4,3 -d]pyrimidine6(5H)-carboxylate (4.00 g, 13.15 mmol) in CH2C12 (15.00 mL) was added HC1/dioxane (4 N,15.00 mL). The mixture was stirred at 15 C for 15 h. LCMS showed one main peak of desired product and about 5% of starting material. The mixture was stirred at 30 C for 1 h. LCMS showed desired product was major. The mixture was concentrated under reduced pressure to afford the title compound (3.07 g, crude, HC1 salt) as a white solid which was used in the next step without further purification.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,635698-56-5, tert-Butyl 2,4-dichloro-7,8-dihydropyrido[4,3-d]pyrimidine-6(5H)-carboxylate, and friends who are interested can also refer to it.

Reference:
Patent; KADMON CORPORATION, LLC; OLSZEWSKI, Kellen; POYUROVSKY, Masha; BARSOTTI, Anthony; KIM, Ji-In; LIU, Kevin; MORRIS, Koi; (143 pag.)WO2016/210331; (2016); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Related Products of 330786-24-8 ,Some common heterocyclic compound, 330786-24-8, molecular formula is C17H13N5O, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

General procedure: To a solution of 8 (1 mmol) and substituted benzyl bromide 9 (1.2 mmol) in N, N-dimethylformamide (5 mL) was added K2CO3 (1.5 mmol) and the reaction mixture was stirred for 5 h at room temperature.The reaction solution was poured into water (50 mL). The suspension was filtered and the crude product was purified by silica gel column chromatography with dichloromethane/methanol (80/1-40/1) to give target compounds 10a – 10n.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 330786-24-8, 3-(4-Phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine, other downstream synthetic routes, hurry up and to see.

Reference:
Article; Ran, Fansheng; Liu, Yang; Liu, Meixia; Zhang, Daoguang; Wang, Peng; Dong, Junze; Tang, Wendi; Zhao, Guisen; Bioorganic Chemistry; vol. 89; (2019);,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 330786-24-8, name is 3-(4-Phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine. A new synthetic method of this compound is introduced below., Safety of 3-(4-Phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine

Example 1-1 : Preparation of (i?)-3-(4-phenoxyphenyl)-l-(pyrrolidin-3-yl)-lH-pyrazolo[3,4- Patent; PHARMACYCLICS, INC.; CHEN, Wei; LOURY, David, J.; MODY, Tarak, D.; WANG, Longcheng; WO2013/10136; (2013); A2;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Related Products of 1197953-49-3, Adding some certain compound to certain chemical reactions, such as: 1197953-49-3, name is (2-((2,5-Dichloropyrimidin-4-yl)amino)phenyl)dimethylphosphine oxide,molecular formula is C12H12Cl2N3OP, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 1197953-49-3.

Add compound 20 (150 mg, 0.6 mmol), compound 5 (189 mg, 0.6 mmol) and ethylene glycol monomethyl ether (3 mL) to a 25 mL single-necked flask equipped with a magnetic stirring and a condensing tube, stir and dissolve, and add hydrogen chloride dropwise. Isopropyl alcohol solution(0.9 mmol, 0.18 mL, 5 M), the temperature was raised to 120 C under a nitrogen atmosphere and the reaction was stirred overnight. Cool to room temperature and add water(10 mL) and saturated sodium bicarbonate (5 mL), dichloromethane (15 mL¡Á3)The combined organic layers were washed with brine, dried over anhydrous sodium sulfateThe residue was passed through a silica gel column to give a white solid160mg,The yield was 50.1%.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 1197953-49-3, (2-((2,5-Dichloropyrimidin-4-yl)amino)phenyl)dimethylphosphine oxide, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Shenzhen Tajirui Bio-pharmaceutical Co., Ltd.; Wang Yihan; Li Huanyin; (67 pag.)CN109369721; (2019); A;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Adding a certain compound to certain chemical reactions, such as: 635698-56-5, tert-Butyl 2,4-dichloro-7,8-dihydropyrido[4,3-d]pyrimidine-6(5H)-carboxylate, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Computed Properties of C12H15Cl2N3O2, blongs to pyrimidines compound. Computed Properties of C12H15Cl2N3O2

To a stirred solution of tert-butyl 2,4-dichloro- 7,8-dihydro-5H-pyrido[4,3-d]pyrimidine-6-carboxylate (0.3 g, 0.99 mmol) in i- PrOH (80 ml) were added 3-(aminomethyl)phenol (0.2 g, 1.18 mmol) and TEA (0.3 g, 2.96 mmol). The resulting mixture was stirred at 100 oC for 16 hrs. The reaction mixture was poured into ice-water (50 mL), and then extracted with EtOAc (50 mL x3). The combined organic layer was dried with Na2SO4, and concentrated to give a crude product which was purified by column (3470) chromatography on silica gel (hexane/ethyl acetate) to afford tert-butyl 2-chloro- 4-[(3-hydroxyphenyl)methylamino]-7,8-dihydro-5H-pyrido[4,3-d]pyrimidine-6- carboxylate (0.35 g, 90.8%) as a white solid. LCMS (M+H+) m/z: calcd.391.1; found 391.2.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,635698-56-5, tert-Butyl 2,4-dichloro-7,8-dihydropyrido[4,3-d]pyrimidine-6(5H)-carboxylate, and friends who are interested can also refer to it.

Reference:
Patent; CLEAVE BIOSCIENCES, INC.; ZHOU, Han-Jie; WUSTROW, David; (498 pag.)WO2016/200840; (2016); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Application of 58536-46-2, Adding some certain compound to certain chemical reactions, such as: 58536-46-2, name is 4-(4-Bromophenyl)-2,6-diphenylpyrimidine,molecular formula is C22H15BrN2, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 58536-46-2.

General procedure: After completely dissolving a compound represented by Chemical Formula E1-P2 (7.8 g, 13.9 mmol) and a compound represented by Chemical Formula E1-A (3.7 g, 13.9 mmol) in tetrahydrofuran (THF) (70 mL), potassium carbonate (5.8 g, 41.8 mmol) dissolved in water (40 mL) was added thereto. After introducing tetrakistriphenyl-phosphinopalladium (0.5 g, 0.418 mmol) thereto, the result was stirred for 8 hours with heating. After lowering the temperature to room temperature, the reaction was terminated, and then the potassium carbonate solution was removed to filter white solids. The filtered white solids were washed twice each with THF and ethyl acetate to prepare a compound represented by Chemical Formula E1 (6.5 g, yield 70%). MS[M+H]+=665

According to the analysis of related databases, 58536-46-2, the application of this compound in the production field has become more and more popular.

Reference:
Patent; LG CHEM, LTD.; HEO, Dong Uk; LEE, Dong Hoon; HUH, Jungoh; JANG, Boonjae; HAN, Miyeon; YANG, Junghoon; YUN, Heekyung; (301 pag.)US2020/48230; (2020); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Related Products of 330786-24-8, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 330786-24-8, name is 3-(4-Phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine. This compound has unique chemical properties. The synthetic route is as follows.

Under nitrogen protection, 20 g of triphenylphosphine supported by nano-Fe3O4 was added to the three-necked flask (particle diameter 100 nm,PPh3 loading 1 mmol/g), adding intermediate (II) (3.04 g, 10 mmol),N-Boc-3S-hydroxypiperidine (III) (2.02 g, 10 mmol), diethyl azodicarboxylate (3.67 g, 21.1 mol)And 1,4-dioxane (100 mL), the reaction was stirred at 20 C until the intermediate (II) was consumed completely, and the reaction was stopped.The external magnet adsorbs the magnetic nano-load, and the reaction solution is decanted, and the nanoparticles are washed with 1,4-dioxane (50 mL¡Á2).The washing liquid and the reaction liquid were combined, concentrated under reduced pressure to (20 mL), and then added to 10 mol/L hydrochloric acid (40 mL), and the mixture was completely removed.Dichloromethane (50 mL x 3) was extracted and the aqueous phase was neutralized with saturated sodium carbonate to pH >Filtration and vacuum drying to obtain a solid intermediate (IV) (3.30 g, yield: 85.3%).No residual phenoxide was detected.

According to the analysis of related databases, 330786-24-8, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Hangzhou China-USA East China Pharmaceutical Co., Ltd.; Hangzhou East China Pharmaceutical Group New Drug Institute Co., Ltd.; Zhou Yubao; Yu Rui; Chen Yu; Hu Haiwen; (7 pag.)CN108623606; (2018); A;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia