Tag: M.W=300-400

Enzymes are biological catalysts that produce large increases in reaction rates and tend to be specific for certain reactants and products. 139756-21-1, Name is 5-(2-Ethoxyphenyl)-1-methyl-3-propyl-1H-pyrazolo[4,3-d]pyrimidin-7(6H)-one, molecular formula is C17H20N4O2, belongs to pyrimidines compound. In a document, author is Spallarossa, Andrea, introduce the new discover, Recommanded Product: 139756-21-1.

Bicyclic Basic Merbarone Analogues as Antiproliferative Agents

Pyrimido-pyrimidine derivatives have been developed as rigid merbarone analogues. In a previous study, these compounds showed potent antiproliferative activity and efficiently inhibited topoisomerase II alpha. To further extend the structure-activity relationships on pyrimido-pyrimidines, a novel series of analogues was synthesized by a two-step procedure. Analogues 3-6 bear small alky groups at positions 1 and 3 of the pyrimido-pyrimidine scaffold whereas at position 6a (4-chloro)phenyl substituent was inserted. The basic side chains introduced at position 7 were selected on the basis of the previously developed structure-activity relationships. The antiproliferative activity of the novel compounds proved to be affected by both the nature of the basic side chain and the substituents on the pyrimido-pyrimidine moiety. Derivatives 5d and 5e were identified as the most promising molecules still showing reduced antiproliferative activity in comparison with the previously prepared pyrimido-pyrimidine analogues. In topoisomerase II alpha-5d docking complex, the ligand would poorly interact with the enzyme and assume a different orientation in comparison with 1d bioactive conformation.

Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law. In my other articles, you can also check out more blogs about 139756-21-1. Recommanded Product: 139756-21-1.

Reference:
Pyrimidine | C4H4N2 – PubChem,
,Pyrimidine – Wikipedia

Chemistry is the science of change. But why do chemical reactions take place? Why do chemicals react with each other? The answer is in thermodynamics and kinetics, Product Details of 330786-24-8, 330786-24-8, Name is 3-(4-Phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine, SMILES is NC1=C2C(NN=C2C3=CC=C(OC4=CC=CC=C4)C=C3)=NC=N1, belongs to pyrimidines compound. In a document, author is Wen, Hui-Min, introduce the new discover.

A novel expanded metal-organic framework for balancing volumetric and gravimetric methane storage working capacities

A novel expanded metal-organic framework (UTSA-111a) with functional pyrimidine sites exhibits simultaneously high gravimetric and volumetric methane storage working capacities of 309 cm(3) (STP) g(-1) and 183 cm(3) (STP) cm(-3) at 298 K and 5.8-65 bar.

A reaction mechanism is the microscopic path by which reactants are transformed into products. Each step is an elementary reaction. In my other articles, you can also check out more blogs about 330786-24-8. Product Details of 330786-24-8.

Reference:
Pyrimidine | C4H4N2 – PubChem,
,Pyrimidine – Wikipedia

Catalysts are substances that increase the reaction rate of a chemical reaction without being consumed in the process. 330786-24-8, Name is 3-(4-Phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine, SMILES is NC1=C2C(NN=C2C3=CC=C(OC4=CC=CC=C4)C=C3)=NC=N1, belongs to pyrimidines compound. In a document, author is Shukla, Manojkumar R., introduce the new discover, Application In Synthesis of 3-(4-Phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine.

Discovery of a Potent and Selective PI3K delta Inhibitor (S)-2,4-Diamino-6-((1-(7-fluoro-1-(4-fluorophenyl)-4-oxo-3-phenyl-4H-quinolizin-2-yl)ethyl)amino)pyrimidine-5-carbonitrile with Improved Pharmacokinetic Profile and Superior Efficacy in Hematological Cancer Models

PI3K delta inhibitors have been approved for B-cell malignancies like CLL, small lymphocytic lymphoma, and so forth. However, currently available PI3K delta inhibitors are nonoptimal, showing weakness against at least one of the several important properties: potency, isoform selectivity, and/or pharmacokinetic profile. To come up with a PI3K delta inhibitor that overcomes all these deficiencies, a pharmacophoric expansion strategy was employed. Herein, we describe a systematic transformation of a three-blade propeller shaped lead, 2,3-disubstituted quinolizinone 11, through a 1,2-disubstituted quinolizinone 20 to a novel four-blade propeller shaped 1,2,3-trisubstituted quinolizinone 34. Compound 34 has excellent potency, isoform selectivity, metabolic stability across species, and exhibited a favorable pharmacokinetic profile. Compound 34 also demonstrated a differentiated efficacy profile in human germinal center B and activated B cell-DLBCL cell lines and xenograft models. Compound 34 qualifies for further evaluation as a candidate for monotherapy or in combination with other targeted agents in DLBCLs and other forms of iNHL.

The proportionality constant is the rate constant for the particular unimolecular reaction. the reaction rate is directly proportional to the concentration of the reactant. I hope my blog about 330786-24-8 is helpful to your research. Application In Synthesis of 3-(4-Phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine.

Reference:
Pyrimidine | C4H4N2 – PubChem,
,Pyrimidine – Wikipedia

One of the major reasons for studying chemical kinetics is to use measurements of the macroscopic properties of a system, such as the rate of change in the concentration of reactants or products with time. 150728-13-5, Name is 4,6-Dichloro-5-(2-methoxyphenoxy)-2,2′-bipyrimidine, formurla is C15H10Cl2N4O2. In a document, author is Yakout, El-Sayed M. A., introducing its new discovery. HPLC of Formula: C15H10Cl2N4O2.

Bioactive Small Molecules Having a Fatty Residue. Part VI: Synthesis, Cytotoxicity Evaluation, and Molecular Docking Studies of New Pyrimidine Derivatives as Antitumor Agents

Difficultly accessible pyrimidine, thiazolopyrimidine, triazolopyrimidine, and thiazinopyrimidine derivatives containing an oleyl residue were synthesized via alkylation of 6-oleyl-2-thiouracil. The structure of the synthesized compounds was established on the basis of their spectral data, elemental analyses, and chemical behavior. The in vitro cytotoxicity of selected compounds was screened against two human cancer cell lines, MCF-7 breast cancer and HepG2 liver cancer cell lines. 8-[(8Z)-Heptadec-8-en-1-yl)-3-hydroxy-3,4-dihydropyrimido[2,1-b][1,3]thiazin-6(2H)-one turned out to be the most potent with IC50 values of 12.5 and 20 mu g/mL against MCF-7 and HepG2 cancer cell lines, respectively. The structure-activity relationship for this compound was interpreted in terms of molecular docking and molecular dynamics studies.

I hope this article can help some friends in scientific research. I am very proud of our efforts over the past few months and hope to 150728-13-5 help many people in the next few years. HPLC of Formula: C15H10Cl2N4O2.

Reference:
Pyrimidine | C4H4N2 – PubChem,
,Pyrimidine – Wikipedia

Application of 150728-13-5, Enzymes are biological catalysts that produce large increases in reaction rates and tend to be specific for certain reactants and products. 150728-13-5, Name is 4,6-Dichloro-5-(2-methoxyphenoxy)-2,2′-bipyrimidine, SMILES is ClC1=NC(=NC(=C1OC2=C(C=CC=C2)OC)Cl)C3=NC=CC=N3, belongs to pyrimidines compound. In a article, author is Algohary, Ayman M., introduce new discover of the category.

Design, Synthesis And Evaluation Of New Chemosensors Containing Quinazolinones Moiety For Ions In An Aqueous Medium And Biological Samples

Quinazolinone derivatives were reported as a varied range of biological activity and played a principal part metabolism of all biological systems. The quinazolinone is an organic compound ring containing two merged aromatic rings benzene and pyrimidine. The current project deals with the design and synthesizing new Quinazolinones derivatives and evaluate them as colorimetric chemosensors to detect the cations in the aqueous medium and biological sample. The synthetic strategy depends on acylation of anthranilic acid (1) with butyroyl chloride followed by ring closure to yield benzoxazinone (2), which was reacted with various nucleophiles hydrazine hydrate, urea, thiourea, p-aminophenol, hydroxylamine, and phenyl hydrazine to give corresponding quinazolinone chemosensors 3-amino-2-propylquinazolin-4(3H)-ones (4), 6-nitro-4-oxo-2-propylquinazoline-3(4H)-carboxamide (5a), 6-nitro-4-oxo-2-propylquinazoline-3(4H)-carbothioamide (5b), 3-(2-hydroxyphenyl)-6-nitro-2-propylquinazolin-4(3H)-one (6), 3-hydroxy-2-propylquinazolin-4(3H)-ones (7) and 6-nitro-3-(phenylamino)-2-propylquinazolin-4(3H)-one (8). The importance of producing chemosensors has increased in the last decade. Therefore, here we developed and synthesized chemosensors 4 and 8 with high-selectivity and specificity to detect copper and mercury in both aqueous solutions and blood samples. Where the results showed that chemosesors 4 and 8 exhibited colormetric responses from pale yellow to green in case of Cu2+ ions and exhibited remarkable color change from pale yellow to rose by interacting with Hg2+. Chemosensors 5b and 7 show high selectivity toward cadmium ion, whereas chemosensors 5b and 7 exhibited remarkable color change from colorless to yellow when adding Cd2+. but the synthesized compounds 5a and 6 did not exhibit colorimetric response in all cation’s samples. In addition, the synthesized chemosensor was established as a strip paper to make the measurement process easy and inexpensive. All the synthesized compounds have been established by instrumental spectroscopy; 1HNMR, 13CNMR, IR, and mass spectra (ms).

Application of 150728-13-5, Consequently, the presence of a catalyst will permit a system to reach equilibrium more quickly, but it has no effect on the position of the equilibrium as reflected in the value of its equilibrium constant.I hope my blog about 150728-13-5 is helpful to your research.

Reference:
Pyrimidine | C4H4N2 – PubChem,
,Pyrimidine – Wikipedia

A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. 302964-08-5, Name is 2-((6-Chloro-2-methylpyrimidin-4-yl)amino)-N-(2-chloro-6-methylphenyl)thiazole-5-carboxamide, molecular formula is C16H13Cl2N5OS. In an article, author is Ignatovich, Zh. V.,once mentioned of 302964-08-5, HPLC of Formula: C16H13Cl2N5OS.

Synthesis of 4,4 ‘-Oxydibenzoic Acid Amides and Sulfonamides Containing 2-Arylaminopyrimidine Moieties

New 4,4 ‘-oxydibenzamides and sulfamoyl derivatives of 4,4 ‘-oxydibenzoic acid containing pharmacophoric 2-arylaminopyrimidine fragments in the amide moiety have been synthesized. Acylation of amines of the pyrimidine series with 2-chlorosulfonyl-substituted 4,4 ‘-oxydibenzoic acid gave the corresponding sulfonamides. Arylaminopyrimidine derivatives of 4,4 ‘-oxydibenzamide were obtained in 75-87% yield by acylation of 3-{[4-(pyridin-3-yl)pyrimidin-2-yl]amino}anilines with 4,4 ‘-oxydibenzoyl chloride. The reactivity of 4,4 ‘-oxydibenzoyl chloride toward amines is discussed.

Interested yet? Keep reading other articles of 302964-08-5, you can contact me at any time and look forward to more communication. HPLC of Formula: C16H13Cl2N5OS.

Reference:
Pyrimidine | C4H4N2 – PubChem,
,Pyrimidine – Wikipedia

Related Products of 139756-21-1, The transformation of simple hydrocarbons into more complex and valuable products via catalytic C¨CH bond functionalisation has revolutionised modern synthetic chemistry. 139756-21-1, Name is 5-(2-Ethoxyphenyl)-1-methyl-3-propyl-1H-pyrazolo[4,3-d]pyrimidin-7(6H)-one, SMILES is O=C1C(N(C)N=C2CCC)=C2N=C(C3=CC=CC=C3OCC)N1, belongs to pyrimidines compound. In a article, author is Lin Junjie, introduce new discover of the category.

Efficient Synthesis of Pyridine [2,3-d]pyrimidine Derivatives by Catalyst-free Tandem Cyclization Under Microwave Irradiation

This work presents a highly efficient and simple method for the synthesis of pyridine [2, 3-d] pyrimidine derivatives. This method took the alpha, beta-unsaturated ketones compounds and 1, 3-dimethyl-6-aminouracil as raw material, 28 pyridine [2, 3-d] pyrimidine derivatives were synthesized by microwave irradiation high-efficiency tandem cyclization in 5-15 min without catalyst, including 21 compounds did not see the literature. This method has the characteristics of simple and easy raw materials, high green efficiency, high bonding efficiency and simple post-treatment.

Related Products of 139756-21-1, Enzymes are biological catalysts that produce large increases in reaction rates and tend to be specific for certain reactants and products. I hope my blog about 139756-21-1 is helpful to your research.

Reference:
Pyrimidine | C4H4N2 – PubChem,
,Pyrimidine – Wikipedia

Let¡¯s face it, organic chemistry can seem difficult to learn. Especially from a beginner¡¯s point of view. Like 302964-08-5, Name is 2-((6-Chloro-2-methylpyrimidin-4-yl)amino)-N-(2-chloro-6-methylphenyl)thiazole-5-carboxamide. In a document, author is Sirakanyan, Samvel N., introducing its new discovery. COA of Formula: C16H13Cl2N5OS.

Synthesis and antimicrobial evaluation of novel polyheterocyclic systems derived from cyclopenta[4 ‘,5 ‘]pyrido[3 ‘,2 ‘:4,5]furo[3,2-d]pyrimidine

The synthesis of new cyclopenta[4′,5′]pyrido[3′,2’:4,5]furo[3,2-d]pyrimidin-7-amines have been carried out to study their antimicrobial activity. The biological tests evidenced that some of the synthesized compounds exhibit pronounced antimicrobial properties. A study of the structure-activity relationship revealed that the 3,5-dimethyl-1H-pyrazol-1-yl moiety linked to the carbon C-9 of the pyrimidine plays a decisive role in the manifestation of activity. The influence of 3,5-dimethyl-1H-pyrazol-1-yl group on the Dimroth rearrangement and azide-tetrazole equilibrium has also been examined.

I hope this article can help some friends in scientific research. I am very proud of our efforts over the past few months and hope to 302964-08-5 help many people in the next few years. COA of Formula: C16H13Cl2N5OS.

Reference:
Pyrimidine | C4H4N2 – PubChem,
,Pyrimidine – Wikipedia

The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature. Application In Synthesis of 2-((6-Chloro-2-methylpyrimidin-4-yl)amino)-N-(2-chloro-6-methylphenyl)thiazole-5-carboxamide, 302964-08-5, Name is 2-((6-Chloro-2-methylpyrimidin-4-yl)amino)-N-(2-chloro-6-methylphenyl)thiazole-5-carboxamide, SMILES is CC1=CC=CC(Cl)=C1NC(=O)C1=CN=C(NC2=CC(Cl)=NC(C)=N2)S1, in an article , author is Galai, M., once mentioned of 302964-08-5.

Chemically functionalized of 8-hydroxyquinoline derivatives as efficient corrosion inhibition for steel in 1.0 M HCl solution: Experimental and theoretical studies

The challenge of this work is the functionalization of new 8-hydroxyquinoline derivatives by a simple method achieving a very good yield (80-90%).The corrosion inhibition performance of two neworganic compounds derived from quinolin-8-ol, namely, BMQ and DEMQ for mild steel in 1.0 M HCl solution was studied usingPotentiodynamic polarization (PDP)and electrochemical impedance spectroscopy (EIS).Scanning electron microscopy (SEM) coupled with the energy dispersive spectroscopy (EDX) were used to characterize and analyze the surface of steel.The theoretical study wasalso carried out by DFT calculations (structure-reactivity) and Monte Carlo, MC (inhibitor-surface) simulations. The electrochemical results showed that both studied molecules provide high resistance and that the inhibition efficiency (eta%) reaches 94% at 10(-3) M for BMQ. PDP measurements revealed that these compounds function as mixed type corrosion inhibitors. In addition, they can be adsorbed on the steel surface by chemical bonds following Langmuir adsorption isotherm. Also, both inhibitors remain effective at high temperatures (86% at 328 K for the concentration 10(-3) M).DFT calculations show that the free heteroatom doublets of oxygen (O), nitrogen (N) and the methyl groups (-CH3) favor the sharing of electrons between the studiedmolecules and the surface of the steel. The data of theoretical methods (DFT and MC) supported the experimental findings.

But sometimes, even after several years of basic chemistry education, it is not easy to form a clear picture on how they govern reactivity! 302964-08-5, you can contact me at any time and look forward to more communication. Application In Synthesis of 2-((6-Chloro-2-methylpyrimidin-4-yl)amino)-N-(2-chloro-6-methylphenyl)thiazole-5-carboxamide.

Reference:
Pyrimidine | C4H4N2 – PubChem,
,Pyrimidine – Wikipedia

Reactions catalyzed within inorganic and organic materials and at electrochemical interfaces commonly occur at high coverage and in condensed media, causing turnover rates to depend strongly on interfacial structure and composition, 330786-24-8, Name is 3-(4-Phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine, SMILES is NC1=C2C(NN=C2C3=CC=C(OC4=CC=CC=C4)C=C3)=NC=N1, in an article , author is Hao, Peng-Fei, once mentioned of 330786-24-8, Quality Control of 3-(4-Phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine.

Agriculture organic wastes fermentation CO2 enrichment in greenhouse and the fermentation residues improve growth, yield and fruit quality in tomato

The concern about fossil fuel shortage and environmental pollution highlighted the necessity to improve the output performance in facility agriculture. We investigated the influence of a climate-smart agricultural production system, namely agriculture organic waste fermentation CO2 enrichment technology (AOWF + CO2) on greenhouse tomato production and the effect of fermentation residues from AOWF + CO2. AOWF + CO2 exhibited positive effect on tomato growth, yield and fruit quality. Soluble sugar, lycopene and carotenoid contents in tomato fruits increased by 24.1%, 53% and 129%, respectively, while the nitrate content decreased by 10.7% when compared with control. The metabolome and proteome studies revealed significant up-regulation of secondary metabolisms, and the differentially expressed proteins (DEPs) were significantly enriched in purine, pyrimidine and linoleic acid metabolism pathways. The fermentation residues also significantly increased tomato growth, yield and fruit quality. It was estimated that each hectare greenhouse furnished with AOWF + CO2 could at least reduce 17951.5 kg CO(2)eq. emission, and store 5314.5 kg CO(2)eq. in soil. In conclusion, AOWF + CO2 and its residues recycling could accelerate tomato growth and productivity. This demonstrates a new climate-smart agriculture approach of reutilizing agricultural organic wastes to improve the sustainability of ecosystem. (C) 2020 Elsevier Ltd. All rights reserved.

But sometimes, even after several years of basic chemistry education, it is not easy to form a clear picture on how they govern reactivity! 330786-24-8, you can contact me at any time and look forward to more communication. Quality Control of 3-(4-Phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine.

Reference:
Pyrimidine | C4H4N2 – PubChem,
,Pyrimidine – Wikipedia