Tag: M.W=300-400

Synthetic Route of 150728-13-5, Catalysts allow a reaction to proceed via a pathway that has a lower activation energy than the uncatalyzed reaction. 150728-13-5, Name is 4,6-Dichloro-5-(2-methoxyphenoxy)-2,2′-bipyrimidine, SMILES is ClC1=NC(=NC(=C1OC2=C(C=CC=C2)OC)Cl)C3=NC=CC=N3, belongs to pyrimidines compound. In a article, author is El-Badawy, Azza A., introduce new discover of the category.

Acryloyl isothiocyanate skeleton as a precursor for synthesis of some novel pyrimidine, triazole, triazepine, thiadiazolopyrimidine and acylthiourea derivatives as antioxidant agents

The reactions of 2-cyano-3-pyrazolylpropenoyl isothiocyanate derivative 2 with some mono- and bidentate nucleophiles namely, dodecan-1-amine, 6-aminothiouracil, hydrazine, phenylhydrazine, phenylurea, semicarbazide, and thiosemicarbazide, in addition to some derivatives of hydrazides, have been investigated to obtain some valuable heterocyclic skeletons gathering with a pyrazole core, viz. pyrimidine, triazole, triazepine, thiadiazolopyrimidine as well as acylthiourea derivatives. Hydrazinolysis of 2 was found to provide a mixture of thiosemicarbazide, diheterylazine, and triazepine derivatives. Treatment of 2 with phenylhydrazine was mainly dependent on the reaction conditions to produce a mixture of pyrimidinethione and triazole derivatives at room temperature or the triazepine derivative at heating conditions. The antioxidant activity screening of these compounds disclosed that pyrimidinethione derivatives 9 and 13 exhibited the most potency.

Synthetic Route of 150728-13-5, Because enzymes can increase reaction rates by enormous factors and tend to be very specific, typically producing only a single product in quantitative yield, they are the focus of active research.you can also check out more blogs about 150728-13-5.

Reference:
Pyrimidine | C4H4N2 – PubChem,
,Pyrimidine – Wikipedia

Let¡¯s face it, organic chemistry can seem difficult to learn. Especially from a beginner¡¯s point of view. Like 139756-21-1, Name is 5-(2-Ethoxyphenyl)-1-methyl-3-propyl-1H-pyrazolo[4,3-d]pyrimidin-7(6H)-one. In a document, author is Tian, Jinglin, introducing its new discovery. Product Details of 139756-21-1.

Metabolic signatures for safety assessment of low-level cadmium exposure on human osteoblast-like cells

Cadmium has been widely detected in the environment and various foods. The association between cadmium burden and osteoporosis has been studied in cohorts. However, the effects and mechanisms of environmental cadmium exposure on bone metabolism is poorly understood. This study aims to investigate the altered me-tabolites in bone cells affected by low-level cadmium by metabolomics analysis. Specifically, we used the dosage of cadmium that do not decrease the cell viability (determined by MTT assay) to treat Saos-2 cells for 24 h. ICPMS was applied to quantify the cadmium in culture medium and cell precipitate. The cellular metabolites were extracted and analyzed by liquid chromatography-mass spectrometry. The pathway analysis based on the identified differential metabolites showed that 1 mu M cadmium significantly affected citric acid cycle and malateaspartate shuttle, while 10 mu M cadmium treatment affected citric acid cycle, alanine metabolism, glucose-alanine cycle, pyrimidine metabolism and glutamate metabolism. Taken together, 1 mu M cadmium exposure could suppress the electrons transportation from the cytosol to mitochondrial matrix in Saos-2, and the impediment of the electron transport chain further inhibited downstream activities in citric acid cycle, which resulted in the accumulation of pyruvic acid. In addition, the suppressed pyrimidine degradation resulted in senescent nucleic acid accumulation and the decrease of mRNA transcription in Saos-2 cells. In general, our studies unveil the cadmium-induced metabolic perturbations in Saos-2 cells and demonstrate the feasibility of our established metabolomics pipeline to understand cadmium-induced effects on bone.

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Reference:
Pyrimidine | C4H4N2 – PubChem,
,Pyrimidine – Wikipedia

Reference of 764659-72-5, The transformation of simple hydrocarbons into more complex and valuable products via catalytic C¨CH bond functionalisation has revolutionised modern synthetic chemistry. 764659-72-5, Name is (2R,5S)-(1R,2S,5R)-2-Isopropyl-5-methylcyclohexyl 5-(4-amino-5-fluoro-2-oxopyrimidin-1(2H)-yl)-1,3-oxathiolane-2-carboxylate, SMILES is O=C([C@@H]1O[C@H](N2C=C(F)C(N)=NC2=O)CS1)O[C@H]3[C@H](C(C)C)CC[C@@H](C)C3, belongs to pyrimidines compound. In a article, author is Farooq, Saba, introduce new discover of the category.

One-pot and two-pot methods for chalcone derived pyrimidines synthesis and applications

Chalcone-derived pyrimidine is a well-known heterocyclic compound that is commonly present in ribonucleic acid (RNA) and deoxyribonucleic acid (DNA) bio-isosteres. Pyrimidine derivatives are effective in both the electronic industry and drug industries. This review highlights the synthesis of pyrimidines, namely mono-pyrimidine, bis-pyrimidine, fused pyrimidine, symmetric, and asymmetric pyrimidine via one-pot and two-pot methods. The one-pot method is the direct reaction of amino derivatives with aldehydes and acetophenones, whereas the two-pot method is frequently reported for the synthesis of chalcone before the cyclization to a pyrimidine. This review is important in organic synthesis, particularly in the heterocyclic field, regarding pyrimidines and their significance in therapeutic and electronic industries.

Reference of 764659-72-5, Enzymes are biological catalysts that produce large increases in reaction rates and tend to be specific for certain reactants and products. I hope my blog about 764659-72-5 is helpful to your research.

Reference:
Pyrimidine | C4H4N2 – PubChem,
,Pyrimidine – Wikipedia

In an article, author is Mityuk, Andrey P., once mentioned the application of 764659-72-5, Quality Control of (2R,5S)-(1R,2S,5R)-2-Isopropyl-5-methylcyclohexyl 5-(4-amino-5-fluoro-2-oxopyrimidin-1(2H)-yl)-1,3-oxathiolane-2-carboxylate, Name is (2R,5S)-(1R,2S,5R)-2-Isopropyl-5-methylcyclohexyl 5-(4-amino-5-fluoro-2-oxopyrimidin-1(2H)-yl)-1,3-oxathiolane-2-carboxylate, molecular formula is C18H26FN3O4S, molecular weight is 399.4802, MDL number is MFCD09753268, category is pyrimidines. Now introduce a scientific discovery about this category.

Efficient Route for the Synthesis of Diverse Heteroannelated 5-Cyanopyridines

The new efficient, convenient protocol for the synthesis of heteroannelated 3-cyanopyridines and pyrimidines starting from diverse aminoheterocycles and 3,3-dimethoxy-2-formylpropionitrile sodium salt was elaborated. The advantages and improvements of the procedure compared to previously known methods are shown. The scope and limitations of the method are determined. The impact of the structural features on regioselectivity are discussed. The preparativeness, scalability, and application scope of the elaborated protocol are demonstrated by the synthesis of five heteroannelated 3-cyanopyridines in quantities up to 100 grams.

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Reference:
Pyrimidine | C4H4N2 – PubChem,
,Pyrimidine – Wikipedia

One of the major reasons for studying chemical kinetics is to use measurements of the macroscopic properties of a system, such as the rate of change in the concentration of reactants or products with time. 302964-08-5, Name is 2-((6-Chloro-2-methylpyrimidin-4-yl)amino)-N-(2-chloro-6-methylphenyl)thiazole-5-carboxamide, formurla is C16H13Cl2N5OS. In a document, author is Yan Yingkun, introducing its new discovery. Quality Control of 2-((6-Chloro-2-methylpyrimidin-4-yl)amino)-N-(2-chloro-6-methylphenyl)thiazole-5-carboxamide.

Discovery of Novel 2,4,6-Trisubstituted Pyrimidine Derivatives as Succinate Dehydrogenase Inhibitors

Thirty-six unreported pyrimidine analogues were designed, synthesized and characterized by IR, H-1 NMR, C-13 NMR and HRMS. Their antifungal activities were determined against five plant pathogenic fungi namely Rhizoctonia solani, Fusarum graminearum, Helminthosporium maydis, Sclerotinia sclerotiorum and Botrytis cinerea. The results indicated that most of them revealed significant antifungal activities at 20 mg/L. Among them, 4-(furan-2-yl)-2-methyl-6-(p-tolyl)pyrimidine (2c) and 4-(4-chlorophenyl)-6-(5-methylfuran-2-yl)-2-(1H-pyrazol-1-yl)pyrimidine (3d) showed the strongest activities against Sclerotinia sclerotiorum and their median effect concentrations (EC50) were 0.072 and 0.077 mg/L, respectively, which implied that they had better antifungal activities than the commercial fungicide fluopyram (EC50=0.244 mg/L). Meanwhile, the inhibitory activities of compounds 2c and 3d were determined against succinate dehydrogenase (SDH). The results exhibited that their half inhibitory concentrations (IC50) were 0.115 and 0.121 mg/L, respectively, indicating that they also had better inhibitory activities than fluopyram (IC50=0.356 mg/L). Molecular docking studies demonstrated that the binding energy of compounds 2c, 3d and fluopyram to SDH was -32.2 kJ/mol, -31.8 kJ/mol and -28.9 kJ/mol, respectively, which represented that they had stronger affinities than fluopyram. The inhibitory activities of compounds 2c and 3d against SDH have been reported for the first time.

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Reference:
Pyrimidine | C4H4N2 – PubChem,
,Pyrimidine – Wikipedia

Chemistry, like all the natural sciences, begins with the direct observation of nature¡ª in this case, of matter.764659-72-5, Name is (2R,5S)-(1R,2S,5R)-2-Isopropyl-5-methylcyclohexyl 5-(4-amino-5-fluoro-2-oxopyrimidin-1(2H)-yl)-1,3-oxathiolane-2-carboxylate, SMILES is O=C([C@@H]1O[C@H](N2C=C(F)C(N)=NC2=O)CS1)O[C@H]3[C@H](C(C)C)CC[C@@H](C)C3, belongs to pyrimidines compound. In a document, author is Huddart, B. M., introduce the new discover, Name: (2R,5S)-(1R,2S,5R)-2-Isopropyl-5-methylcyclohexyl 5-(4-amino-5-fluoro-2-oxopyrimidin-1(2H)-yl)-1,3-oxathiolane-2-carboxylate.

Magnetic order and ballistic spin transport in a sine-Gordon spin chain

We report the results of muon-spin spectroscopy (mu+SR) measurements on the staggered molecular spin chain [pym-Cu(NO3)(2)(H2O)(2)] (pym = pyrimidine), a material previously described using sine-Gordon field theory. Zero-field mu+SR reveals a long range magnetically ordered ground state below a transition temperature T-N = 0.23(1) K. Using longitudinal-field (LF) mu+SR we investigate the dynamic response in applied magnetic fields 0 < B < 500 mT and find evidence for ballistic spin transport. Our LF mu+SR measurements on the chiral spin chain [Cu(pym)(H2O)(4)]SiF6 center dot H2O instead demonstrate one-dimensional spin diffusion, and the distinct spin transport in these two systems suggests that additional anisotropic interactions play an important role in determining the nature of spin transport in S = 1/2 antiferromagnetic chains. The proportionality constant is the rate constant for the particular unimolecular reaction. the reaction rate is directly proportional to the concentration of the reactant. I hope my blog about 764659-72-5 is helpful to your research. Name: (2R,5S)-(1R,2S,5R)-2-Isopropyl-5-methylcyclohexyl 5-(4-amino-5-fluoro-2-oxopyrimidin-1(2H)-yl)-1,3-oxathiolane-2-carboxylate.

Reference:
Pyrimidine | C4H4N2 – PubChem,
,Pyrimidine – Wikipedia

Electric Literature of 139756-21-1, The transformation of simple hydrocarbons into more complex and valuable products via catalytic C¨CH bond functionalisation has revolutionised modern synthetic chemistry. 139756-21-1, Name is 5-(2-Ethoxyphenyl)-1-methyl-3-propyl-1H-pyrazolo[4,3-d]pyrimidin-7(6H)-one, SMILES is O=C1C(N(C)N=C2CCC)=C2N=C(C3=CC=CC=C3OCC)N1, belongs to pyrimidines compound. In a article, author is Pan, Y-Q, introduce new discover of the category.

A single nucleotide distinguishes the SARS-CoV-2 in the Wuhan outbreak in December 2019 from that in Beijing-Xinfadi in June 2020, China

Two major locally transmitted outbreaks of coronavirus disease 2019 occurred in China, one in Wuhan from December 2019 to April 2020, another in Beijing-Xinfadi in June 2020. Severe acute respiratory syndrome coronavirus 2 isolated from these two outbreaks can be distinguished by a conserved pyrimidine nucleotide located at nucleotide position 241 in the 5′-untranslated region of the virus genome. (C) 2020 The Authors. Published by Elsevier Ltd.

Electric Literature of 139756-21-1, Consequently, the presence of a catalyst will permit a system to reach equilibrium more quickly, but it has no effect on the position of the equilibrium as reflected in the value of its equilibrium constant.I hope my blog about 139756-21-1 is helpful to your research.

Reference:
Pyrimidine | C4H4N2 – PubChem,
,Pyrimidine – Wikipedia

The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature. Quality Control of 3-(4-Phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine, 330786-24-8, Name is 3-(4-Phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine, SMILES is NC1=C2C(NN=C2C3=CC=C(OC4=CC=CC=C4)C=C3)=NC=N1, in an article , author is Tsibizova, A. A., once mentioned of 330786-24-8.

SYNTHESIS AND IMMUNOTROPIC ACTIVITY OF NEW QUINAZOLINE DERIVATIVES IN MICE

New condensed pyrimidine compounds with a benzoannelated quinazoline structure and various functional substituents at the pyrimidine N3-position were synthesized and included 2-methyl-3-(2-phenyl-2-oxoethyl) quinazolin-4(3H)-one; 3-(2-tert-butyl-2-oxoethyl)quinazolin-4(3H)-one; 3-[2-(1-naphthyl)-2-oxoethyl]-6-bromoquinazolin-4(3H)-one; 3-(2-isopropyloxy-2-oxoethyl)quinazolin-4(3H)-one; and 3-{2-[(4,6-dimethylpyrimidin- 2-yl)amino]-2-oxoethyl}quinazolin-4(3H)-one. The new quinazoline derivatives were found to produce a corrective action on proliferation processes in immunocompetent organs as manifested by restoration of the number of splenocytes and thymocytes on the background of cyclophosphan-induced immunosuppression in CBA mice of both sexes aged 3 – 4 months.

But sometimes, even after several years of basic chemistry education, it is not easy to form a clear picture on how they govern reactivity! 330786-24-8, you can contact me at any time and look forward to more communication. Quality Control of 3-(4-Phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine.

Reference:
Pyrimidine | C4H4N2 – PubChem,
,Pyrimidine – Wikipedia

Electric Literature of 1981-58-4, Enzymes are biological catalysts that produce large increases in reaction rates and tend to be specific for certain reactants and products. 1981-58-4, Name is Sulfamethazine sodium, SMILES is CC1=CC(C)=NC([N-]S(=O)(C2=CC=C(N)C=C2)=O)=N1.[Na+], belongs to pyrimidines compound. In a article, author is Tigreros, Alexis, introduce new discover of the category.

Pyrazolo[1,5-a]pyrimidines-based fluorophores: a comprehensive theoretical-experimental study

Fluorescent molecules are crucial tools for studying the dynamics of intracellular processes, chemosensors, and the progress of organic materials. In this study, a family of pyrazolo[1,5-a]pyrimidines (PPs) 4a-g has been identified as strategic compounds for optical applications due to several key characteristics such as their simpler and greener synthetic methodology (RME: 40-53%) as compared to those of BODIPYS (RME: 1.31-17.9%), and their tunable photophysical properties (going from epsilon = 3320 M-1 cm(-1) and phi(F) = 0.01 to epsilon = 20 593 M-1 cm(-1) and phi(F) = 0.97), in which electron-donating groups (EDGs) at position 7 on the fused ring improve both the absorption and emission behaviors. The PPs bearing simple aryl groups such as 4a (4-Py), 4b (2,4-Cl2Ph), 4d (Ph) and 4e (4-MeOPh), allow good solid-state emission intensities (QY(SS) = 0.18 to 0.63) in these compounds and thus, solid-state emitters can be designed by proper structural selection. The properties and stability found in 4a-g are comparable to commercial probes such as coumarin-153, prodan and rhodamine 6G. Ultimately, the electronic structure analysis based on DFT and TD-DFT calculations revealed that EDGs at position 7 on the fused ring favor large absorption/emission intensities as a result of the ICT to/from this ring; however, these intensities remain low with electron-withdrawing groups (EWGs), which is in line with the experimental data and allows us to understand the optical properties of this fluorophore family.

Electric Literature of 1981-58-4, Because enzymes can increase reaction rates by enormous factors and tend to be very specific, typically producing only a single product in quantitative yield, they are the focus of active research.you can also check out more blogs about 1981-58-4.

Reference:
Pyrimidine | C4H4N2 – PubChem,
,Pyrimidine – Wikipedia

Related Products of 764659-72-5, Chemo-enzymatic cascade processes are invaluable due to their ability to rapidly construct high-value products from available feedstock chemicals in a one-pot relay manner. 764659-72-5, Name is (2R,5S)-(1R,2S,5R)-2-Isopropyl-5-methylcyclohexyl 5-(4-amino-5-fluoro-2-oxopyrimidin-1(2H)-yl)-1,3-oxathiolane-2-carboxylate, SMILES is O=C([C@@H]1O[C@H](N2C=C(F)C(N)=NC2=O)CS1)O[C@H]3[C@H](C(C)C)CC[C@@H](C)C3, belongs to pyrimidines compound. In a article, author is Yadav, Maruti B., introduce new discover of the category.

One-pot four-component synthesis of methyl 4-(4-chlorophenyl)-5,7-dioxo-1-phenyl-1,4,5,6,7,8-hexahydropyrazolo [4 ‘,3 ‘:5,6] pyrano [2,3-d] pyrimidine-3-carboxylate; a green approach

A simple and efficient synthetic protocol for the synthesis of methyl 4-(4-chlorophenyl)-5,7-dioxo-1-phenyl-1,4,5,6,7,8-hexahydropyrazolo [4’,3]:5,6] pyrano[2,3-d] pyrimidine-3-carboxylate derivatives via a one pot four-component reaction catalyzed by L-Proline has been successfully developed. This new protocol produces pyrano pyrimidine carboxylate derivatives in good to excellent yields, with operational simplicity. The remarkable features of this methodology are high yields, metal-free catalyst, easy work-up procedure, and a greener method that avoids toxic catalyst and hazardous solvents. (C) 2021 Elsevier Ltd. All rights reserved.

Related Products of 764659-72-5, Enzymes are biological catalysts that produce large increases in reaction rates and tend to be specific for certain reactants and products. I hope my blog about 764659-72-5 is helpful to your research.

Reference:
Pyrimidine | C4H4N2 – PubChem,
,Pyrimidine – Wikipedia