Tag: M.W=300-400

Related Products of 186046-78-6, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 186046-78-6, name is 2-(4-(((Benzhydryloxy)carbonyl)amino)-2-oxopyrimidin-1(2H)-yl)acetic acid, molecular formula is C20H17N3O5, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

Example 60 1-(5-Chloro-benzothiazole-2-sulfonyl)-4-{[4-N-(benzhydryloxycarbonyl)-cytosin-1-yl]-acetyl}-piperazin-2-one The title compound was synthesised by the reaction of 1-(5-chloro-benzothiazole-2-sulfonyl)-piperazin-2-one trifluoroacetic acid salt with [4-N-(benzhydryloxycarboniyl)-cytosin-1-yl]-acetic acid as per the procedure of Example 52. 1H NMR (500 MHz; DMSO-d6) delta 10.98 (brs, 1H), 8.40 (m, 2H), 7.96 (s, 1H), 7.79 (m, 1H), 7.45 (d, 4H), 7.38 (t, 4H), 7.30 (t, 2H), 6.96 (t, 1H), 6.80 (s, 1H), 4.83 (s, 2H), 4.72 (s, 0.8H), 4.46 (s, 0.8H), 4.28 (s, 1.2H), 4.22 (t, 1.2H), 4.06 (t, 0.8H), 3.99 (t, 1.2H), 3.87 (t, 0.8H).

According to the analysis of related databases, 186046-78-6, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Kim, Sung Kee; Lee, Hyunil; Lim, Jong Chan; Choi, Hoon; Jeon, Jae Hoon; Ahn, Sang Youl; Lee, Sung Hee; Yoon, Won Jun; US2003/225252; (2003); A1;,
Pyrimidine | C4H4N2 – PubChem,
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Synthetic Route of 374930-88-8 ,Some common heterocyclic compound, 374930-88-8, molecular formula is C13H19BrN4O2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

tert-Butyl 4-(5-bromopyrimidin-2-yl)piperazine-1-carboxylate (0.242 g, 0.705 mmol) was taken up in THF (3.5 mL) and cooled to -78 C. A solution of nBuLi, 2.5 M in hexanes (0.31 mL, 0.775 mmol) was added at a fast dropwise rate from a syringe. The resulting mixture was stirred at -78 C. for 15 minutes. A solution of (R,Z)-2-methyl-N-(2,2,2-trifluoro-1-(4-fluorophenyl)ethylidene)propane-2-sulfinamide (0.225 g, 0.762 mmol) in THF (0.5 mL) was added at a fast dropwise rate from a syringe. The reaction mixture was stirred at -78 C. for 5 minutes before warming to room temperature. After 45 minutes, saturated NH4Cl was added and the products extracted into EtOAc (×2). The combined organic extracts were washed with brine, dried over Na2SO4, filtered, and concentrated in vacuo. Purification of the residue by MPLC (0-80% EtOAc-hexanes) gave tert-butyl 4-(5-((S)-1-(((R)-tert-butylsulfinyl)amino)-2,2,2-trifluoro-1-(4-fluorophenyl)ethyl)pyrimidin-2-yl)piperazine-1-carboxylate (304 mg, 0.543 mmol, 77% yield) as a pale yellow gum. The absolute stereochemistry was assigned randomly. MS (ES+) C25H33F4N5O3S requires: 559. found: 560 [M+H]+.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,374930-88-8, its application will become more common.

Reference:
Patent; Hodous, Brian L.; Kim, Joseph L.; Wilson, Kevin J.; Wilson, Douglas; Zhang, Yulian; US2015/111887; (2015); A1;,
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As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 252723-16-3, name is 7-Benzenesulfonyl-4-chloro-6-methyl-7H-pyrrolo[2,3-d]pyrimidine, molecular formula is C13H10ClN3O2S, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. Formula: C13H10ClN3O2S

The compound 1 (10.83 mmol), compound 2 (10.83 mmol), PdCl2(Dppf) (527 mg, 0 . 72 mmol) and KOAc (235 mg, 2.4 mmol) in toluene (30 ml) in the mixture is heated to 110 C maintain 6 hours. The reaction liquid evaporation and adding water (100 ml), and ethyl acetate (2 × 40 ml) extraction. Separating the organic phase, using anhydrous Na2SO4 drying, filtering and evaporation. Through column chromatography ethyl acetate/petroleum ether=1:4 – 1:1 to carry out the purification, to obtain 2 g solid, in THF: H 20 (24 ml: 6 ml) in the mixed solvent are added in the solution of NaIO4(18.6 Mmol), and stirring at room temperature 30 minutes. By adding 2 N HCl aqueous solution. Its stirring at room temperature 3 hours. The mixture of ethyl acetate dilution, salt water for washing, then separating and anhydrous Na2SO4Drying, filtering and concentrating. Through the use of MeOH/DCM=1:10 of column chromatography purification to obtain compound 4.

With the rapid development of chemical substances, we look forward to future research findings about 252723-16-3.

Reference:
Patent; Chengdu Shibeikang Bio-pharmaceutical Technology Co., Ltd.; Cen Guodong; Yang Maoting; Tan Shaojun; (8 pag.)CN108191874; (2018); A;,
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Adding a certain compound to certain chemical reactions, such as: 153435-63-3, 2-(Tributylstannyl)pyrimidine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 153435-63-3, blongs to pyrimidines compound. SDS of cas: 153435-63-3

General procedure 8Intermediates 46-50 (1 eq) was dissolved dry DMF (20ml/mmol), then CsF (2 eq), CuI (0.2 eq), [Ph3P]4Pd (0.1 eq) and the corresponding Ar2-tributylstannane (1.5 eq; prepared according to Eur. J. Org. Chem. 2003, 171 1 -1721 ) were added. The mixture was warmed at 130 C for 10 minutes (microwave), then poured in aqueous saturated solution of NH4CI and extracted with AcOEt . The organic layers were combined, dried (Na2SO4) and concentrated under vacuum; crude product was purified by silica gel column chromatography (DCM to DCM/MeOH 9/1 ). The enantiomeric purity was calculated as enantiomeric eccess (ee%) by chiral HPLC methods.According to general procedure 8 the following compounds were prepared:

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,153435-63-3, its application will become more common.

Reference:
Patent; ROTTAPHARM S.P.A.; STASI, Luigi, Piero; ROVATI, Lucio; WO2011/6960; (2011); A1;,
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Synthetic Route of 356058-42-9, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.356058-42-9, name is 2-(2-((4-Fluorobenzyl)thio)-4-oxo-4,5,6,7-tetrahydro-1H-cyclopenta[d]pyrimidin-1-yl)acetic acid, molecular formula is C16H15FN2O3S, molecular weight is 334.3653, as common compound, the synthetic route is as follows.

To an ice cold suspension ofintermediateA4 (2.0 g, 1 equiv) in dichloromethane (15 ml) (wherein a drying tube was used to insulate moisture) were added thionyl chloride (0.47 ml) and DMF (2 drops, catalyst). The mixture was stirred for 0.5 h to get a brown clear solution and then added slowly to a flask containing strong aqua (20 ml) over 10 mm in an ice bath with vigorous stirring. The solid thus formed was collected by filtration, washed to white with water and ethanol, and then dried in vacuo to give the title compound(1.0 g). MS (ESI): 334 (M+H).

Statistics shows that 356058-42-9 is playing an increasingly important role. we look forward to future research findings about 2-(2-((4-Fluorobenzyl)thio)-4-oxo-4,5,6,7-tetrahydro-1H-cyclopenta[d]pyrimidin-1-yl)acetic acid.

Reference:
Patent; Shen, Jianhua; Wang, Yiping; Wang, Kai; US2014/171431; (2014); A1;,
Pyrimidine | C4H4N2 – PubChem,
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Synthetic Route of 428854-24-4, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 428854-24-4, name is 2-(1-(2-Fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl)pyrimidine-4,5,6-triamine. This compound has unique chemical properties. The synthetic route is as follows.

Example 51 4-Amino-2-[1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]-5,8-dihydropteridine-6,7-dione 300 mg (0.856 mmol) of the compound from example 1A were dissolved in 3 ml of ethanol, and 116 mul (0.856 mmol) of diethyl oxalate and 79 mg (1.156 mmol) of sodium methoxide were added. The mixture was heated to reflux for 10 h. The reaction mixture was stirred with 10 ml of ethanol. The precipitate was filtered off and stirred with 10 ml of water and then with 10 ml of acetonitrile. The precipitate was filtered off and dried under high vacuum. 112 mg of the title compound were obtained (30% of theory). LC-MS (method 2): Rt=0.80 min; MS (EIpos): m/z=405 (M+H)+. 1H NMR (400 MHz, DMSO-d6): delta [ppm]=5.82 (s, 2H), 7.12-7.25 (m, 4H), 7.33-7.40 (m, 2H), 8.64 (dd, 1H), 9.14 (dd, 1H), 12.44 (s, 1H).

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 428854-24-4, 2-(1-(2-Fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl)pyrimidine-4,5,6-triamine.

Reference:
Patent; BAYER INTELLECTUAL PROPERTY GMBH; Follmann, Markus; Stasch, Johannes-Peter; Redlich, Gorden; Ackerstaff, Jens; Griebenow, Nils; Knorr, Andreas; Wunder, Frank; Li, Volkhart Min-Jian; Baerfacker, Lars; Weigand, Stefan; US2014/148433; (2014); A1;,
Pyrimidine | C4H4N2 – PubChem,
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Electric Literature of 1197953-49-3, Adding some certain compound to certain chemical reactions, such as: 1197953-49-3, name is (2-((2,5-Dichloropyrimidin-4-yl)amino)phenyl)dimethylphosphine oxide,molecular formula is C12H12Cl2N3OP, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 1197953-49-3.

The above compound B (0.1g, 0.53mmol) and 4-(ortho dimethyl phosphinyl anilino)- 5- chloro – 2-chloro pyrimidine (0.17g, 0.53mmol) were dissolved in a mixture of 2-butanol (1.2mL) & trifluoroacetic acid (0.25 mL) and were heated to 100 C in a seal tube for overnight. The reaction mixture was then cooled to rt and poured into a saturated NaHCC solution while stirring to afford an orange solid which was filtered, washed with Et.20 to remove final traces of water. The product was dried to afford C (0.19g) which was directly used in the next step.

According to the analysis of related databases, 1197953-49-3, the application of this compound in the production field has become more and more popular.

Reference:
Patent; ARIAD PHARMACEUTICALS, INC.; ZHU, Xiaotian; WANG, Yihan; SHAKESPEARE, William, C.; HUANG, Wei-Sheng; DALGARNO, David, C.; WO2013/169401; (2013); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Adding a certain compound to certain chemical reactions, such as: 1012785-51-1, 2,4-Dichloro-5-iodo-7H-pyrrolo[2,3-d]pyrimidine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 1012785-51-1, blongs to pyrimidines compound. Application In Synthesis of 2,4-Dichloro-5-iodo-7H-pyrrolo[2,3-d]pyrimidine

[00491] A mixture of 2,4-dichloro-5-iodo-7H-pyrrolo[2,3-djpyrimidine (0.66 g, 2.1 mmol, 1.0 eq), 4- methylbenzenesulfonyl chloride (0.46 g, 2.4 mmol, 1.1 eq), triethylamine (0.40 mL, 29 mmol, 1.4 eq), and DMAP (0.033 g, 0.27 mmol, 0.13 eq) in 4 mL of dichloromethane was stirred at room temperature for 1 hr. The reaction mixture was diluted with dichloromethane and washed with iN HC1 (2X), followed by a wash with saturated aqueous sodium bicarbonate. The worked-up solution was dried over MgSO4, filtered, rotary evaporated, and dried under vacuum giving 1.1 g of yellow solid as the crude 2,4-dichloro-5-iodo-7-tosyl- 7H-pyrrolo [2,3 -d]pyrimidine. LC-MS: M+H=467. 7.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,1012785-51-1, its application will become more common.

Reference:
Patent; PHARMACYCLICS LLC; CHEN, Wei; JIA, Zhaozhong, J.; THOMAS, William, D.; WONE, David; (190 pag.)WO2017/205762; (2017); A1;,
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Pyrimidine – Wikipedia

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 131860-97-4, name is (E)-Methyl 2-(2-((6-chloropyrimidin-4-yl)oxy)phenyl)-3-methoxyacrylate. A new synthetic method of this compound is introduced below., category: pyrimidines

Methyl (£)-2-{2-[6-chloropyiimidin-4-yloxy]phenyl}-3-methoxyacrylate (E) (3g of 95.4% strength) was charged to the reaction tube followed by the solvent (10 ml) then 2- cyanophenol (1.2g), base (1.5 mol equivalents) and the compound being tested as a catalyst (15 mol%). The reaction mixtures were held, with stirring, at 400C for 4hrs, then at 6O0C for 2 hrs. The reaction was monitored for formation of product, throughout the hold period, by Gas Chromatography. Results are recorded as area % levels of methyl (£)-2-{2-[6- chloropyrimidin-4-yloxy]phenyl}-3-methoxyacrylate (II) and methyl (E)-2-{2-[6-(2- cyanophenoxy)pyrimidin-4-yloxy]phenyl}-3-methoxyacrylate (I) in the reaction mixture.The following systems were tested:TABLE l The results are shown in Table 2 below:TABLE 2

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 131860-97-4, (E)-Methyl 2-(2-((6-chloropyrimidin-4-yl)oxy)phenyl)-3-methoxyacrylate.

Reference:
Patent; SYNGENTA LIMITED; WO2008/43977; (2008); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Related Products of 1197953-49-3 ,Some common heterocyclic compound, 1197953-49-3, molecular formula is C12H12Cl2N3OP, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

Synthesis of 5 (0798) A solution of 2 (1.0 eq), 4 (1.4 eq), and 2.5 M HCl in ethanol (excess) in 2-methoxyethanol was sealed and heated at 120 C. with stirring for 5.5 hours and then cooled to r.t. The reaction was repeated 5 times and combined. The mixture was filtered and evaporated. Saturated Na2CO3 was added, followed by DCM with stirring strongly. The layers were separated and the aqueous layer was extracted with DCM. The organics were dried, evaporated and chromatographed [EtOAc/MeOH (7M ammonia) 20:1] to give a yellow solid. EtOAc was added and the suspension was refluxed for 30 minutes. After cooled to r.t., filtration gave a solid, which was dissolved in DCM, filtered, and evaporated to afford 5 as an off-white solid (66% yield).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 1197953-49-3, (2-((2,5-Dichloropyrimidin-4-yl)amino)phenyl)dimethylphosphine oxide, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; ARIAD PHARMACEUTICALS, INC.; Wang, Yihan; Huang, Wei-Sheng; Liu, Shuangying; Shakespeare, William C.; Thomas, Ranny M.; Qi, Jiwei; Li, Feng; Zhu, Xiaotian; Kohlmann, Anna; Dalgarno, David C.; Romero, Jan Antoinette C.; Zou, Dong; US2015/225436; (2015); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia