Sources of common compounds: 934524-10-4

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 934524-10-4, 2,4-Dichloro-7-tosyl-7H-pyrrolo[2,3-d]pyrimidine.

Electric Literature of 934524-10-4, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 934524-10-4, name is 2,4-Dichloro-7-tosyl-7H-pyrrolo[2,3-d]pyrimidine. This compound has unique chemical properties. The synthetic route is as follows.

General procedure: To a solution of S2a (142mg, 0.415mmol) in nBuOH (4mL) was added DIPEA (67mg, 0.5187mmol) and 2-methoxyethylamine (37mg, 0.4980mmol). The mixture was stirred at 50C for 1 hr until starting material was consumed at which point the reaction was allowed to cool to rt and the nBuOH was removed under reduced pressure. The resulting residue was taken up in EtOAc and washed with saturated NH4Cl. The organic layer was isolated, dried over MgSO4, and concentrated under reduced pressure to yield 2-chloro-N-(2-methoxyethyl)-5-(p-tolylsulfonyl)pyrrolo[3,2-d]pyrimidin-4-amine (S3a) as a solid (100mg, 63% yield).

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 934524-10-4, 2,4-Dichloro-7-tosyl-7H-pyrrolo[2,3-d]pyrimidine.

Reference:
Article; Wormald, Michael M.; Ernst, Glen; Wei, Huijun; Barrow, James C.; Bioorganic and Medicinal Chemistry Letters; vol. 29; 19; (2019);,
Pyrimidine | C4H4N2 – PubChem,
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Sources of common compounds: 131860-97-4

According to the analysis of related databases, 131860-97-4, the application of this compound in the production field has become more and more popular.

Related Products of 131860-97-4, Adding some certain compound to certain chemical reactions, such as: 131860-97-4, name is (E)-Methyl 2-(2-((6-chloropyrimidin-4-yl)oxy)phenyl)-3-methoxyacrylate,molecular formula is C15H13ClN2O4, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 131860-97-4.

Methyl (£)-2-{2-[6-chloropyiimidin-4-yloxy]phenyl}-3-methoxyacrylate (E) (3g of 95.4% strength) was charged to the reaction tube followed by the solvent (10 ml) then 2- cyanophenol (1.2g), base (1.5 mol equivalents) and the compound being tested as a catalyst (15 mol%). The reaction mixtures were held, with stirring, at 400C for 4hrs, then at 6O0C for 2 hrs. The reaction was monitored for formation of product, throughout the hold period, by Gas Chromatography. Results are recorded as area % levels of methyl (£)-2-{2-[6- chloropyrimidin-4-yloxy]phenyl}-3-methoxyacrylate (II) and methyl (E)-2-{2-[6-(2- cyanophenoxy)pyrimidin-4-yloxy]phenyl}-3-methoxyacrylate (I) in the reaction mixture.The following systems were tested:TABLE l The results are shown in Table 2 below:TABLE 2; A stirred solution of (E)-2-{2-[6-chloropyrimidin-4-yloxy]phenyl}-3-methoxyacrylate (80.0g at 98%w/w, 0.24mols) in DMF (80g) was heated to approximately 500C and then potassium carbonate (51.6g at 98%w/w, 0.37mols) was added. The mixture was heated to 6O0C and a solution of 2-cyanophenol in DMF was added (63.9g at 50%w/w, 0.27mols), followed by quinuclidine hydrochloride (1.85g at 97%w/w, 0.012mols). The reaction mixture was heated to 8O0C (exotherm took the temperature to 910C) and held for 20 minutes when analysis indicated that the reaction was complete. The DMF was distilled off under vacuum to a final temperature of 1000C and then toluene (134.8g) was charged, followed by hot water (259.4g), maintaining the temperature of the mixture above 700C. The mixture was stirred at 800C for 30 minutes, settled and then the aqueous phase separated. The toluene phase (233.Og) contained methyl (E)-2-{2-[6-(2-cyanophenoxy)pyrimidm-4-yloxy]phenyl}-3- methoxyacrylate (41.4%w/w) 98.1 % of theory.; stirred solution of (JS)-2-{2-[6-chloropyrimidiri-4-yloxy]phenyl}-3-methoxyacrylate (80.0g at 98%w/w, 0.24mols) in DMF (80g) was heated to approximately 500C and then potassium carbonate (51.6g at 98%w/w, 0.37mols) was added. The mixture was heated to 600C and quinuclidine hydrochloride (1.85g at 97%w/w, 0.012mols) was charged. The mixture was held at 600C for 10 minutes before adding a solution of 2-cyanophenol in DMF (63.9g at 50%w/w, 0.27mols). The mixture was heated to 80C (exotherm took the temperature to 850C) and held for 90 minutes when analysis indicated that the reaction was complete. The DMF was distilled off under vacuum to a final temperature of 100C and then toluene (134.8g) was charged, followed by hot water (259.4g), maintaining the temperature. of the mixture above 70C. The mixture was stirred at 8O0C for 30 minutes, settled and then the aqueous phase separated. The toluene phase (230.6g) contained methyl (E)-2-{2-[6-(2- cyanophenoxy)pyrimidin-4-yloxy]phenyl}-3-methoxyacrylate (35.8%w/w) 84.0% of theory.; A stirred solution of (E)-2-{2-[6-chloropyrimidin-4-yloxy]phenyl}-3-methoxyacrylate (80.0g at 98%w/w, 0.24mols) in DMF (80g) was heated to approximately 5O0C and then potassium carbonate (51.6g at 98%w/w, 0.37mols) was added. The mixture was heated to 60C and a solution of 2-cyanophenol in DMF was added (63.9g at 50%w/w, 0.27mols), followed by quinuclidine hydiOchloride (0.37g at 97%w/w, 0.002mols). The reaction mixture was heated to 8O0C (exotherm took the temperature to 890C) and held for 20 minutes when analysis indicated that the reaction was complete. The DMF was distilled off under vacuum to a final temperature of 1000C and then toluene (134.8g) was charged, followed by hot water (259.4g), maintaining the temperature of the mixture above 700C. The mixture was stirred at 800C for 30 minutes, settled and then the aqueous phase separated. The toluene phase (233.Og) contained methyl (E)-2-{2-[6-(2-cyanophenoxy)pyrimidin-4-yloxy]phenyl}-3- methoxyacrylate (41.3%w/w) 97.9% of theory.; A stirred solution of (E)-I- {2- [6-chloiOpyrimidin-4-yloxy]phenyl} -3 -methoxyacrylate (80.0g at 98%w/w, 0.24mols) in DMF (80g) was heated to approximately 5O0C and then potassium carbonate (51.6g at 98%w/w, 0.37mols) was added. The mixture was heated to 600C and a solution of 2-cyanophenol (32.8g at 97.5%w/w, 0.27mols) in DMF (32g) was added, followed by quinuclidine hydrochloride (0.07g at 97%w/w, 0.0005mols). The reaction mixture was heated to 8O0C (exotherm took the temperature to 85C) and held for 105 minutes when analysis indicated that the reaction was complete. The DMF was distilled off under vacuum to a final temperature of 1000C and then toluene (134.8g) was charged, followed by hot water (259.4g), maintaining the temperature of the mixture above 700C. The mixture was stirred at 8O0C for 30 minutes, settled and then the aqueous phase separated. The toluene phase (229.8g) contained methyl (E)-2-{2-[6-(2-cyanorhohenoxy)pyrimidin-4- yloxy]phenyl}-3-methoxyacrylate (40.5%w/w) 94.7% of theory.; A stirred DMF solution of (E)-2-{2-[6-chloropyrimidin-4-yloxy]phenyl}-3-methoxyacrylate (193.Og at 47.12%w/w, 0.283mols) was heated to …

According to the analysis of related databases, 131860-97-4, the application of this compound in the production field has become more and more popular.

Reference:
Patent; SYNGENTA LIMITED; WO2008/43977; (2008); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Sources of common compounds: 1197953-49-3

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,1197953-49-3, its application will become more common.

Reference of 1197953-49-3, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 1197953-49-3, name is (2-((2,5-Dichloropyrimidin-4-yl)amino)phenyl)dimethylphosphine oxide. A new synthetic method of this compound is introduced below.

Compound a6 (150 mg, 0.5 mmol) was dissolved in acetone/water (3:1 by volume,A total of 8 mL), adding compound b3-1 (200 mg, 0.6 mmol), 3 drops of concentrated hydrochloric acid, sealed, heated to 100 C, stirred overnight.Cool to room temperature and adjust to pH 12 with 10% aqueous sodium hydroxide.Extract three times with dichloromethane, dry the organic phase, filter and concentrate.Column chromatography was carried out with ethyl acetate, dichloromethane/methanol (10:1 by volume) as mobile phase.Yield 110 mg of a pale yellow solid.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,1197953-49-3, its application will become more common.

Reference:
Patent; Zhejiang Tongyuankang Pharmaceutical Co., Ltd.; Wu Yusheng; Zhi Wubin; Wang Xin; Wu Shiyong; Li Jingya; Guo Ruiyun; Zheng Maolin; Liang Apeng; Wang Guohui; Chen Mingtao; Ma Jie; Niu Chengshan; (65 pag.)CN108689994; (2018); A;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Share a compound : (E)-Methyl 2-(2-((6-chloropyrimidin-4-yl)oxy)phenyl)-3-methoxyacrylate

According to the analysis of related databases, 131860-97-4, the application of this compound in the production field has become more and more popular.

Synthetic Route of 131860-97-4, Adding some certain compound to certain chemical reactions, such as: 131860-97-4, name is (E)-Methyl 2-(2-((6-chloropyrimidin-4-yl)oxy)phenyl)-3-methoxyacrylate,molecular formula is C15H13ClN2O4, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 131860-97-4.

A slurry containing methyl (£)-2-{2-[6-chloropyrimidin-4-yloxy]phenyl}-3-methoxyacrylate (80.9g at 99%, 0.25mols), potassium carbonate (52.8g at 98%, 0.375mols) and 2- cyanophenol (33.6g at 97.5%, 0.275mols) in isopropyl acetate (13OmIs) was heated to approximately 6O0C. A solution of DABCO (0.28g, 0.0025mols) in isopropyl acetate (1 OmIs) was added. The mixture was heated to 8O0C and held at this temperature for 360 minutes. The isopropyl acetate was removed by vacuum distillation to a maximum temperature of 8O0C. Toluene (160ml) was added to the distillation residues, maintaining the temperature between 60-700C, followed by water (265mls) which had been heated to 6O0C, again maintaining the temperature between 60-700C. The mixture was stirred for 40 minutes at 8O0C and then settled and the lower aqueous phase separated. The toluene solution (229.8g) EPO contained methyl (E)-2- {2-[6-(2-cyanophenoxy)pyrimidin-4-yloxy]phenyl} -3- methoxyacrylate (41.2%w/w) 94.2% of theory.

According to the analysis of related databases, 131860-97-4, the application of this compound in the production field has become more and more popular.

Reference:
Patent; SYNGENTA LIMITED; WO2006/114572; (2006); A2;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Sources of common compounds: 4-(Tributylstannyl)pyrimidine

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,332133-92-3, its application will become more common.

Reference of 332133-92-3, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 332133-92-3, name is 4-(Tributylstannyl)pyrimidine. A new synthetic method of this compound is introduced below.

A mixture of 3 -(8-amino-S -bromo-2-(pyridin-2-ylmethyl)- [1 ,2,4jtriazolo [1,5 – ajpyrazin-6-yl)benzonitrile (15 mg, 0.037 mmol), 4-(tributylstannyl)pyrimidine (20mg, 0.055 mmol), and copper(I) chloride (4.4 mg, 0.044 mmol), lithium chloride (1.9 mg, 0.044 mmol) and tetrakis(triphenylphosphine)palladium(0) (4.3 mg, 3.7 imol) in THF (1 mL) was purged with N2, and stirred at 90 C for 2 h. The reaction mixture was then cooled to room temperature, diluted with methanol, and purified via prepLCMS (pH 2, acetonitrile/water with TFA) to give the desired product as a TFA salt.LC-MS calculated for C22H16N9 (M+H): mlz = 406.2; found 406.2.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,332133-92-3, its application will become more common.

Reference:
Patent; INCYTE CORPORATION; HOANG, Gia; WANG, Xiaozhao; CARLSEN, Peter Niels; GAN, Pei; LI, Yong; QI, Chao; WU, Liangxing; YAO, Wenqing; YU, Zhiyong; ZHU, Wenyu; (333 pag.)WO2020/10197; (2020); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Sources of common compounds: 4-(Tributylstannyl)pyrimidine

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,332133-92-3, its application will become more common.

Reference of 332133-92-3, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 332133-92-3, name is 4-(Tributylstannyl)pyrimidine. A new synthetic method of this compound is introduced below.

A mixture of 3 -(8-amino-S -bromo-2-(pyridin-2-ylmethyl)- [1 ,2,4jtriazolo [1,5 – ajpyrazin-6-yl)benzonitrile (15 mg, 0.037 mmol), 4-(tributylstannyl)pyrimidine (20mg, 0.055 mmol), and copper(I) chloride (4.4 mg, 0.044 mmol), lithium chloride (1.9 mg, 0.044 mmol) and tetrakis(triphenylphosphine)palladium(0) (4.3 mg, 3.7 imol) in THF (1 mL) was purged with N2, and stirred at 90 C for 2 h. The reaction mixture was then cooled to room temperature, diluted with methanol, and purified via prepLCMS (pH 2, acetonitrile/water with TFA) to give the desired product as a TFA salt.LC-MS calculated for C22H16N9 (M+H): mlz = 406.2; found 406.2.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,332133-92-3, its application will become more common.

Reference:
Patent; INCYTE CORPORATION; HOANG, Gia; WANG, Xiaozhao; CARLSEN, Peter Niels; GAN, Pei; LI, Yong; QI, Chao; WU, Liangxing; YAO, Wenqing; YU, Zhiyong; ZHU, Wenyu; (333 pag.)WO2020/10197; (2020); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

The important role of 330785-81-4

According to the analysis of related databases, 330785-81-4, the application of this compound in the production field has become more and more popular.

Reference of 330785-81-4, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 330785-81-4, name is Ethyl 4-((3-chloro-4-methoxybenzyl)amino)-2-(methylthio)pyrimidine-5-carboxylate. This compound has unique chemical properties. The synthetic route is as follows.

Ethyl 4-(3-chloro-4-methoxybenzylamino)-2-(methylthio)pyrimidine-5-carboxylate (200 mg, 0.59 mmol) was dissolved in dichloromethane (20 mL), m-CPBA (101 mg, 0.59 mmol) was added under ice-water bath, the reaction was heated to room temperature and conducted for 5 h. Water was added to the reaction and extracted with dichloromethane. The organic layer was dried, concentrated to obtain solid. The product was used in next reaction without any purification.

According to the analysis of related databases, 330785-81-4, the application of this compound in the production field has become more and more popular.

Reference:
Patent; XUANZHU PHARMA CO., LTD.; Shu, Chutian; Wu, Yongqian; (34 pag.)US2016/46654; (2016); A1;,
Pyrimidine | C4H4N2 – PubChem,
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Some scientific research about 356058-42-9

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 356058-42-9, 2-(2-((4-Fluorobenzyl)thio)-4-oxo-4,5,6,7-tetrahydro-1H-cyclopenta[d]pyrimidin-1-yl)acetic acid.

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 356058-42-9, name is 2-(2-((4-Fluorobenzyl)thio)-4-oxo-4,5,6,7-tetrahydro-1H-cyclopenta[d]pyrimidin-1-yl)acetic acid. A new synthetic method of this compound is introduced below., Computed Properties of C16H15FN2O3S

Amine 8 (1 eq, 52 mg) and acid 12′ (1 eq, 50 mg) were dissolved in DMF (1 mL) then stirred with DIPEA (2 eq, 52 mu) for 10 min at rt. The reaction was then cooled with an ice bath to 0C and COMU (1 eq, 64 mg) was added. The mixture was stirred at 0C for lh then the bath was removed and the reaction was allowed to reach rt and continued for 5h. The compound was extracted using EtOAc three times (5 mL x 3). The combined organic layers were then washed several times with saturated NaHC03 until washing solution was colourless. The resulting organic solution was dried, filtered and evaporated. The product was then purified using column chromatography on silica gel DCM/MeOH (90/10) (Rf = 0.2) as a pale yellow solid (65 mg, 65%). 1H NMR (600 MHz, CDC13) Mix of rotamers ratio (1/1) delta 7.69 (d, J = 7.9 Hz, 2H), 7.62 (d, J = 7.9 Hz, 1H), 7.56 (d, J = 6.7 Hz, 1H), 7.46 (m, 2H), 7.37-7.26 (m, 4H), 6.96 (t, J = 7.4 Hz, 1H), 6.89 (t, J = 7.4 Hz, 1H), 4.95 (s, 1H), 4.69 (m, 3H), 4.50 (s, 1H), 4.40 (s, 1H), 3.64 (m, 1H), 3.30 (m, 1H), 2.88 (m, 1H), 2.81 (t, J = 6.7 Hz, 1H), 2.76 (t, J = 6.7 Hz, 4H), 2.59 (t, J = 7.1Hz, 2H), 2.51 (q, J = 7.0 Hz, 2H), 2.11 (quint, J = 7.4 Hz, 1H), 2.05 (quint, J = 7.4 Hz, 1H), 1.10 (t, J = 7.1Hz, 3H), 0.98 (t, J = 7.1Hz, 3H). 13C-NMR (CDC13, 150 MHz) Mix of rotamers delta: 167.5, 166.5, 162.2 (d, JCF = 240 Hz), 161.4, 161.3, 156.8, 156.5, 144.1, 143.6, 139.8, 139.3, 136.8, 135.4, 131.5 (d, JCF = 3 Hz), 131.2 (d, JCF = 9 Hz), 131.1 (d, JCF = 3 Hz), 129.8 (m), 128.8, 128.0 (m), 127.7 (m), 127.4, 127.3, 127.2, 125.9 (m), 124.4 (m), 121.3, 121.2, 115.7 (d, JCF = 23 Hz), 115.6 (d, JCF = 23 Hz), 51.4, 50.4, 50.3, 50.1, 49.2, 47.8, 47.3, 46.1, 36.6, 36.5, 32.1, 32.0, 28.5, 28.4, 20.9, 20.8, 11.8;

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 356058-42-9, 2-(2-((4-Fluorobenzyl)thio)-4-oxo-4,5,6,7-tetrahydro-1H-cyclopenta[d]pyrimidin-1-yl)acetic acid.

Reference:
Patent; INSERM (INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE); UNIVERSITE DE LA REUNION; MEILHAC, Olivier; JESTIN, Emmanuelle; GUIBBAL, Florian; BENARD, Sebastien; (80 pag.)WO2019/63634; (2019); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Some tips on 4-(4-Bromophenyl)-2,6-diphenylpyrimidine

The synthetic route of 58536-46-2 has been constantly updated, and we look forward to future research findings.

Adding a certain compound to certain chemical reactions, such as: 58536-46-2, 4-(4-Bromophenyl)-2,6-diphenylpyrimidine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, COA of Formula: C22H15BrN2, blongs to pyrimidines compound. COA of Formula: C22H15BrN2

Synthesis of Intermediate GIn a 500 ml three necked round bottom flask, 38.7 g (100 mmol) of 4-(4-bromophenyl)-2,6-diphenylpyrimidine, 2.7 g (3 mmol) of Pd2(dba)3,2.21 g (6 mmol) tricyclohexylphosphine,55.9 g (220 mmol) of bis (pinacorate) diborane and 39.25 g (400 mmol) of potassium acetate put it in nitrogen,300 ml of 1,4-dioxane was added and stirred for 4 hours at reflux.After completion of the reaction, the mixture was extracted with Methylene Chloride, the organic layer was dried with MgSO4, purified by column chromatography, and crystallized with n-Hexane to give 36 g (82.9.%) As intermediate G.

The synthetic route of 58536-46-2 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Jinung Industry Co., Ltd.; Lee Eung; Lee Jong-ryun; Cho Eun-sang; Lee Ji-hwan; Kuk Chang-hun; (29 pag.)KR102052332; (2019); B1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

The origin of a common compound about 7-Benzenesulfonyl-4-chloro-6-methyl-7H-pyrrolo[2,3-d]pyrimidine

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 252723-16-3, 7-Benzenesulfonyl-4-chloro-6-methyl-7H-pyrrolo[2,3-d]pyrimidine, other downstream synthetic routes, hurry up and to see.

Electric Literature of 252723-16-3, Adding some certain compound to certain chemical reactions, such as: 252723-16-3, name is 7-Benzenesulfonyl-4-chloro-6-methyl-7H-pyrrolo[2,3-d]pyrimidine,molecular formula is C13H10ClN3O2S, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 252723-16-3.

Step 3To the solution of 4-chloro-6-methyl-7-(phenylsuIfonyl)-7H-pyrrolo[‘2,3-d]pyrimidine(10 g, 32.5. mmol, 1.0 eq) in THF (400 mL), t-BuOK (18.23 g, 163.0 mmol, 5 eq) was added and stirred at RT for 12 h. Sat, NaHC03 (50 mL) was added and extracted with EtOAc. The organic layers were separated, dried and concentrated to afford 4-chloro-6-methyl-7H- pyrrolo[2,3-d]pyrimidine as a brown solid (2.7 g, 50 % in yield).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 252723-16-3, 7-Benzenesulfonyl-4-chloro-6-methyl-7H-pyrrolo[2,3-d]pyrimidine, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; PRINCIPIA BIOPHARMA INC.; GOLDSTEIN, David Michael; BRAMELD, Kenneth Albert; WO2012/158764; (2012); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia