Tag: M.W:200-300

Adding a certain compound to certain chemical reactions, such as: 93416-51-4, 2,4,6-Trichloropyrimidine-5-carboxylic acid, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Recommanded Product: 2,4,6-Trichloropyrimidine-5-carboxylic acid, blongs to pyrimidines compound. Recommanded Product: 2,4,6-Trichloropyrimidine-5-carboxylic acid

(1) A N,N-dimethylformamide solution 6 ml of 3-chloro-4-methoxybenzylamine 1.51 g and triethylamine 2.46 g is dropped over a period of 25 minutes under ice cooling a solution of 5-carboxy-2,4,6-trichloropyrimidine (prepared in Example 318(1)) 2.00 g in N,N-dimethylformamide 12 ml, and the mixture is further stirred for 90 minutes. The reaction mixture is diluted with a 10% aqueous citric acid solution and extracted with ethyl acetate. The combined extract is washed with water and an aqueous sodium chloride solution, dried over anhydrous sodium sulfate and concentrated in vacuo to give 4-(3-chloro-4-methoxybenzylamino)-2,6-dichloropyrimidine-5-carboxylic acid as a pale brown crystalline powder 2.92 g. mp 144-151 C.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,93416-51-4, 2,4,6-Trichloropyrimidine-5-carboxylic acid, and friends who are interested can also refer to it.

Reference:
Patent; Yamada, Koichiro; Matsuki, Kenji; Omori, Kenji; Kikkawa, Kohei; US2004/142930; (2004); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Related Products of 126728-20-9, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 126728-20-9, name is 2,4-Dichloropyrido[2,3-d]pyrimidine, molecular formula is C7H3Cl2N3, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

General procedure: A mixture of 5 (5.0 mmol), the respective amine (12 mmol), equimolecular amounts of triethylamine, and ethanol (15 mL) was heated at 70 C for 5 h with stirring. The solvent was removed under vacuum and the residue was dissolved in water (30 mL); the mixture was extracted with chloroform (3 × 25 mL) and the organic extracts were dried over anhydrous sodium sulfate and the solvent was removed in vacuum. For compounds 6t-y the resulting solid was purified by recrystallization as indicated in Table 1. For compounds 6z-ai the residual material isolated after removal of the solvent was washed with 5% HCl (25 mL) and the resulting solid was isolated and purified as indicated in Table 1.

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 126728-20-9, 2,4-Dichloropyrido[2,3-d]pyrimidine.

Reference:
Article; Font, Maria; Gonzalez, Alvaro; Palop, Juan Antonio; Sanmartin, Carmen; European Journal of Medicinal Chemistry; vol. 46; 9; (2011); p. 3887 – 3899;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Application of 205672-25-9, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 205672-25-9, name is 4-Amino-5-bromo-2-chloropyrimidine. A new synthetic method of this compound is introduced below.

1 L reaction flask was charged with 20.8 g (0.1 mol) of Compound I and 208 mL of tetrahydrofuran,After stirring and dissolving,The system was cooled to -78 C. After the temperature was stabilized, 62.5 mL of n-butyllithium-n-hexane (15% concentration) was added dropwise. A solution of 12.9 g (0.125 mol) of N-methoxy-N-methylacetamide and 129 mL of tetrahydrofuran was added dropwise while maintaining the temperature for 10 min. After stirring for 1 h, the system was warmed to 0 C and 100 mL of saturated ammonium chloride solution was added. After stirring for 30 min, the mixture was extracted with 3X 300 mL of ethyl acetate. The organic layers were combined and the organic layer was washed with 3X 300 mL of saturated brine and dried over anhydrous magnesium sulfate Dried, filtered and concentrated to give 15.8 g of crude yellow solid, yield: 91.9%, used directly in the next step.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,205672-25-9, 4-Amino-5-bromo-2-chloropyrimidine, and friends who are interested can also refer to it.

Reference:
Patent; Jiangsu Zhongbang Pharmaceutical Co., Ltd.; Han Xiaojun; Huang Shuang; Qian Gang; Liu Liping; Sheng Zecui; (9 pag.)CN105153149; (2017); B;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 50270-27-4, name is 2,4,6-Trichloropyrimidine-5-carbaldehyde. A new synthetic method of this compound is introduced below., HPLC of Formula: C5HCl3N2O

Step 3: To a solution of 7f (1.5g, 7.1mmol) in EtOH (50mL) was added drop-wise a solution of 7e (6.8g, 20mmol) in EtOH (30mL), followed by TEA (4.46mL, 32mmol) at -78°C. The resulting mixture was stirred at -78°C for 30min, warmed to 0°C for 30min and adjusted to pH=5~6 with 3N HCl subsequently. The solid was collected by filtration, washed with water and cold ethanol and dried to give 7g (1.04g, 60percent).

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 50270-27-4, 2,4,6-Trichloropyrimidine-5-carbaldehyde.

Reference:
Patent; TYROGENEX, INC.; LIANG, Congxin; WO2011/41399; (2011); A2;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Reference of 13544-44-0 , The common heterocyclic compound, 13544-44-0, name is 2,4-Dichloro-5-iodopyrimidine, molecular formula is C4HCl2IN2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

(S)-3-(l-Aminoethyl)-8-(l-methyl-lH-pyrazol-4-yl)-2-phenylisoquinolin-l(2H)-one (63) (570 mg, 1.66 mmol), 2,4-dichloro-5-iodopyrimidine (455 mg, 1.66 mmol) and DIEA (0.27 mL, 1.66 mmol) were dissolved in n-butanol (12 mL) in a sealed tube, and the resulting mixture was stirred at 100 C for 16 h. The mixture was allowed to cool to RT, quenched with water and extracted with ethyl acetate (150 mL x 2). The combined organic layers were washed with brine, dried over Na2SC>4 and filtered. The filtrate was concentrated in vacuo to afford the product (S)-3-(l- ((2-chloro-5 odopyrimidin-4-yl)amino)ethyl)-8-(l-methyl-lH-pyrazol-4-yl)-2-phenylisoquinolin-l(2H)-one (64) as an oil. The product obtained was used in the next step without purification. ESI-MS m/z: 583.0 [M+H]+.

The synthetic route of 13544-44-0 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; INTELLIKINE, INC.; INFINITY PHARMACEUTICALS, INC.; REN, Pingda; LIU, Yi; LI, Liansheng; CHAN, Katrina; CASTRO, Alfredo, C.; EVANS, Catherine, A.; WO2011/146882; (2011); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Reference of 205672-25-9 ,Some common heterocyclic compound, 205672-25-9, molecular formula is C4H3BrClN3, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

A 500 mL round bottomed flask is charged with 5-bromo-2-chloropyrimidin-4-ylamine (1) (lOg, 48 mmol), tetrakis(triphenylphosphine)palladium(0) (2.8g, 2.5 mmol), and toluene (200 mL). Tributyl- (2-ethoxyvinyl)-stannane (22g, 60 mmol) is added and the reaction heated to 110C with stirring for approximately 15 hours. After cooling to room temperature, the solution is diluted with 100 mL ethyl acetate and washed with water and brine. The organic extract is dried over Na2S04, filtered, and concentrated under reduced pressure. Purification by column chromatography (Si02, Hexane : Ethyl acetate/ 5 :1) provides 2 (4.4 g, 46%) as a yellow solid.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,205672-25-9, its application will become more common.

Reference:
Patent; IRM LLC; WO2005/107760; (2005); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Adding a certain compound to certain chemical reactions, such as: 39551-54-7, 2,4-Dichloropyrido[3,2-d]pyrimidine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 39551-54-7, blongs to pyrimidines compound. Recommanded Product: 39551-54-7

To a solution of 2,4-dichloropyrido[3,2-d]pyrimidine (CAS39551-54-7, supplied by Astatech, Inc.) (50 mg, 0.25 mmol) in THF (2 mL) was added butan-1-amine (0.03 mL, 0.28 mmol) and N,N-diisopropylethylamine (0.13 ml, 0.75 mmol). After stirring at room temperature for 30 minutes, 2,4-dimethoxybenzylamine (0.19 ml, 1.25 mmol) and N,N-diisopropylethylamine (0.13 ml, 0.75 mmol) were added and the mixture was heated to 100 C. After 16 hours, the reaction was cooled to room temperature, diluted with ethyl acetate, washed with water and brine, dried over Na2SO4, and concentrated in vacuo. The product ( 1A) was obtained after flash chromatography. MS (m/z): 368.14 [M+H]+

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,39551-54-7, its application will become more common.

Reference:
Patent; Gilead Sciences, Inc.; Aktoudianakis, Evangelos; Chin, Gregory; Mackman, Richard L.; Metobo, Samuel E.; Mish, Michael R.; Pyun, Hyung-jung; Zablocki, Jeff; (175 pag.)US2016/289229; (2016); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 137281-08-4, name is N-(4-Oxo-4,7-dihydro-1H-pyrrolo[2,3-d]pyrimidin-2-yl)pivalamide, molecular formula is C11H14N4O2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. Recommanded Product: 137281-08-4

N-Methyl benzylamine (3.63 g, 30 mmol) and paraformaldehyde(1.05 g, 35 mmol) were added to water (20 mL). To this solution, aceticacid (20 mL) was added dropwise. The mixture was stirred at 80 C for3 h. Compound 21 (2.34 g, 10 mmol) and KOAc (2.94 g, 30 mmol) wereadded and the stirring was continued at 80 C overnight. The solventwas removed by a rotary evaporator and acetone (40 mL) was added.The suspension was filtered and the filtrate was concentrated into asemisolid residue. This residue was purified by a silica column, whichwas flushed with CHCl3 and MeOH, to provide 2.86 g of a white solid,22, in 78% yield. mp: 181.1-182.5 C; TLC Rf 0.37 (CHCl3: MeOH,20:1); 1H NMR (DMSO-d6) delta 1.24 (s, 9H, Piv), 2.09 (s, 3H, NCH3), 3.48(s, 2H, NCH2), 3.58 (s, 2H, NCH2), 6.31 (s, 1H, 5-H), 7.32 (m, 5H, Ph),10.85 (br, 1H, exch, PivNH), 11.55 (br, 1H, exch, NH), 11.95 (br, 1H,exch, NH); Anal. calcd. for (C20H25N5O2·0.5H2O) C, H, N; UPLCMS> 95%; m/z [M-MePhNH]+, calcd 247.12, found 247.25.

With the rapid development of chemical substances, we look forward to future research findings about 137281-08-4.

Reference:
Article; Xiang, Weiguo; Dekhne, Aamod; Doshi, Arpit; O’Connor, Carrie; Hou, Zhanjun; Matherly, Larry H.; Gangjee, Aleem; Bioorganic and Medicinal Chemistry; vol. 27; 23; (2019);,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Related Products of 876343-10-1 , The common heterocyclic compound, 876343-10-1, name is 4-Chloro-6-iodo-7H-pyrrolo[2,3-d]pyrimidine, molecular formula is C6H3ClIN3, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

te^-ButyI4-(4-chloro-7Jy-pyrrolo[2,3-«qpyrimidm-6-yl)-3,6-dihydropyridine-l(2fl)-carboxylate (compound of Formula VIII-Boc).; IXMKCn[228] To a suspension of 4-chloro-6-iodo-7H-pyrrolo[2,3-d]pyrimidine (5.0g,O.OlSmol) in 1,4-dioxane (120mL) and water (30mL) were added 4-(4,4,5,5-tetramethyl-[l,3,2]dioxaborolan-2-yl)-3,6-dihydro-2H-pyridine-l-carboxylic acid tert-butyl ester (5.97g,0.0193mol), potassium carbonate (4.9g, 0.036mol) and PdCl2(dppf)-CH2Cl2 (0.73g,0.89mmol). The flask was evacuated and refilled with N2 (3x). The mixture was heated at100C overnight. LC-MS showed the reaction was complete. The mixture was diluted withethyl acetate (200mL), then washed with brine (2x50mL), and dried over anhydrous sodiumsulfate. The filtrate was concentrated under reduced pressure to wlOOmL, the resulting whiteprecipitate was collected by filtration to give the first batch of the title compound. The filtratewas concentrated and the residue was purified by chromatography on silica gel, eluting withHex:EtOAc = 70:30 -> 50:50 to give a white solid (containing pinacol), which was furthercrystallized with EtOAc/hexanes to give the second batch of the title compound as a whitesolid. LC-MS (ES, Pos.): 335/337 (3/1) [MH+]. ‘H NMR (CDC13,400 MHz): 5 = 1.51 (s,9H), 2.61 (m, 2H), 3.70 (m, 2H), 4.20 (m, 2H), 6.27 (s, 1H), 6.55 (s, 1H), 8.61 (s, 1H), 10.3(brs, 1H).

The synthetic route of 876343-10-1 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; OSI PHARMACEUTICALS, INC.; WO2006/17443; (2006); A2;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Adding a certain compound to certain chemical reactions, such as: 514854-13-8, 6-Ethyl-5-iodopyrimidine-2,4-diamine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 514854-13-8, blongs to pyrimidines compound. Recommanded Product: 6-Ethyl-5-iodopyrimidine-2,4-diamine

General procedure: The alkyne (1.2 eq), iododiaminoethyl pyrimidine (1.0 eq) was dissolved in anhydrous DMF (0.15M) and sonicated under argon. Pd(PPh3)2Cl2 (0.1 eq), CuI (0.21 eq), Et3N (24 eq) were added and again sonicated under argon for 15 minutes. The reaction mixture was heated at 60 C for 12h under argon. The reaction mixture was then concentrated in vacuo before preabsorbing onto a mixture of amine and 25% cysteine preabsorbed silica gel (1:1 /wt) and filterted through a plug of silica gel with 5% MeOH/ CH2Cl2. The collected reaction mixture was concentrated in vacuo, and further purified by preparative HPLC to furnish the final product

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,514854-13-8, its application will become more common.

Reference:
Article; Lombardo; Dayanandan; Keshipeddy; Zhou; Si; Reeve; Alverson; Barney; Walker; Hoody; Priestley; Obach; Wright; Drug Metabolism and Disposition; vol. 47; 9; (2019); p. 995 – 1003;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia