Tag: M.W:200-300

Adding a certain compound to certain chemical reactions, such as: 57054-92-9, 5-Bromo-2-chloro-4-methoxypyrimidine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Recommanded Product: 5-Bromo-2-chloro-4-methoxypyrimidine, blongs to pyrimidines compound. Recommanded Product: 5-Bromo-2-chloro-4-methoxypyrimidine

To a solution of 5-bromo-2-chloro-4-methoxypyrimidine (Frontier Scientific, Logan, USA, 0.895 mmol) in THF (2.5 ml) cooled with an ice-bath was added a 2 M solution of ethylamine in MeOH (Aldrich, Buchs, Switzerland, 0.492 ml). The RM was stirred at 00C for 1 h and at rt for 66 h then the reaction mixture was diluted with EtOAc, washed with saturated aqueous NaHCO3, with brine, dried over Na2SO4, filtered and evaporated. The residue was absorbed on silica gel and purified by flash chromatography (CH2CI2/iPr0H 0% to 6%) to give after evaporation of the fractions containing the title compound an off-white solid. (HPLC: tR 2.16min (Method C); M+H = 232, 234 MS-ES).

The synthetic route of 57054-92-9 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; NOVARTIS AG; FURET, Pascal; IMBACH, Patricia; MAH, Robert; STAUFFER, Frederic; WO2010/139747; (2010); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 113583-35-0, name is 2-Methanesulfonyl-4,6-dimethoxypyrimidine. This compound has unique chemical properties. The synthetic route is as follows. Product Details of 113583-35-0

Example 2 Methyl 3-azido-3-phenyl-2-(4,6-dimethoxypyrimidin-2-yl)oxybutyrate 5.9 g (25 mmol) of methyl 3-azido-3-phenyl-2-hydroxybutyrate (Ex. 1) are dissolved in 80 ml of DMF, treated with 1.7 g (12.5 mmol) of potassium carbonate and 5.5 g (25 mmol) of 4,6-dimethoxy-2-methylsulfonylpyrimidine, and stirred for 6 hours at 50 C. and 12 hours at room temperature. The mixture is then poured onto 400 ml of water, and the precipitate formed is filtered off with suction, washed with water and dried. 6.3 g of a white powder are obtained. Yield: 67.2%, m.p.: 118-120 C.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 113583-35-0, 2-Methanesulfonyl-4,6-dimethoxypyrimidine.

Reference:
Patent; BASF Aktiengesellschaft; US5750469; (1998); A;,
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Synthetic Route of 663193-80-4 ,Some common heterocyclic compound, 663193-80-4, molecular formula is C4H3BrClN3, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

Intermediate (138.1 ): [1-(6-Amino-5-bromo^yrimidin-4-yl)-piperidin-4-yl]-(4-chloro- phenyl)-methanoneThe mixture of 5-bromo-6-chloro-pyrimidine-4-ylamine (2.0 g, 9.59 mmol, 1 .0 eq), 4- chlorophenyl-piperidin-4-yl-methanone (2.36 g, 10.55 mmol, 1 .10 eq) and potassium carbonate (6.63 g, 47.97 mmol, 5.0 eq) in DMF (5 ml_) was stirred at 50 C overnight. After pouring the reaction mixture to water, the precipitate was collected to give Intermediate (138.1 ). LC-MS (M+1 : 396, obsd: 396).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,663193-80-4, its application will become more common.

Reference:
Patent; MERCK PATENT GMBH; LAN, Rouxi; HUCK, Bayard R.; CHEN, Xiaoling; DESELM, Lizbeth Celeste; XIAO, Yufang; QIU, Hui; NEAGU, Constantin; MOCHALKIN, Igor; JOHNSON, Theresa L.; WO2013/40044; (2013); A1;,
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Adding a certain compound to certain chemical reactions, such as: 1979-96-0, 4,6-Dichloro-2-(methylthio)-5-nitropyrimidine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, COA of Formula: C5H3Cl2N3O2S, blongs to pyrimidines compound. COA of Formula: C5H3Cl2N3O2S

EXAMPLE 28 9-Ethyl-7-methyl-4-(dimethylamino)-2-(methylthio)imidazo[5,1-h]-pteridin-6(5H)-one Prepared by treatment of 4,6-dichloro-5-nitro-2-(methylthio)pyrimidine with dimethylamine, followed by reaction with 2-ethyl-4-methylimidazole, reduction with tin (II) chloride, and cyclization with carbonyldiimidazole.

The synthetic route of 1979-96-0 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Berlex Laboratories, Inc.; US5602252; (1997); A;,
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Synthetic Route of 696-07-1, Adding some certain compound to certain chemical reactions, such as: 696-07-1, name is 5-Iodouracil,molecular formula is C4H3IN2O2, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 696-07-1.

5-Iodouracil (23.8 g), TEA (30.3 g), Tol (240 mL) were placed in a 500 mL three-necked flask and heated to 100 C.When the internal temperature of the bottle reached 90 C, phosphorus oxychloride (33.7 g) was slowly added dropwise.After the addition was completed, the temperature was kept stirring for 1 h, then cooled to room temperature, suction filtered, and the filtrate was collected.The solid was washed with PE/EA=5/1, and the filtrate and washing solution were combined.Spin dry to obtain a crude product and then beat with PE to give the product 24.5 g of an off-white solid.The yield was 89%.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 696-07-1, 5-Iodouracil, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Beijing Ruiboao Biological Technology Co., Ltd.; Liu Zhiqiang; Li Yazhou; Chen Zhenchang; Zhang Hongjuan; (7 pag.)CN109761914; (2019); A;,
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Adding a certain compound to certain chemical reactions, such as: 2915-16-4, 2-Chloro-4,6-diphenylpyrimidine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Safety of 2-Chloro-4,6-diphenylpyrimidine, blongs to pyrimidines compound. Safety of 2-Chloro-4,6-diphenylpyrimidine

First Step: Synthesis of the Compound Represented by Chemical Formula 11In a 500 mL round-bottomed flask having a thermometer, a reflux condenser, and an agitator under the nitrogen atmosphere, 6.0 g (10.72 mmol) of compound (A), 6.58 g (24.67 mmol) of compound (B), and 0.8 g (0.69 mmol) of tetrakis(triphenylphosphine)palladium were mixed with 300 mL of tetrahydrofuran, and then the mixed solution was mixed with 100 mL of 2 M potassium carbonate (K2CO3) and agitated at 80 C. for 12 hours to provide a white solid.By cooling to room temperature, the reaction was completed, and then the potassium carbonate solution was removed to filter the white solid. The filtered white solid was washed with tetrahydrofuran three times, washed with water three times, and washed with methanol three times and dried. The solid was dissolved in monochlorobenzene, active carbon was added, and the solution was agitated for 30 minutes, and the solution was filtered through a silica gel. The remaining amount of monochlorobenzene was removed to provide a white solid. The solid was filtered to provide a compound represented by Chemical Formula 11 in 7.1 g (yield: 86.2%).The obtained compound for an organic photoelectric device was analyzed by an atomic analyzer, and the results (in Atomic %) are as follows:Calculated: C, 86.02; H, 4.86; N, 9.12Found: C, 86.01; H, 4.87; N, 9.12

The synthetic route of 2915-16-4 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; JUNG, Sung-Hyun; KANG, Myeong-Soon; JUNG, Ho-Kuk; KIM, Nam-Soo; LEE, Nam-Heon; KANG, Eui-Su; KANG, Dong-Min; CHAE, Mi-Young; US2012/256174; (2012); A1;,
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Reference of 1337532-51-0, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 1337532-51-0, name is 5-Bromo-7-methyl-7H-pyrrolo[2,3-d]pyrimidin-4-amine. This compound has unique chemical properties. The synthetic route is as follows.

To a stirred solution of 5-bromo-2-(3,5-dimethylbenzyl)-2H-indazole (0.5 g, 1 .60mmol, 1 equiv) in 1 ,4-dioxane (15 mL) was added bis(pinacolato)diboron (0.4 g, 1 .60mmol, 1 equiv), and potassium acetate (0.47 g, 4.80mmol, 3 equiv) and the mixture was degassed for 15 minutes with argon. PdCl2(dppf)-CH2Cl2 adduct (0.065 g, 0.08mmol, 0.05 equiv) was added and the reaction was heated to 100 C for 5h and the consumption of the starting material was monitored by LCMS. The reaction mixture was cooled to room temperature. 5-bromo-7-methyl-7H-pyrrolo[2,3-d]pyrimidin-4-amine (0.363 g, 1 .60mmol, 1 equiv) and saturated aqueous NaHC03 (5 mL) were added, and the mixture was degassed for 15 minutes. PdCI2(dppf)-CH2Cl2 adduct (0.065 g, 0.08mmol, 0. 05 equiv) was added, and the reaction mixture was stirred overnight at 100 C. The mixture was filtered through celite and the filtrate was dried over Na2S04 filtered and concentrated to give crude product. The crude product was purified by flash column chromatography (Silicagel pack) using 3 – 4 % MeOH in DCM mobile phase. The product was further purified by preparative HPLC. Prep HPLC condition: Column: Inertsil ODS 3V( 250 mm X4.6 mm X 5 mic) , Mobile Phase (A)/(B): 0.01 % Ammonia in water : Acetonitrile, Flow rate: 1 mL/min. The fractions containing the desired product were combined and concentrated. The product was basified and extracted with DCM and concentrted to afford the desired product 5-(2-(3,5- dimethylbenzyl)-4-fluoro-2H-indazol-5-yl)-7-methyl-7H-pyrrolo[2,3-d]pyrimidin-4-amine (0.055 g, 9 %) as an off white solid. LCMS (ES) m/z = 383.2 [M+H]+. NMR (400 MHz, DMSO-c/6) delta ppm 2.23 (s, 6H), 3.73 (s, 3 H), 5.54 ( s, 2H), 6.01 (br.s, 2 H), 6.93 (s, 1 H), 6.98 (s, 2H),7.27 (s,1 H), 7.34 – 7.31 (m, 1 H), 7.68 (d, J = 10 Hz, 2 H), 8.13 (s, 1 H), 8.46 (s, 1 H).HPLC: 99.94 % of purity by HPLC254nM

According to the analysis of related databases, 1337532-51-0, the application of this compound in the production field has become more and more popular.

Reference:
Patent; GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED; AXTEN, Jeffrey Michael; KRISTAM, Rajendra; VENKATESHAPPA, Chandregowda; (105 pag.)WO2019/21208; (2019); A1;,
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Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 31169-25-2, name is 7-Bromothieno[3,2-d]pyrimidin-4(3H)-one. This compound has unique chemical properties. The synthetic route is as follows. HPLC of Formula: C6H3BrN2OS

7-Bromo-4-chloro-thieno[3,2-d]pyrimidine (192): A solution of 7-bromo-3H-thieno[3,2-d]pyrimid-4-one (191, 153.0 mg, 0.66 mmol) in phosphorus oxychloride (2 mL) was refluxed under N2 for 2 hours. The resulting solution was allowed to cool to room temperature and then neutralized by carefully pouring into a saturated aqueous solution of sodium carbonate. The aqueous mixture was extracted with ethyl acetate and the organic layer washed with water and brine, before drying over anhydrous magnesium sulfate. The solvent was evaporated under reduced pressure and the residue dried over P2O5 under vacuum overnight (156.0 mg, 95percent yield, white solid).

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Reference:
Patent; Thrash, Thomas; Cabell, Larry A.; Lohse, Daniel; Budde, Raymond J.A.; US2006/4002; (2006); A1;,
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Application of 113583-35-0, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 113583-35-0, name is 2-Methanesulfonyl-4,6-dimethoxypyrimidine, molecular formula is C7H10N2O4S, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

0.04 mol of 2,6-dihydroxybenzoic acid was weighed separately,0.05 mol of 2-methanesulfonyl-4,6-dimethoxypyrimidine,0.004 mol of tetrabutylammonium bromide,0.08 mol of potassium carbonate was placed in a reaction vessel,Add 300mL toluene heated reflux reaction 8 ~ 1 Oh,The reaction is cooled and filtered,The filter cake was washed with toluene,dry,The resulting solid was mixed with 500 mL of water,Stir,Dropping 30% HC1 to the system PH = 3 ~ 4,filter,dry,Was gray and solidbodyBispyribac15.7g,Purity 97%Yield 85%.

According to the analysis of related databases, 113583-35-0, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Zibo Xinnong Jinongyao Chemical Co.,Ltd; ZHENG, YOUKUI; SONG, JUN; WANG, XIAOWEI; (5 pag.)CN106083738; (2016); A;,
Pyrimidine | C4H4N2 – PubChem,
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Reference of 51940-64-8 ,Some common heterocyclic compound, 51940-64-8, molecular formula is C7H6Cl2N2O2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

Potassium carbonate (78 g, 565 mmol) was added to ethyl 2,4-dichloropyrimidine-5- carboxylate (50.0 g, 226 mmol) and cis-4-aminocyclohexanol hydrochloride (34.3 g, 226 mmol) in acetonitrile (700 mL) at rt under air. The reaction mixture was stirred at rt for 16 h. The mixture was filtered through a Celite pad. The filtrate was concentrated under reduced pressure. The precipitate was collected by filtration, washed with MeCN (100 mL) and dried under vacuum to afford the title compound (41.0 g, 61%) as a white solid; 1H NMR (400 MHz, DMSO) 1.32 (3H, t), 1.42 – 1.58 (2H, m), 1.60 – 1.75 (6H, m), 3.66 (1H, d), 4.06 (1H, dd), 4.33 (2H, q), 4.57 (1H, d), 8.46 (1H, d), 8.63 (1H, s); m/z MH+ 300.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 51940-64-8, Ethyl 2,4-Dichloro-5-pyrimidinecarboxylate, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; ASTRAZENECA AB; CANCER RESEARCH TECHNOLOGY LIMITED; FINLAY, Maurice, Raymond, Verschoyle; GOLDBERG, Frederick, Woolf; TING, Attilla, Kuan, Tsuei; (103 pag.)WO2018/114999; (2018); A1;,
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