Tag: M.W:200-300

Related Products of 89392-03-0, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 89392-03-0, name is Phenyl (4,6-dimethoxypyrimidin-2-yl)carbamate, molecular formula is C13H13N3O4, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

5-Amino-2-dimethylaminocarbonyl-N-[(4,6-dimethoxypyrimidin-2-yl)-aminocarbonyl]benzenesulfonamide 0.6 ml of 1,8-diazabicyclo[5.4.0]undec-7-ene (DBU) is added with stirring at 0 C. to a suspension of 1.0 g of 5-amino-2-dimethylaminocarbonylbenzene-sulfonamide and 1.1 g of 4,6-dimethoxy-2-(phenoxycarbonylamino)-pyrimidine in 10 ml of acetonitrile. The mixture is stirred again until complete reaction has taken place. Following the distillative removal of the volatile components, the residue is taken up in a little water and washed with diethyl ether. The aqueous phase is subsequently acidified with concentrated hydrochloric acid (pH=2-3). The deposited solid is washed with diisopropyl ether and then dried, to give 1.4 g of a solid which comprises the two compounds 5-amino-2-dimethylaminocarbonyl-N-[(4,6-dimethoxypyrimidin-2-yl)-aminocarbonyl]-benzenesulfonamide and 5-[(4,6-dimethoxypyrimidin-2-yl)aminocarbonylamino]-2-dimethylaminocarbonyl-N-[(4,6-dimethoxypyrimidin-2-yl)aminocarbonyl]benzenesulfonamide in a ratio of about 2:1.

According to the analysis of related databases, 89392-03-0, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Hoechst Schering AgrEvo GmbH; US6500952; (2002); B1;,
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Pyrimidine – Wikipedia

Electric Literature of 130049-82-0, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 130049-82-0 as follows.

To a methanol (500 mL) solution, nitrogen was purged for 30 minutes to remove the nascent oxygen. 6-Fluoro-3-piperidin-4-yl-benzo[d]isoxazole Hydrochloride (50 g), 9-Hydroxy-3-(2-chloroethyl)-2-methyl-6,7,8,9-tetrahydro-4H-pyrido (1,2-a) pyrimidine-4-one (52 g) and triethylamine (55) were added and stirred at reflux for 30-32 hours. The reaction mixture was cooled to 25-35 C, and filtered off to yield paliperidone base. Yield: 75 g.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,130049-82-0, its application will become more common.

Reference:
Patent; ORCHID CHEMICALS & PHARMACEUTICALS LIMITED; US2010/298566; (2010); A1;,
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Pyrimidine – Wikipedia

Application of 1448307-66-1, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 1448307-66-1, name is 1-(2-Chloropyrimidin-4-yl)-3-methyl-1H-pyrazole-4-carbaldehyde, molecular formula is C9H7ClN4O, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

A stirred suspension of commercially available l-(2-chloro-4-pyrimidinyl)-3-methyl- lH-pyrazole-4-carbaldehyde (222 mg, 1.0 mmol) and 3-azetidinol hydrochloride (219 mg, 2.0 mmol) in dichloromethane (10 mL) was treated with triethylamine (700 muTau, 5.0 mmol) followed by portionwise addition of Na(OAc)3BH (636 mg, 3.0 mmol). The resulting mixture was stirred at room temperature overnight. Next morning, LCMS indicated clean conversion to product. The reaction mixture was transferred to a separately funnel, diluted with dichloromethane, washed with saturated aqueous NaHC03 solution. The organic layer was dried over anhydrous MgS04, filtered and concentrated in vacuo. The crude product was obtained as a white foam (185 mg, 0.66 mmol, 66%) and used directly in the next step. LC/MS – HPLC (254 nm) – Rt 1.04 min. MS (ESI) m/z 280.5 [M+ + H+]. Purity = 95 % by UV (254 nm).

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 1448307-66-1, 1-(2-Chloropyrimidin-4-yl)-3-methyl-1H-pyrazole-4-carbaldehyde.

Reference:
Patent; SIGNALRX PHARMACEUTICALS, INC.; MORALES, Guillermo, A.; GARLICH, Joseph, R.; DURDEN, Donald, L.; (155 pag.)WO2018/226739; (2018); A1;,
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Electric Literature of 2972-52-3, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.2972-52-3, name is 2,4-Dichloro-5-pyrimidinecarbonyl chloride, molecular formula is C5HCl3N2O, molecular weight is 211.43, as common compound, the synthetic route is as follows.

2,4-dichIoro-2,4-(morpho A solution of 2,4-dichloropyrimidine-5-carbonyl chloride (422mg, 2,0 mmoi) in dichloromethane (10 mL) was added 4-(morpholinosulfonyl)aniline (508 nig. 2.1 mmoi) and DIEA (387 mg, 3.0 mmoi) at 0 C. The resulting mixture was stirred at 0 C for 1 h, Then, water was added. The resulting mixture was extracted with EtOAc (3x). The combined organic layers were dried (NaSO4), filtered and concentrated. The residue was purified on ISCO to give the title compound as a white solid (701.2 mg, 84%). 1H NMR (400 MHz, DMSO-d6) delta 1 1.98 – 1 1.90 (m5 I B), 8.29 (d, J = 6.4 Hz, IH), 7.89 (d, J = 8.8 Hz, 2H), 7.69 (d, J= 8.8 Hz, 2H), 3.65 – 3.56 (m, 4H), 2.87 – 2.78 (m, 4H); MS m/z 418,30 [M+H]+

Statistics shows that 2972-52-3 is playing an increasingly important role. we look forward to future research findings about 2,4-Dichloro-5-pyrimidinecarbonyl chloride.

Reference:
Patent; THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL; WANG, Xiaodong; ZHANG, Weihe; KIREEV, Dmitri; LIU, Jing; MCIVER, Andrew Louis; WO2014/85225; (2014); A1;,
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Pyrimidine – Wikipedia

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 26830-94-4, name is 2,6-Dichloropyrimidine-4-carbonyl chloride, the common compound, a new synthetic route is introduced below. Formula: C5HCl3N2O

To a solution of 2,6-dichloropyrimidine-4-carbonyl chloride (1-158) (500 mg, 2.37 mmol), and TEA (718 mg, 7.1 1 mmol) in CH2CI2 (30 ml_) was added (2R)-2-aminopropyl benzoate hydrochloride (354 mg, 1 .98 mmol) in portions at 0 C under a nitrogen atmosphere, and the mixture was stirred at 0 ~ 10 C for 1 hr. TLC (EtOAc) showed the reaction was completed. The mixture was quenched with H20 (20 ml_) and extracted with CH2CI2 (2 x 50 ml_). The combined organic layers were washed with brine (3 x 30 ml_), dried over Na2S04 and concentrated. The residue was purified by silica gel chromatography (petroleum ether/EtOAc = 6/1 , Rf = 0.4) to give (2R)-2-{[(2,6-dichloropyrimidin-4-yl)carbonyl]amino}propyl benzoate (1-182) (3S5 mg, 46%) as an oil, which was used without further purification.

The synthetic route of 26830-94-4 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; PFIZER INC.; JOHNSON, Ted William; RICHARDSON, Paul Francis; COLLINS, Michael Raymond; RICHTER, Daniel Tyler; BURKE, Benjamin Joseph; GAJIWALA, Ketan; NINKOVIC, Sacha; LINTON, Maria Angelica; LE, Phuong Thi Quy; HOFFMAN, Jacqui Elizabeth; (335 pag.)WO2016/97918; (2016); A1;,
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Pyrimidine – Wikipedia

Adding a certain compound to certain chemical reactions, such as: 74901-69-2, 2,4-Dichloro-6,7-dihydrothieno[3,2-d]pyrimidine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Recommanded Product: 2,4-Dichloro-6,7-dihydrothieno[3,2-d]pyrimidine, blongs to pyrimidines compound. Recommanded Product: 2,4-Dichloro-6,7-dihydrothieno[3,2-d]pyrimidine

Intermediates VII (180 g, 852 mmol) and A (129 g, 937 mol) were sequentially charged into a multi-neck vessel equipped with a condenser, thermocouple thermometer and nitrogen line. Acetonitrile (900 ml) and triethylamine (594 ml, 4.26 mol) were then added at 22 C and the mixture was stirred at 75-77 C for 12 h. Water (1 .2 I) was charged slowly over 20 min, the mixture was seeded with Compound VIII crystals (0.3 g) at 40 C and then cooled to 25 C over 2 h. The mixture was stirred for an additional 12h at normal room temperature and the resulting solid was collected by filtration. The filter cake was rinsed with 2:1 mixture of water/MeCN (400 mL) followed by water (200 ml). The resulting solid was dried under vacuum at 50 C for 12 h to afford 132 g (57% yield) of compound VIII: 1H NMR (400 MHz, CDCIs) delta 1 .85-2.05 (m, 2H), 2.10-2.21 (m, 2H), 2.32-2.41 (m, 2H), 3.27 (dd, J = 8.0, 8.4 Hz, 2H), 3.43 (dd, J = 8.0, 8.4 Hz, 2H), 3.91 (s, 2H), 4.67 (s, 1 H); 13C NMR (CDCI3, 100 MHz) delta 14.8, 30.7, 31 .2, 36.7, 59.7, 67.6, 1 14.7, 156.1 , 156.2, 168.0.

The synthetic route of 74901-69-2 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; BOEHRINGER INGELHEIM INTERNATIONAL GMBH; LUIPPOLD, Gerd; NICKOLAUS, Peter; STREICHER, Ruediger; WO2014/124860; (2014); A1;,
Pyrimidine | C4H4N2 – PubChem,
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Adding a certain compound to certain chemical reactions, such as: 6303-46-4, 6-Chloro-N-(3,4-dichlorophenyl)pyrimidin-4-amine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 6303-46-4, blongs to pyrimidines compound. Computed Properties of C10H6Cl3N3

General procedure: 5.1.4 4-(6-{[4-(Trifluoromethyl)phenyl]amino}pyrimidin-4-yl)benzoic acid (4-1) 22 Under a nitrogen atmosphere, 6-chloro-N-[4-(trifluoromethyl)phenyl]pyrimidin-4-amine (3-1) (4.10 g, 10 mmol), 4-carboxyphenylboronic acid (2) (2.00 g, 12 mmol), Pd(PPh3)4 (0.60 g, 0.50 mmol) and Cs2CO3 (13.0 g, 30 mmol) were suspended in a mixture of CH3CN/H2O (100 mL, V:V = 1:1). The mixture was heated under reflux for 48 h at 90 C. The hot suspension was filtered and the filtrate distilled by rotary evaporation to remove acetonitrile. Water was added, and the mixture was extracted three times with EtOAc (3 * 30 ml). The aqueous layer was acidified with conc. HCl and extracted two more times with EtOAc. The combined organic layers were washed with brine and dried over Na2SO4. Evaporation of the solvent gave the crude product, which was purified by flash column chromatography to afford the product (2.90 g, 81%). The key intermediate Compounds (4-1) – (4-19) were preparedby using the general procedure described above.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,6303-46-4, its application will become more common.

Reference:
Article; Dong, Jinyun; Lu, Wen; Pan, Xiaoyan; Su, Ping; Shi, Yaling; Wang, Jinfeng; Zhang, Jie; Bioorganic and Medicinal Chemistry; vol. 22; 24; (2014); p. 6876 – 6884;,
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Electric Literature of 1189169-37-6, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.1189169-37-6, name is 1-(5-Bromopyrimidin-2-yl)ethanone, molecular formula is C6H5BrN2O, molecular weight is 201.02, as common compound, the synthetic route is as follows.

At -78 C, n-butyllithium (2.5 M, 4.38 mL, 10.94 mmol) was added to a THF (99 mL) solution containing N,N-bis(2,4- dimethoxybenzyl)ethanesulfonamide (4.07 g, 9.95 mmol, prepared following the procedure described in Example 467.0 employing2,4-methoxybenzylamine and 2,4- methoxybenzaldehyde). The resulting mixture was stirred for 30 min at -78 C. Next, a THF solution of 1-(5-bromopyrimidin-2-yl)ethanone (2.0 g, 9.95 mmol) was added at -78 C. Stirring was continued at -78 , and then the reaction was allowed to slowly warm to RT and stirred overnight. The reaction was then quenched with a saturated aqueous ammonium chloride solution and extracted with EtOAc (3 x 100 mL). After concentration, the product thus obtained was purified on silica eluting with a hexanes/EtOAc gradient (0-100%). Desired fractions were then pooled and concentrated in vacuo to give the title compound. LCMS-ESI (pos.) m/z: 629.9 (M+H2O).

Statistics shows that 1189169-37-6 is playing an increasingly important role. we look forward to future research findings about 1-(5-Bromopyrimidin-2-yl)ethanone.

Reference:
Patent; AMGEN INC.; CHEN, Ning; CHEN, Xiaoqi; CHEN, Yinhong; CHENG, Alan C.; CONNORS, Richard V.; DEIGNAN, Jeffrey; DRANSFIELD, Paul John; DU, Xiaohui; FU, Zice; HARVEY, James S.; HEATH, Julie Anne; HEUMANN, Lars V.; HORNE, Daniel B.; HOUZE, Jonathan; KALLER, Matthew R.; KAYSER, Frank; KHAKOO, Aarif Yusuf; KOPECKY, David J.; LAI, Su-Jen; MA, Zhihua; MEDINA, Julio C.; MIHALIC, Jeffrey T.; NISHIMURA, Nobuko; OLSON, Steven H.; PATTAROPONG, Vatee; SWAMINATH, Gayathri; WANG, Xiaodong; WANSKA, Malgorzata; YANG, Kevin; YEH, Wen-Chen; (700 pag.)WO2018/97945; (2018); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Reference of 1445-39-2, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 1445-39-2, name is 2-Amino-5-iodopyrimidine. This compound has unique chemical properties. The synthetic route is as follows.

To a solution of 2-amino-5-iodopyrimidine (0.50 g, 2.26 mmol)in anh. DMF (100 mL) under direct nitrogen bubbling was added bis(tributyltin) (1.37 mL, 2.71 mmol)and Pd2dba3*CHCl3 (0.23 g, 0.23 mmol). Then, the reaction was heated to 65 C with stirring for3 h under direct nitrogen bubbling. After completion, the solvent was removed in vacuo to give ablack thick oil. The crude mixture was resuspended in EtOAc and filtered over a celite pad; then,the filtrate was concentrated in vacuo to give a dark liquid. Purification was performed using flashcolumn chromatography on silica (0-100% EtOAc in hexanes) to give the pure product as a yellowoil (0.75 g, 86%); Rf = 0.76 (1:1 EtOAc: Hex); 1H NMR (500 MHz, CDCl3)delta 8.17 (s, 2H), 6.08 (br, 2H),1.45-1.51 (m, 6H), 1.39-1.44 (m, 6H), 1.21-1.29 (m, 6H), 0.83-1.06 (m, 9H); 13C NMR (126 MHz, CDCl3) delta164.32, 163.16, 119.22, 28.84, 27.44, 13.57, 8.09; MS (ESI+) m/z calcd for C16H31N3Sn [M + H]+ 386.15,found: 386.19.

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 1445-39-2, 2-Amino-5-iodopyrimidine.

Reference:
Article; Yates, Mary K.; Chatterjee, Payel; Flint, Mike; Arefeayne, Yafet; Makuc, Damjan; Plavec, Janez; Spiropoulou, Christina F.; Seley-Radtke, Katherine L.; Molecules; vol. 24; 17; (2019);,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Application of 914612-23-0, Adding some certain compound to certain chemical reactions, such as: 914612-23-0, name is 6-Benzyl-4-chloro-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine,molecular formula is C14H14ClN3, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 914612-23-0.

1-[(S)-3-(6-Benzyl-5,6,7,8-tetrahydro-pyrido[4,3-d]pyrimidin-4-yloxy)-pyrrolidin-1-yl]-propan-1-one Step 1 To a solution of 1-((S)-3-hydroxy-pyrrolidin-1-yl)-propan-1-one (intermediate 2) (358 mg, 2.503 mmol) in 5 mL of THF was added NaH (108 mg, 2.70 mmol) under Ar. The mixture was stirred at rt for 15 min, then 6-benzyl-4-chloro-5,6,7,8-tetrahydro-pyrido[4,3-d]pyrimidine (500 mg, 1.925 mmol) and 5 mL of THF were added and stirred at rt for 5 h. The reaction was quenched with H2O and extracted with ethylacetate, the org. layer was washed with brine, dried over MgSO4, filtered and evaporated to dryness. The residue was purified by flash-chromatography using Isco Companion system (12 g of SiO2) CH2Cl2/MeOH (95/5). The collected fractions were combined, evaporated and dried over high vacuum to give 1-[(S)-3-(6-benzyl-5,6,7,8-tetrahydro-pyrido[4,3-d]pyrimidin-4-yloxy)-pyrrolidin-1-yl]-propan-1-one. (m=560 mg, yield 78%) MS: [M+H]+=367.6, Rt(7)=0.64 min.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 914612-23-0, 6-Benzyl-4-chloro-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; NOVARTIS AG; COOKE, Nigel Graham; FERNANDES GOMES DOS SANTOS, Paulo Antonio; FURET, Pascal; HEBACH, Christina; HOGENAUER, Klemens; HOLLINGWORTH, Gregory; KALIS, Christoph; LEWIS, Ian; SMITH, Alexander Baxter; SOLDERMANN, Nicolas; STAUFFER, Frederic; STRANG, Ross; STOWASSER, Frank; TUFFILLI, Nicola; VON MATT, Anette; WOLF, Romain; ZECRI, Frederic; US2015/342951; (2015); A1;,
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Pyrimidine – Wikipedia