Tag: M.W:200-300

Application of 36082-50-5, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.36082-50-5, name is 5-Bromo-2,4-dichloropyrimidine, molecular formula is C4HBrCl2N2, molecular weight is 227.8741, as common compound, the synthetic route is as follows.

12a Production of 4-(5-Bromo-2-chloro-pyrimidin-4-ylamino)-butan-1-ol A solution of 2.28 g (10.0 mmol) of 5-bromo-2,4-dichloro-pyrimidine and 1.7 ml (12.0 mmol) of triethylamine in 10 ml of acetonitrile is mixed at 0 C. with 1.1 ml (12.0 mmol) of 4-amino-butanol. The reaction mixture is slowly heated to room temperature while being stirred by removal of the ice bath. After 16 hours, the precipitate that is formed is filtered off. The filtrate is completely concentrated by evaporation and digested with diisopropyl ether. 2.74 g (9.8 mmol, corresponding to 98% of theory) of the product is obtained. 1H-NMR (DMSO): 8.19 (s, 1H), 7.72 (t, 1H), 4.45 (br, 1H), 3.38 (m, 4H), 1.56 (m, 2H), 1.45 (m, 2H). MS: 279 (EI).

The chemical industry reduces the impact on the environment during synthesis 36082-50-5, I believe this compound will play a more active role in future production and life.

Reference:
Patent; Schering AG; US2004/209895; (2004); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Related Products of 1088994-22-2, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 1088994-22-2, name is 5-Methyl-2-(pyrimidin-2-yl)benzoicacid, molecular formula is C12H10N2O2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

1- (5- (4-fluorophenyl) pyrimidin-2-yl) -1,4-diazepan (0.163g, 0.6mmol), 5- methyl-2- (pyrimidin-2 yl) benzoic acid 0.128g, 0.6mmol) and anhydrous N, N- dimethylformamide (5mL) were added sequentially to a 50mL round bottom flask, and then at -20 deg.] C, slowly added sequentially N, N- two diisopropylethylamine (0.32mL, 1.8mmol) and 1-propyl phosphoric acid cyclic anhydride (1.336g, 2.1mmol) in ethyl acetate in 50% wt solution, the reaction solution after 1 hour reaction, the reaction temperature was raised to 50 20 hours and then at room temperature for 24 hours trans. To stop the reaction, under ice-cooling, to the reaction mixture was slowly added water (20 mL) and a saturated aqueous solution of sodium hydroxide (5ml) to the reaction solution to pH 7-8, and (100mL × 2) and extracted with methylene chloride, The combined dichloromethane layer was washed with water (50mL × 3) and saturated brine (10 mL), dried organic layer was separated, dried over anhydrous sodium sulfate. The filtrate was concentrated under reduced pressure, the resulting residue was purified by silica gel column chromatography (methylene chloride / methanol (v / v) = 50/1) to give the title compound as a yellow via solid (57mg, 20.1%).

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 1088994-22-2, 5-Methyl-2-(pyrimidin-2-yl)benzoicacid.

Reference:
Patent; Guangdong East Sunshine Pharmaceutical Co., Ltd.; Jinchuan, Fei; Gao, Heng; Zhang, Ji; Zhang, Yingjun; (84 pag.)CN105461699; (2016); A;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 33097-11-9, name is 4,6-Dichloro-2-(methylthio)pyrimidine-5-carbaldehyde. This compound has unique chemical properties. The synthetic route is as follows. Safety of 4,6-Dichloro-2-(methylthio)pyrimidine-5-carbaldehyde

(2) A solution of 2,4-dichlorobenzylamine(1.89 g) and triethylamine(1.36 g) in methanol(10 mL) was added dropwise to a solution of 4,6-dichloro-2-methylsulfanylpyridine-5-carboaldehyde(2.0 g) in methanol(80 mL) cooled at 0C. The reaction mixture was stirred at room temperature for an hour, an aqueous saturated sodium bicarbonate solution and ethyl acetate were added thereto, and the organic layer was separated. The organic layer was dried and the solvent was concentrated. Diisopropyl ether and hexane were added to the residue and the precipitates were filtered and dried to give 4-chloro-6-(2,4-dichlorobenzylamino)-2-methylsulfanylpyrimidine-5-carboaldehyde(2.88 g) as a colorless powder. APCI-MS(m/e):362/364[M+H]+.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 33097-11-9, 4,6-Dichloro-2-(methylthio)pyrimidine-5-carbaldehyde.

Reference:
Patent; Mitsubishi Tanabe Pharma Corporation; EP1970373; (2008); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Related Products of 56844-12-3, Adding some certain compound to certain chemical reactions, such as: 56844-12-3, name is 6-Bromo-4-chlorothieno[2,3-d]pyrimidine,molecular formula is C6H2BrClN2S, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 56844-12-3.

General procedure: Compound 1 (1.00 g, 4.01 mmol) was mixed with the benzylamine (12.03 mmol) and 1-butanol (3.5 mL) and agitated at 145 C for 18-24 h. Then the mixture was cooled to rt, diluted with water (50 mL) and diethyl ether (150 mL) or EtOAc (150 mL). After phase separation, the water phase was extracted with more diethyl ether (2 × 50 mL) or EtOAc (2 × 50 mL). The combined organic phases were washed with saturated aq NaCl solution (50 mL), dried over anhydrous Na2SO4, filtered and concentrated in vacuo, before the crude oil was dried under reduced pressure to constant weight to remove excess benzylamine. The compounds were purified by silica-gel column chromatography or crystallized as specified for each individual compound

According to the analysis of related databases, 56844-12-3, the application of this compound in the production field has become more and more popular.

Reference:
Article; Bugge, Steffen; Kaspersen, Svein Jacob; Larsen, Synne; Nonstad, Unni; Bj°rk°y, Geir; Sundby, Eirik; Hoff, Bard Helge; European Journal of Medicinal Chemistry; vol. 75; (2014); p. 354 – 374;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Adding a certain compound to certain chemical reactions, such as: 145783-15-9, 4,6-Dichloro-2-(propylthio)pyrimidin-5-amine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 145783-15-9, blongs to pyrimidines compound. Quality Control of 4,6-Dichloro-2-(propylthio)pyrimidin-5-amine

ake a 500ml three-necked flask,Equipped with a condensing return tube and nitrogen ball protection.Add 2-[[(3AR,4S,6R,6AS)-6-aminotetrahydro-2,2-dimethyl-4H-cyclopenten-1,3-dioxolan-4-yl ]oxy]ethanol (88.7 g, 408.3 mmol, 1.0 eq), 4,6-dichloro-2-(propylthio)-5-aminopyrimidine (98.0 g, 408.3 mmol, 1.0 eq), N,N- Diisopropylethylamine (79.1 g, 612.5 mmol, 1.5 eq),Stir at 120-125 C for 10 hours (HPLC detection,The peak area percentage was 4,6-dichloro-2-(propylthio)-5-aminopyrimidine <1.0%), the heating was stopped and the temperature was lowered to <60 C, and ethyl acetate and water were added for washing and extraction. Concentrated to 200 ml of ethyl acetate under reduced pressure and recrystallized from petroleum ether.Made a white solid 160g,The yield is 93.5%.HPLC peak area percentage SM-C ? 98.5%. These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,145783-15-9, its application will become more common. Reference:
Patent; Huaren Pharmaceutical Co., Ltd.; Feng Xinguang; Li Xuechao; Li Wei; (5 pag.)CN105198864; (2018); B;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 130049-82-0, name is 3-(2-Chloroethyl)-6,7,8,9-tetrahydro-9-hydroxy-2-methyl-4H-pyrido[1,2-a]pyrimidine-4-one. A new synthetic method of this compound is introduced below., COA of Formula: C11H15ClN2O2

(II) hydrochloride (48.77 g, 0.195 mol), (III) (48.54 g, 0.2 mol)(50.4 g, 0.6 mol), potassium iodide (3.3 g, 0.02 mol), 400 mL of acetonitrile and 100 mL of water were heated to 65 G in a 1000 mL three-necked flask and stopped for 16 h reaction. Cooling to 25 G, slowly add lOOmL of water to the system, a large number of solid material precipitation, stirring 30 min, the filter to get crude, filter cake with acetonitrile and water were washed solid, dryingOf crude 72.0 g.The crude product of 72.0 g of (I) was placed in 720 mL of water at a temperature of 20-25 C, 16.8 mL of concentrated hydrochloric acid was added, stirred to form (I) hydrochloride, and the aqueous solution of (I) was washed with 500 mL of dichloromethane 2 times, take the aqueous solution layer, add 7.2g activated carbon decolorization, heating to 50 e, stirring 30min, the filter (I) hydrochloric acid solution.The aqueous solution of (I) salt was cooled to 0-10 C and 500 mL of isopropyl alcohol was added to the system at a temperature of 0-10 C,A solution of 20% sodium hydroxide was slowly added with stirring to adjust the pH of the system to 8-9 to give (I) as a white solid. After the dropwise addition, the mixture was stirred at this temperature for 1 hour and filtered to obtain a solid material. Isopropyl alcohol and water (100 mL + 100 mL), and the resulting solid was (I), about 55.0 g.The above-obtained (I) was added to a mixed solvent of 1100 mL of ethanol and 333 mL of water and heated to reflux to a solid materialDissolved in the lh, slowly cooled to 0-5 e, stirring at this temperature for 16h, to obtain a white solid crystalline material, filtration, to obtain high purity (I), drying to get the product 49.2g, yield 60 %.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 130049-82-0, 3-(2-Chloroethyl)-6,7,8,9-tetrahydro-9-hydroxy-2-methyl-4H-pyrido[1,2-a]pyrimidine-4-one.

Reference:
Patent; JIANGSU CHIATAI QINGJIANG PHARMACEUTICAL CO LTD (CTQJ); WANG, WUWEI; CHEN, JIE; WU, TINGZHAO; GU, HAICHENG; HE, JIA; (7 pag.)CN103214485; (2016); B;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 39551-54-7, name is 2,4-Dichloropyrido[3,2-d]pyrimidine. A new synthetic method of this compound is introduced below., Application In Synthesis of 2,4-Dichloropyrido[3,2-d]pyrimidine

To a solution of 116E (50 mg, 0.22 mmol) and 2,4-dichloropyrido[3,2-d]pyrimidine (45 mg, 0.22 mmol) in THF (3 mL) was added N,N-diisopropylethylamine (0.12 mL, 0.67 mmol). After stirring at 80 C. for 18 h, the reaction was cooled to ambient temperature, diluted with EtOAc (25 mL), washed with water (25 mL) and brine (25 mL), dried over Na2SO4, and concentrated in vacuo. The residue was subjected to silica gel chromatography eluting with hexanes-EtOAc (0-100%) to provide 116F. LCMS (m/z): 350.06 [M+H]+; tR=1.09 min. on LC/MS Method A

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 39551-54-7, 2,4-Dichloropyrido[3,2-d]pyrimidine.

Reference:
Patent; Gilead Sciences, Inc.; Aktoudianakis, Evangelos; Chin, Gregory; Mackman, Richard L.; Metobo, Samuel E.; Mish, Michael R.; Pyun, Hyung-jung; Zablocki, Jeff; (175 pag.)US2016/289229; (2016); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Synthetic Route of 33097-13-1, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 33097-13-1, name is 4,6-Dichloro-2-(methylthio)pyrimidine-5-carbonitrile. A new synthetic method of this compound is introduced below.

To the solution of 4,6-dichloro-2-(methylthio)-5-pyrimidinecarbonitrile (2.20 g, 10.0 mmol) in DMF (10 mL) was added 2,6-difluoroaniline (2.17 mL, 20.0 mmol). The solution was stirred at 50 0C for about 60 minutes. The mixture was slowly added into a solution of MeOH (20 mL) and water (30 mL). The resultant solid was filtered and washed with MeOH / H2O (20 mL, 1 : 1) to give 4-chloro-6-[(2,6-difluorophenyl)amino]-2-(methylthio)-5-pyrimidinecarbonitrile as a white solid (2.82 g, 90 %). LC-MS m/z 313 (M + H)+; 1H-NMR (CDCl3) delta 2.33 (s, 3 H), 6.94 (s, 1 H), 7.04 (m, 2 H), 7.35 (m, 1 H).

At the same time, in my other blogs, there are other synthetic methods of this type of compound,33097-13-1, 4,6-Dichloro-2-(methylthio)pyrimidine-5-carbonitrile, and friends who are interested can also refer to it.

Reference:
Patent; GLAXO GROUP LIMITED; WO2006/104917; (2006); A2;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Application of 16879-53-1, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 16879-53-1, name is 2-Phenylpyrimidine-4-carboxylic acid. A new synthetic method of this compound is introduced below.

A solution of 150 mg of 2-phenyl-4pyrimidinecarboxylic acid in 1 mL of thionyl chloride was heated at 70 C. for 1 hr, cooled to room temperature and the excess thionyl chloride removed by evaporation under reduced pressure to yield 145 mg of 2-phenyl-4-pyrimidinecarboxylic acid chloride which was used in the next step without further purification or characterization.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,16879-53-1, 2-Phenylpyrimidine-4-carboxylic acid, and friends who are interested can also refer to it.

Reference:
Patent; Neurogen Corporation; US5594141; (1997); A;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Reference of 155690-79-2, Adding some certain compound to certain chemical reactions, such as: 155690-79-2, name is 6-Bromopyrido[2,3-d]pyrimidin-4(1H)-one,molecular formula is C7H4BrN3O, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 155690-79-2.

6-Bromopyrido[2,3-d]pyrimidin-4(3H)-one (3.Og) and POC13 (15 mL)were heated at 130 C under nitrogen for 3h. The homogeneous dark solution was concentrated under reduced pressure and diluted with EtOAc (150 mL). The heterogeneous brown slurry was poured onto mixture of ice/aq. NaHCO3 and allowed the mixture warm to room temperature. The heterogeneous brown mixture was further diluted with EtOAc (75 mL) and separated the organic layer. The organic layer was partitioned with aq. NaC1, separated, stirred with MgSO4 and filtered through a pad of Celite and silica gel. The pale yellow filtrate was concentrated and the crude solid was stirred in 50% EA/hexanes. 6-Bromo-4-chloropyrido[2,3-d]pyrimidine was obtained as a pale yellow crystalline solid (1.8 g, purity: 95%) upon filtration.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 155690-79-2, 6-Bromopyrido[2,3-d]pyrimidin-4(1H)-one, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; RIGEL PHARMACEUTICALS, INC.; SINGH, Rajinder; BHAMIDIPATI, Somasekhar; DING, Pingyu; PAYAN, Donald; GELMAN, Marina; KINSELLA, Todd; WO2015/157093; (2015); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia