Tag: M.W:200-300

Electric Literature of 3177-20-6, Adding some certain compound to certain chemical reactions, such as: 3177-20-6, name is Methyl 2,4-dichloropyrimidine-5-carboxylate,molecular formula is C6H4Cl2N2O2, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 3177-20-6.

Methyl 2-chloTo-4-{i2-(2-hYdroxyethoxy)ethyl amino}pyrimidine-5-carboxylate (1254) (1255) A solution of methyl 2,4-dichloropyrimidine-5-carboxylate (252 mg, 1.22 mmol) in i- PrOH (6 mL) was added 2-(2-aminoethoxy)ethanol (122 iL, 1.22 mmol) and DIEA (319 mu,, 1.83 mmol) at 0 °C. After 1.5 h the volatiles were removed under a reduced pressure and the residue was purified by ISCO silica gel column to provide the title compound (243 mg, 72 percent) as a white solid. 1H N R (400 MHz, CDCI3) delta 8.67 (s, 1H), 3.90 (s, 3H), 3.82-3.74 (m, 4H), 3.70 (t, J = 5.2 Hz, 2H), 3.67-3.61 (m, 2H), 2.17 (t, J = 6.3 Hz, 1H).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 3177-20-6, Methyl 2,4-dichloropyrimidine-5-carboxylate, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL; WANG, Xiaodong; ZHANG, Weihe; FRYE, Stephen; WO2015/157127; (2015); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 74901-69-2, name is 2,4-Dichloro-6,7-dihydrothieno[3,2-d]pyrimidine, molecular formula is C6H4Cl2N2S, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. Computed Properties of C6H4Cl2N2S

6. SYNTHESIS OF [2-(5-BENZOXAZOL-2-YL-2,5-DIAZABICYCLO[2,2,1]HEPT-2-YL)-5-OXO-6,7-DIHYDRO-5H-5lambda4-THIENO[3,2-D]PYRIMIDIN-4-YL]-(TETRAHYDROPYRAN-4-YL)-AMINEExample 296.1 (2-chloro-6,7-dihydrothieno[3,2-d]pyrimidin-4-yl)-(tetrahydropyran-4-yl)-amine (III-5)0.68 g (II) are placed in 6 ml dioxane, then 1.72 ml diisopropylethylamine followed by 0.6 g 4-aminotetrahydropyran are added. The reaction mixture is heated at 130 C. until there is no further reaction and after cooling evaporated down. The product is treated with water in the ultrasound bath, suction filtered and dried. 0.66 g (III-5) are obtained as a solid.Analytical HPLC-MS (method A): RT=1.08 min.

With the rapid development of chemical substances, we look forward to future research findings about 74901-69-2.

Reference:
Patent; BOEHRINGER INGELHEIM INTERNATIONAL GMBH; US2011/46096; (2011); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Synthetic Route of 74901-69-2, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.74901-69-2, name is 2,4-Dichloro-6,7-dihydrothieno[3,2-d]pyrimidine, molecular formula is C6H4Cl2N2S, molecular weight is 207.08, as common compound, the synthetic route is as follows.

25.1 2-[1-(2-chloro-6,7-dihydrothieno[3,2-d]pyrimidin-4-ylamino)-cyclopropyl]-propan-2-ol (III-8) 2.7 g (II) are placed in 30 ml dioxane, then 6.8 ml diisopropyl-ethylamine and 1.8 g 2-(1-aminocyclopropyl)-propan-2-ol (see Liebigs Ann. Chem. 1978, 1194) are added. The reaction mixture is heated to 160 C. until there is no further reaction, and after cooling it is evaporated to dryness. The residue is combined with ice water. The product is extracted with dichloromethane and purified by chromatography. 125 mg (III-8) are obtained as a solid. Analytical HPLC-MS (method A): RT=1.08 min.

Statistics shows that 74901-69-2 is playing an increasingly important role. we look forward to future research findings about 2,4-Dichloro-6,7-dihydrothieno[3,2-d]pyrimidine.

Reference:
Patent; BOEHRINGER INGELHEIM INTERNATIONAL GMBH; Nickolaus, Peter; US2013/225609; (2013); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Adding a certain compound to certain chemical reactions, such as: 36082-45-8, 2-Amino-5-bromo-4-methoxypyrimidine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Formula: C5H6BrN3O, blongs to pyrimidines compound. Formula: C5H6BrN3O

Intermediate U: 4-Methoxy-5-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-pyrimidin-2-ylamine A mixture of 2-amino-5-bromo-4-methoxypyrimidine [36082-45-8] (11.1 mmol), bis(pinacolato)diboron (12.2 mmol), PdCl2(dppf).CH2Cl2 adduct (0.555 mmol) and potassium acetate (33.3 mmol) in dioxane (60 mL) was stirred at 115 C. under argon for 20 h, allowed to cool to rt, diluted with toluene (60 mL), sonicated, and filtered through celite. The celite cake was rinsed with hot toluene (2*). The filtrate was concentrated to afford the title compound (30% purity) which was used without purification. ESI-MS: tR=0.22 min; [M+H]+ 170 (boronic acid) (LC-MS 1).

At the same time, in my other blogs, there are other synthetic methods of this type of compound,36082-45-8, 2-Amino-5-bromo-4-methoxypyrimidine, and friends who are interested can also refer to it.

Reference:
Patent; NOVARTIS AG; Cotesta, Simona; Furet, Pascal; Guagnano, Vito; Holzer, Philipp; Kallen, Joerg; Mah, Robert; Masuya, Keiichi; Schlapbach, Achim; Stutz, Stefan; Vaupel, Andrea; US2013/317024; (2013); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Related Products of 16234-14-3, Adding some certain compound to certain chemical reactions, such as: 16234-14-3, name is 2,4-Dichlorothieno[3,2-d]pyrimidine,molecular formula is C6H2Cl2N2S, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 16234-14-3.

To a solution of 2,4-dichloro-thieno[3,2-d]pyrimidine 1 (300 mg, 1.46 mmol) in EtOAc, DIPEA (0.52 mL, 2.92 mmol) was added, followed by 10 % Pd/C (300 mg) and the suspension shaken in a Parr hydrogenator at 45 psi of H2 pressure for 5 h. The reaction mixture was filtered over celite, the filtrate evaporated and the crude material loaded onto silica. The crude reaction mixture was purified using column chromatography eluting with 9:1 hexanes/EtOAc to obtain 5 as an off-white solid (200 mg, 1.17 mmol, 80 %). Rf 0.1 in 9:1 hexanes/EtOAc. Mp 166.3-169.6 C. 1H NMR (400 MHz, CDCl3): delta 7.47 (d, 1H, J=5.5Hz), 8.00 (d, 1H, J=5.0Hz), 9.11 (s, 1H). 13C NMR (100 MHz, CDCl3): delta 123.8, 129.8, 139.1, 153.6, 157.5, 163.1. FAB-MS m/z for C6H3ClN2S calculated [M+H]+ 170.9778, found 170.9784 (35Cl), 170.9766 (37Cl).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 16234-14-3, 2,4-Dichlorothieno[3,2-d]pyrimidine, other downstream synthetic routes, hurry up and to see.

Reference:
Article; Temburnikar, Kartik W.; Zimmermann, Sarah C.; Kim, Nathaniel T.; Ross, Christina R.; Gelbmann, Christopher; Salomon, Christine E.; Wilson, Gerald M.; Balzarini, Jan; Seley-Radtke, Katherine L.; Bioorganic and Medicinal Chemistry; vol. 22; 7; (2014); p. 2113 – 2122;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Reference of 16097-63-5, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 16097-63-5 as follows.

To a mixture of 4 ml of water, 1.4 g of sodium cyanide and 0.29 g of 1, 4-diazabicyclo [2.2.2] octane, 20 ml of dimethyl sulfoxide and the crude product were added at 00C. This mixture was stirred for 1 hour. The reaction mixture was poured into water and then extracted three times with tert-butyl methyl ether. The organic layer was washed with saturated brine, dried over anhydrous magnesium sulfate and then concentrated. The residue was subjected to silica gel column chromatography to obtain 3.2 g of 2-methylthio-6- trifluoromethylpyrimidine-4-carbonitrile . 2-methylthio-6-trifluoromethylpyrimidine-4-carbonitrile1H-NMR: 2.63(s,3H), 7.53(s,lH)

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,16097-63-5, its application will become more common.

Reference:
Patent; SUMITOMO CHEMICAL COMPANY, LIMITED; MIZUNO, Hajime; WO2010/134478; (2010); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.148550-51-0, name is Ethyl 2-(methylsulfonyl)pyrimidine-5-carboxylate, molecular formula is C8H10N2O4S, molecular weight is 230.24, as common compound, the synthetic route is as follows.Recommanded Product: Ethyl 2-(methylsulfonyl)pyrimidine-5-carboxylate

Step 3: Ethyl 2-morpholinopyrimidine-5-carboxylate (122); [0727] A solution of sulfone 121 (0.184 g, 0.80 mmol) in ethyleneglycol dimethylether (5 mL) was treated with neat morpholine (0.3 mL, 3.4 mmol) and the mixture was stirred at room temperature for 48 h. The reaction mixture was then diluted with DCM and washed with saturated NaHCO3 in brine, dried over MgSO4, filtered, concentrated and stored under vacuum to give intermediate 122 (0.205 g, >99percent yield).[0728] 1H NMR (DMSO-d6) delta (ppm): 8.78 (s, 2H), 4.26 (q, J= 7.0 Hz, 2H), 3.83 (t, J= 4.7Hz, 4H), 3.66 (t, J= 5.1 Hz, 4H), 1.30 (t, J= 7.0 Hz, 3H).

At the same time, in my other blogs, there are other synthetic methods of this type of compound,148550-51-0, Ethyl 2-(methylsulfonyl)pyrimidine-5-carboxylate, and friends who are interested can also refer to it.

Reference:
Patent; METHYLGENE INC.; WO2007/118137; (2007); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 3029-64-9, name is 2,4,6-Trichloro-5-cyanopyrimidine. A new synthetic method of this compound is introduced below., Computed Properties of C5Cl3N3

EXAMPLE VIII 4,6-Dichloro-2-diethylamino-5-pyrimidinecarbonitrile A stirred solution of 6.3 grams of 2,4,6-trichloro-5-pyrimidinecarbonitrile in 150 ml of diethyl ether was cooled to -10°, and a solution of 4.4 grams of diethylamine in 75 ml of diethyl ether was added dropwise. Upon complete addition, the reaction mixture was stirred at -10° for 1 hour. Water was added to the reaction mixture. The diethyl ether layer was separated and dried over magnesium sulfate. The mixture was filtered, and the filtrate was evaporated under reduced pressure to a residue. The residue was recrystallized from methylcyclohexane to give 3.8 grams of 4,6-dichloro-2-diethylamino-5-pyrimidinecarbonitrile; mp, 125°-126°. Analysis: Calculated for C9 H10 Cl2 N4: C,44.10; H,4.07; N,22.85; Found: C,44.l3; H,4.28; N,23.14.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 3029-64-9, 2,4,6-Trichloro-5-cyanopyrimidine.

Reference:
Patent; FMC Corporation; US4092150; (1978); A;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Synthetic Route of 3740-92-9 ,Some common heterocyclic compound, 3740-92-9, molecular formula is C10H6Cl2N2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

The title compound was prepared from 4,6-dichloro-2-phenyl-pyriinidine (Ig, 4.42 mmol) and 4-thiomethiotayl aniline (0.61 g, 4.42 mmol) in the presence of triethyl amine in n-butanol at refluxing temperature for 12 hours.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,3740-92-9, its application will become more common.

Reference:
Patent; REDDY US THERAPEUTICS, INC.; KALLEDA, Srinivas; PADAKANTI, Srinivas; KUMAR SWAMY, Nalivela; YELESWARAPU, Koteswar, Rao; ALEXANDER, Christopher, W.; KHANNA, Ish, Kumar; IQBAL, Javed; PILLARISETTI, Sivaram; PAL, Manojit; BARANGE, Deepak; WO2006/34473; (2006); A2;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 696-07-1, name is 5-Iodouracil. This compound has unique chemical properties. The synthetic route is as follows. category: pyrimidines

5-bromo- or 5-iodouracil (1.0 equiv.) is suspended in N,N-dimethylaniline, treated with phosphorus oxychloride (10.0 equiv.) and stirred for 90 minutes at 125 C. After cooling to room temperature, excess phosphorus oxychloride is removed under vacuum. The residue is poured into ice-water. After 2 hours the crystals that have formed are filtered off at the pump and washed with water. Next, the crystals are dissolved in ethyl acetate. The organic phase is washed with saturated sodium hydrogen carbonate solution and saturated sodium sulphite solution and dried over sodium sulphate. After removal of the solvent the chromatographic purification is performed.; Starting from 5-iodouracil (10g, 42 mmol)) and N,N-dimethylaniline (11.0 mL), the desired product is obtained according to procedure 1 in 92% yield (10.6 g) after chromatographic purification (silica gel, dichloromethane). 1H-NMR (400 MHz, CDCl3): delta 8.90 (s, 1H).

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 696-07-1, 5-Iodouracil.

Reference:
Patent; Lucking, Ulrich; Nguyen, Duy; Von Bonin, Arne; Von Ahsen, Oliver; Kruger, Martin; Briem, Hans; Kettschau, Georg; Prien, Olaf; Mengel, Anne; Konrad, Krolikiewicz; Boemer, Ulf; Bothe, Ulrich; Hartung, Ingo; US2007/232632; (2007); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia