Tag: M.W:200-300

Related Products of 31462-58-5, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 31462-58-5, name is 5-Iodopyrimidine, molecular formula is C4H3IN2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

General procedure: Aryl halide (1 mmol) and n-butyl acrylate (1.5 mmol) were added to a flask containing the aminoclay picolinic acid nano-Pd(0) complex catalyst (0.5 mg of the catalyst, containing 1.2 x 10-3 mmol of palladium) and n-Pr3N (1.5 mmol, 0.29 mL) in the absence of solvent. The mixture was stirred at 120 C in the air. After completion of the reaction (monitored by TLC), the reaction mixture was diluted with diethyl ether (5 mL) and the catalyst was separated by centrifuging. The diluted reaction mixture was extracted with water (3 9 15 mL). The ethereal layer was dried over anhydrous MgSO4 and condensed under the reduced pressure to provide the crude product. The crude product was purified by column chromatography using ethyl acetate and hexane mixtures as eluent to obtain the pure Heck product.

According to the analysis of related databases, 31462-58-5, the application of this compound in the production field has become more and more popular.

Reference:
Article; Fahimi, Nafiseh; Sardarian, Ali Reza; Research on Chemical Intermediates; vol. 43; 8; (2017); p. 4923 – 4941;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 220041-42-9, name is tert-Butyl 2-chloropyrimidine-4-carboxylate. This compound has unique chemical properties. The synthetic route is as follows. Safety of tert-Butyl 2-chloropyrimidine-4-carboxylate

Step 2: Synthesis of ( R )-tert-butyl 2-(2-methyl-4-(4-(methylsulfonyl)phenyl)piperazin-1-yl)pyrimidine-4-carboxylate [596] Tert-butyl 2-chloropyrimidine-4-carboxylate (70 mg, 0.326 mmol) and (R)-3-methyl-1-(4-(methylsulfonyl)phenyl)piperazine (166 mg, 0.652 mmol) were dissolved in acetonitrile (2 ml), followed by addition of N,N-diisopropylethylamine (0.11 ml, 0.652 mmol), and then the resulting liquid was stirred at 100oC under nitrogen stream for 24 hours. The resulting reaction liquid was concentrated under reduced pressure, and then the residue thus obtained was subjected to MPLC (50% EtOAc/Hexanes), to obtain 120 mg of pale yellow solid (85%).

With the rapid development of chemical substances, we look forward to future research findings about 220041-42-9.

Reference:
Patent; SK Chemicals Co.,Ltd.; RYU, Je Ho; KIM, Shin Ae; RYU, Keun Ho; KIM, Jae Sun; KIM, Nam Ho; HAN, Hye Young; KIM, Yong Hyuk; YOUN, Won-No; LEE, Yoon-Jung; SON, Hyun Joo; LEE, Bong-yong; PARK, Sung Hoon; LEE, Ju Young; LEE, Hyun Jung; JUNG, Hoe Chul; SHIN, Young Ah; LEE, Jung A; LEE, Bo Ram; SA, Joon Ho; WO2011/139107; (2011); A2;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Related Products of 163263-91-0, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.163263-91-0, name is 2,4-Dichloro-6-(4-methoxyphenyl)pyrimidine, molecular formula is C11H8Cl2N2O, molecular weight is 255.1, as common compound, the synthetic route is as follows.

2,4-Dichloro-6-(4-methoxyphenyl)pyrimidine (1.01 g, 3.92 mmol)And (+/-)-trans-3-aminobicyclo[2.2.2]octane-2-carboxylic acid methyl ester (1.02 g, 5.88 mmol)Dissolved in DMF (20 mL), then added potassium carbonate (0.81 g, 5.88 mmol).The reaction solution was stirred at 50 C overnight, and water (70 mL) was added.After dilution, extract with ethyl acetate (100 mL × 3).The combined organic phases were washed with brine (150 mL)Dry over anhydrous sodium sulfate, filter,The filtrate was concentrated under reduced pressure to dryness.The residue was purified by EtOAc EtOAc EtOAc (EtOAc)The title compound is white solid(1.01 g, 64%).

Statistics shows that 163263-91-0 is playing an increasingly important role. we look forward to future research findings about 2,4-Dichloro-6-(4-methoxyphenyl)pyrimidine.

Reference:
Patent; Guangdong Dongyangguang Pharmaceutical Co., Ltd.; Ren Qingyun; Tang Changhua; Yin Junjun; Yi Kai; Lei Yibo; Wang Yejun; Zhang Yingjun; (138 pag.)CN108276401; (2018); A;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 43024-61-9, name is Ethyl 7-hydroxypyrazolo[1,5-a]pyrimidine-6-carboxylate. This compound has unique chemical properties. The synthetic route is as follows. Safety of Ethyl 7-hydroxypyrazolo[1,5-a]pyrimidine-6-carboxylate

Ethyl 7-hydroxypyrazolo[1,5-a]pyrimidine-6-carboxylate () (3.20 g, 15.5 mmol) was dissolved in phosphorus oxychloride (30 mL), N,N-diisopropylethylamine (5.4 mL, 30.9 mmol) was added, and the mixture was stirred with heating at 100 C for 3 hr. After confirmation of consumption the starting materials, phosphorus oxychloride was evaporated under reduced pressure, and the residue was dissolved in ethyl acetate. The solution was added dropwise to a saturated aqueous sodium hydrogen carbonate solution under ice-cooling. To the saturated aqueous sodium hydrogen carbonate solution was added ethyl acetate, and the mixture was extracted 3 times. The combined organic layer was dried over anhydrous magnesium sulfate, and concentrated under reduced pressure.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 43024-61-9, Ethyl 7-hydroxypyrazolo[1,5-a]pyrimidine-6-carboxylate.

Reference:
Patent; Kyowa Hakko Kirin Co., Ltd.; YAMAMOTO, Keisuke; ARATAKE, Seiji; HEMMI, Kazuki; EP2543670; (2013); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Adding a certain compound to certain chemical reactions, such as: 313339-35-4, 4,6-Dichloro-2-(methylthio)pyrimidine-5-carboxylic acid, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, category: pyrimidines, blongs to pyrimidines compound. category: pyrimidines

4,6-dichloro-2-(methylthio)pyrimidine-5-carboxylic acid (Compound of Reference Example 1; 3.59g) and N, N-dimethylformamide (0.2mL) were added to thionyl chloride (11ml_). While heated, the mixture was refluxed for 2 hours. The reaction mixture was then distilled under reduced pressure to obtain a yellow residue. Meanwhile, 1-(t-butoxycarbonylamino)-3-[3,5-(trifluoromethyl)benzylamino]propane (Compound of Refer-ence Example 2; 6.61 g) was dissolved in tetrahydrofuran (40mL) along with triethylamine (10ml_). While this solution was chilled on an ice bath, a tetrahydrofuran solution of the yellow residue (10ml) obtained above was added. The mixture was stirred for 1 hour and then additional 3 hours at room temperature. The reaction mixture was then diluted with ethyl acetate, was sequentially washed with water and a saturated aqueous solution of sodium chloride, and was then dried over anhydrous sodium sulfate. Following removal of the solvent, the residue was purified on a silica gelcolumn chromatography (ethyl acetate: hexane = 1: 3) to obtain N-[3,5-bis(trifluoromethyl)benzyl]-N-[3-(t-butoxycarb-onylamino)propyl]-4,6-dichloro-2-(methylthio)pyrimidine-5-carboxylic acid amide (8.49g, 91%). MS(FAB+)m/z: 621 (M+H+) HRMS(FAB+): Calcd for C23H25CI2F6N4O3S: 621.0929; found: 621.0938

At the same time, in my other blogs, there are other synthetic methods of this type of compound,313339-35-4, 4,6-Dichloro-2-(methylthio)pyrimidine-5-carboxylic acid, and friends who are interested can also refer to it.

Reference:
Patent; Kyorin Pharmaceutical Co., Ltd.; EP1496059; (2005); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 17326-27-1, name is 2-Chloro-9-methyl-4-oxo-4H-pyrido[1,2-a]pyrimidine-3-carbaldehyde, molecular formula is C10H7ClN2O2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. COA of Formula: C10H7ClN2O2

G2 (0.5 mmol) was dissolved in 10.4 mL of tert-butyl alcohol and 2.5 mL of 2-methyl-2-butene. A solution of sodium chlorite (4.59 mmol) and sodium dihydrogenphosphate (3.46 mmol) in 4.2 mL of water was added dropwise. The reaction mixture was stirred at room temperature overnight. Volatile components were then removed under vacuum, and the residue was dissolved in 10 ml of water and extracted with two 10 ml portions of hexane. The aqueous layer was acidified to pH=3 with HCl(aq) and extracted with 10 mL portions of methylene chloride. The combined organic layers were washed with 20 mL of cold water, dried and concentrated to give G4. 1H NMR (400 MHz, DMSO-d6) delta 2.58 (s, 3H), 7.53 (t, J=7.0 Hz, 1H), 8.14 (d, J=7.2 Hz, 1H), 8.97 (d. J=6.8 Hz, 1H), 13.53 (brs, 1H); 13C NMR (100 MHz, DMSO-d6) delta 16.7, 108.1, 117.1, 125.6, 133.3, 138.7, 148.2, 152.0, 154.6, 163.9.

With the rapid development of chemical substances, we look forward to future research findings about 17326-27-1.

Reference:
Patent; Brodin, Priscille; Christophe, Thierry; No, Zaesung; Kim, Jaeseung; Genovesio, Auguste; Fenistein, Denis Philippe Cedric; Jeon, Heekyoung; Ewann, Fanny Anne; Kang, Sunhee; Lee, Saeyeon; Seo, Min Jung; Park, Eunjung; Contreras Dominguez, Monica; Nam, Ji Youn; Kim, Eun Hye; US2011/178077; (2011); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Electric Literature of 890094-38-9, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 890094-38-9 as follows.

N-(3-aminophenyl)acrylamide(3.2g) was added to a solution of Compound 2-3(4.3g) in n-butanol(150ml). The mixture was reacted at 90C for 3 hours, cooled to room temperature, filtered, washed and dried to obtain a red solid(6.0g) in a yield of 88.3%. MS m/z(ESI): 344[M+H]+.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,890094-38-9, its application will become more common.

Reference:
Patent; Si Chuan University; CSPC Zhongqi Pharmaceutical Technology (Shijiazhuang) Co., Ltd.; YANG, Shengyong; WEI, Yuquan; EP2578584; (2013); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.4319-87-3, name is 5-Bromo-4-methoxy-6-methylpyrimidine, molecular formula is C6H7BrN2O, molecular weight is 203.04, as common compound, the synthetic route is as follows.Product Details of 4319-87-3

A microwavable vial was charged with {2-[(diethylamino)carbonyl]-5-fluorophenyl}boronic acid (0.424 g, 1.77 mmol), 5-bromo-4-methoxy-6-methylpyrimidine (0.200 g, 0.985 mmol) of Step A, sodium carbonate (0.313 g, 2.96 mmol), toluene (1.5 mL) and water (0.5 mL). The solution was degassed by purging with nitrogen for 10 minutes. Afterwards, tetrakis(triphenylphosphine)palladium(0) (0.110 g, 0.098 mmol) was added. The vial was sealed and microwaved at 160 C for 10 minutes. The reaction mixture was partitioned between water and ethyl acetate. The aqueous layer was extracted with two further portions of ethyl acetate. The combined organic extracts were washed with brine, dried over Na2S04, filtered and concentrated. The mixture was chromatographed (50-75% ethyl acetate/hexane) to afford N,N-diethyl-4-fluoro-2-(4-methoxy-6- methylpyrimidin-5-yl) benzamide (250 mg, 80%). ‘H NMR (CDCl3,500 MHz) : No. 8.65 (s, 1H); 7.36 (dd, J = 9.2, 6.0 Hz, 1H) ; 7.13 (dt, J = 8.4, 2.6 Hz, 1H); 6.93 (dd, J = 9.1,2.4 Hz, 1H) ; 3.88 (s, 3H), 3.70-2.85 (br, 4H) ; 2.31 (s, 3H); 1.05 (t, J = 7.1 Hz, 3H) ; 0.80 (t, J = 7.2 Hz, 3H). MS (ES) 318(M+1).

At the same time, in my other blogs, there are other synthetic methods of this type of compound,4319-87-3, 5-Bromo-4-methoxy-6-methylpyrimidine, and friends who are interested can also refer to it.

Reference:
Patent; INCYTE CORPORATION; WO2005/105814; (2005); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Application of 914347-48-1, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 914347-48-1, name is 2-[4-(6-Amino-2-methylpyrimidin-4-yl)piperazin-1-yl]ethanol. A new synthetic method of this compound is introduced below.

General procedure: Scheme 1 compound 8 (180.0 mg, 0.636 mmol) and 2-[4-(6-amino-2-methyl- pyrimidin-4-yl)-piperazin-l-yl]-ethanol (180.0 mg, 0.763 mmol) were dissolved in anhydrous dioxane (8 mL) in a flask. To this flask were added t-BuONa (183.0 mg, 1.908 mmol), X- PHOS (60.6 mg, 0.127 mmol), Pd(dba)2 (36.6 mg, 0.0636 mmol) under nitrogen atmosphere. The mixture was stirred at 80 C under nitrogen atmosphere overnight. TLC showed the starting material was consumed completely. The reaction mixture was concentrated, the residue was purified by prep-HPLC to give Compound 5 (90.0 mg, yield: 29.0%>) as a white solid. 1H NMR (400 MHz, CDC13+ MeOD + D20): delta 8.43 (s, 1H, CH), 7.97 (s, 1H, ArH), 7.61-7.25 (m, 5H, ArH), 6.44 (s, 1H, ArH), 4.30 (q, J= 7.2 Hz, 2H, CH2), 3.65-3.59 (m, 6H, 3CH2), 2.56-2.53 (m, 6H, 3CH2), 2.41 (s, 3H, CH3), 1.38 (t, J= 7.2 Hz, 3H, CH3). EXAMPLE 7

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,914347-48-1, its application will become more common.

Reference:
Patent; MANNKIND CORPORATION; TOLERO PHARMACEUTICALS, INC.; ZENG, Qingping; FARIS, Mary; MOLLARD, Alexis; WARNER, Steven L.; FLYNN, Gary A.; WO2014/52365; (2014); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.38275-34-2, name is 5-Chloro-2-(methylsulfonyl)pyrimidine-4-carboxylic acid, molecular formula is C6H5ClN2O4S, molecular weight is 236.6329, as common compound, the synthetic route is as follows.Application In Synthesis of 5-Chloro-2-(methylsulfonyl)pyrimidine-4-carboxylic acid

3B. 5-Chloro-2-(methylsulfonyl)pyrimidine 5-Chloro-2-(methylsulfonyl)pyrimidine-4-carboxylic acid (5.7 g, 24 mmol) was refluxed in anisole (8 mL) until the evolution of carbon dioxide ceased. The reaction mixture was cooled to room temperature and filtered. The solid was washed with light petroleum ether (1×50 mL) and dried to obtain the title compound (4.10 g, 88% yield) as a light orange solid. ESI-MS: 193.5 (MH+); HPLC Rf: 1.8 minutes (HPLC method 1); HPLC purity: 100%.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,38275-34-2, 5-Chloro-2-(methylsulfonyl)pyrimidine-4-carboxylic acid, and friends who are interested can also refer to it.

Reference:
Patent; Pfizer Inc; US2007/270438; (2007); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia