Tag: M.W:200-300

Related Products of 1224944-77-7, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 1224944-77-7, name is Ethyl 5-chloropyrazolo[1,5-a]pyrimidine-3-carboxylate. This compound has unique chemical properties. The synthetic route is as follows.

Combined triethylamine (1 187 mL, 8518 mmol), (R)- 5-fluoro-2-methoxy-3-(pyrrolidin-2-yl) pyridine (7) (889 g, 4259 mmol) in EtOH (200 proof, 5 mL/g, 4.4 L) and then ethyl 5-chloropyrazolo[l,5-a]pyrimidine-3-carboxylate (8)(1001 g, 4259 mmol) were added. The reaction was stirred overnight at ambient temp (19 h). The next day, water (10 mL/g, 8.9 L) was added and after stirring at room temperature for 2 h it was filtered through polypropylene filter cloth (PPFC), 23 C and washed with 2: 1 watenEtOH (2 x 1.8 L) then heptane (1.8 L). The product was placed in trays and dried under vacuum (with N2 bleed) at 55C to give 9.

According to the analysis of related databases, 1224944-77-7, the application of this compound in the production field has become more and more popular.

Reference:
Patent; ZHAO, Qian; SPENCER, Stacey; JIANG, Yutong; HAAS, Julia; EARY, Charles Todd; (335 pag.)WO2018/81417; (2018); A2;,
Pyrimidine | C4H4N2 – PubChem,
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In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 145783-15-9, name is 4,6-Dichloro-2-(propylthio)pyrimidin-5-amine, the common compound, a new synthetic route is introduced below. Recommanded Product: 145783-15-9

Vc (63.29 g, 0.21 mol) was added to 500 mL of absolute ethanol.VI (50.00 g, 0.21 mol) and triethylamine (63.63 g, 0.63 mol) were added.The reaction is sealed, protected by nitrogen, and heated to 100-130 C.The reaction is carried out for 25 to 30 hours, the temperature is lowered, and the solvent is distilled off under reduced pressure.Add 300 mL of ethyl acetate and 300 mL of water.The pH of the solution was adjusted to 5 with 3M hydrochloric acid to separate the organic phase.It was dried over anhydrous sodium sulfate for 2 hours, and concentrated under reduced pressure to half.Add 400 mL of isooctane, stir and crystallize at 15 C for 10 hours, and filter.Collect solids and dry to give compound IVc92.96 g, yield 88%.

The synthetic route of 145783-15-9 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Tianfang Pharmaceutical Co., Ltd.; Fan Zhen; Ma Junxia; Zhou Xinjian; Wang Junchen; Ren Zhen; Ma Qi; Wang Hui; Wu Xiangyong; Zhang Xiangfei; Zhao Zhen; Ma Zhenzhen; (12 pag.)CN108690026; (2018); A;,
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Related Products of 663193-80-4, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.663193-80-4, name is 5-Bromo-6-chloropyrimidin-4-amine, molecular formula is C4H3BrClN3, molecular weight is 208.44, as common compound, the synthetic route is as follows.

Example 48 5-bromo-4-N-{1-[3-(pyridin-2-yl)indolizin-2-yl]ethyl}pyrimidine-4,6-diamine Prepared similarly to Example 47, starting from 1-[3-(pyridin-2-yl)indolizin-2-yl]ethan-1-amine Q2 (0.171 g, 0.72 mmol) and 5-bromo-6-chloropyrimidin-4-amine (0.150 g, 0.72 mmol), heating to reflux for 6 days, and purified by flash chromatography on 28 g Biotage silica-NH SNAP cartridge (DCM to DCM_MeOH=99.5:0.5) followed by flash chromatography on Biotage silica-NH SNAP cartridge (cyclohexane:EtOAc=90:10 to 80:20) to afford title compound as a white solid (0.144 g). MS/ESI+ 408.9-410.9 [MH]+, Rt 0.63 min (Method A). 1H NMR (400 MHz, DMSO-d6) delta ppm 8.73-7.77 (m, 1H), 8.67 (d, 1H), 7.92 (td, 1H), 7.82 (s, 1H), 7.74 (d, 1H), 7.49 (d, 1H), 7.32-7.37 (m, 1H), 6.77-6.86 (m, 2H), 6.68 (s, 1H), 6.57-6.64 (m, 1H), 6.43 (br. s., 2H), 5.58-5.68 (m, 1H), 1.40 (d, 3H).

Statistics shows that 663193-80-4 is playing an increasingly important role. we look forward to future research findings about 5-Bromo-6-chloropyrimidin-4-amine.

Reference:
Patent; CHIESI FARMACEUTICI S.P.A.; BIAGETTI, Matteo; ACCETTA, Alessandro; CAPELLI, Anna Maria; GUALA, Matilde; RETINI, Michele; US2015/361100; (2015); A1;,
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Electric Literature of 1209459-32-4, Adding some certain compound to certain chemical reactions, such as: 1209459-32-4, name is 4-(2-Bromopyrimidin-4-yl)morpholine,molecular formula is C8H10BrN3O, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 1209459-32-4.

To a microwave tube was added N-isopropyl-3-(trimethylstannyl)-1-trityl-1H-pyrazolo[4,3-c]pyridin-4-amine (200 mg, 0.344 mmol), 4-(2-bromopyrimidin-4-yl)morpholine (168 mg, 0.688 mmol), LiCl (58.0 mg, 1.38 mmol), CuI (13.0 mg, 0.0688 mmol), Pd(PPh3)4 (40.0 mg, 0.0344 mmol), and THF (3.0 mL). After three cycles of vacuum/argon flash, the reaction mixture was heated at 100 C. for 1 hour under microwave irradiation. After cooling down to room temperature, the mixture was filtered via Celite. The filtrate was concentrated under reduced pressure. The residue was purified by prep-TLC eluting with petroleum ether/ethyl acetate (1:2) to afford the title compound as a yellow solid (25 mg, 13%).

According to the analysis of related databases, 1209459-32-4, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Genentech, Inc.; Chan, Bryan; Estrada, Anthony; Shore, Daniel; Sweeney, Zachary; US2014/288043; (2014); A1;,
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Related Products of 938443-20-0, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.938443-20-0, name is 2,4,7-Trichloropyrido[2,3-d]pyrimidine, molecular formula is C7H2Cl3N3, molecular weight is 234.4699, as common compound, the synthetic route is as follows.

The 2,4,7-trichloro-pyrido [2,3-d] pyrimidine (1g, 4.29mmol), and 8-oxa-3-azabicyclo [3.2.1] nonane hydrochloride (640mg, 4.29 mmol) were dissolved 20mLDCM added dropwise DIEA (0.9mL, 5.15mmol) under ice-cooling.After the reaction was stirred at room temperature for 18H, reaction mixture was washed, the organic layer was dried and concentrated to give a solid, which was used without purification was used directly in the next reaction.

The chemical industry reduces the impact on the environment during synthesis 938443-20-0, I believe this compound will play a more active role in future production and life.

Reference:
Patent; Shandong Xuanzhu Pharmaceutical Technology co., LTD; WU, YONG QIAN; WANG, AI CHEN; (35 pag.)CN102887895; (2016); B;,
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Synthetic Route of 2915-16-4, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.2915-16-4, name is 2-Chloro-4,6-diphenylpyrimidine, molecular formula is C16H11ClN2, molecular weight is 266.73, as common compound, the synthetic route is as follows.

TP2 is further reacted with 2-chloro-4,6-diphenylpyrimidine (1.0 equivalents, CAS: 2915-16-4), tris(dibenzylideneacetone)dipalladium(0) (Pd2(dba)3 (0.03 equivalents; CAS 51364-51 -3), Tricyclohexylphosphine (PCy3; 0.07 equivalents, CAS 2622-14-2) and potassium phosphate tribasic (K3PO4, 1 .7 equivalents). The reaction mixture is stirred under nitrogen atmosphere in a dioxane/toluen e/water (6/1/1 ) mixture at 100 C overnight. After cooling down to room temperature (RT) the reaction mixture is extracted with DCM/brine. The organic phases are collected, washed with brine and dried over MgS04. The organic solvent is removed, the crude product was washed with cyclohexane and recrystallized from EtOH (Yield: 98%).

Statistics shows that 2915-16-4 is playing an increasingly important role. we look forward to future research findings about 2-Chloro-4,6-diphenylpyrimidine.

Reference:
Patent; CYNORA GMBH; SZAFRANOWSKA, Barbara; PINGEL, Patrick; BERGMANN, Larissa; AMBROSEK, David; KASPAREK, Christian; (0 pag.)WO2019/162332; (2019); A1;,
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Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 50593-92-5, name is 5-Bromo-2-(methylthio)pyrimidine-4-carboxylic acid. A new synthetic method of this compound is introduced below., Product Details of 50593-92-5

Acetyl chloride (6.26ml, 0.088mol) was added dropwise at 0-50C to methanol (100ml). The mixture was stirred at 0-50C for 5min. 5-Bromo-2- methylsulfanylpyrimidine-4-carboxylic acid (2Og, O.Odeltamol) was added in portions at 0-50C then the mixture was heated under reflux for Ih, during which time the slurry dissolved, then it was cooled to ambient temperature and poured into saturated aqueous sodium hydrogencarbonate solution (100ml). The product was extracted into dichloromethane (3xl00ml), the extracts were washed with water(100ml), dried (MgSO4) and evaporated in vacuo. The residual solid was crystallised from hexane to give 5-bromo-2-methylsulfanylpyrimidine-4-carboxylic acid methyl ester (12.27g) as an off white crystalline solid, m.pt. 67-700C; 250 MHz 1H-NMR (CDCl3) delta (ppm): 2.6 (s, 3H) (-SCH3), 4.05 (s, 3H) (-OCH3), 8.7 (s, IH) (ArH); m/z (M+H)+’ 249; HPLC purity 96%; HPLC retention time 1.58min.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 50593-92-5, 5-Bromo-2-(methylthio)pyrimidine-4-carboxylic acid.

Reference:
Patent; F. HOFFMANN-LA ROCHE AG; WO2007/88014; (2007); A1;,
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Application of 171887-03-9, Adding some certain compound to certain chemical reactions, such as: 171887-03-9, name is N-(2-Amino-4,6-dichloropyrimidine-5-yl)formamide,molecular formula is C5H4Cl2N4O, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 171887-03-9.

7-Chloro-3-r6-ri-hvdroxy-l-methylethyl1pyridine-2-ylmethyl)-3H-ri,2,31triazolor4.5- Patent; VERNALIS (R&D) LIMITED; WO2009/156737; (2009); A1;,
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Reference of 13544-44-0, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.13544-44-0, name is 2,4-Dichloro-5-iodopyrimidine, molecular formula is C4HCl2IN2, molecular weight is 274.88, as common compound, the synthetic route is as follows.

S-62 (20 g) was converted to S-63 by reaction S-63b and S-62 in the presence of NaHCOs in DMA at 80 C for 12h. After purification, 12 g of S-63 was obtained .

The chemical industry reduces the impact on the environment during synthesis 13544-44-0, I believe this compound will play a more active role in future production and life.

Reference:
Patent; G1 THERAPEUTICS, INC.; STRUM, Jay, Copeland; JUNG, David; (207 pag.)WO2019/136244; (2019); A1;,
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Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 2915-16-4, name is 2-Chloro-4,6-diphenylpyrimidine. This compound has unique chemical properties. The synthetic route is as follows. name: 2-Chloro-4,6-diphenylpyrimidine

To a 1 L flask was placed 11- (3- (dibenzo [b, d] furan-4-yl) phenyl) – 11,12-dihydroindolo [2,3- a] – carbazole (20 g), sodium hydride 4.8 g) and toluene (300 ml), and the mixture was stirred at 40 C. under a nitrogen atmosphere. After 1 hour, 2-chloro-4,6-diphenyl-1,3-pyrimidine (12.8 g) was added and stirring was continued at 80 F.The reaction was monitored by thin layer chromatography. After the reaction was completed, the reaction mixture was quenched with water (200 ml) and extracted using ethyl acetate (150 ml). The organic layer was extracted with water (3 ¡Á 100 ml) and dried over anhydrous sodium sulfate. For further purification, the collected ethyl acetate layer was passed through Celite column chromatography. Subsequently, the ethyl acetate layer was evaporated and dried under reduced pressure using a rotary evaporator. 100 ml of n-hexane was added, filtrated, and reduced pressure The residue was further precipitated by drying. As a yellow solid, 18 g (85%) of Compound F5 having an HPLC purity of 99% or more was obtained.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 2915-16-4, 2-Chloro-4,6-diphenylpyrimidine.

Reference:
Patent; E-RAY OPTOELECTRONICS TECHNOLOGY COMPANY LIMITED; BALAGANESAN, BANUMATHY; HUANG, HEHLUNG; GUO, HUNG MING; HSU, POWEI; (23 pag.)JP2017/31112; (2017); A;,
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