Tag: M.W:200-300

Related Products of 53554-29-3, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 53554-29-3, name is Ethyl 2-(methylthio)-6-oxo-1,6-dihydropyrimidine-5-carboxylate. A new synthetic method of this compound is introduced below.

General procedure: To a Radley reaction carousel tube, add 1 equivalent 1, 1.1 equivalents of the amine, a stir bar, and 5 mL 95% ethanol. Reflux while stirring for 24 hours. After cooling to room temperature the resulting precipitate was collected by vacuum filtration, washing with 10 mL deionized water and 5 mL chloroform.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,53554-29-3, Ethyl 2-(methylthio)-6-oxo-1,6-dihydropyrimidine-5-carboxylate, and friends who are interested can also refer to it.

Reference:
Article; Watkins, Sydney M.; Ghose, Debarati; Blain, Joy M.; Grote, Dakota L.; Luan, Chi-Hao; Clare, Michael; Meganathan; Horn, James R.; Hagen, Timothy J.; Bioorganic and Medicinal Chemistry Letters; vol. 29; 20; (2019);,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Reference of 89284-85-5 , The common heterocyclic compound, 89284-85-5, name is Methyl 2,5,6-trichloropyrimidine-4-carboxylate, molecular formula is C6H3Cl3N2O2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

Furfurylamine (0.155 g, 1.60 mmol) was added to a stirred solution of 6- methoxycarbonyl-2,4,5-trichloropyrimidine (prepared as described in example 1) (0.193 g, 0.80 mmol) and triethylamine (0.24 ml, 1.7 mmol) in dichloromethane (3 ml). The solution was stirred at ambient temperature for 18 hours, and then added to a mixture of ethyl acetate and brine. The organic phase was dried over magnesium sulphate, filtered and evaporated under reduced pressure to give an orange solid. This was purified by column chromatography on silica using ethyl acetate: hexane (1 :2) as eluent to provide 2,5-dichloro-4-(furan-2-ylmethylamino)-6-methoxycarbonylpyrimidine as a pale yellow solid (0.195 g, 81 %). M.p. 110-112 0C; 1H nmr (400 MHz, CDCI3) deltaH 7.40 (1 H, m), 6.35 (2H, m), 6.16 (1 H1 br s), 4.72 (2H, d), 3.98 (3H, s) ppm.

The synthetic route of 89284-85-5 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; SYNGENTA LIMITED; WHITTINGHAM, William Guy; WINN, Caroline Louise; GLITHRO, Harry; ASPINALL, Mary Bernadette; SCREPANTI, Claudio; WO2010/125332; (2010); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 3177-20-6, name is Methyl 2,4-dichloropyrimidine-5-carboxylate. A new synthetic method of this compound is introduced below., Safety of Methyl 2,4-dichloropyrimidine-5-carboxylate

methyl 2,4,-dichloropyrimidine-5-carboxylate (20.70 g, 100 mmol), N,N-dimethylformamide (104 mL) was added to a three-necked flask, stirred and dissolved, and sodium carbonate (26.50 g, 250 mmol) was added. stir evenly and add 2-cyclopentylamino-N,N-dimethylformamide (17.03 g, 100 mmol) was reacted at room temperature for 6-8 hours. At the end of the reaction, water (207 mL), ethyl acetate (207 mL),The extract was extracted once more with ethyl acetate (104 mL), and the organic phase brine (110 mL) was washed once, dried over anhydrous sodium sulfate, filtered, concentrated with ethyl acetate and petroleum ether, and the solid was separated by filtration. drying in vacuo to gave methyl 2-chloro-4-(cyclopentyl(2-(dimethylamino)-2-oxoethyl)amino)pyrimidine-5-carboxylate (30.33 g, 89percent).

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 3177-20-6, Methyl 2,4-dichloropyrimidine-5-carboxylate.

Reference:
Patent; Hangzhou Kechao Biological Technology Co., Ltd.; Yu Wei; Zhang Yiping; (21 pag.)CN108586356; (2018); A;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Electric Literature of 113583-35-0 ,Some common heterocyclic compound, 113583-35-0, molecular formula is C7H10N2O4S, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

At 40 to 45 C,2-[(Phenylamino)methyl]-1-azabenzene-3-ol (6.50 g, 32.46 mmol),4,6-dimethoxy-2-methylsulfonylpyrimidine (6.94 g, 31.81 mmol),Anhydrous potassium carbonate (11.22 g, 81.15 mmol)With anhydrous acetonitrile (100 mL)The mixture was stirred for 10 h,The reaction is over.The reaction mixture was filtered through a pad of celite.The filter cake was washed three times with a small amount of acetonitrile.The filtrate was concentrated to a pale yellow solid.The solid was isolated by flash chromatography eluting EtOAc EtOAcN-[2-(4,6-Dimethoxypyrimidinyloxy)-6-azabenzyl]phenylamine (1, 9.45 g, 86%)

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,113583-35-0, its application will become more common.

Reference:
Patent; Chinese Academy Of Sciences Shanghai Organic Chemistry Institute; Lv Long; Yang Zhengmin; Tang Qinghong; Fu Qunmei; (22 pag.)CN104844575; (2018); B;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Application of 941685-26-3, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 941685-26-3, name is 4-Chloro-7-((2-(trimethylsilyl)ethoxy)methyl)-7H-pyrrolo[2,3-d]pyrimidine. A new synthetic method of this compound is introduced below.

233 mg (0. 82mmo 1) 2- [(4-chloropyrrolo [2,3 -d]pyrimidin-7-yl)methoxy] ethyl-trimethylsilane was dissolved in 4 ml dry THF and cooled down to -78 C and 500 jiL (1.8 M stocksolution, 0.9 mmol, 1.1 eq.) LDA was added. The mixture was stirred under nitrogen for40 minutes at -78 C then 208 mg iodine (0.82 mmol, 1 eq.) was added and allowed to warm to r.t. It was stirred for 40 minutes, then water was added. The solution was extracted with EEO (2 x 15 ml), combined organic phase was dried (magnesium sulfate) and evaporated. The residue was purified by flash chromatography (Eluent: heptane-EEOgradient).

At the same time, in my other blogs, there are other synthetic methods of this type of compound,941685-26-3, 4-Chloro-7-((2-(trimethylsilyl)ethoxy)methyl)-7H-pyrrolo[2,3-d]pyrimidine, and friends who are interested can also refer to it.

Reference:
Patent; LES LABORATOIRES SERVIER; VERNALIS (R&D) LIMITED; KOTSCHY, Andras; WEBER, Csaba; VASAS, Attila; MOLNAR, Balazs; KISS, Arpad; MACIAS, Alba; MURRAY, James Brooke; LEWKOWICZ, Elodie; GENESTE, Olivier; CHANRION, Maia; DEMARLES, Didier; (105 pag.)WO2017/212012; (2017); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.13544-44-0, name is 2,4-Dichloro-5-iodopyrimidine, molecular formula is C4HCl2IN2, molecular weight is 274.88, as common compound, the synthetic route is as follows.Recommanded Product: 2,4-Dichloro-5-iodopyrimidine

To a solution of 2,4-dichloro-5-iodopyrimidine (5.50 g, 20.00 mmol) in dioxane (100 mL) was slowly added a solution of tert-butyl l-(4-aminophenyl) cyclobutylcarbamate (5.2 g, 20.00 mmol) in dioxane (20 mL) and triethylamine (5 ml). The reaction mixture was stirred at 80 C overnight. Lc-ms indicated 2,4-dichloro-5-iodopyrimidine was completed consumed. The solvents were removed under reduced pressure to produce a residue, which was dissolved in ethyl acetate (250 mL). The mixture was washed with brine. The combined organic layer was dried over Na2S04 and then filtered. The filtrate was concentrated to give the crude product, which was purified by flash chromatography to afford tert-butyl l-(4-(2-chloro-5- iodopyrimidin-4-ylamino)phenyl)cyclobutylcarbamate. (5.00 g, 50% yield). LC/MS: (ESI+): 501 [M+l]+ , 503 [M+l]+ .

At the same time, in my other blogs, there are other synthetic methods of this type of compound,13544-44-0, 2,4-Dichloro-5-iodopyrimidine, and friends who are interested can also refer to it.

Reference:
Patent; ARRAY BIOPHARMA INC.; GENENTECH, INC.; SKELTON, Nicholas; GRADL, Stefan; BLAKE, James F.; GRAHAM, James M.; GUNAWARDANA, Indrani W.; HENTEMANN, Martin; MARLOW, Allison L.; TANG, Tony P.; WO2013/78254; (2013); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 720-01-4, name is Ethyl 4-chloro-2-trifluoromethylpyrimidine-5-carboxylate, molecular formula is C8H6ClF3N2O2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. Product Details of 720-01-4

(3,5-Bis-trifluoromethyl-ben2yl)-(5-morpholin-4-yl-pyrimidin-2-yl)-[2- (4 , 4 , 5 , 5 -tetramethyl- [ 1 , 3 , 2] dioxaborolan- 2 -yl) – 5 – trifluoromethyl-benzyl] – amine (250mg) is dissolved in 1,4-dioxane (5ml) and thereto are added ethyl 4-chloro-2-trifluoromethyl-pyrimidine-5-carboxylate (140mg), [I5 I1- bis(diphenylphosphino)ferrocene]dichloropalladium dichloromethane complex (30mg) and cesium carbonate (177mg), and the mixture is stirred under nitrogen atmosphere at 80C overnight. The reaction solution is cooled to room temperature, and thereto are added water and ethyl acetate and the insoluble materials are removed by filtration through Celite. The filtrate is separated, and the organic layer is washed with a saturated brine, dried over magnesium sulfate, and concentrated under reduced pressure. The resulting residue is purified by silica gel column chromatography (hexane : ethyl acetate = 9: 1-?4: 1) to give ethyl 4-(2-{[(3,5-bis- trifluoromethyl-benzyl) – (5-morpholin-4-yl-pyrimidin-2 -yl) -amino] -methyl}- 4-trifluoromethyl-phenyl)-2-trifluoromethyl-pyrimidine-5-carboxylate (199mg). MS (m/z): 783 [M+H]+.

With the rapid development of chemical substances, we look forward to future research findings about 720-01-4.

Reference:
Patent; TANABE SEIYAKU CO., LTD.; WO2007/88996; (2007); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.1215787-31-7, name is 6-Bromo-4-chloropyrido[2,3-d]pyrimidine, molecular formula is C7H3BrClN3, molecular weight is 244.4758, as common compound, the synthetic route is as follows.Formula: C7H3BrClN3

Add 24.2 g (0.1 mol) of 4-chloro-6-bromopyrido[2,3-d]pyrimidine, 7.4 g (0.1 mol) of propylenediamine and 400 ml of 1,4-dioxane to a 1 L round bottom flask. The mixture was heated to 60 C, and the reaction was monitored by TLC until the reaction was completed, and the solvent was evaporated to givethe compound 8-1 18.9 g of white solid (yield: 79.8%).

At the same time, in my other blogs, there are other synthetic methods of this type of compound,1215787-31-7, 6-Bromo-4-chloropyrido[2,3-d]pyrimidine, and friends who are interested can also refer to it.

Reference:
Patent; Heilongjiang University Of Traditional Chinese Medicine; Chen Hong; Chen Qun; Li Yan; Liu Yan; Song Qiannan; Wang Lin; Su Yuming; Liu Linlin; Dai Jinzhu; Guo Jianbo; Li Fei; Lu Lu; Guo Wei; (18 pag.)CN109836423; (2019); A;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Reference of 148550-51-0, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.148550-51-0, name is Ethyl 2-(methylsulfonyl)pyrimidine-5-carboxylate, molecular formula is C8H10N2O4S, molecular weight is 230.24, as common compound, the synthetic route is as follows.

A solution of (E)-2-chloro-l l-(piperazin-l-yl)dibenzo[b,f][l,4]oxazepine (0.25 g, 0.8 mmol) and ethyl 2-(methylsulfonyl)pyrimidine-5-carboxylate (0.13 g, 0.57 mmol) in DME was stirred at room temperature for 1 h. The reaction mixture was diluted with water and extracted with ethyl acetate. The organic extract was washed with saturated aqueous solution of bicarbonate, water, acetic acid and sodium acetate (pH=4), dried over sodium sulfate and solvent evaporated. The resulting crude residue was purified by flash chromatography (0percent to 30percent ethyl acetate in hexane) to afford title compound 116 (0.265 g, quant.).

Statistics shows that 148550-51-0 is playing an increasingly important role. we look forward to future research findings about Ethyl 2-(methylsulfonyl)pyrimidine-5-carboxylate.

Reference:
Patent; METHYGENE INC.; EN VIVO PHARMACEUTICALS, INC.; WO2008/55068; (2008); A2;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia