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Extended knowledge of 659729-09-6

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 659729-09-6, 4-Chloro-6-(4-(trifluoromethyl)phenyl)pyrimidine.

Synthetic Route of 659729-09-6, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 659729-09-6, name is 4-Chloro-6-(4-(trifluoromethyl)phenyl)pyrimidine. This compound has unique chemical properties. The synthetic route is as follows.

1.27 g (4.92 mmol) of 4-chloro_6_ (4′-trifluoromethylphenyl) pyrimidine was weighed out,(0.85 g, 5.18 mmol) of trimethylbenzeneboronic acid,4 g of tetrakis (triphenylphosphine) palladium and 3 g of anhydrous sodium carbonate were placed in a 120 mL sealed tube,A mixture of tetrahydrofen sitan 30 mL and 20 mL of deionized water was placed in a sealed tube as a solvent, and a stirrer was added and the stopper was capped.The entire device vacuum nitrogen nitrogen replacement 3 ~ 4 times, placed in the oil bath pot,The mixture was heated to 115 C on a magnetic stirrer and refluxed for about 8 h.After the reaction,Sealed to cool to room temperature, the solution inside the sealed tube into the rotary bottle,The tetrahydrofuran solvent was distilled off under reduced pressure by rotary evaporator.The organic product was extracted with ethyl acetate and water for 3 to 4 times. The solvent was distilled off under reduced pressure. The spheroidized product was separated by petroleum ether: ethyl acetate 20: 1,To give a pale yellow solid, about 0.87 g, yield 51.6%.

Reference:
Patent; Anhui University of Technology; Tong Bihai; He Yuheng; Liu Yuanyuan; Jin Long; Zuo Dashuai; Wang Song; (25 pag.)CN106632488; (2017); A;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

The origin of a common compound about 2-Amino-5-iodopyrimidine

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 1445-39-2, 2-Amino-5-iodopyrimidine.

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 1445-39-2, name is 2-Amino-5-iodopyrimidine. A new synthetic method of this compound is introduced below., Computed Properties of C4H4IN3

Preparation Example 7 To a mixture of 2-amino-5-iodopyrimidine (1 g), 3-ethynyl-2,4-difluoro-1,5-dimethoxybenzene (897 mg), tetrakistriphenylphosphine palladium (261 mg), copper iodide (43 mg), and N,N-dimethylformamide (20 mL), N,N-diisopropylethylamine (1.55 mL) was added under an argon atmosphere followed by stirring at 80 C. for 1 hour. The reaction mixture was concentrated under reduced pressure, and to the obtained residue were added chloroform and water, and insoluble materials were removed by filtration through celite. After the filtrate was extracted with chloroform, the organic layer was washed with saturated brine, dried over anhydrous sodium sulfate, and then filtered. After the filtrate was concentrated under reduced pressure, the resulting residue was purified by silica gel column chromatography (chloroform/methanol) to give 5-[(2,6-difluoro-3,5-dimethoxyphenyl)ethynyl]pyrimidin-2-amine (1.07 g).

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 1445-39-2, 2-Amino-5-iodopyrimidine.

Reference:
Patent; KOTOBUKI PHARMACEUTICAL CO., LTD.; Astellas Pharma Inc.; Kameda, Minoru; Kuriwaki, Ikumi; Iikubo, Kazuhiko; Hisamichi, Hiroyuki; Kawamoto, Yuichiro; Moritomo, Hiroyuki; Suzuki, Tomoyuki; Futami, Takashi; Suzuki, Atsushi; Tsunoyama, Kazuhisa; Asaumi, Makoto; Tomiyama, Hiroshi; Noda, Atsushi; Iwai, Yoshinori; Tokuzaki, Kazuo; Okada, Haruki; Miyasaka, Kozo; US2014/142084; (2014); A1;,
Pyrimidine | C4H4N2 – PubChem,
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Extended knowledge of 3029-64-9

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,3029-64-9, its application will become more common.

Reference of 3029-64-9 ,Some common heterocyclic compound, 3029-64-9, molecular formula is C5Cl3N3, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

Under nitrogen protection, 6.28 g (25 mmol) of isopropyl carbazole,2.83 g (10 mmol) of 2,4,6-trichloro-5-cyanopyrimidine, 1.92 g (20 mmol) of NaOBu-t, 1.92 g (0.2 mmol) (t-Bu)3HBF4, 0.09 g (0.1 mmol) Pd2 ( Dba) 3 was added to a 250 ml three-necked flask, 100 ml of toluene was added as a reaction solvent, the temperature was raised to reflux temperature, and the mixture was stirred overnight on a magnetic stirrer. After completion of the reaction, the reaction solution was dried to dryness, and the obtained crude product was purified from petroleum ether and methylene chloride (PE: DCM = 5:1) as a mobile phase. Intermediate 1 was obtained as a white solid powder weighing 4.70 g, yield 73.7percent.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,3029-64-9, its application will become more common.

Reference:
Patent; Beijing Dingcai Technology Co., Ltd.; Gu’an Dingcai Technology Co., Ltd.; Gao Wenzheng; Huang Xinxin; Ren Xueyan; (27 pag.)CN109553606; (2019); A;,
Pyrimidine | C4H4N2 – PubChem,
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Sources of common compounds: 4-Chloro-7-((2-(trimethylsilyl)ethoxy)methyl)-7H-pyrrolo[2,3-d]pyrimidine

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,941685-26-3, its application will become more common.

Synthetic Route of 941685-26-3 ,Some common heterocyclic compound, 941685-26-3, molecular formula is C12H18ClN3OSi, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

Step 1: 4-methyl-7-((2-(trimethylsilyl)ethoxy)methyl)-7H-pyrrolo[2,3-d]pyrimidine 103.6 g of 4-chloro-7-((2-(trimethylsilyl)ethoxy)methyl)-7H-pyrrolo[2,3-d]pyrimidine and 2.96 g of [1,1′-bis(diphenylphosphino)ferrocene]dichloropalladium were added to 1.13 L of tetrahydrofuran, and cooled down to -15?-5 C., and then 200 mL of methylmagnesium bromide (3M dissolved in ether) was slowly added dropwise thereto. After the addition was completed, the resulting mixture was heated to 60?65 C. and reacted under reflux for 2 hours. After the reaction was completed, the temperature was lowered to -15?-5 C., and then the reaction was quenched by slowly dropwise adding 455 mL of a saturated ammonium chloride solution. The resulting mixture was filtered, the filter cake was rinsed with 455 mL of tetrahydrofuran, and then the filter cake was discarded, and the filtrate was concentrated under reduced pressure. To the residue was added 455 mL of purified water, and 1.13 L of ethyl acetate was added to extract the resulting mixture twice. The organic phases were combined and washed with 150 g of saturated brine. Then, the organic phase was concentrated under reduced pressure to distill off the solvent to obtain 103.2 g 4-methyl-7-((2-(trimethylsilyl)ethoxy)methyl)-7H-pyrrolo[2,3-d]pyrimidine. 1H-NMR (500 MHz, DMSO-d6): delta=8.67 (s, 1H), 7.63 (d, J=3.7 Hz, 1H), 6.70 (d, J=3.6 Hz, 1H), 5.60 (s, 2H), 3.54?3.45 (m, 2H), 2.64 (s, 3H), 0.81 (t, J=8.0 Hz, 2H), 0.12 (s, 9H); MS (ES): 264.15 (M+H+).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,941685-26-3, its application will become more common.

Reference:
Patent; CHIA TAI TIANQING PHARMACEUTICAL GROUP CO., LTD.; Zhang, Xiquan; Zhang, Aiming; Zhou, Zhou; Yang, Leilei; Yao, Huadong; Zhu, Xueyan; Wang, Hubo; (29 pag.)US2019/23712; (2019); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Sources of common compounds: 514854-13-8

The synthetic route of 514854-13-8 has been constantly updated, and we look forward to future research findings.

Application of 514854-13-8 , The common heterocyclic compound, 514854-13-8, name is 6-Ethyl-5-iodopyrimidine-2,4-diamine, molecular formula is C6H9IN4, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

General procedure: The alkyne (1.2 eq), iododiaminoethyl pyrimidine (1.0 eq) was dissolved in anhydrous DMF (0.15M) and sonicated under argon. Pd(PPh3)2Cl2 (0.1 eq), CuI (0.21 eq), Et3N (24 eq) were added and again sonicated under argon for 15 minutes. The reaction mixture was heated at 60 C for 12h under argon. The reaction mixture was then concentrated in vacuo before preabsorbing onto a mixture of amine and 25% cysteine preabsorbed silica gel (1:1 /wt) and filterted through a plug of silica gel with 5% MeOH/ CH2Cl2. The collected reaction mixture was concentrated in vacuo, and further purified by preparative HPLC to furnish the final product

The synthetic route of 514854-13-8 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Lombardo; Dayanandan; Keshipeddy; Zhou; Si; Reeve; Alverson; Barney; Walker; Hoody; Priestley; Obach; Wright; Drug Metabolism and Disposition; vol. 47; 9; (2019); p. 995 – 1003;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

New learning discoveries about 5-(Benzyloxy)-2-chloropyrimidine

With the rapid development of chemical substances, we look forward to future research findings about 138274-14-3.

The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 138274-14-3, name is 5-(Benzyloxy)-2-chloropyrimidine. This compound has unique chemical properties. The synthetic route is as follows. Recommanded Product: 138274-14-3

Sodium hydride (400 mg, 8.33 mmol) was suspended in toluene (10 mL), ethyl 2-hydroxyacetate (0.70 mL,7.40 mmol) was added and the mixture was stirred at room temperature for 30 min. To the reaction mixture was added(M-30) (1.00 g, 4.53 mmol), and the mixture was stirred at 60C for 18 hr. The reaction mixture was allowed to cool,saturated ammonium chloride solution was added and the mixture was extracted with ethyl acetate. The organic layerwas dried over anhydrous magnesium sulfate, and the solvent was evaporated under reduced pressure. The residuewas purified by silica gel column chromatography (n-hexane:ethyl acetate) to give compound (M-31) (yield 650 mg,50%) as a colorless oil

With the rapid development of chemical substances, we look forward to future research findings about 138274-14-3.

Reference:
Patent; Kaken Pharmaceutical Co., Ltd.; WATANABE, Atsushi; SATO, Yuuki; OGURA, Keiji; TATSUMI, Yoshiyuki; (331 pag.)EP3351533; (2018); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Extracurricular laboratory: Synthetic route of 54675-23-9

The synthetic route of 54675-23-9 has been constantly updated, and we look forward to future research findings.

Reference of 54675-23-9, A common heterocyclic compound, 54675-23-9, name is 6-Bromo-4-hydroxyquinolin-2(1H)-one, molecular formula is C9H6BrNO2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: To the appropriate 4-hydroxy-2-quinolone (1.0 mmol), K2CO3 (6.0 mmol) and TFE (8.0 mL) were added. The slurry was magnetically stirred until partial dissolution of the quinolone. After this, the halide (6.0 mmol; 12.0 mmol in case of MeI) was added, the system was capped with a septum and stirred under argon atmosphere at 60 C until consumption of starting material. For the methylation, Ag2O (2.0 mmol) was added before the MeI. The mixture was stirred at room temperature for 12 h, protected from light with an aluminum foil. Then, the solvent was recovered by careful distillation at atmospheric pressure, and the resulting solids were suspended in EtOAc (10 mL). The solids were filtered under reduced pressure through a Celite pad and washed with small portions of EtOAc (4¡Á2 mL). The combined liquids were concentrated in vacuum and the residue was purified by column chromatography.

The synthetic route of 54675-23-9 has been constantly updated, and we look forward to future research findings.

Some scientific research about 52980-28-6

The synthetic route of Ethyl 4-oxo-1,4-dihydroquinoline-3-carboxylate has been constantly updated, and we look forward to future research findings.

These common heterocyclic compound, 52980-28-6, name is Ethyl 4-oxo-1,4-dihydroquinoline-3-carboxylate, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Recommanded Product: Ethyl 4-oxo-1,4-dihydroquinoline-3-carboxylate

General procedure: Oxoquinolines 9a-c(8 mmol) were reacted with the appropriate amine (8 mmol) in diphenyl ether(30 mL) at 210 C under magnetic stirring for 1 h. The resulting mixture was poured into petroleum ether. The obtained solid was filtered and recrystallized from dichloromethane/petroleum ether (1/1) to yield the derivatives listed below [28-30].

The synthetic route of Ethyl 4-oxo-1,4-dihydroquinoline-3-carboxylate has been constantly updated, and we look forward to future research findings.

Introduction of a new synthetic route about 406204-90-8

The synthetic route of 406204-90-8 has been constantly updated, and we look forward to future research findings.

Application of 406204-90-8, A common heterocyclic compound, 406204-90-8, name is 6-Bromo-2,4-dichloroquinoline, molecular formula is C9H4BrCl2N, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Preparation of6-Bromo-2,4-dichloro-quinoline-3-carboxylic acid ethyl ester:; To the cooled solution (-20 0C) of LDA (DIPA, 66ml, 49mmol; n- BuLi, 27.07 mL, 43 mmol) m dry THF (40 mL) the compound 6-Bromo-2,4dichloro quinoline (10 g, 36.10 mmol) m dry THF (200 mL) was added dropwise, changing reaction colour to reddish brown and stirred at -78 0C for 40 mm. After the anion formation ethylchloroformate (4.14 mL, 43.32 mmol) was added. Reaction was stirred at -78 0C for 2 h and quenched by ice cold water. Reaction mixture was concentrated on rotatory evaporator, and extracted with ethyl acetate (200 mL x 3 times). The combined organic layer was washed with brme. The crude product was purified by column chromatography (silica gel 100-200 mesh, 2-3% ethyl acetate m n- hexane) to get 6-Bromo-2,4-dichloro-qumolme-3-carboxylic acid ethyl ester (8 5 g, 67%) as white solid. Mp 120-121 0C 1H NMR (CDCl3, 400 MHz): delta 1.44 (t, J = 7 Hz, 3 H), 4.52 (q, /= 7 Hz, 2 H), 7.90 (d, J = 1 Hz, 2 H), 8 37 (s, 1 H).

The synthetic route of 406204-90-8 has been constantly updated, and we look forward to future research findings.

The important role of 2005-43-8

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 2-Bromoquinoline, its application will become more common.

Electric Literature of 2005-43-8,Some common heterocyclic compound, 2005-43-8, name is 2-Bromoquinoline, molecular formula is C9H6BrN, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: A mixture of aryl halide (0.5 mmol), potassium aryltrifluoroborate (0.6 mmol), K2CO3 (1.0 mmol), Pd/C (5%; 0.5 mol%), ethanol (3 mL), and distilled water (1 mL) was stirred at 80 C in air for the time indicated. The reaction mixture was added to brine (15 mL) and extracted with ethyl acetate (4¡Á15 mL). The organic solvent was removed under vacuum, and the product was isolated by short-column chromatography.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 2-Bromoquinoline, its application will become more common.