Tag: M.W:200-300

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 1189169-37-6, name is 1-(5-Bromopyrimidin-2-yl)ethanone. A new synthetic method of this compound is introduced below., Application In Synthesis of 1-(5-Bromopyrimidin-2-yl)ethanone

E. 6-(5-bromopyrimidin-2-yl)pyridazin-3(2H)-one To a 50 mL 1 neck flask equipped with magnetic stirrer, nitrogen inlet and thermometer was charged 0.22 grams (g) of 1-(5-bromopyrimidin-2-yl)ethanone (1.09 mmol), 0.17 g (1.1 mmol) glyoxylic acid, and 2.5 mL of methanol and 2.5 mls of water. To this solution was added 0.3 g (2.2 mmol) of potassium carbonate. The reaction was stirred overnight at room temperature. Methanol was then concentrated under vacuum on a rotary evaporator, and the resulting aqueous solution was washed twice with 5 mls of methylene chloride. To the aqueous solution was then added 0.6 mls of acetic acid and 0.07 g (1.4 mmol) of hydrazine monohydrate. This solution was refluxed for 2 hours, then cooled at 5 C. The resulting solid was collected by vacuum filtration to afford 30 mg of a brown solid which was consistent with the target compound upon analysis by NMR. The NMR data is as follows: 300 MHz 1H NMR (CDCl3, TMS=0 ppm) 2.75 (s, 3H); 9.00 (s 2H).

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 1189169-37-6, 1-(5-Bromopyrimidin-2-yl)ethanone.

Reference:
Patent; DOW AGROSCIENCES LLC; US2009/253708; (2009); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Related Products of 138274-14-3, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 138274-14-3, name is 5-(Benzyloxy)-2-chloropyrimidine, molecular formula is C11H9ClN2O, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

To 5-benzyloxy-2-chloro-pyrimidine 34b (0.20 g, 0.91 mmol) of N-methylpyrrolidone (5 mL)Potassium fluoride (0.17 g, 2.9 mmol) was added to the solution.Thiomorpholine dioxide (0.13 g, 0.91 mmol). After the addition, the reaction solution was heated to 140 C for 23 hours.The heating was stopped, and after the reaction solution was cooled to room temperature, dichloromethane (30 mL) and water (10 mL) were added and stirred for 10 minutes.The lower organic phase was separated, the aqueous phase was extracted with dichloromethane (10 mL¡Á3), and the combined organic phases were washed with saturated sodium chloride solution (10 mL).Dry over anhydrous sodium sulfate, concentrate by suction filtration, and the residue obtained was purified by silica gel column chromatography[Petroleum ether / ethyl acetate (v / v) = 5 / 1] purified to give the title compound50a (60 mg, 21% yield) as a pale yellow solid.

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 138274-14-3, 5-(Benzyloxy)-2-chloropyrimidine.

Reference:
Patent; Guangdong Dongyangguang Pharmaceutical Co., Ltd.; Gu Zheng; Li Jianhao; Li Zheng; Wang Weihua; Tan Haoxiong; Wang Xuli; Cui Yunzeng; Xie Zeqiang; Zhang Yingjun; (101 pag.)CN109251166; (2019); A;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 183438-24-6, name is 5-Bromo-2-iodopyrimidine. This compound has unique chemical properties. The synthetic route is as follows. Product Details of 183438-24-6

First of all, 5-bromo-2-iodopyrimidine 1.97g and phenyl boronic acid 0.85g, 2M sodium carbonate aqueous solution 7.0mL, toluene 18mL, reflux condenser put in a 200mL three-necked flask equipped with a, in the flask was replaced with nitrogen. After degassing with stirring under reduced pressure, tetrakis (triphenylphosphine) palladium (0) (abbreviation: Pd (PPh 3 ) 4 ) 0.081 g and the mixture was refluxed for 8 hours. Here, Pd (PPh 3 ) 4 0.040 g was added, and the mixture was refluxed for 8 hours, more Pd (PPh 3 ) 4 0.040 g was added and reacted by refluxing for 8 hours. Water was added to the reaction solution, and the organic layer was extracted with dichloromethane. The resulting extract was washed with saturated brine, and dried over magnesium sulfate. After the drying, the solution was filtered. After evaporating the solvent of this solution, the resulting residue, hexane: ethyl acetate = 5: 1 was purified by flash column chromatography as a developing solvent, to give a pyrimidine derivative of interest (white powder, yield: 59percent).

With the rapid development of chemical substances, we look forward to future research findings about 183438-24-6.

Reference:
Patent; SEMICONDUCTOR ENERGY LABORATORY COMPANY LIMITED; INOUE, HIDEKO; HARA, TOMOKA; SEO, SATOSHI; SASAKI, TOSHIKI; SUZUKI, KUNIHIKO; (60 pag.)JP2016/6041; (2016); A;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Adding a certain compound to certain chemical reactions, such as: 304693-64-9, Ethyl 2-(trifluoromethyl)pyrimidine-5-carboxylate, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Application In Synthesis of Ethyl 2-(trifluoromethyl)pyrimidine-5-carboxylate, blongs to pyrimidines compound. Application In Synthesis of Ethyl 2-(trifluoromethyl)pyrimidine-5-carboxylate

To a solution of ethyl 2-(trifluoromethyl)pyrimidine-5-carboxylate (56.8 g, 252.8 mmol) dissolved in THF (500 mL) was added 1M aq. LiCH (380 mL, 379.3 mmol). The reaction mixture was stirred at RT for 16 h, concentrated under vacuum toremove the organic solvent and the remaining aqueous acidified to pH 1 with conc.HCI. The resultant precipitate was collected by vacuum filtration to afford 44.4(91 % yield) of the title compound as off-white powder.1H NMR (500 MHz, DMSO-d6): 6 [ppm] 9.44 (5, 2H).LCMS (Analytical Method A) Rt = 0.81 mm, MS (ESineg): m/z = 190.9 (M)-.

The synthetic route of 304693-64-9 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; EVOTEC AG; DAVENPORT, Adam James; BRAEUER, Nico; FISCHER, Oliver Martin; ROTGERI, Andrea; ROTTMANN, Antje; NEAGOE, Ioana; NAGEL, Jens; GODINHO-COELHO, Anne-Marie; (703 pag.)WO2016/91776; (2016); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Application of 130049-82-0, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 130049-82-0, name is 3-(2-Chloroethyl)-6,7,8,9-tetrahydro-9-hydroxy-2-methyl-4H-pyrido[1,2-a]pyrimidine-4-one. This compound has unique chemical properties. The synthetic route is as follows.

Example 36 3-(2-(4-(benzo[b]thiophen-4-yl)piperidin-1-yl)ethyl)-9-hydroxy-2-methyl-6,7,8,9-tetrahydro-4H-pyrido[1,2-a]pyrimidin-4-one 3-(2-chloroethyl)-9-hydroxy-2-methyl-6,7, 8,9-tetrahydro-4H-pyrido[1,2-a]pyrimidin-4-on e 10-a (133 mg, 0.55 mmol), the product of Reference Example 31 (120 mg, 0.55 mmol), potassium carbonate (229 mg, 1.65 mmol), potassium iodide (92 mg, 0.55 mmol) and acetonitrile (5 ml) were added to the flask. The mixture was stirred at reflux for 12 hours, concentrated, and the residue was purified by column chromatography to obtain a white solid (115 mg, yield: 49%). 1H-NMR (400 Hz, DMSO-d6): delta ppm 7.84 (d, 1H), 7.76 (d, 1H), 7.62 (d, 1H), 7.33 (t, 1H), 7.26 (d, 1H), 5.71 (d, 1H), 4.45 (q, 1H), 3.91 (m, 1H), 3.68 (m, 1H), 3.08 (m, 3H), 2.65 (m, 2H), 2.41 (t, 2H), 2.28 (s, 3H), 2.21 (t, 2H), 2.06-1.70 (m, 8H). ESI-MS (m/z): 424.4 [M+H]+.

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 130049-82-0, 3-(2-Chloroethyl)-6,7,8,9-tetrahydro-9-hydroxy-2-methyl-4H-pyrido[1,2-a]pyrimidine-4-one.

Reference:
Patent; SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES; SUZHOU VIGONVITA LIFE SCIENCES CO., LTD.; TOPHARMAN SHANDONG CO., LTD.; JIANG, Hualiang; WANG, Zhen; LI, Jianfeng; ZHANG, Rongxia; HE, Yang; LIU, Yongjian; BI, Minghao; LIU, Zheng; TIAN, Guanghui; CHEN, Weiming; YANG, Feipu; WU, Chunhui; WANG, Yu; JIANG, Xiangrui; YIN, Jingjing; WANG, Guan; SHEN, Jingshan; (70 pag.)US2017/158680; (2017); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Application of 720-01-4, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 720-01-4, name is Ethyl 4-chloro-2-trifluoromethylpyrimidine-5-carboxylate, molecular formula is C8H6ClF3N2O2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

A solution of P(t-Bu)3 (0.32 g, 1.57 mmol) and Tris(dibenzylideneacetone)dipalladium(0) (Pd2(dba)3) (0.72 g, 0.78 mmol), in 10 ml of THF, stirred at room temperature for 30 min, the dark red heterogeneous solution Pd(P(t-Bu)3)2 formed. Then KF (2.74 g, 47.24 mmol), and 3,4-dimethoxyphenylboronicacid (2.15 g, 11.80 mmol) in dry THF (50ml) was added. Finally ethyl-4-chloro-2-(trifluoromethyl)pyrimidine-5-carboxylate (2g, 7.87 mmol), was added under N2 atmosphere. The reaction mixture was heated to 65C for 14 h. TLC showed the completion of the reaction. Then the mixture was cooled and concentrated under vacuo to get crude residue, which was purified by column chromatography over silica gel (Ethylacetate/ Hexane, 1:3) to afford title product as an off-white solid in 74% yield. ESI-MS: 357 (M+1).

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 720-01-4, Ethyl 4-chloro-2-trifluoromethylpyrimidine-5-carboxylate.

Reference:
Article; Purushothaman, Baskaran; Arumugam, Parthasarathy; Kulsi, Goutam; Song, Joon Myong; European Journal of Medicinal Chemistry; vol. 145; (2018); p. 673 – 690;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Reference of 1445-39-2, Adding some certain compound to certain chemical reactions, such as: 1445-39-2, name is 2-Amino-5-iodopyrimidine,molecular formula is C4H4IN3, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 1445-39-2.

5-[(3-aminophenyl)ethynyl]pyrimidin-2-amine 2-Amino-5-iodopyrimidine (2.21 g), bis(triphenylphosphine)palladium dichloride (350 mg) and copper(I) iodide (40 mg) were stirred in DMF (100 mL)-triethylamine (20 mL) and degassed with nitrogen for 10 min. 3-Ethynyl aniline (1.29 g) was added and the mixture heated to 95 C. for 2 hours. The solvent was evaporated and the residue was purified by trituration with DCM (20 mL) to give the title compound as a brown solid (1.25 g, 60%); 1H NMR (DMSO-d6) 5.21 (bs, 2H), 6.58-6.70 (m, 3H), 7.03-7.07 (m, 3H), 8.40 (s, 2H); MS m/e MH+211.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 1445-39-2, 2-Amino-5-iodopyrimidine, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; ASTRAZENECA AB; US2008/194552; (2008); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Synthetic Route of 51940-64-8, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 51940-64-8, name is Ethyl 2,4-Dichloro-5-pyrimidinecarboxylate. This compound has unique chemical properties. The synthetic route is as follows.

In a 20 mL vial, (R)-3-amino-10-methyl-9,10,11,12-tetrahydro-8H-[1,4]diazepino[5?,6?:4,5]thieno[3,2-f]quinolin-8-one (INT-3) (0.095 g, 0.318 mmol), ethyl 2,4-dichloropyrimidine-5-carboxylate (0.084 g, 0.382 mmol), and Huenig’s Base (0.111 ml, 0.637 mmol) were added to 5 mL of i-PrOH. The vial was sealed and the suspension warmed to 95 C. for 24 hours. Once determined to be complete, the reaction was cooled and a precipitate formed. 5 mL of ethyl ether was added, the vial was sonicated briefly, and the product was isolated by filtration to afford compound I-18 (0.112 g, 0.232 mmol, 72.8% yield). 1H NMR (400 MHz, DMSO-d6): delta 1.18 (d, J=6.7 Hz, 3H), 1.35 (t, J=7 Hz, 3H), 3.42-3.46 (m, 2H), 3.60 (m, 1H), 4.39 (q, J=7 Hz, 2H), 7.08 (br s, 1H), 7.81 (d, J=9.0 Hz, 1H), 8.06 (d, J=4 Hz, 1H), 8.10 (d, J=9.0 Hz, 1H), 8.54 (d, J=9.2 Hz, 1H), 8.93 (s, 1H), 9.27 (d, J=9.3 Hz, 1H), 10.99 (s, 1H). MS m/z (M+H): 483.29.

According to the analysis of related databases, 51940-64-8, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Celgene Avilomics Research, Inc.; Alexander, Matthew David; Chuaqui, Claudio; Malona, John; McDonald, Joseph John; Ni, Yike; Niu, Deqiang; Petter, Russell C.; Singh, Juswinder; (164 pag.)US2016/75720; (2016); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Related Products of 4489-34-3, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 4489-34-3, name is 4,6-Dichloro-2-methylsulfonylpyrimidine. This compound has unique chemical properties. The synthetic route is as follows.

A suspension of compound A (1Og, 44.04 mmol) and cyclopropane carboxylic acid (4-mercapto~phenyl)-amide (B, 8.51 g, 44.04 mmol) in t-butanol (300 ml) was degassed by evacuation, then flushing with nitrogen. The mixture was stirred at 90 C under nitrogen atmosphere for 1 hour then the solvent was removed in vacuo. The residue was dissolved in ethyl acetate (600 ml) and washed with an aqueous solution of potassium carbonate and sodium chloride. The organic extract was dried over magnesium sulphate, concentrated to a low volume and allowed to crystallize. The product C was collected as colourless crystals, (11.15 g, 74%). 1H-NMR DMSO-d6, delta 0.82-0.89 (4H, m), 1.80-1.88 (IH, m), 7.55 (2H, d), 7.70-7.76 (3H, m), 10.49 (IH, s); M+H, 340.

According to the analysis of related databases, 4489-34-3, the application of this compound in the production field has become more and more popular.

Reference:
Patent; MERCK & CO., INC.; BANYU PHARMACEUTICAL CO., LTD.; VERTEX PHARMACEUTICALS INCORPORATED; BUSER-DOEPNER, Carolyn, A.; WO2007/136615; (2007); A2;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Electric Literature of 633328-95-7, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 633328-95-7, name is 5-Bromo-2-chloro-4-methylpyrimidine, molecular formula is C5H4BrClN2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

Sodium hydride (550 mg, 60% purity, 13.75 mmol) was added batchwise into a solution of 2-propanol (1.75 g, 29.12 mmol) in tetrahydrofuran (50 mL) at 0 C. The resulting solution was stirred for 30 minutes at room temperature. 5-Bromo-2-chloro-4-methylpyrimidine (1.0 g, 4.82 mmol) was added at 0 C. The resulting solution was stirred for 16 hours at room temperature. The mixture was diluted with brine. The resulting solution was extracted with ethyl acetate, dried with anhydrous sodium sulfate. After filtration, the filtrate was concentrated under vacuum. The residue was purified by flash chromatography on silica gel eluting with petroleum ether/dichloromethane (2/1) to afford 5-bromo-2-isopropoxy-4-methyl-pyrimidine (350 mg, 1.51 mmol) as light yellow oil. LCMS (ESI) [M+H]+=231

According to the analysis of related databases, 633328-95-7, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Genentech, Inc.; Chan, Bryan; Drobnick, Joy; Gazzard, Lewis; Heffron, Timothy; Liang, Jun; Malhotra, Sushant; Mendonca, Rohan; Rajapaksa, Naomi; Stivala, Craig; Tellis, John; Wang, Weiru; Wei, BinQing; Zhou, Aihe; Cartwright, Matthew W.; Lainchbury, Michael; Gancia, Emanuela; Seward, Eileen; Madin, Andrew; Favor, David; Fong, Kin Chiu; Hu, Yonghan; Good, Andrew; US2018/282282; (2018); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia