Tag: M.W:200-300

The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 114040-29-8, name is Ethyl 5,7-dimethyl-[1,2,4]triazolo[1,5-a]pyrimidine-2-carboxylate. This compound has unique chemical properties. The synthetic route is as follows. Quality Control of Ethyl 5,7-dimethyl-[1,2,4]triazolo[1,5-a]pyrimidine-2-carboxylate

In 100ml RB flask 2-amino triazole 5-ethyl carboxylate (5gm) was taken. To it 2,4-pentandione (4.1ml) was added followed by addition of piperidine (4ml). This reaction mixture was refluxed for 3 daysunder nitrogen. Reaction mixture was cooled. Solvent from the RM was evaporated. To the residue water was added and neutralized with 6N HCl, solid precipitated. It was filtered and washed with diethyl ether and dried to give pure product as white solid (4 g, 55 %).

With the rapid development of chemical substances, we look forward to future research findings about 114040-29-8.

Reference:
Article; Patil, Vikas; Kale, Manoj; Raichurkar, Anandkumar; Bhaskar, Brahatheeswaran; Prahlad, Dwarakanath; Balganesh, Meenakshi; Nandan, Santosh; Shahul Hameed; Bioorganic and Medicinal Chemistry Letters; vol. 24; 9; (2014); p. 2222 – 2225;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Application of 16019-34-4, Adding some certain compound to certain chemical reactions, such as: 16019-34-4, name is 7-Benzyl-4-chloro-7H-pyrrolo[2,3-d] pyrimidine,molecular formula is C13H10ClN3, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 16019-34-4.

General procedure: A typical procedure for the preparation of 3a:2-bromopropane (74 mg, 0.6 mmol) was added to a solution of 1a (92 mg, 0.6 mmol) and K2CO3 (110 mg, 0.8 mmol) in 5 mL DMF at 70 C. According to TLC the reaction went to completion after 4 h. The mixture was extracted with ethyl acetate (3 * 10 mL). The combined organic layers were washed with brine(10 mL), dried over anhydrous Na2SO4, filtered and concentrated to give the crude product 2a, which was added to a solution of amino-phenol(66 mg, 0.6 mmol) and Cs2CO3 (585 mg, 1.8 mmol) in 10 mL DMSO without further purification. After stirring for 6 h at 80 C, the mixture was cooled to room temperature and extracted with ethyl acetate (3 * 10 mL). The combined organic layers were washed with brine (10 mL), dried over anhydrous Na2SO4, filtered and concentrated to give the crude product, which was further purified by column chromatography(petroleum ether/ethyl acetate 2:1) to afford compound 3a as a brown solid(121 mg, 75% over two steps): 1H NMR (300 MHz, CDCl3) delta 8.44 (s, 1H), 7.16 (d, J = 3.6 Hz, 1H), 7.02 (d, J = 8.9 Hz, 2H), 6.73 (d, J = 8.9 Hz, 2H), 6.39 (d, J = 3.6 Hz, 1H), 5.11 (m, 1H), 3.70 (s, 2H), 1.51 (d, J = 6.8 Hz, 6H).; 13C NMR (100 MHz, d6-DMSO) delta 162.5, 151.5, 150.0, 146.3, 142.7, 124.5, 122.2, 114.3, 104.6, 98.0, 46.0, 22.3.; HRMS [M]+ calcd for C15H16N4O268.1324, found 268.1326. The purity of the compound was >98% by HPLC.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 16019-34-4, 7-Benzyl-4-chloro-7H-pyrrolo[2,3-d] pyrimidine, other downstream synthetic routes, hurry up and to see.

Reference:
Article; Liu, Yang; Fang, Jianping; Cai, Haiyan; Xiao, Fei; Ding, Kan; Hu, Youhong; Bioorganic and Medicinal Chemistry; vol. 20; 18; (2012); p. 5473 – 5482;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 87789-35-3, name is 5,7-Dichloro-2-(methylthio)thiazolo[4,5-d]pyrimidine. A new synthetic method of this compound is introduced below., COA of Formula: C6H3Cl2N3S2

The crude brown solid was slurried in methanol and morpholine (6eq) was added. The solution was stirred at room temperature for 30 min, solvent was removed under vacuum and ethyl acetate was added. The organic was washed with saturated sodium bicarbonate solution. Both the precipitate and the organic layers contained product and were subjected to silica gel chromatography to yield 5-chloro-2-(methylthio)-7-morpholinothiazolo[4,5-d]pyrimidine 78 and 5-chloro-2,7-dimorpholinothiazolo[4,5-d]pyrimidine 79.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 87789-35-3, 5,7-Dichloro-2-(methylthio)thiazolo[4,5-d]pyrimidine.

Reference:
Patent; GENENTECH, INC.; F. HOFFMANN – LA ROCHE AG; WO2009/42607; (2009); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Reference of 313339-35-4, Adding some certain compound to certain chemical reactions, such as: 313339-35-4, name is 4,6-Dichloro-2-(methylthio)pyrimidine-5-carboxylic acid,molecular formula is C6H4Cl2N2O2S, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 313339-35-4.

To a suspension of 4, 6-dich.oro-2-methylsulfanylpyrimidine-5-carboxyiic acid (2.1 mmol) inCH2CI2 (20 ml) are added oxalyl chloride (4.2 mmol) and one drop of DMF at 0 C. Afterstirred at room temperature for 3 h under N2 atmosphere, the reaction mixture isconcentrated and dried in vacuo, to give 4, 6~dichloro-2-methylsulfanylpyrimidine-5-carbonylchloride as a yellow crystal.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 313339-35-4, 4,6-Dichloro-2-(methylthio)pyrimidine-5-carboxylic acid, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; NOVARTIS AG; NOVARTIS PHARMA GMBH; WO2006/18284; (2006); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Adding a certain compound to certain chemical reactions, such as: 900789-14-2, 5-Bromo-2,4-dichloro-7H-pyrrolo[2,3-d]pyrimidine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 900789-14-2, blongs to pyrimidines compound. Recommanded Product: 900789-14-2

(3) 200g of pure 5-bromo-2,4-dichloro-7H-pyrrolo [2,3-d] pyrimidine, 150g of zinc powder, 1000ml of acetic acid and 1000ml of ethanol are mixed, and the mixture is heated and refluxed after the mixing is completed 7h, filtered, distilled off ethanol, and sequentially dissolved in ethyl acetate, washed with saturated aqueous sodium bicarbonate solution, washed with saturated brine, dried, and evaporated to obtain 220 g of crude product; (4) The crude product obtained in step (3) was recrystallized from n-hexane to obtain pure 5-bromo-2-chloro-7H-pyrrolo [2,3-d] pyrimidine, with a purity of more than 98% and a yield of 94.5%.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,900789-14-2, its application will become more common.

Reference:
Patent; Nanjing Puruida Pharmaceutical Technology Co., Ltd.; Wang Xiaobo; (5 pag.)CN110372704; (2019); A;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Reference of 392326-81-7 ,Some common heterocyclic compound, 392326-81-7, molecular formula is C10H8BrN3, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

Compound 8a (12.5 g, 50.0 mmol), 2-bromo-2-phenylacetophenone (16.5 g, 60.0 mmol), NaHCO3(5.04g, 60.0mmol) were dissolved in isopropanol (100 mL), refluxed and Stir for 12h.The isopropanol was removed by rotary evaporation in vacuo, and then dichloromethane (60 mL) and water (30 mL) were added to the solid residue.After the organic phase was separated, it was washed twice with saturated saline.The solvent was removed by vacuum rotary evaporation, and the residue was purified by silica gel chromatography to obtain solid compound 8b (13.2 g, 31.0 mmol) in a yield of 62%.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 392326-81-7, 4-(4-Bromophenyl)pyrimidin-2-amine, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Shenzhen Huaxing Optoelectric Semiconductor Display Co., Ltd.; Wang Shipan; (37 pag.)CN110357882; (2019); A;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Application of 43024-61-9, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 43024-61-9, name is Ethyl 7-hydroxypyrazolo[1,5-a]pyrimidine-6-carboxylate. This compound has unique chemical properties. The synthetic route is as follows.

(b) Ethyl 4,7-dihydro-4-ethyl-7-oxo-pyrazolo[1,5-a]pyrimidine-6-carboxylate4 A mixture of ethyl 7-hydroxypyrazolo[1,5-a]pyrimidine-6-carboxylate (2.07g, 10mM), anhydrous potassium carbonate (1.38g, 10mM) and ethyl iodide (2.34g, 15mM) in dry N,N-dimethylformamide (50ml) was heated under reflux for 5 hours. The reaction mixture was evaporated in vacuo to given an oil, which was dissolved in water (50ml) and the pH adjusted to 1.0 with 5N hydrochloric acid. The solution was extracted with chloroform and dried over anhydrous magnesium sulphate. The chloroform extract was evaporated in vacuo and the residue was recrystallized from acetone. Yield 980 mg (41.7%). m.p. 164-5 C. delta (DMSO-d6), STR43 4.36 (4H, q, –CH2 CH3), 1.45 (3H, t, –CH2 CH3), 1.33 (3H, t, –CH2 CH3); numax (nujol) 17.12 (ester C=O), 1680 (lactam C=O)cm-1 (Found: C, 56.21; H, 5.67; N, 18.13%. C11 H13 N3 O3 requires C, 56.12; H, 5.57; N, 17.80%).

According to the analysis of related databases, 43024-61-9, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Beecham Group Limited; US4081545; (1978); A;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Related Products of 375857-62-8, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 375857-62-8, name is 3-Bromo-7-methylimidazo[1,2-a]pyrimidine. This compound has unique chemical properties. The synthetic route is as follows.

Finally, the compound of the formula (I) obtained above (323 mg, 1.0 mmol) was added to a 100 ml Schlenk tube.Then Pd(OAc)2 (purchased from Strem) (11.22 mg, 0.05 mmol) as a catalyst, DavePhos as a ligand was added.(2-Dicyclohexylphosphino-2′-(N,N-dimethylamine)-biphenyl, available from Strem) (39.354 mg, 0.1 mmol) and as a baseCs2CO3 (purchased from TCI (Shanghai) Chemical Industry Development Co., Ltd.) (358.82mg, 1.1mmol), and the Schlenk tubeFill the vacuum line with argon three times. Then, under an argon atmosphere, add to the Schlenk tube.3-bromo-7-methylimidazo[1,2-A]pyrimidine (purchased from Shanghai Bi De Pharmaceutical Technology Co., Ltd.) (233.75 mg, 1.1 mmol), then addedN,N-dimethylacetamide (purchased from TCI (Shanghai) Chemical Industry Development Co., Ltd.) (1.0 ml), and the reaction was stirred at room temperature for 4 hours.After the reaction was completed, the reaction mixture was washed with brine and extracted with ethyl acetate.Dry over sodium sulfate and evaporate to dryness on a rotary evaporator. Finally, it was separated through a silica gel column (eluent: petroleum ether: ethyl acetate: 4:1) to afford the compound of formula 7 as a white solid, yield 78%.

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 375857-62-8, 3-Bromo-7-methylimidazo[1,2-a]pyrimidine.

Reference:
Patent; University of Science and Technology of China; Xiao Bin; Wang Guofu; Song Haijie; (17 pag.)CN108715593; (2018); A;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 42212-19-1, name is 6-Amino-3-methyl-1-phenylpyrimidine-2,4(1H,3H)-dione. A new synthetic method of this compound is introduced below., Safety of 6-Amino-3-methyl-1-phenylpyrimidine-2,4(1H,3H)-dione

In a microwave reaction vessel at room temperature 6-amino-3-methyl-1-phenylpyrimidine-2,4(1H,3H)dione (217.2 mg, 1.0 mmol) and phenyl isocyanate (142.9 mg, 1.2 mmol) was dissolved in nitrobenzene (1 ml). The reaction mixture was allowed to react for 10 to 20 minutes under microwave conditions at 210 . After completion of the reaction was evaporated under reduced pressure and the reaction mixture transferred to a round bottom flask. Hexane and ethyl acetate was purified by silica gel column chromatography to give the titled compound the reaction mixture concentrated to a 6-amino-3-methyl-2,4-oxo Using -N, diphenyl-1,2,3,4-1- to give a tetra hydro-pyrimidine-5-carboxamide (282.5mg, 84%).

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 42212-19-1, 6-Amino-3-methyl-1-phenylpyrimidine-2,4(1H,3H)-dione.

Reference:
Patent; Dongguk University Academic Cooperation; Chung-Ang University Academic Cooperation; Kong, Young Dae; Min, Kyung Hoon; Yang, Sung Joo; Song, Ji HO; (38 pag.)KR2016/106837; (2016); A;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Application of 1211522-68-7, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 1211522-68-7, name is 4,6-Dichloro-3-methyl-1H-pyrazolo[3,4-d]pyrimidine, molecular formula is C6H4Cl2N4, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

After 4,6-dicMoro-3-memyl-lH-pyrazolo[3,4-d]pyrimidine (300.0 mg, 1.5 mmol) was dissolved in ethanol (10 mL), N,N-disopropylethylarnine (695.0 L, 2.2 mmol) and tert-butyl (R)-3-aminopiperidine-l-carboxylate (355.0 mg, 1.8 mmol) were added thereto. The reaction mixture was stirred at 110 C for 12 hours, and then the organic layer was isolated, treated with magnesium sulfate, filtered and then concentrated under reduced pressure. The residue was isolated by column chromatography to obtain a title compound (414.5 mg, yield: 76.3%). (1398) NMR (500MHz, CD3OD) delta 4.59-4.50(m, 1H), 4.30-4.24(m, 1H), 3.93-3.89(m, 1H), 3.72-3.67(m, 1H), 3.19-3.17(m, 1H), 2.59(s, 3H), 2.10-2.00(m, 1H), 1.88-1.77(m, 2H), 1.63-1.30(m, 10H)

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 1211522-68-7, 4,6-Dichloro-3-methyl-1H-pyrazolo[3,4-d]pyrimidine.

Reference:
Patent; DAEWOONG PHARMACEUTICAL CO., LTD.; KIM, In Woo; HAN, Mi Ryeong; YOO, Jakyung; OH, Yun Ju; KIM, Ji Duck; KIM, Nam Youn; JUN, Sun Ah; LEE, Jun Hee; PARK, Joon Seok; (197 pag.)WO2018/4306; (2018); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia