Tag: M.W:200-300

Electric Literature of 1032452-86-0, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 1032452-86-0, name is 3-(2-Chloropyrimidin-4-yl)-1-methyl-1H-indole. This compound has unique chemical properties. The synthetic route is as follows.

N- (2- ( (2- (Dimethylamino) ethyl) (methyl) amino) -6-methoxy-5- (4- (1-methyl-1H-indol-3-yl)pyrimidin-2-ylamino) pyridin-3-yl) acrylamide (1) The mixture of N- (5-Amino-2- ( (2- (dimethylamino) ethyl) (methyl) amino) -6-methoxypyridin-3-yl) acrylamide (1g) (3.6 mg, 0.012 mmol) , 3- (2-chloropyrimidin-4-yl) -1-methyl-1H-indole (1h) (6.0 mg, 0.025 mmol) (prepared by following the literature, WO2013/14448) , and p-TsOH¡¤H2O (4.7 mg, 0.025 mmol) in 2-pentanol (0.5 mL) was heated at 105 for 2 h. Solvent was evaporated under reduced pressure. The residue was purified by column chromatography on silica gel eluting with DCM/methanol (95:5) to give N- (2- ( (2- (Dimethylamino) ethyl) (methyl) amino) -6-methoxy-5- (4- (1-methyl-1H-indol-3-yl) pyrimidin-2-ylamino) pyridin-3-yl) acrylamide (1) (5.0 mg, 82) . MS-ESI (m/z) : 500 [M + 1]+.

According to the analysis of related databases, 1032452-86-0, the application of this compound in the production field has become more and more popular.

Reference:
Patent; SHANGHAI FOCHON PHARMACEUTICAL CO LTD; LI, Tongshuang; ZHAO, Xingdong; TIAN, Qiang; ZHANG, Weipeng; LIU, Hongbin; WANG, Xianlong; TAN, Haohan; TAN, Rui; LIU, Qihong; JIANG, Lihua; LIU, Yanxin; LINGHU, Li; LIN, Min; SUN, Jing; WANG, Weibo; WO2015/188777; (2015); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Electric Literature of 1004524-64-4, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.1004524-64-4, name is 2-((4-(Aminomethyl)benzyl)oxy)pyrimidin-4-amine, molecular formula is C12H14N4O, molecular weight is 230.27, as common compound, the synthetic route is as follows.

Added to a 1.5 ml Eppendorf tube were 1 mumol of aminomethylbenzylcytosine in solution in 26 mul of anhydrous dimethylsulfoxide, 1 mumol of Tb(KR)-NHS in solution in 110 mul of anhydrous dimethylsulfoxide and 4 mul of diisopropylethylamine. The reaction mixture was stirred for two hours. The reaction was monitored by HPLC on a Merck Lichrospher RP 18, 5 mum, 125*4.6 column with a gradient of acetonitrile in water containing 25 mM of triethylammonium acetate. A purification by preparative HPLC was carried out on a Vydac C18, 10 mum, 250*22 column with a gradient of acetonitrile in water containing 25 mM of triethylammonium acetate. The fractions were collected and concentrated under reduced pressure. A white solid was obtained (350 nmol by optical density measurement, 35%) corresponding to the desired product. MS (ES+) m/z: [M+H+] 1645.2 [M+2H+]/2 823.4.

Statistics shows that 1004524-64-4 is playing an increasingly important role. we look forward to future research findings about 2-((4-(Aminomethyl)benzyl)oxy)pyrimidin-4-amine.

Reference:
Patent; Cis Bio International; Bourrier, Emmanuel; Laget, Michel; Lamarque, Laurent; Tinel, Norbert; Trinquet, Eric; Bazin, Herve; US9024022; (2015); B2;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 2915-16-4, name is 2-Chloro-4,6-diphenylpyrimidine, molecular formula is C16H11ClN2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. SDS of cas: 2915-16-4

Intermediates in a nitrogen environment I-3 (10 g, 23.1 mmol)Was dissolved in 0.1 L of tetrahydrofuran (THF), and the solution was added thereto by the Tokyo Chemical Industry (http://www.tcichemicals.com/)2-chloro-4,6-diphenylpyrimidine (6.16 g, 23.1 mmol)And tetrakis (triphenylphosphine) palladium (0.27 g, 0.23 mmol)And the mixture was stirred. Saturated water-saturated potassuim carbonate (7.98 g, 57.8 mmol) was added and heated at 80 C for 10 hours to reflux. After completion of the reaction, water was added to the reaction mixture, and the mixture was extracted with dichloromethane (DCM). The extract was dried over anhydrous MgSO 4, filtered, and concentrated under reduced pressure. The residue thus obtained was separated and purified by flash column chromatography to obtain Compound 2 (10.5 g, 85%).

With the rapid development of chemical substances, we look forward to future research findings about 2915-16-4.

Reference:
Patent; Samsung SDI Co., Ltd; Lee Han-il; Ryu Eun-seon; Jeong Seong-hyeon; Han Su-jin; Kang Dong-min; Shin Chang-ju; Lee Byeong-gwan; Jeong Su-yeong; (46 pag.)KR2018/123660; (2018); A;,
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Application of 161489-05-0, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 161489-05-0 as follows.

To a microwave vial charged with N-(4-fluoro-5-(l, 2,3,6- tetrahydropyridin-4-yl)-2-((3S,5R)-3,4,5-trimethylpiperazin-1-yl)phenyl)-6-oxo-4- (trifluoromethyl)-l,6-dihydropyridine-3-carboxamide (25.5 mg, 0.050 mmol) and 4- iodo-6-methoxy pyrimidine (13.64 mg, 0.058 mmol) in ethanol (3 ml) at RT, was added N,N-diisopropylethylamine (0.018 ml, 0.100 mmol) . The mixture was heated at 130 C for 3 h. The reaction was worked up and the product was purified by sgc to afford the title compound (19 mg, 58 % yield). 1H NMR (500 MHz, METHANOL- d4) delta = 8.26 – 8.21 (m, 1H), 7.98 – 7.93 (m, 1H), 7.85 – 7.76 (m, 1H), 6.99 – 6.94 (m, 1H), 6.94 – 6.90 (m, 1H), 6.12 (br s, 1H), 6.04 (s, 1H), 4.26 – 4.16 (m, 2H), 4.00 – 3.88 (m, 5H), 3.03 (br d, J=11.0 Hz, 2H), 2.65 – 2.52 (m, 6H), 2.38 (s, 3H), 1.19 – 1.15 (m,6H); LCMS [M+H]+ 616.6

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,161489-05-0, its application will become more common.

Reference:
Patent; ONTARIO INSTITUTE FOR CANCER RESEARCH (OICR); AL-AWAR, Rima; ZEPEDA-VELAZQUEZ, Carlos Armando; PODA, Gennady; ISAAC, Methvin; UEHLING, David; WILSON, Brian; JOSEPH, Babu; LIU, Yong; SUBRAMANIAN, Pandiaraju; MAMAI, Ahmed; PRAKESCH, Michael; STILLE, Julia Kathleen; (1053 pag.)WO2017/147700; (2017); A1;,
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Pyrimidine – Wikipedia

Adding a certain compound to certain chemical reactions, such as: 56844-40-7, 6-Bromothieno[2,3-d]pyrimidin-4(3H)-one, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, category: pyrimidines, blongs to pyrimidines compound. category: pyrimidines

1 L cc. sulfuric acid was cooled with ice-water bath and 72.0 g potassium iodide (0.434mol) was added in portions during 15 minutes and then 32.4 g sodium periodate (0.151mol) during a 10 minutes period. The resulting mixture was stirred at room temperature for30 minutes then 80.0 g 6-bromo-3H-thieno[2,3-djpyrimidin-4-one (0.346 mol) was addedto the mixture in portions in 30 minutes while the internal temperature was kept between -21 C and -19 C. The reaction mixture was stirred at -20 C for 1,5 hours. lee (3 kg) was added to the suspension then the precipitate was filtered off, washed with water (3×500 mL), finally with diethyl ether (3×200 mL) and air dried to give the product as a tan crystalline solid.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,56844-40-7, 6-Bromothieno[2,3-d]pyrimidin-4(3H)-one, and friends who are interested can also refer to it.

Reference:
Patent; LES LABORATOIRES SERVIER; VERNALIS (R&D) LIMITED; KOTSCHY, Andras; SZLAVIK, Zoltan; CSEKEI, Marton; PACZAL, Attila; SZABO, Zoltan; SIPOS, Szabolcs; RADICS, Gabor; PROSZENYAK, Agnes; BALINT, Balazs; BRUNO, Alain; GENESTE, Olivier; DAVIDSON, James Edward Paul; MURRAY, James Brooke; CHEN, I-Jen; PERRON-SIERRA, Francoise; WO2015/97123; (2015); A1;,
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Pyrimidine – Wikipedia

Application of 61727-34-2, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 61727-34-2, name is Ethyl 2-(4-chloro-2-(methylthio)pyrimidin-5-yl)acetate. This compound has unique chemical properties. The synthetic route is as follows.

To a solution of 121 (2.6 g, 10 mrnoi) in EtOH (20 mL) is added zinc powder (2.6 g, 40 mrnol) and HOAc (2 mL). After stirring at room temperature overnight, the mixture is filtered and concentrated. The residue is dissolved in EA (30 mL), washed with brine, diied over anhydrous sodium sulfate, filtered, and concentrated to give 122 as a yellow oil (1,2 g, 56% yield). (MS: [M+H] 213.1)

According to the analysis of related databases, 61727-34-2, the application of this compound in the production field has become more and more popular.

Reference:
Patent; IMMUNE SENSOR, LLC; THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM; ZHONG, Boyu; SUN, Lijun; SHI, Heping; LI, Jing; CHEN, Chuo; CHEN, Zhijian; (270 pag.)WO2017/176812; (2017); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.573675-29-3, name is 7-Bromopyrido[3,2-d]pyrimidin-4(3H)-one, molecular formula is C7H4BrN3O, molecular weight is 226.0302, as common compound, the synthetic route is as follows.COA of Formula: C7H4BrN3O

7-Bromopyrido[3,2-d]pyrimidin-4-ol (1.02 g, 4.51 mmol) was suspended in dry toluene (80 mL) under nitrogen. Phosphorus oxychloride (5.0 mL, 54.6 mmol) was added and the mixture heated to reflux under nitrogen. After 5 hours the reaction was cooled to RT. The solution was placed in a water bath and saturated sodium bicarbonate (50 mL) was added slowly with strong stirring. After 45 minutes the phases were separated and the organic evaporated to dryness under reduced pressure. The crude 7-bromo-4-chloropyrido[3,2-d]pyrimidine (0.46 g, 1.89 mmol, 42% yield) was used without further purification. 1H NMR (400 MHz, CHLOROFORM-d) delta ppm 8.59 (d, J=1.96 Hz, 1H) 9.11-9.15 (m, 2H). LC/MS (ESI+) m/z=243.8 (M+H).

At the same time, in my other blogs, there are other synthetic methods of this type of compound,573675-29-3, 7-Bromopyrido[3,2-d]pyrimidin-4(3H)-one, and friends who are interested can also refer to it.

Reference:
Patent; LEWIS, Richard T.; ALLEN, Jennifer R.; BROWN, James; GUZMAN-PEREZ, Angel; HUA, Zihao; JUDD, Ted; LIU, Qingyian; OLIVIERI, Philip R.; ROMERO, Karina; SCHENKEL, Laurie; STELLWAGEN, John; WHITE, Ryan; US2015/38497; (2015); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Electric Literature of 216959-91-0, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 216959-91-0, name is 4-(Pyrimidin-5-yl)benzoic acid. This compound has unique chemical properties. The synthetic route is as follows.

A mixture of Co(NO3)2¡¤6H2O (0.2 mmol, 0.058 g), HL(0.020 g, 0.1 mmol), and H2O 10 mL was placed in a ParrTeflon-lined stainless steel vessel (23 mL). Then the pH valuewas tuned into 8 using NaOH solution (0.5 M). After that themixturewas heated to 160C and held for 60 h. Then the reactantmixture was cooled at a rate of 0.5C/min to lead to the formationof red block crystal 1. Yield: 37% based on HL. ElementalAnal. Calcd. for C22H18CoN4O6 (493.33): C, 53.51; H, 3.65;N, 11.35%. Found: C, 53.50; H, 3.58; N, 11.45%. IR (KBr,cm-1): 3395(w), 1648(s), 1573(s), 1433(m), 1385(s), 1082(s),778(s).

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 216959-91-0, 4-(Pyrimidin-5-yl)benzoic acid.

Reference:
Article; An, Zhe; Hu, Ying-Shuang; Zhu, Li-Hua; Zhu, Ling; Synthesis and Reactivity in Inorganic, Metal-Organic, and Nano-Metal Chemistry; vol. 44; 10; (2014); p. 1435 – 1438;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Synthetic Route of 64224-60-8, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.64224-60-8, name is 5-Bromo-4-pyrimidinecarboxylic acid, molecular formula is C5H3BrN2O2, molecular weight is 202.99, as common compound, the synthetic route is as follows.

General procedure: To a solution of Intermediate 7 (110 mg, 0.37 mmol), 3-methoxybenzene-1,2- diamine (50 mg, 0.34 mmol) and DIPEA (0.2 mL, 1 mmol) in DMF (2 mL) was added HATU (160 mg, 0.41 mmol). The reaction mixture was stirred at r.t. for 48 h, then partitioned between DCM and water. The organic phase was separated, then dried and concentrated in vacuo. The crude residue was purified by flash column chromatography (0-100% EtOAc/hexanes) to give the title compound (28.7 mg, 20%) as a white solid. LCMS (Method 5): [M+H]+ m/z 415, RT 1.31 minutes.

The chemical industry reduces the impact on the environment during synthesis 64224-60-8, I believe this compound will play a more active role in future production and life.

Reference:
Patent; UCB BIOPHARMA SPRL; BRACE, Gareth Neil; CHAPPELL, Rose Elizabeth; FOULKES, Gregory; FROST, James Richard; HORSLEY, Helen Tracey; JONES, Elizabeth Pearl; LECOMTE, Fabien Claude; REUBERSON, James Thomas; SCHULZE, Monika-Sarah Elisabeth Dorothea; TAYLOR, Richard David; YAU, Wei Tsung; ZHU, Zhaoning; (246 pag.)WO2019/138017; (2019); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Related Products of 2915-16-4, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 2915-16-4, name is 2-Chloro-4,6-diphenylpyrimidine. This compound has unique chemical properties. The synthetic route is as follows.

20 g of 11-(3-(dibenzo[b,d]furan-4-yl)phenyl)-11,12-dihydroindole[2,3-a]carbazole,4. A mixture of 8 g of sodium hydride and 300 ml of toluene in a 1 liter flask,And stirred at 40 C under a nitrogen atmosphere. After one hour,Add 12. 8 g of 2-chloro-4,6-diphenyl-1,3-pyrimidine,And continue to stir at 80 C. The reaction was monitored by thin layer chromatography.After completion of the reaction, the reaction mixture was quenched with 200 ml of water,And extracted with 150 ml of ethyl acetate. The organic layer was extracted with 100 ml of water three times and dried over anhydrous sodium sulfate. The collected ethyl acetate layer was further purified by celite column chromatography. The ethyl acetate layer is followed by a rotary evaporatorIn the vacuum was evaporated to dry. The residue was further precipitated by the addition of 100 ml of n-hexane, and 18 g of a yellow solid compound F5 (85% yield) having more than 99% HPLC purity was obtained under vacuum.

According to the analysis of related databases, 2915-16-4, the application of this compound in the production field has become more and more popular.

Reference:
Patent; e-Ray Optoelectronics Technology Co., Ltd; Balaganesan, Banumathy; HUANG, HEH LUNG; KAU, HUANG MING; HSU, PO WEI; (22 pag.)CN106608878; (2017); A;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia