Tag: M.W=150-200

Pyrimidine is an aromatic heterocyclic organic compound similar to pyridine. One of the three diazines (six-membered heterocyclics with two nitrogen atoms in the ring), it has the nitrogen atoms at positions 1 and 3 in the ring. 2927-71-1, formula is C4HCl2FN2, Name is 2,4-Dichloro-5-fluoropyrimidine. The pyrimidine ring system has wide occurrence in nature as substituted and ring fused compounds and derivatives, including the nucleotides cytosine, thymine and uracil, thiamine (vitamin B1) and alloxan. Product Details of C4HCl2FN2.

Deng, Zhou;Chen, Guyue;Liu, Shuang;Li, Yunzhan;Zhong, Jiaji;Zhang, Baoding;Li, Li;Huang, Huiying;Wang, Zheng;Xu, Qingyan;Deng, Xianming research published 《 Discovery of methyl 3-((2-((1-(dimethylglycyl)-5-methoxyindolin-6-yl)amino)-5-(trifluoro-methyl) pyrimidin-4-yl)amino)thiophene-2-carboxylate as a potent and selective polo-like kinase 1 (PLK1) inhibitor for combating hepatocellular carcinoma》, the research content is summarized as follows. Hepatocellular carcinoma (HCC) is the second leading cause of cancer-related death worldwide and targeted therapeutics exhibit limited success. Polo-like kinase 1 (PLK1), a Ser/Thr kinase, plays a pivotal role in cell-cycle regulation and is considered a promising target in HCC. Here, via structural optimization using both biochem. kinase assays and cellular antiproliferation assays, we discovered a potent and selective PLK1 kinase inhibitor, compound 31. Compound 31 exhibited biochem. activity with IC₅₀ of < 0.508 nM against PLK1 and a KINOMEscan selectivity score (S(1)) of 0.02 at a concentration of 1μM. Furthermore, 31 showed broad antiproliferative activity against a variety of cancer cell lines, with the lowest antiproliferative IC₅₀ (11.1 nM) in the HCC cell line HepG2. A detailed mechanistic study of 31 revealed that inhibition of PLK1 by 31 induces mitotic arrest at the G2/M phase checkpoint, thus leading to cancer cell apoptosis. Moreover, 31 exhibited profound antitumor efficacy in a xenograft mouse model. Collectively, these results establish compound 31 as a good starting point for the development of PLK1 targeted therapeutics for HCC.

Product Details of C4HCl2FN2, 2,4-Dichloro-5-fluoropyrimidine is a useful research compound. Its molecular formula is C4HCl2FN2 and its molecular weight is 166.97 g/mol. The purity is usually 95%.
2,4-Dichloro-5-fluoropyrimidine is an aromatic hydrocarbon that has been shown to inhibit the growth of mouse tumor cells in vitro. It also inhibits the production of amines by reacting with industrial chemicals and sodium carbonate. This compound has potent inhibitory activity against autoimmune diseases and cytotoxic potency on mcf-7 cells. Furthermore, 2,4-Dichloro-5-fluoropyrimidine has been shown to have a chlorinating effect on cancer cells., 2927-71-1.

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

The systematic study of pyrimidines began in 1884 with Pinner, who synthesized derivatives by condensing ethyl acetoacetate with amidines. Pinner first proposed the name “pyrimidin” in 1885. 4595-59-9, formula is C4H3BrN2, Name is 5-Bromopyrimidine. The parent compound was first prepared by Gabriel and Colman in 1900, by conversion of barbituric acid to 2,4,6-trichloropyrimidine followed by reduction using zinc dust in hot water. HPLC of Formula: 4595-59-9.

Dewan, Anindita;Sarmah, Manashi;Bharali, Pankaj;Thakur, Ashim J.;Boruah, Purna K.;Das, Manash R.;Bora, Utpal research published 《 Pd Nanoparticles-Loaded Honeycomb-Structured Bio-nanocellulose as a Heterogeneous Catalyst for Heteroaryl Cross-Coupling Reaction》, the research content is summarized as follows. Distorted honeycomb-like hollow cage-structured bio-nanocellulose (with 1-16.7μm diameters) is derived from cellulosic waste of pomegranate peel using a simple microwave technique in water under neutral conditions without using external chems. in a very short period of time. Pd nanoparticles are loaded onto the bio-nanocellulose surface by simple stirring at room temperature (25°C) and characterized by X-ray diffraction, SEM, transmission electron microscopy, Fourier-transform IR spectroscopy, Brunauer-Emmett-Teller surface area analyses, and so on. The newly developed nanocomposite material has been utilized as an efficient heterogeneous catalyst for the synthesis of potential bioactive biaryl/heterobiaryl and alkynyl/heteroalkynyl derivatives up to 98% yield via the Suzuki-Miyaura and Sonogashira cross-coupling reactions. The catalyst is reusable up to five catalytic cycles without significant loss of its catalytic activity. Waste pomegranate peel-derived honeycomb-like bio-nanocellulose serves as a heterogeneous surface for Pd nanoparticles which catalyze a variety of cross-coupling reactions.

4595-59-9, 5-Bromopyrimidine is a reactive intermediate that is used in the synthesis of 4-methoxyphenylboronic acid. 5-Bromopyrimidine has been shown to be nucleophilic, reacting with β-amino acids under basic conditions to form the corresponding 2-bromo amide. It also undergoes cross-coupling reactions with halides and can be used as a building block for other organic compounds. 5-Bromopyrimidine has optical properties that are characteristic of aromatic molecules, including strong absorption bands in the ultraviolet region and visible light region.
5-Bromopyrimidine undergoes direct metallation with lithuium diisopropylamide to yield 4-lithio-5-bromopyrimidine., HPLC of Formula: 4595-59-9

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Pyrimidine is an aromatic heterocyclic organic compound similar to pyridine. One of the three diazines (six-membered heterocyclics with two nitrogen atoms in the ring), it has the nitrogen atoms at positions 1 and 3 in the ring. 4595-59-9, formula is C4H3BrN2, Name is 5-Bromopyrimidine. The pyrimidine ring system has wide occurrence in nature as substituted and ring fused compounds and derivatives, including the nucleotides cytosine, thymine and uracil, thiamine (vitamin B1) and alloxan. Computed Properties of 4595-59-9.

Dewan, Anindita;Sarmah, Manashi;Bhattacharjee, Prantika;Bharali, Pankaj;Thakur, Ashim J.;Bora, Utpal research published 《 Sustainable nano fibrillated cellulose supported in situ biogenic Pd nanoparticles as heterogeneous catalyst for C-C cross coupling reactions》, the research content is summarized as follows. This manuscript reports the design, synthesis and application of naturally occurring cellulose, generated from agro waste pomegranate peel, as novel support for active biogenic Pd (0) nanoparticles (NPs) for room temperature Suzuki-Miyaura and Sonogashira cross-coupling reactions. The presence of hydroxyl groups and unsaturated hanging bonds on their surfaces in cellulose matrix enable well dispersion of PdNPs over the support matrix to generate Pd@cellulose. This in turn exhibits excellent catalytic activity, easy removal from the reaction mixture, recyclable without loss of catalytic activity for Suzuki-Miyaura and Sonogashira reactions under ligand-free mild reaction conditions. The synthesized cellulosic nanofibers and Pd-anchored heterogeneous nanofibers were characterized by SEM, EDX, TEM, Powder XRD, FT-IR spectroscopy and BET surface anal.

Computed Properties of 4595-59-9, 5-Bromopyrimidine is a reactive intermediate that is used in the synthesis of 4-methoxyphenylboronic acid. 5-Bromopyrimidine has been shown to be nucleophilic, reacting with β-amino acids under basic conditions to form the corresponding 2-bromo amide. It also undergoes cross-coupling reactions with halides and can be used as a building block for other organic compounds. 5-Bromopyrimidine has optical properties that are characteristic of aromatic molecules, including strong absorption bands in the ultraviolet region and visible light region.
5-Bromopyrimidine undergoes direct metallation with lithuium diisopropylamide to yield 4-lithio-5-bromopyrimidine., 4595-59-9.

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

The pyrimidine ring system has wide occurrence in nature as substituted and ring fused compounds and derivatives, including the nucleotides cytosine, thymine and uracil, thiamine (vitamin B1) and alloxan. 2927-71-1, formula is C4HCl2FN2, Name is 2,4-Dichloro-5-fluoropyrimidine. It is also found in many synthetic compounds such as barbiturates and the HIV drug, zidovudine. Quality Control of 2927-71-1.

Diao, Peng-Cheng;Lin, Wei-Yuan;Jian, Xie-Er;Li, Yan-Hong;You, Wen-Wei;Zhao, Pei-Liang research published 《 Discovery of novel pyrimidine-based benzothiazole derivatives as potent cyclin-dependent kinase 2 inhibitors with anticancer activity》, the research content is summarized as follows. To develop novel CDK2 inhibitors as anticancer agents, a series of novel pyrimidine-based benzothiazole derivatives I (R = 4-(S(O)₂NH₂), 4-(piperidin-1-yl), 3-F, etc.) and II (R¹ = H, F, Cl, Me, MeO; R² = H, Me, F; R³ = Me, NH₂) was designed and synthesized. Initial biol. evaluation demonstrated that some of target compounds displayed potent antitumor activity in vitro against five cancer cell lines. Especially, the analog II (R¹ = F; R² = H; R³ = NH₂) exhibited approx. potency with AZD5438 toward four cells including HeLa, HCT116, PC-3, and MDA-MB-231 with IC₅₀ values of 0.45, 0.70, 0.92, 1.80 μM, resp. More interestingly, the most highly active compound II (R¹ = F; R² = H; R³ = NH₂) in this study also possessed promising CDK2/cyclin A2 inhibitory activities with IC₅₀ values of 15.4 nM, which was almost 3-fold potent than pos. control AZD5438, and mol. docking studies revealed that the analog bound efficiently with the CDK2 binding site. Further studies indicated that compound II (R¹ = F; R² = H; R³ = NH₂) could induce cell cycle arrest and apoptosis in a concentration-dependent manner. These observations suggest that pyrimidine-benzothiazole hybrids represent a new class of CDK2 inhibitors and well worth further investigation aiming to generate potential anticancer agents.

Quality Control of 2927-71-1, 2,4-Dichloro-5-fluoropyrimidine is a useful research compound. Its molecular formula is C4HCl2FN2 and its molecular weight is 166.97 g/mol. The purity is usually 95%.
2,4-Dichloro-5-fluoropyrimidine is an aromatic hydrocarbon that has been shown to inhibit the growth of mouse tumor cells in vitro. It also inhibits the production of amines by reacting with industrial chemicals and sodium carbonate. This compound has potent inhibitory activity against autoimmune diseases and cytotoxic potency on mcf-7 cells. Furthermore, 2,4-Dichloro-5-fluoropyrimidine has been shown to have a chlorinating effect on cancer cells., 2927-71-1.

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

The nomenclature of pyrimidines is straightforward. However, like other heterocyclics, tautomeric hydroxyl groups yield complications since they exist primarily in the cyclic amide form. 4595-59-9, formula is C4H3BrN2, Name is 5-Bromopyrimidine. For example, 2-hydroxypyrimidine is more properly named 2-pyrimidone. A partial list of trivial names of various pyrimidines exists. Name: 5-Bromopyrimidine.

Dilauro, Giuseppe;Azzollini, Claudia S.;Vitale, Paola;Salomone, Antonio;Perna, Filippo M.;Capriati, Vito research published 《 Scalable Negishi Coupling between Organozinc Compounds and (Hetero)Aryl Bromides under Aerobic Conditions when using Bulk Water or Deep Eutectic Solvents with no Additional Ligands》, the research content is summarized as follows. Pd-catalyzed Negishi cross-coupling reactions between organozinc compounds and (hetero)aryl bromides have been reported when using bulk water as the reaction medium in the presence of NaCl or the biodegradable choline chloride/urea eutectic mixture Both C(sp³)-C(sp²) and C(sp²)-C(sp²) couplings have been found to proceed smoothly, with high chemoselectivity, under mild conditions (room temperature or 60°C) in air, and in competition with protonolysis. Addnl. benefits include very short reaction times (20 s), good to excellent yields (up to 98%), wide substrate scope, and the tolerance of a variety of functional groups. The proposed novel protocol is scalable, and the practicability of the method is further highlighted by an easy recycling of both the catalyst and the eutectic mixture or water.

Name: 5-Bromopyrimidine, 5-Bromopyrimidine is a reactive intermediate that is used in the synthesis of 4-methoxyphenylboronic acid. 5-Bromopyrimidine has been shown to be nucleophilic, reacting with β-amino acids under basic conditions to form the corresponding 2-bromo amide. It also undergoes cross-coupling reactions with halides and can be used as a building block for other organic compounds. 5-Bromopyrimidine has optical properties that are characteristic of aromatic molecules, including strong absorption bands in the ultraviolet region and visible light region.
5-Bromopyrimidine undergoes direct metallation with lithuium diisopropylamide to yield 4-lithio-5-bromopyrimidine., 4595-59-9.

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

The pyrimidine ring system has wide occurrence in nature as substituted and ring fused compounds and derivatives, including the nucleotides cytosine, thymine and uracil, thiamine (vitamin B1) and alloxan. 4595-59-9, formula is C4H3BrN2, Name is 5-Bromopyrimidine. It is also found in many synthetic compounds such as barbiturates and the HIV drug, zidovudine. HPLC of Formula: 4595-59-9.

Dilauro, Giuseppe;Messa, Francesco;Bona, Fabio;Perrone, Serena;Salomone, Antonio research published 《 Cobalt-catalyzed cross-coupling reactions of aryl- and alkylaluminum derivatives with (hetero)aryl and alkyl bromides》, the research content is summarized as follows. A simple cobalt complex, such as Co(phen)Cl₂, turned out to be a highly efficient and cheap precatalyst for a host of cross-coupling reactions involving aromatic and aliphatic organoaluminum reagents with aryl, heteroaryl and alkyl bromides. New C(sp²)-C(sp²) and C(sp²)-C(sp³) bonds were formed in good to excellent yields and with high chemoselectivity, under mild reaction conditions.

HPLC of Formula: 4595-59-9, 5-Bromopyrimidine is a reactive intermediate that is used in the synthesis of 4-methoxyphenylboronic acid. 5-Bromopyrimidine has been shown to be nucleophilic, reacting with β-amino acids under basic conditions to form the corresponding 2-bromo amide. It also undergoes cross-coupling reactions with halides and can be used as a building block for other organic compounds. 5-Bromopyrimidine has optical properties that are characteristic of aromatic molecules, including strong absorption bands in the ultraviolet region and visible light region.
5-Bromopyrimidine undergoes direct metallation with lithuium diisopropylamide to yield 4-lithio-5-bromopyrimidine., 4595-59-9.

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

The systematic study of pyrimidines began in 1884 with Pinner, who synthesized derivatives by condensing ethyl acetoacetate with amidines. Pinner first proposed the name “pyrimidin” in 1885. 2927-71-1, formula is C4HCl2FN2, Name is 2,4-Dichloro-5-fluoropyrimidine. The parent compound was first prepared by Gabriel and Colman in 1900, by conversion of barbituric acid to 2,4,6-trichloropyrimidine followed by reduction using zinc dust in hot water. Related Products of 2927-71-1.

Dittus, Lars;Werner, Thilo;Muelbaier, Marcel;Bantscheff, Marcus research published 《 Differential Kinobeads Profiling for Target Identification of Irreversible Kinase Inhibitors》, the research content is summarized as follows. Chemoproteomics profiling of kinase inhibitors with kinobeads enables the assessment of inhibitor potency and selectivity for endogenously expressed protein kinases in cell lines and tissues. Using a small panel of targeted covalent inhibitors, we demonstrate the importance of measuring covalent target binding in live cells. We present a differential kinobeads profiling strategy for covalent kinase inhibitors where a compound is added either to live cells or to a cell extract that enables the comprehensive assessment of inhibitor selectivity for covalent and noncovalent targets. We found that Acalabrutinib, CC-292, and Ibrutinib potently and covalently bind TEC family kinases, but only Ibrutinib also potently binds to BLK. ZAK was identified as a submicromolar affinity Ibrutinib off-target due to covalent modification of Cys22. In contrast to Ibrutinib, 5Z-7-Oxozeaenol reacted with Cys150 next to the DFG loop, demonstrating an alternative route to covalent inactivation of this kinase, e.g., to inhibit canonical TGF-β dependent processes.

Related Products of 2927-71-1, 2,4-Dichloro-5-fluoropyrimidine is a useful research compound. Its molecular formula is C4HCl2FN2 and its molecular weight is 166.97 g/mol. The purity is usually 95%.
2,4-Dichloro-5-fluoropyrimidine is an aromatic hydrocarbon that has been shown to inhibit the growth of mouse tumor cells in vitro. It also inhibits the production of amines by reacting with industrial chemicals and sodium carbonate. This compound has potent inhibitory activity against autoimmune diseases and cytotoxic potency on mcf-7 cells. Furthermore, 2,4-Dichloro-5-fluoropyrimidine has been shown to have a chlorinating effect on cancer cells., 2927-71-1.

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

The nomenclature of pyrimidines is straightforward. However, like other heterocyclics, tautomeric hydroxyl groups yield complications since they exist primarily in the cyclic amide form. 2927-71-1, formula is C4HCl2FN2, Name is 2,4-Dichloro-5-fluoropyrimidine. For example, 2-hydroxypyrimidine is more properly named 2-pyrimidone. A partial list of trivial names of various pyrimidines exists. SDS of cas: 2927-71-1.

Chen, Xiaojing;Liu, Lu;Liu, Peng;Chen, Yingying;Lin, Dan;Yan, Hao;Yan, Qi;Wang, Yi;Qiu, Yinda;Fang, Bo;Huang, Huijing;Qian, Jianchang;Zhao, Yunjie;Du, Zhou;Zhang, Qianwen;Li, Xiaokun;Zheng, Xiaohui;Liu, Zhiguo research published 《 Discovery of Potent and Orally Bioavailable Platelet-Derived Growth Factor Receptor (PDGFR) Inhibitors for the Treatment of Osteosarcoma》, the research content is summarized as follows. Herein design, synthesis and structure-activity relationships of novel pyrimidine-2,4-diamine derivatives I [R¹ = H, CF₃, Me; R² = F, Cl, Me, etc.; R¹R² = CH=CH-S], I [R⁴ = H, 2-OMe, 3-OMe, etc.; R⁵ = (indol-5-yl), (indol-4-yl), (1-methyl-1H-indol-5-yl), etc.], III [R⁴ = H, 2-OMe, 3-OMe, etc.; R⁵ = indazol-6-yl, (4-ethylpiperazin-1-yl), (indazol-6-yl), etc.] that selectively inhibit PDGFRα/β kinases was studied. The screening cascades revealed that I [R⁴ = 3-OMe; R⁵ = (4-Ethylpiperazin-1-yl)] was the preferred compound among these derivatives, with IC₅₀ values of 2.4 and 0.9 nM for PDGFRα and PDGFRβ, resp. Moreover, the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) experiment revealed that I [R⁴ = 3-OMe; R⁵ = (4-ethylpiperazin-1-yl)] has a substantial cytotoxic effect against all osteosarcoma cancer cell lines; I [R⁴ = 3-OMe; R⁵ = (4-Ethylpiperazin-1-yl)] also displayed robust antitumor effects and low toxicity in a xenograft model. Addnl., I [R⁴ = 3-OMe; R⁵ = (4-ethylpiperazin-1-yl)] showed excellent bioavailability (F = 62.9%), suitable half-life (T1/2 = 2.12 h), satisfactory metabolic stability, and weak CYP isoform inhibitory activity, suggesting that I [R⁴ = 3-OMe; R⁵ = (4-ethylpiperazin-1-yl)] was a potential drug candidate for PDGFR-driven osteosarcoma.

2927-71-1, 2,4-Dichloro-5-fluoropyrimidine is a useful research compound. Its molecular formula is C4HCl2FN2 and its molecular weight is 166.97 g/mol. The purity is usually 95%.
2,4-Dichloro-5-fluoropyrimidine is an aromatic hydrocarbon that has been shown to inhibit the growth of mouse tumor cells in vitro. It also inhibits the production of amines by reacting with industrial chemicals and sodium carbonate. This compound has potent inhibitory activity against autoimmune diseases and cytotoxic potency on mcf-7 cells. Furthermore, 2,4-Dichloro-5-fluoropyrimidine has been shown to have a chlorinating effect on cancer cells., SDS of cas: 2927-71-1

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

The nomenclature of pyrimidines is straightforward. However, like other heterocyclics, tautomeric hydroxyl groups yield complications since they exist primarily in the cyclic amide form. 2927-71-1, formula is C4HCl2FN2, Name is 2,4-Dichloro-5-fluoropyrimidine. For example, 2-hydroxypyrimidine is more properly named 2-pyrimidone. A partial list of trivial names of various pyrimidines exists. Application In Synthesis of 2927-71-1.

Chen, Xing;Yan, Yaoyao;Zhang, Zhaoyan;Zhang, Faming;Liu, Mingming;Du, Leran;Zhang, Haixia;Shen, Xiaobao;Zhao, Dahai;Shi, Jing Bo;Liu, Xinhua research published 《 Discovery and In Vivo Anti-inflammatory Activity Evaluation of a Novel Non-peptidyl Non-covalent Cathepsin C Inhibitor》, the research content is summarized as follows. Cathepsin C (Cat C) participates in inflammation and immune regulation by affecting the activation of neutrophil serine proteases (NSPs). Therefore, cathepsin C is an attractive target for treatment of NSP-related inflammatory diseases. Here, the complete discovery process of the first potent “non-peptidyl non-covalent cathepsin C inhibitor” was described with hit finding, structure optimization, and lead discovery. Starting with hit 14, structure-based optimization and structure-activity relationship study were comprehensively carried out, and lead compound 54 was discovered as a potent drug-like cathepsin C inhibitor both in vivo and in vitro. Also, compound 54 (with cathepsin C Enz IC₅₀ = 57.4 nM) exhibited effective anti-inflammatory activity in an animal model of chronic obstructive pulmonary disease. These results confirmed that the non-peptidyl and non-covalent derivative could be used as an effective cathepsin C inhibitor and encouraged us to continue further drug discovery on the basis of this finding.

Application In Synthesis of 2927-71-1, 2,4-Dichloro-5-fluoropyrimidine is a useful research compound. Its molecular formula is C4HCl2FN2 and its molecular weight is 166.97 g/mol. The purity is usually 95%.
2,4-Dichloro-5-fluoropyrimidine is an aromatic hydrocarbon that has been shown to inhibit the growth of mouse tumor cells in vitro. It also inhibits the production of amines by reacting with industrial chemicals and sodium carbonate. This compound has potent inhibitory activity against autoimmune diseases and cytotoxic potency on mcf-7 cells. Furthermore, 2,4-Dichloro-5-fluoropyrimidine has been shown to have a chlorinating effect on cancer cells., 2927-71-1.

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Pyrimidine is a nitrogenous base similar to benzene (a six-membered ring) and includes cytosine, thymine, and uracil as bases used for DNA or RNA. 4595-59-9, formula is C4H3BrN2, Name is 5-Bromopyrimidine. Pyrimidine also found in many synthetic compounds such as barbiturates and the HIV drug, zidovudine. Computed Properties of 4595-59-9.

Chen, Ya-Jing;Lei, Tao;Hu, Hui-Lan;Wu, Hao-Lin;Zhou, Shuai;Li, Xu-Bing;Chen, Bin;Tung, Chen-Ho;Wu, Li-Zhu research published 《 Tandem photoelectrochemical and photoredox catalysis for efficient and selective aryl halides functionalization by solar energy》, the research content is summarized as follows. Solar energy conversion is the most important chem. transformation for green and sustainable society. Represented herein is a coupled catalytic strategy for efficient, selective, and energy-saving organic transformations, i.e., a coupled photoelectrochem./photoredox setting with Sb₂(S,Se)₃ as a photocathode and N,N-bis(2,6-diisopropylphenyl)perylene-3,4,9,10-bis(dicarboximide) (PDI) as a photocatalyst shows full-solar-spectrum response extending visible and near-IR (Vis-NIR) light to 1,060 nm. At -0.84 V vs. SCE, the Vis-NIR photoexcited electron from Sb₂(S,Se)₃ reduces PDI to PDI·-. Then, the second photoexcitation by Vis light creates higher reducing PDI·-t (-1.86 V vs. SCE) for reduction of unactivated aryl halides. The resultant aryl radicals are applied for C-C, C-P, and C-B bond-forming reactions with excellent chemoselectivity and efficacy under external sacrificial agent-free conditions. This strategy not only utilizes full solar spectrum and surmounts the limited light absorption of photocatalysis, but also overcomes the high biased potential issue in electrocatalysis.

4595-59-9, 5-Bromopyrimidine is a reactive intermediate that is used in the synthesis of 4-methoxyphenylboronic acid. 5-Bromopyrimidine has been shown to be nucleophilic, reacting with β-amino acids under basic conditions to form the corresponding 2-bromo amide. It also undergoes cross-coupling reactions with halides and can be used as a building block for other organic compounds. 5-Bromopyrimidine has optical properties that are characteristic of aromatic molecules, including strong absorption bands in the ultraviolet region and visible light region.
5-Bromopyrimidine undergoes direct metallation with lithuium diisopropylamide to yield 4-lithio-5-bromopyrimidine., Computed Properties of 4595-59-9

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia