Tag: M.W=150-200

Khamrai, Jagadish; Ghosh, Indrajit; Savateev, Aleksandr; Antonietti, Markus; Koenig, Burkhard published the artcile< Photo-Ni-Dual-Catalytic C(sp2)-C(sp3) Cross-Coupling Reactions with Mesoporous Graphitic Carbon Nitride as a Heterogeneous Organic Semiconductor Photocatalyst>, Related Products of 89793-12-4, the main research area is cross coupling reaction photocatalyst organic semiconductor nickel carbon nitride.

The synergistic combination of a heterogeneous organic semiconductor mesoporous graphitic carbon nitride (mpg-CN) and a homogeneous nickel catalyst with visible-light irradiation at room temperature affords the C(sp2)-C(sp3) cross-coupling of aryl halides and potassium alkyl trifluoroborates by single electron transmetallation. Like the homogeneously catalyzed protocol, the reaction is compatible with a variety of functional groups including electron-donating and electron-withdrawing aryl and heteroaryl moieties. Moreover, this protocol allows the installation of allyl groups onto (hetero)arenes, enlarging the scope of the method. The heterogeneous mpg-CN photocatalyst is easily recovered from the reaction mixture and reused several times, paving the way for larger-scale industrial applications of this type of photocatalytic bond-forming reactions.

ACS Catalysis published new progress about Cross-coupling reaction catalysts. 89793-12-4 belongs to class pyrimidines, and the molecular formula is C7H7ClN2O2, Related Products of 89793-12-4.

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Elston, C.; Holmes, D. E.; Moorthy, P. N.; Pleticha-Lansky, R. published the artcile< Effects of γ-radiation on alloxantin. Polarographic, oscillopolarographic, and electron spin resonance studies>, Computed Properties of 2244-11-3, the main research area is alloxantin irradiation ESR.

Polarographic and oscillopolarographic investigation of the effects of γ-radiation on an aqueous solution of alloxantin showed the formation of alloxan, parabanic acid, and oxaluric acid. In addition an unidentified product X was observed, exhibiting cathodic wave at E1/2≈-1 V on polarography in acetate buffer of pH 3.6. This product is due probably to a higher oxidation state of alloxan and undergoes polarographic reduction at more neg. potentials than parabanic acid. ESR signals have been observed in γ-irradiated polycrystalline alloxantin-dihydrate, alloxan-monohydrate, dialuric acid, and parabanic acid. The G-values for the formation of the radicals responsible for these signals were determined Signals were also observed from organic free radicals formed through the reactions of electrons induced in irradiated H2SO4 ices containing alloxantin and alloxan.

International Journal for Radiation Physics and Chemistry published new progress about ESR (electron spin resonance). 2244-11-3 belongs to class pyrimidines, and the molecular formula is C4H4N2O5, Computed Properties of 2244-11-3.

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Solberg, Jan; Undheim, Kjell published the artcile< Regiochemistry in palladium-catalyzed organotin reactions with halopyrimidines>, Recommanded Product: 4,5-Dichloro-2-(methylthio)pyrimidine, the main research area is halopyrimidine coupling organotin palladium catalyzed; regiochem halopyrimidine coupling organotin.

Chlorines in activated pyrimidine position are replaced by carbon substituents in Pd-catalyzed reactions with organotin compounds The 4(6)-position is more reactive than the 2-position allowing for regioselective coupling in 2,4(6)-dihalopyrimidines. A bromine substituent is required for coupling in the benzenoid 5-position. In 5-bromo-2,4-dichloropyrimidine the 4-chlorine is replaced before the 5-bromine and the latter before the 2-chlorine substituent, all in a regioselective manner. The methodol. can be used to introduce functionalized carbon substituents into any pyrimidine position.

Acta Chemica Scandinavica published new progress about Coupling reaction. 99469-85-9 belongs to class pyrimidines, and the molecular formula is C5H4Cl2N2S, Recommanded Product: 4,5-Dichloro-2-(methylthio)pyrimidine.

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Lee, Kuan Han; Han, Chein Hwa; Hwang, Long Chih; Wang, Eng Chi; Tzeng, Cherng Chyi published the artcile< Acyclic nucleosides. Part 3: Synthesis of certain 1-[(1,3-dihydroxy-2-propoxy)methyl]-6-azauracils as potential antiviral agents>, Category: pyrimidines, the main research area is acyclic nucleoside azauracil preparation virucide; hydroxypropoxymethylazauracil acyclic nucleoside.

A number of 6-azauracils were trimethylsilylated and then coupled with 1,3-dibenzyloxy-2-chloromethoxypropane to give 1-[(1,3-dibenzyloxy-2-propoxy)methyl]-6-azauracils which were debenzylated with either BCl3 or Pd2O to yield the title compounds I (R = H, Me, Cl, Br).

Gaoxiong Yixue Kexue Zazhi published new progress about Acyclonucleosides Role: SPN (Synthetic Preparation), PREP (Preparation). 4956-05-2 belongs to class pyrimidines, and the molecular formula is C3H2BrN3O2, Category: pyrimidines.

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Chen, Yong; Wang, Xiaoyan; Xiang, Wei; He, Lin; Tang, Minghai; Wang, Fang; Wang, Taijin; Yang, Zhuang; Yi, Yuyao; Wang, Hairong; Niu, Ting; Zheng, Li; Lei, Lei; Li, Xiaobin; Song, Hang; Chen, Lijuan published the artcile< Development of Purine-Based Hydroxamic Acid Derivatives: Potent Histone Deacetylase Inhibitors with Marked in Vitro and in Vivo Antitumor Activities>, HPLC of Formula: 89793-12-4, the main research area is purine hydroxamic acid derivative preparation histone deacetylase inhibitor cancer.

In the present study, a series of novel histone deacetylase (HDAC) inhibitors using the morpholinopurine as the capping group were designed and synthesized. Several compounds demonstrated significant HDAC inhibitory activities and antiproliferative effects against diverse human tumor cell lines. Among them, compound 10o was identified as a potent class I and class IIb HDAC inhibitor with good pharmaceutical profile and druglike properties. Western blot anal. further confirmed that 10o more effectively increased acetylated histone H3 than panobinostat (LBH-589) and vorinostat (SAHA) at the same concentration in vitro. In in vivo efficacy evaluations of HCT116, MV4-11, Ramos, and MM1S xenograft models, 10o showed higher efficacy than SAHA or LBH-589 without causing significant loss of body weight and toxicity. All the results indicated that 10o could be a suitable candidate for treatment of both solid and hematol. cancer.

Journal of Medicinal Chemistry published new progress about Antitumor agents. 89793-12-4 belongs to class pyrimidines, and the molecular formula is C7H7ClN2O2, HPLC of Formula: 89793-12-4.

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Yoon, Hyung; Galls, Alexandra; Rozema, Soren D.; Miller, Scott J. published the artcile< Atroposelective Desymmetrization of Resorcinol-Bearing Quinazolinones via Cu-Catalyzed C-O Bond Formation>, Formula: C7H7ClN2O2, the main research area is resorcinol quinazolinone preparation enantioselective; quinazolinone aryl bromide Ullmann coupling atroposelective desymmetrization copper catalyst.

Enantioselective Cu-catalyzed C-O cross coupling reactions yielding atropisomeric resorcinol-bearing quinazolinones have been developed. By utilizing a new guanidinylated dimeric peptidic ligand, products I (R = H, Br, R1 = H, NO2, CF3, R2 = Me, Et, R3 = H, Me, OMe, R4 = H, OMe, X = CH; R = R1 = R3 = R4 = H, R2 = Me, X = N) were generated in good yields with excellent stereocontrol. The transformation was readily scalable and a range of product derivatizations were performed.

Organic Letters published new progress about Aryl bromides Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 89793-12-4 belongs to class pyrimidines, and the molecular formula is C7H7ClN2O2, Formula: C7H7ClN2O2.

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Mohammadi, Ali; Eshghi, Hossein; Bakavoli, Mehdi; Hadizadeh, Farzin; Moradi, Hassanali published the artcile< Synthesis of novel 3-substituted-5H-benzo[5,6][1, 4]thiazino[3,2-e][1,2,4]triazines and their 15-lipoxygenase inhibitory activity>, Synthetic Route of 4956-05-2, the main research area is benzothiazinotriazine preparation mol docking lipoxygenase inhibitor.

A new group of 3-substituted-5H-benzo[5,6][1,4]thiazino[3,2-e][1,2,4]triazines I (R = morpholin-4-yl, pyrrolidin-1-yl, 4-methylpiperidin-1-yl, etc.) was designed, synthesized and evaluated as inhibitors of 15-lipoxygenase (15-LO), and the results were compared with those of standard ligand 4-methyl-2-(4-methylpiperazin-1-yl)pyrimido[4,5-b][1,4]benzothiazine (4-MMPB). Among the newly designed ligands I, compound I (R = 4-phenylpiperazin-1-yl) showed the best IC50 of 15-LO inhibition (IC50 = 38 μM). The docking calculations were performed in MOE software based on the function of force-field scoring, in order to study the interaction of these new compounds I and standard ligand with 15-LO. The docking study implied that these ligands I have hydrogen bond interaction with the residue of active site of 15-LO.

Journal of the Iranian Chemical Society published new progress about Cyclic amines Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 4956-05-2 belongs to class pyrimidines, and the molecular formula is C3H2BrN3O2, Synthetic Route of 4956-05-2.

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Hin, Niyada; Duvall, Bridget; Ferraris, Dana; Alt, Jesse; Thomas, Ajit G.; Rais, Rana; Rojas, Camilo; Wu, Ying; Wozniak, Krystyna M.; Slusher, Barbara S.; Tsukamoto, Takashi published the artcile< 6-Hydroxy-1,2,4-triazine-3,5(2H,4H)-dione Derivatives as Novel D-Amino Acid Oxidase Inhibitors>, Quality Control of 4956-05-2, the main research area is hydroxytriazinedione preparation amino acid oxidase inhibitor.

A series of 2-substituted 6-hydroxy-1,2,4-triazine-3,5(2H,4H)-dione derivatives were synthesized as inhibitors of D-amino acid oxidase (DAAO). Many compounds in this series were found to be potent DAAO inhibitors, with IC50 values in the double-digit nanomolar range. The 6-hydroxy-1,2,4-triazine-3,5(2H,4H)-dione pharmacophore appears metabolically resistant to O-glucuronidation unlike other structurally related DAAO inhibitors. Among them, compound I was found to be selective over a number of targets and orally available in mice. Furthermore, oral coadministration of D-serine with I enhanced the plasma levels of D-serine in mice compared to the oral administration of D-serine alone, demonstrating its ability to serve as a pharmacoenhancer of D-serine.

Journal of Medicinal Chemistry published new progress about Alkylation. 4956-05-2 belongs to class pyrimidines, and the molecular formula is C3H2BrN3O2, Quality Control of 4956-05-2.

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Casimiro-Garcia, Agustin; Allais, Christophe; Brennan, Agnes; Choi, Chulho; Dower, Gabriela; Farley, Kathleen A.; Fleming, Margaret; Flick, Andrew; Frisbie, Richard K.; Hall, Justin; Hepworth, David; Jones, Hannah; Knafels, John D.; Kortum, Steve; Lovering, Frank E.; Mathias, John P.; Mohan, Sashi; Morgan, Paul M.; Parng, Chuenlei; Parris, Kevin; Pullen, Nick; Schlerman, Franklin; Stansfield, John; Strohbach, Joseph W.; Vajdos, Felix F.; Vincent, Fabien; Wang, Hong; Wang, Xiaolun; Webster, Robert; Wright, Stephen W. published the artcile< Discovery of a Series of Pyrimidine Carboxamides as Inhibitors of Vanin-1>, Recommanded Product: Ethyl 2-chloropyrimidine-5-carboxylate, the main research area is pyrimidine carboxamide vanin inhibitor pharmacokinetic ADME.

A diaryl ketone series was identified as vanin-1 inhibitors from a high-throughput screening campaign. While this novel scaffold provided valuable probe 2 that was used to build target confidence, concerns over the ketone moiety led to the replacement of this group. The successful replacement of this moiety was achieved with pyrimidine carboxamides derived from cyclic secondary amines that were extensively characterized using biophys. and crystallog. methods as competitive inhibitors of vanin-1. Through optimization of potency and physicochem. and ADME properties, and guided by co-crystal structures with vanin-1, 3 was identified with a suitable profile for advancement into preclin. development.

Journal of Medicinal Chemistry published new progress about Crystal structure. 89793-12-4 belongs to class pyrimidines, and the molecular formula is C7H7ClN2O2, Recommanded Product: Ethyl 2-chloropyrimidine-5-carboxylate.

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Shih, Chuan; Gossett, L. S. published the artcile< The synthesis of N-{2-amino-4-substituted [(pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl}-L-glutamic acids as antineoplastic agents>, Computed Properties of 84955-32-8, the main research area is neoplasm inhibitor aminopyrrolopyrimidinylethylbenzoylglutamic acid; pyrrolopyrimidine folate antagonist antitumor; LY 231514 analog neoplasm inhibitor.

A variety of 4-substituted pyrrolo[2,3-d]pyrimidine based folate antagonists, e.g. I (R = Cl, H, OMe, NH2, SH, NEt2) which are closely related to the novel thymidylate synthase inhibitor LY231514 were prepared 2-Amino-4-chloropyrrolo[2,3-d]pyrimidine (II; R = Cl, R1 = R2 = H) was selected as an important precursor for the preparation of key intermediates such as II (R = Cl, OMe, NEt2, NHCH2Ph, R1 = iodo, CCH, R2 = Me3CCO) (III). Pyrrolopyrimidines III were coupled with either 4-ethynylbenzoylglutamate or 4-iodobenzoylglutamate in a Pd-catalyzed Heck reaction to provide the basic skeleton of the targeted mols. The availability of the chlorine atom allowed the efficient introduction of different substituents at the 4-position of the pyrrolopyrimidine ring. In vitro anal. demonstrated that some I are highly cytotoxic against human leukemic cells (CCRF-CEM) in culture.

Heterocycles published new progress about Antitumor agents. 84955-32-8 belongs to class pyrimidines, and the molecular formula is C7H8N4O, Computed Properties of 84955-32-8.

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia