Tag: M.W:100-200

Related Products of 14001-69-5, Adding some certain compound to certain chemical reactions, such as: 14001-69-5, name is 2-Methoxy-5-nitropyrimidine,molecular formula is C5H5N3O3, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 14001-69-5.

Under 2 atmosphere, a suspension of 2-methoxy-5-nitropyrimidine (180 mg, 1.16 mmol, 1.00 equiv) and 5% Rh/C (13.8 mg, 0.60 moll Rh) in THF (11.6 mL, 0.100 M) was stirred at 23 C. Hydrazine monohydrate (69.7 mg, 1.39 mmol, 1.20 equiv) was added dropwise. The reaction 15 mixture was stirred at 23 C for 20 min. NaHCC>3 (117 mg, 1.39 mmol, 1.20 equiv) was added, followed by dropwise addition of a solution of acetyl chloride (109 mg, 1.39 mmol, 1.20 equiv) in THF (11.6 mL, 0.120 M) . The reaction mixture was stirred at 23 C for 30 min and then filtered through a short pad of celite. The celite was washed 20 with EtOAc. The combined organic solution was concentrated in vacuo. . The residue was purified by chromatography on silica gel, eluting with hexanes : EtOAc (2:1 to 0:1 (v/v)), to afford the title compound as a gray gum (125 mg, 0.682 mmol, 59% yield). Rf = 0.33 (EtOAc). NMR Spectroscopy: NMR (700 MHz, (CD3)2SO, 25 C, delta) : 10.93 (br. s, 1H) , 25 8.81 (s, 2H) , 3.91 (s, 3H) , 2.22 (br. s., 3H) . 13C NMR (175 MHz, (CD3)2SO, 25 C, delta) : 170.7, 161.8, 151.0, 131.8, 54.9, 21.6. Mass Spectrometry: HRMS (ESI-TOF) (m/z): calcd for C7H10N3O3 ( [M + H] + ), 184.0717, found, 184.0718.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 14001-69-5, 2-Methoxy-5-nitropyrimidine, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; THE RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK; NGAI, Ming-Yu; HOJCZYK, Katarzyna, N.; (214 pag.)WO2016/57931; (2016); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 55405-67-9, name is 3-Bromopyrazolo[1,5-a]pyrimidine, molecular formula is C6H4BrN3, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. Product Details of 55405-67-9

PREPARATION 107 3-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)pyrazolo[1,5-a]pyrimidine [Show Image] A mixture of 3-bromopyrazolo[1,5-a]pyrimidine (1.00 g, 5.1 mmol), potassium acetate (1.78 g, 18.1 mmol) and bis(pinacolato)diboron (5.77 g, 22.7 mmol) in 1,4-dioxane (20 mL) contained in a Schlenck vessel was submitted to three vacuum-argon cycles and bis(triphenylphosphine)palladium(II) dichloride (0.180 g, 0.26 mmol) was then added. The mixture was further submitted to three vacuum-argon cycles, sealed and then was stirred and heated to 100 C. After 20 hours, the reaction mixture was cooled, evaporated and then taken up in pentane and filtered through diatomaceous earth (Celite) and the filter cake was washed with a mixture of ethyl acetate/ether (3:2). The combined filtrate and washings were evaporated and the residue was stirred with n-pentane (15 mL) at -40 C for 30 minutes. The solid was filtered, washed with cold pentane and dried in vacuo to give the title compound (1.66 g, >100%) as a solid which was used without further purification. LRMS (m/z): 246 (M+1)+.1H NMR (300 MHz, CDCl3) delta ppm 1.26 (s, 12H), 6.89 (dd, 1H), 8.44 (s, 1H), 8.63 – 8.83 (m, 2H).

With the rapid development of chemical substances, we look forward to future research findings about 55405-67-9.

Reference:
Patent; Almirall, S.A.; EP2397482; (2011); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Electric Literature of 2164-84-3, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 2164-84-3, name is 4,6-Diamino-5-nitropyrimidine. A new synthetic method of this compound is introduced below.

0022; 0025; 0027; 0030; 0032; 0035; 0037; 0040

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,2164-84-3, its application will become more common.

Reference:
Patent; Nanjing Puruida Pharmaceutical Technology Co., Ltd.; Wang Xiaobo; (6 pag.)CN110407757; (2019); A;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Electric Literature of 30129-57-8, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 30129-57-8, name is 6-Methyl-1H-pyrazolo[3,4-d]pyrimidin-4(7H)-one. This compound has unique chemical properties. The synthetic route is as follows.

3-Iodo-6-methyl-1 ,5-dihydro-4H-pyrazolo[3,4-dJpyrimidin-4-one. To a stirred20 suspension of 6-methyl-1H-pyrazolo[3,4-d]pyrimidin-4(5H)-one (80.0 g, 533 mmol) in dimethylacetamide (800 mL) was added N-iodosuccinimide (180 g, 799 mmol) portion-wise over aperiod of 30 min. The reaction mixture vas heated to 130C for 3 hours. The reaction mixturewas cooled to 0C and poured into a saturated aqueous solution ofNa2S203 (1.8 L) with stining.The mixture was allowed to settle for 3 h and the precipitated brown solid was filtered. The25 isolated brown solid was suspended in THF:Cf:bCN:MeOH:FhO (3:3:2:3) and stirred for 16 h.The resulting solid was filtered and dried under vacuum to provide the title compound (60 g,41 ~o) as a brown solid. 1H NNIR (400 NIHz, DMSO-do) 8 13.02 (s, 1H), 12.04 (s, 1H), 2.32 (s,3H). [M+H] ‘” 276.9.

According to the analysis of related databases, 30129-57-8, the application of this compound in the production field has become more and more popular.

Reference:
Patent; DART NEUROSCIENCE, LLC; GOMEZ, Laurent; VERNIER, William, Francois; (104 pag.)WO2018/125810; (2018); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Synthetic Route of 274-71-5, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 274-71-5, name is Pyrazolo[2,3-a]pyrimidine, molecular formula is C6H5N3, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

To a solution of pyrazolo[1,5-ajpyrimidine (1 g, 8.39 mmol) in acetonitrile (5 mL) was added NBS (1.494 g, 8.39 mmol) and the reaction mixture stirred at room temperature for 8 h. The reaction mixture was concentrated under reduced pressure and the residue purified by silica gel chromatography (0-30% petroleum ether/EtOAc) to afford 3-bromopyrazolo[1,5-ajpyrimidine (1.2 g, 6.06 mmol, 72% yield) as a brown solid. LCMS (ESI) m/e 198.0 [(M+H), calcd for C6H5BrN3198.01; LC/MS retention time (method A2): tR = 1.43 mm.

According to the analysis of related databases, 274-71-5, the application of this compound in the production field has become more and more popular.

Reference:
Patent; BRISTOL-MYERS SQUIBB COMPANY; BRONSON, Joanne J.; CHEN, Ling; DITTA, Jonathan L.; DZIERBA, Carolyn Diane; JALAGAM, Prasada Rao; LUO, Guanglin; MACOR, John E.; MAISHAL, Tarun Kumar; NARA, Susheel Jethanand; RAJAMANI, Ramkumar; SISTLA, Ramesh Kumar; THANGAVEL, Soodamani; (318 pag.)WO2017/59080; (2017); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Synthetic Route of 38275-61-5 ,Some common heterocyclic compound, 38275-61-5, molecular formula is C5H3ClN2O2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

5-Chloro-pyrimidine-2-carboxylic acid {4-[2-((S)-2-amino-4,5-dihydro-oxazol-4-yl)-ethyl]-phenyl}-amide The title compound was obtained in analogy to example S3 using 5-chloropyrimidine-2-carboxylic acid (CAS 38275-61-5) instead of 4-chlorobenzoic acid in step c). White solid. MS (ISP): 348.3 ([{37Cl}M+H]+), 346.1 ([{35Cl}M+H]+).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 38275-61-5, 5-Chloropyrimidine-2-carboxylic acid, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Hoener, Marius; Raab, Susanne; Risterucci, Celine; Sewing, Sabine; US2012/28964; (2012); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Electric Literature of 20651-30-3, Adding some certain compound to certain chemical reactions, such as: 20651-30-3, name is 5-Methyl-2-(methylthio)pyrimidin-4(3H)-one,molecular formula is C6H8N2OS, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 20651-30-3.

(4) 15 g of the Compound [156-3] was dissolved in 50 mL of phosphorus oxychloride, and the solution was stirred at 120°C for 2 hours. The reaction solution was immersed in broken ice, extracted with chloroform, filtered, concentrated, and purified by silica gel column chromatography to obtain 13 g of the target compound [156-4]. [Show Image] The spectral data of the compound represented by the above Formula [156-4] is presented below. mass: 175 (M+1)+.

According to the analysis of related databases, 20651-30-3, the application of this compound in the production field has become more and more popular.

Reference:
Patent; BANYU PHARMACEUTICAL CO., LTD.; EP1754706; (2007); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Adding a certain compound to certain chemical reactions, such as: 99420-75-4, 5-Methylpyrimidine-2-carboxylic acid, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Safety of 5-Methylpyrimidine-2-carboxylic acid, blongs to pyrimidines compound. Safety of 5-Methylpyrimidine-2-carboxylic acid

To a solution of methanol (50 mL) was added SOCl2 (5.17 g, 43.5 mmol, 3.00 equiv) dropwise at 0 C. The resulting solution was stirred for 0.5 h at 25 C. This was followed by the addition of 5-methylpyrimidine-2-carboxylic acid [Example 9, Step 1] (2 g, 14.5 mmol, 1.00 equiv). The resulting solution was stirred for 1 h at 65 C. The resulting mixture was concentrated under vacuum to remove methanol and SOCl2. The resulting solution was diluted with H2O (30 mL). The resulting solution was extracted with ethyl acetate (3×30 mL). The organic layers were dried over anhydrous sodium sulfate and concentrated under vacuum to afford 2 g (90.7%) of methyl 5-methylpyrimidine-2-carboxylate as a yellow solid. LC-MS: m/z=153 [M+H]+.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,99420-75-4, 5-Methylpyrimidine-2-carboxylic acid, and friends who are interested can also refer to it.

Reference:
Patent; Auspex Pharmaceuticals, Inc.; ZHANG, Chengzhi; (94 pag.)US2018/79742; (2018); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Synthetic Route of 89792-07-4, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 89792-07-4, name is 2-Methyl-7H-pyrrolo[2,3-d]pyrimidine. This compound has unique chemical properties. The synthetic route is as follows.

An equal volume of dichloromethane (50 ml) and tetrahydrofuran (50 ml) were mixed,The compound 2-methyl-7H- [2,3-d] pyrrolopyrimidine (10 mmol) was added to the system,After stirring for 20 minutes,System cooling to 0-5 ,JoinTribromopyridinium(20 mmol),The system continues at 0-5 CStirring for 1 hour,The reaction mixture was slowly added to an aqueous solution of saturated sodium carbonate. The system was stirred at 20 C overnight and under reduced pressure Filtered, washed with water, dried at 55 C,To give 1.8 g of a yellow solid 4-bromo-2-methyl-7H- [2,3-d] pyrrolopyrimidine in 85% yield.

According to the analysis of related databases, 89792-07-4, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Liu Shuangwei; (11 pag.)CN106967073; (2017); A;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 1321618-96-5, name is 4-Chloro-5-methylfuro[2,3-d]pyrimidine. This compound has unique chemical properties. The synthetic route is as follows. Application In Synthesis of 4-Chloro-5-methylfuro[2,3-d]pyrimidine

To a solution of 4-chloro-5-methylfuro[2,3-d]pyrimidine (12, 85 mg, 0.5 mmol) and 4-methoxy-N-methylaniline (5, 80 mg, 5.75 mmol) in 2 mL of anhydrous isopropanol (IPA) added 2 drops of concentrated HC1 and the reaction mixture was stirred at room temperature overnight. The brown precipitate was collected by filtration, washed with cold isopropanol, and dried under vacuum to afford compound 2 (95 mg, 75 %) as brown solid. Analytical data of compound 2 is identical with the product obtained using previous method.12

With the rapid development of chemical substances, we look forward to future research findings about 1321618-96-5.

Reference:
Patent; THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK; KUMAR, Dileep; MANN, J., John; (109 pag.)WO2019/89575; (2019); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia