Tag: M.W:100-200

Reference of 1993-63-1, Adding some certain compound to certain chemical reactions, such as: 1993-63-1, name is 5-Fluoro-2-methoxypyrimidin-4-amine,molecular formula is C5H6FN3O, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 1993-63-1.

Take 27.2kg of Intermediate 5 prepared in the previous step and mix with sulfuric acid, raise the temperature to 95-105 C, maintain the temperature for 1.5h, and then lower the temperature. Then add the mixture to water, adjust the pH to 8-9, cool, and stand still. Set, filter, and dry to obtain 23.3 kg of crude product with a yield of 95.0%. Step 6: Take 20.5 kg of the crude product prepared in the previous step and mix it with 200 kg of water, add 0.6 kg of activated carbon, stir and raise the temperature, maintain the temperature for 1 h, and filter. The resulting mother liquor is cooled and crystallized, filtered, and dried to obtain 19.7 kg of 5-fluorocytosine. The yield is 96.1%, and the purity of HPLC is 99.9% or more. According to the reaction yield of each step, the total yield of the process route provided by the present invention is 57.3%.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 1993-63-1, 5-Fluoro-2-methoxypyrimidin-4-amine, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Zhejiang Pioneer Technology Co., Ltd.; Gao Junlong; Gao Feifei; Li Ming; Chen Xiaoping; Wei Chenhui; (8 pag.)CN108033917; (2019); B;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 87253-62-1, name is 5,7-Dimethyl-[1,2,4]triazolo[1,5-a]pyrimidine-2-carboxylic acid. This compound has unique chemical properties. The synthetic route is as follows. Formula: C8H8N4O2

General procedure: In 25ml RB flask to a solution of Compound 9 (200 mg) in dry DMF (5ml), EDCI (250 mg, 1.25eq) and DMAP (130 mg,1eq) were added followed by addition of Sulfonamide (1eq). RM was stirred at RT for 4hrs. Solvent from the reaction mixture was evaporated. To the residue water was added and acidified with 6N HCl, solid precipitated out. Solid was filtered and dried. Crude solid was purified by flash chromatography eluating with 4-8% MeOH/DCM as solvent system to give pure product.

With the rapid development of chemical substances, we look forward to future research findings about 87253-62-1.

Reference:
Article; Patil, Vikas; Kale, Manoj; Raichurkar, Anandkumar; Bhaskar, Brahatheeswaran; Prahlad, Dwarakanath; Balganesh, Meenakshi; Nandan, Santosh; Shahul Hameed; Bioorganic and Medicinal Chemistry Letters; vol. 24; 9; (2014); p. 2222 – 2225;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Related Products of 3438-61-7 ,Some common heterocyclic compound, 3438-61-7, molecular formula is C5H7N3, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

4-methylpyrimidin-5-amine (1.09 g, 10 mmol) was dissolved in dry THF (150 mL) under nitrogen. The solution was cooled to -78C and a solution of n-BuLi was added dropwise. The solution was kept at the same temperature for 30min and then warm to r.t., stirred for 2h. Then cooled to -78C, ethyl benzoate (1.5 g, 10 mmol) in THF (30 mL) was added, and the resulting mixture was stirred at -78C for 30min, and was warmed to r.t. for lh. The reaction mixture was quenched with drop some water, and neutralized with NaHC03. EtOAc and water were added, portioned. The organic layer was concentrated and purified by by flush column chromatography on silica gel (eluting with petroleum ether/ethyl acetate =100/1-0/1), to give the title product 6-phenyl-5H-pyrrolo[3,2-d]pyrimidine (0.8 g, 41%). MS (ESI) m/z :196.1 [M+1]+.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 3438-61-7, 5-Amino-4-methylpyrimidine, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; ARRAY BIOPHARMA INC.; GENENTECH, INC.; SKELTON, Nicholas; GRADL, Stefan; BLAKE, James F.; GRAHAM, James M.; GUNAWARDANA, Indrani W.; HENTEMANN, Martin; MARLOW, Allison L.; TANG, Tony P.; WO2013/78254; (2013); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Electric Literature of 85989-61-3 ,Some common heterocyclic compound, 85989-61-3, molecular formula is C6H3Cl2N3, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

Example 16A; 6-({2-[(7-Chloroimidazo[1,2-c]pyrimidin-5-yl)amino]ethyl}amino)nicotinonitrile 707 mg (3.20 mmol) of 5,7-dichloroimidazo[1,2-c]pyrimidine (Example 11A) are suspended in 25 ml of 2-propanol, and 1.35 g (3.52 mmol) of 6-[(2-aminoethyl)amino]nicotinonitrile trifluoroacetate (Example 13A) and 1.03 g (7.99 mmol) of DIPEA are added. The mixture is heated at 80 C. for 16 h. After this time, water is added and the precipitate which has separated out is filtered off with suction. It is washed with a little 2-propanol/water and the resulting solid is dried under high vacuum. 523 mg (50% of theory) of the product are obtained.LCMS (method 3): Rt=1.31 min. (m/z=314 (M+H)+)1H-NMR (400 MHz, DMSO-d6): delta=8.37 (d, 1H), 8.33 (t, 1H), 7.93 (s, 1H), 7.80 (s, 1H), 7.68 (d, 1H), 7.50 (d, 1H), 6.90 (s, 1H), 6.56 (s, br, 1H), 3.62 (m, 2H), 3.31 (m, 2H).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,85989-61-3, its application will become more common.

Reference:
Patent; BAYER SCHERING PHARMA AKTIENGESELLSCHAFT; US2010/113441; (2010); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Reference of 1122-47-0, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 1122-47-0, name is 4-Amino-1-methylpyrimidin-2(1H)-one. A new synthetic method of this compound is introduced below.

To a water solution (5 mL) of 1-Methylcytosine (1-Mecyt) (0.025 g, 0.2 mmol) was added dropwise and under stirring, an aqueous solution of BaCl2·2H2O (0.049 g, 0.2 mmol) at 60 C.The colorless mixture was left to evaporate and afforded colorless crystals within 2-3 days, upon very slow evaporation at room temperature. Yield: 65%; IR (KBr, nu/cm-1): 3421, 3326,3245, 3155 (O-H), 2911 (C-H), 1665, 1632, 1630, 1570 (C=O). Anal. Calcd for C5H9N3O2Cl2Ba(350.91 g mol-1): C, 17.09; H, 2.58; N, 11.96%. Found C, 17.89; H, 2.92; N, 10.99%. Compound 2 was prepared following the same synthetic protocol as for 1 using an aqueous solution(5 mL) of BaBr2·2H2O (0.067 g, 0.2 mmol). Yield: 65%; IR (KBr, nu/cm-1): 3420, 3321, 3236, 3149(O-H), 2907 (C-H), 1670, 1639, 1622, 1569 (C=O). Anal. Calcd for C5H9N3O2Br2Ba (440.28 gmol-1): C, 13.64; H, 2.06; N, 9.54%. Found C, 13.24; H, 2.50; N, 9.05%.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,1122-47-0, 4-Amino-1-methylpyrimidin-2(1H)-one, and friends who are interested can also refer to it.

Reference:
Article; Marino, Nadia; Bruno, Rosaria; Armentano, Donatella; De Munno, Giovanni; Journal of Coordination Chemistry; vol. 71; 6; (2018); p. 828 – 844;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 175277-33-5, name is 4-(Dimethoxymethyl)-2-methylpyrimidine. This compound has unique chemical properties. The synthetic route is as follows. Application In Synthesis of 4-(Dimethoxymethyl)-2-methylpyrimidine

4-Dimethoxymethyl-2-methyl-pyrimidine (4.5 g, 26.7 mmol) was added to a solution of HBr (48% in H2O, 10 niL) and stirred at room temperature for 2 hours. It was then diluted with water and washed with diethylether (2x). The aqueous layer was carefully neutralized with saturated sodium carbonate and extracted with ethyl acetate (2x). The combined extracts were dried over MgSO4. 2-Propanol (100 mL) was added. To this solution, aniline (2.5 mL, 26.7 mmol) was added and followed with diphenylphosphite (5.1 mL, 26.7 mmol). The reaction mixture was stirred at room temperature overnight and then concentrated. The residue was purified on silica gel column with 20% ethyl acetate/CH2Cl2 to give a yellow solid (3.3 g, 29% for 2 steps) as the desired product. MS (ESP+) m/z 432.2 (M + 1).

With the rapid development of chemical substances, we look forward to future research findings about 175277-33-5.

Reference:
Patent; BIOGEN IDEC MA INC; WO2006/26305; (2006); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Electric Literature of 13053-88-8, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 13053-88-8, name is N-(Pyrimidin-2-yl)acetamide. This compound has unique chemical properties. The synthetic route is as follows.

General procedure: For complexes 1-8, a warm solution of ca. two equivalents of ligand (0.151 mmol) in absolute EtOH (10 cm3) was added to a warm solution of [Cd(tsac)2(H2O)] (0.040 g, 0.076 mmol) in absolute EtOH (10 cm3). The mixture was heated to reflux for 3 h. After cooling to room temperature it was filtered and evaporated to half volume. Further slow evaporation of EtOH over several days gave a yellow solid which was collected, washed with absolute EtOH anddried under vacuum

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 13053-88-8, N-(Pyrimidin-2-yl)acetamide.

Reference:
Article; Al-Jibori, Subhi A.; Al-Bayati, Mohamed M.A.; Gergees, Hayfa M.; Wagner, Christoph; Hogarth, Graeme; Inorganica Chimica Acta; vol. 459; (2017); p. 73 – 79;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Electric Literature of 1480-66-6 ,Some common heterocyclic compound, 1480-66-6, molecular formula is C5H3ClF3N3, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

Key Intermediate 5 fljit-5″): (6-Chloro-24rifluoromethyl-pyrimidin-4-ylV[“5-(3-ethoxy- benzenesulfonyl)-thiazol-2-vn-amine[0114] A mixture of 4-amino-6-chloro-2-trifluoromethyl-pyrimidine [(Inoue, S. et al, J.Org. Chem., 1961, 26, 4504) 185 mg, 0.94 mol] and NaH (60% dispersion in mineral oil, 40 mg, 1.0 mmol) in DMF (4.0 mL) was stirred, under Ar, at RT for 30 min. A solution of Intl -A (326 mg, 0.94 mmol) in DMF (2.0 mL) was added. The reaction mixture was stirred at RT for 30 min and was heated at 55 0C for Ih. Additional NaH (60% dispersion in mineral oil, 20 mg, 0.05 mmol) was added, and the reaction mixture was heated at 55 0C overnight. Additional NaH (60% dispersion in mineral oil, 20 mg, 0.05 mmol) was added, and the reaction mixture was heated at 55 0C for 1 h. The reaction mixture was cooled to RT and partitioned between EtOAc (ca. 100 mL) and water (ca. 25 mL). The layers were separated and the organic phase was washed with saturated aqueous NaCl (I x 100 mL), dried (Na2SO4), and concentrated under reduced pressure to give an oil. This oil was purified by flash chromatography, elution with 25-75% EtOAc in hexanes, to give Int-5 (182 mg, 42%) as a foam. LCMS (m/z): 465, 467 (M+H)+

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 1480-66-6, 6-Chloro-2-(trifluoromethyl)pyrimidin-4-amine, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; ICAGEN, INC.; WO2007/75852; (2007); A2;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Application of 831203-15-7, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 831203-15-7, name is 2-(5-Bromopyrimidin-2-yl)acetonitrile. This compound has unique chemical properties. The synthetic route is as follows.

A solution of 2- (5-bromopyrimidin-2-yl) acetonitrile (0.1 (^, 0.50%)4-fluorophenylboronic acid (0.088, 0.601111111)Potassium carbonate (0.21 g, 1.50 mmol),Tetrakis (triphenylphosphine) palladium (0.3 g, 0.30 mmol)And toluene (10 mL) were successively added to a 50 mL reaction flask,The reaction was carried out with nitrogen and the reaction was carried out at 100 C for 8 hours.The reaction was quenched and the solvent was removed by distillation under reduced pressure. The remaining solid was extracted with dichloromethane (10 mL X), washed with organic phase, saturated brine (20 mL) and dried over anhydrous sodium sulfate. The solvent was removed by distillation under reduced pressure. The title compound (white solid, 0.088, 80.1%) was obtained by silica gel column chromatography (petroleum ether / acetone (nu / nu) = 20/1)

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 831203-15-7, 2-(5-Bromopyrimidin-2-yl)acetonitrile.

Reference:
Patent; Guangdong Dongyangguang Pharmaceutical Co., Ltd.; Jin Chuanfei; Wei Dehuo; Xue Yaping; Zhang Yingjun; (44 pag.)CN106674207; (2017); A;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 55405-67-9, name is 3-Bromopyrazolo[1,5-a]pyrimidine. This compound has unique chemical properties. The synthetic route is as follows. Product Details of 55405-67-9

Weigh into a round bottom flask 3-bromopyrazolo [1, 5-a] pyrimidine (Lynch et al. Can. J. Chem. 1975, 53, 119-122; 0.095 g, 0.48 mmol), 2- (pyridin-2-yl)-5, 6-dihydro- 4H-pyrrolo [1, 2-b] pyrazole-3-boronic acid (Preparation 5; 0.10 g, 0.44 MMOL), triphenylphosphine (Aldrich; 0.007 g, 0.027 mmol) and tris (dibenzylideneacetone) dipalladium (0) (Aldrich; 0.015 g, 0.016 mmol). Add p-dioxane (6 ml) and 2. 0M aqueous potassium carbonate (2 mL). Stir and reflux under nitrogen for 6 h. Dilute with ethyl acetate, separate the organic layer, concentrate under reduced pressure, and chromatograph on flash silica using neat acetonitrile. Purify on a preparative reverse phase C-18 high-performance chromatography column using a gradient from 5% to 100% acetonitrile in 0.03% aqueous hydrochloric acid. Concentrate the pure fractions under reduced pressure, dissolve the residue in distilled water, and make basic by adding 1. OM aqueous sodium hydroxide. Extract with dichloromethane, dry the organic layer over anhydrous sodium sulfate, filter, and concentrate under reduced pressure to obtain 6 mg (4.5%) of the title compound as a yellow solid. TOF MS ES+ exact mass calculated for C17HL5N6 (MA : m/z = 303.1358 ; Found: 303. 1371.’H NMR (400 MHz, CDCL3) 8 8.66 (d, J = 2 Hz, 1H), 8. 64 (d, J = 2 Hz, 1H), 8.41 (dd, J = 4,2 Hz, 1H), 8.31 (s, 1H), 7.70 (M, 2H), 7.21 (M, 1H), 6.79 (dd, J = 7,4 Hz, 1H), 4.30 (t, J = 7 Hz, 2H), 3.10 (t, J = 8 Hz, 2H), 2.68 (M, 2H).

With the rapid development of chemical substances, we look forward to future research findings about 55405-67-9.

Reference:
Patent; ELI LILLY AND COMPANY; WO2004/50659; (2004); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia