Tag: M.W:100-200

Electric Literature of 4763-35-3 ,Some common heterocyclic compound, 4763-35-3, molecular formula is C5H7N3O2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

Preparation of 89 10240] Step 3. Into a 100 mE round bottom flask equippedwith a magnetic stir bar was placed 2-Amino-4-hydroxy-S-methoxy-pyrimidine (500 mg, 3.54 mmol), anhydrous DMF (30 mE), AA-13 (1.27 g, 5.31 mmol), DI3U (2.12 mE, 14.17 mmol), and HOP (1.96 g, 4.43 mmol). The reaction mixture was allowed to stir at room temperature for 30 minutes then at 50 c. for 16 hours. The solvent was removed under reduced pressure and the residue was partitioned between brine and ethyl acetate. The organic layers were combined, dried (magnesium sulfate), the solids were removed via filtration, andthe solvents of the filtrate were removed under reduced pressure. The crude was purified via reverse phase liquid chromatography (RP Vydac Denali c18-10 jim, 250 g, Scm. Mobilephase 0.25% NH4HcO3 solution in water, methanol), the bestfractions were pooled, the solvents were removed underreduced pressure to afford 89.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,4763-35-3, its application will become more common.

Reference:
Patent; McGowan, David; Raboisson, Pierr Jeane-Marie Bernar; Embrechts, Werner; Jonckers, Tim Hugo Maria; Last, Stefaan Julien; Pieters, Serge Maria Aloysius; Vlach, Jaromir; US2014/45849; (2014); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Electric Literature of 19858-50-5, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 19858-50-5, name is (2-(Methylthio)pyrimidin-5-yl)methanol. This compound has unique chemical properties. The synthetic route is as follows.

To a mixture of 113 (1.02 g, 653 mrnoi) and PPh3 (3.4g, 131 mmol)in DCM (50 mL) is added carbon tetrabromide (4.3 g, 13.1 rnrnoi). After stirring at room temperature for 16 hours, the mixture is diluted with DCM, washed with brine, dried over anhydrous sodium sulfate, filtered, concentrated, and purified by silica gel column chromatography (EA:PE 1:20) to give 137 as a pale yellow oil (900 mg, 63percent). (MS: [M÷H] 2190)

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 19858-50-5, (2-(Methylthio)pyrimidin-5-yl)methanol.

Reference:
Patent; IMMUNE SENSOR, LLC; THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM; ZHONG, Boyu; SUN, Lijun; SHI, Heping; LI, Jing; CHEN, Chuo; CHEN, Zhijian; (270 pag.)WO2017/176812; (2017); A1;,
Pyrimidine | C4H4N2 – PubChem,
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Electric Literature of 37482-64-7, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.37482-64-7, name is 2-Chloro-4-ethoxy-6-methylpyrimidine, molecular formula is C7H9ClN2O, molecular weight is 172.61, as common compound, the synthetic route is as follows.

EXAMPLE 11 4-Ethoxy-6-methyl-2-(1-pyrazolyl)pyrimidine In anhydrous tetrahydrofuran, 173 mg of 2-chloro-4-ethoxy-6-methylpyrimidine was substituted with 68 mg of pyrazole. The reaction mixture was treated according to the procedure of Example 5 to yield 110 mg of 4-ethoxy-6-methyl-2-(1-pyrazolyl)pyrimidine, an oily compound. NMR(CDCl3)delta: 1.40(3H,t,J=7 Hz), 2.40(3H,s), 4.50(2H,q,J=7 Hz), 6.4-6.6(2H,m), b 7.81(1H,bs), 8.28(1H,d,J=3 Hz).

The chemical industry reduces the impact on the environment during synthesis 37482-64-7, I believe this compound will play a more active role in future production and life.

Reference:
Patent; Nissin Shokuhin Kabushiki Kaisha; US4849424; (1989); A;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 110960-73-1, name is Ethyl 4-methylpyrimidine-5-carboxylate, the common compound, a new synthetic route is introduced below. Product Details of 110960-73-1

[229] Intermediate: 53: 4-methylpyrimidine-5-carboxylic acid: Intermediate 52 (2.6 g, 15.64 mmol) dissolved in sodium hydroxide solution (1.88 g, 47 mmol in 4 ml water) and refluxed. The reaction mixture was cooled to rt and acidified with con HCl to obtain the solid. Solid that obtained was filtered and dried to obtain the title compound (1.5 g) as an yellow solid. -NMR (delta ppm, DMSO-i , 400 MHz): 13.5 (bs, 1H), 9.14 (s, 1H), 9.05 (s, 1H), 2.71 (s, 3H).

The synthetic route of 110960-73-1 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; ICOZEN THERAPEUTICS PVT. LTD.; RHIZEN PHARMACEUTICALS S.A.; MUTHUPPALANIAPPAN, Peyyappan; VISWANADHA, Srikant; MERIKAPUDI, Gayatri, Swaroop; VAKKALANKA, Swaroop, Kumar, V.S.; WO2011/42797; (2011); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Related Products of 63206-77-9, Adding some certain compound to certain chemical reactions, such as: 63206-77-9, name is [1,2,4]Triazolo[4,3-a]pyrimidin-3(2H)-one,molecular formula is C5H4N4O, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 63206-77-9.

A mixture of 2H,3H-[1,2,4]triazolo[4,3-a]pyrimidin-3-one (20 mg, 0.15 mmol) (Intermediate 22) , 2-bromo-N-[(1S)-1-(4-chloro-3- fluorophenyl)ethyl]acetamide (43 mg, 0.15 mmol) (Intermediate 3) and potassium carbonate (61 mg, 0.44 mmol) in acetonitrile (2 mL) was heated to 60 C for 3 hours. The reaction was cooled and quenched into water. The aqueous layer was extracted into ethyl acetate three times, the combined organics were washed with brine, dried over MgSO4 and concentrated in vacuo. The residue was triturated with ethyl acetate and the solid material dried in vacuo to yield the title compound (22 mg, 43% yield).1H NMR (500 MHz, DMSO-d6) d 8.62 (d, J = 7.7 Hz, 1H), 8.55 (dd, J = 2.0, 3.8 Hz, 1H), 8.37 (dd, J = 2.0, 7.0 Hz, 1H), 7.54 (t, J = 8.1 Hz, 1H), 7.36 (dd, J = 1.9, 10.7 Hz, 1H), 7.20 (dd, J = 1.9, 8.3 Hz, 1H), 6.73 (dd, J = 3.8, 7.0 Hz, 1H), 4.94 (p, J = 7.0 Hz, 1H), 4.64 (d, J = 16.6 Hz, 1H), 4.59 (d, J = 16.6 Hz, 1H), 1.37 (d, J = 7.0 Hz, 3H). LCMS (Analytical Method A) Rt = 2.31min, MS (ESIpos): m/z= 350 [M+H]+, Purity = 98%.

According to the analysis of related databases, 63206-77-9, the application of this compound in the production field has become more and more popular.

Reference:
Patent; BLACKTHORN THERAPEUTICS, INC.; JONES, Robert M.; BRANDT, Gary; (506 pag.)WO2020/97609; (2020); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Application of 15846-19-2, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 15846-19-2, name is 4-Chloro-6-methoxypyrimidin-5-amine. This compound has unique chemical properties. The synthetic route is as follows.

Example P1 Preparation of STR6 N-(3′-Chloro-2′,6′-dinitro-4′-trifluoromethylphenyl)-5-amino-4-chloro-6-methoxypyrimidine 2.84 g (17.8 mmoles) of 5-amino-4-chloro-6-methoxypyrimidine are dissolved in 20 ml of dimethylsulfoxide. With stirring, a solution of 6.24 g (20.5 mmoles) of 1,3-dichloro-2,6-dinitro-4-trifluoromethylbenzene in 15 ml of dimethylsulfoxide and a solution of 2.30 g (20.5 mmoles) of potassium tert-butylate in 15 ml of dimethylsulfoxide are added simultaneously dropwise at 15 C. The dark red solution so obtained is stirred for 1 hour at 15-20 C. and then poured into ice-water, neutralised with acetic acid and extracted three time with chloroform. The extracts are dried over sodium sulfate and the solvent is removed by rotary evaporation, affording 7.9 g of an oil. This crude product is purified by chromatography through a column of silica gel affording 3.19 g of a crystalline product. Recrystallisation from a mixture of 2 ml of toluene and 8 ml of cyclohexane yields 2.52 g of yellow crystals of m.p. 114-116 C.

According to the analysis of related databases, 15846-19-2, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Ciba-Geigy Corporation; US4840662; (1989); A;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Adding a certain compound to certain chemical reactions, such as: 15846-19-2, 4-Chloro-6-methoxypyrimidin-5-amine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, HPLC of Formula: C5H6ClN3O, blongs to pyrimidines compound. HPLC of Formula: C5H6ClN3O

[Reference Example 1]; 4-Chloro-N-(4-chloro-6-methoxy-5-pyrimidinyl)-3-nitrobenzamide; 4-Chloro-3-nitrobenzoic acid (30.2 g, 150 mmol) was suspended in ethyl acetate (150 mL), and thionyl chloride (22 mL, 300 mmol) was added to the resulting suspension. The suspension was then heated under refluxing for 5 hours. The reaction mixture was concentrated under reduced pressure. The residue was concentrated utilizing two portions of dry benzene and two portions of dichloromethane. The resulting acid chloride was dissolved in dichloromethane (20 mL), and the resulting solution was added to a solution of 5-amino-4-chloro-6-methoxypyrimidine (16.0 g, 100 mmol) in dichloromethane (100 mL). The resulting mixture was heated under refluxing for 16 hours. The heated mixture was then cooled to room temperature, and the precipitated crystalline product was collected by filtration and washed with four portions of dichloromethane (20 mL), to obtain 34.3 g (yield 100%) of the titled compound as a white crystalline product. 1H-NMR (CDCl3) delta : 4.07 (3H, s), 7.35 (1H, s), 7.74 (1H, d, J=8Hz), 8.08 (1H, dd, J=2Hz, 8Hz), 8.42 (1H, d, J=2Hz), 8.55 (1H, s).

At the same time, in my other blogs, there are other synthetic methods of this type of compound,15846-19-2, 4-Chloro-6-methoxypyrimidin-5-amine, and friends who are interested can also refer to it.

Reference:
Patent; Nippon Chemiphar Co., Ltd.; EP1757610; (2007); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Related Products of 31737-09-4, Adding some certain compound to certain chemical reactions, such as: 31737-09-4, name is 6-Chloro-1-methylpyrimidine-2,4(1H,3H)-dione,molecular formula is C5H5ClN2O2, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 31737-09-4.

Scheme 85 represents an alternative method of synthesizing compounds of formula [I-EII.] Briefly, compound IX, which is prepared as described in [KAZIMIERCZUK,] et al., Intermediates in the synthesis of purines and [PTERIDINES] : N- methylated 6-chlorouracils, Acta Biochim. Pol. (1970), 17 (4), 325-9; Pfleider, et al. , Liebigs Ann. Chem, 612,158, (1958); and Hirota, et al. , Pyrimidines. 65. Synthesis of 6-substituted thieno [2,3-d] pyrimidine-2,4 (1H, 3H)-diones, J. Heterocycl. Chem. (1990), 27 (3), 717-21; each of which are incorporated herein by reference, is reacted with 3,4-di-fluorobenzyl bromide (1.1 equiv. ) in DMF at room temperature for 18 hours in the presence of cesium carbonate 1.5 equiv. ) to give product X. Reaction of X (1.0 equiv. ) with thiogylcolic acid ethyl ester (1.0 equiv. ) in room temperature ethanol in the presence of triethyl amine (1.0 equiv. ) for 1.5 hour provided [[1- (3,] 4-Difluoro-benzyl) -3-methyl-2, 6-oxo-1, 2,3, 6-tetrahydro- [PYRIMIDIN-4-YLSULFANYL]-ACETIC] acid ethyl ester, compound XI. This material is treated with POC13 (1.2 equiv. ) and DMF (1.1 equiv. ) in methylene chloride at [0 XB0;C] to reflux under Vilsmeier-Haack conditions to provide [FORMYLATED] product XII. Heating this material in the presence of sodium carbonate (1.5 equiv. ) in ethanol at-reflux for 18 hours provides the cyclized product [3- (3,] 4-difluoro- [BENZYL)-1-METHYL-2,] 4-dioxo-1,2, 3,4-tetrahydro-thieno [2,3-d] pyrimidine-6- carboxylic acid ethyl ester XIII. Saponification of XIII with sodium hydroxide sodium hydroxide (1.2 equiv) in methanol/water (1: 1) mixture at room temperature for 18 hours gives XIV. EDAC HCl (1.3 equiv. ) coupling of XIV in DMF with [3- (OR 4-)- (Z-L)-BENZYLAMINE] (1.3 equiv. ), and HOBT (1.3 equiv. ) for 18 hours at room temperature provided [Z-L- {3- (3, 4-DIFLUORO-BENZYL)-1-METHYL-] 2, 4-oxo-1, 2,3, 4-tetrahydro-thieno [2,3-d] pyrimidine-6-carboxylic acid [BENZYLAMIDE}] XV.

According to the analysis of related databases, 31737-09-4, the application of this compound in the production field has become more and more popular.

Reference:
Patent; WARNER-LAMBERT COMPANY LLC; WO2004/14384; (2004); A2;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 1450-86-8, name is Pyrimidine-4(3H)-thione, molecular formula is C4H4N2S, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. Application In Synthesis of Pyrimidine-4(3H)-thione

EXAMPLE 1 4-(N-oxidopyridyl-3-methyl)thiopyrimidine 11.2 g (0.1 moles) 4-mercaptopyrimidine is dissolved in 100 ml ethanol containing 10.8 g sodium methoxide. 18 g (0.1 moles) 3-chloromethylpyridine-N-oxide hydrochloride is added; the mixture is heated under reflux for about one hours. The solution is cooled to ambient temperature, the sodium chloride filtered off, and the filtrate evaporated under vacuum to eliminate the solvent. The residue is crystallized from ethyl acetate to give 15.35 g of product (M.P.=105-108 C.; yield=70%).

With the rapid development of chemical substances, we look forward to future research findings about 1450-86-8.

Reference:
Patent; Poli Industria Chimica S.p.A.; US4224327; (1980); A;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Related Products of 1159818-57-1 ,Some common heterocyclic compound, 1159818-57-1, molecular formula is C4H4BrN3, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

To a solution of 6-bromopyrimidin-4-amine (4.17 g, 24 mmol) in 100 mL of HI was added Nal (14.4 g, 96 mmol). The mixture was stirred at ambient temperature for 2 days. Then, the mixture was adjusted to pH=10 with NaOH solution, and the solid was separated and filtered to give 6-iodopyrimidin-4- amine. H NMR (400Mz, DMSO-c/6) delta (ppm): 6.85 (s, 1 H), 6.99(s, 2 H), 7.99 (s, 1 H).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,1159818-57-1, its application will become more common.

Reference:
Patent; SYNGENTA PARTICIPATIONS AG; EDMUNDS, Andrew; JEANGUENAT, Andre; JUNG, Pierre Joseph Marcel; MUEHLEBACH, Michel; (150 pag.)WO2016/71214; (2016); A1;,
Pyrimidine | C4H4N2 – PubChem,
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