Tag: M.W:100-200

Adding a certain compound to certain chemical reactions, such as: 108-53-2, 2-Aminopyrimidin-4(1H)-one, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 108-53-2, blongs to pyrimidines compound. Recommanded Product: 2-Aminopyrimidin-4(1H)-one

The synthetic route of this comparative example is as follows:Isocytosine (4g) and phosphorus oxybromide (10g) were mixed well at room temperature,The reaction was stirred at 80 C for 2 hours,Then slowly warmed to 135 ,The reaction was held at 135 C until the reaction was complete.The reaction was cooled to 0 C and the pH was adjusted to 12 and 1 g of product was filtered off (16% yield).Elemental analysis showed that the yellow solid could be identified as 2-amino-4-bromopyrimidine. c

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,108-53-2, its application will become more common.

Reference:
Patent; Shanghai Zaiqi Biological Co., Ltd.; Wang Zhiguo; Song Yanhong; Ma Xiujuan; Tian Beibei; Li Shijiang; Li Chao; Li Qiang; Li Tao; (5 pag.)CN106632077; (2017); A;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.4214-85-1, name is 2-Amino-6-methyl-5-nitro-3H-pyrimidin-4-one, molecular formula is C5H6N4O3, molecular weight is 170.13, as common compound, the synthetic route is as follows.Formula: C5H6N4O3

(E)-iV.H/V-Dimethyl-Lambdarf-(4-methyl-5-nitro-6-oxo-l,6-dihydropyrimidin-2- yl)formimidamideTo a suspension of 2-Amino-6-methyl-5-nitropyrimidin-4(3H)-one (54.8 g, 0.32 mol) in CH2Cl2 (461 mL) was added DMF-dimethylacetal (103.1 mL, 0.77 mol) and stirred at room temperature for 1.5 h. The reaction mixture was filtered, washed with CH2Cl2, and used for the next step without further purification (31.9 g, 44% yield).

At the same time, in my other blogs, there are other synthetic methods of this type of compound,4214-85-1, 2-Amino-6-methyl-5-nitro-3H-pyrimidin-4-one, and friends who are interested can also refer to it.

Reference:
Patent; VALEANT RESEARCH & DEVELOPMENT; WO2006/122003; (2006); A2;,
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Pyrimidine – Wikipedia

Adding a certain compound to certain chemical reactions, such as: 42839-08-7, Ethyl pyrimidine-2-carboxylate, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Formula: C7H8N2O2, blongs to pyrimidines compound. Formula: C7H8N2O2

Step-1: Pyrimidin-2-carboxylic acid hydrazide A mixture of ethyl pyrimidin-2-carboxylate (100 gm) and hydrazine hydrate (50 ml in ethanol (500 ml) was stirred at 30 C. over a period of 14 h. The suspension was filtered at suction and the wet cake washed with small quantity of ethanol (25 ml) followed by diethyl ether (50 ml) to provide title compound in 80 gm quantity (88%) as a white solid. Mass: m/z: 139.0 (M+1) 1H NMR: (400 Mhz, DMSO d6): 4.60 (br s, 2H, exchangeable), 7.64 (t, 1H), 8.91 (d, 2H), 10.00 (br s, 1H, exchangeable)

At the same time, in my other blogs, there are other synthetic methods of this type of compound,42839-08-7, Ethyl pyrimidine-2-carboxylate, and friends who are interested can also refer to it.

Reference:
Patent; Trivedi, Bharat Kalidas; Patel, Mahesh Vithalbhai; US2012/142710; (2012); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Adding a certain compound to certain chemical reactions, such as: 911461-47-7, 4,6-Dichloropyrimidine-5-carboxamide, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, HPLC of Formula: C5H3Cl2N3O, blongs to pyrimidines compound. HPLC of Formula: C5H3Cl2N3O

The compound 4,6-dichloropyrimidine-5-carboxamide (1.65 g, 8.6 mmol) was dissolved in methanol (30 mL) and then treated withSodium methoxide (1.15 g, 21.3 mmol) was added thereto, and the mixture was heated to 40 C and the reaction was stirred for 12 hours. Then, the mixedThe material was filtered, and the filtrate was concentrated under reduced pressure. The resulting residue was purified by silica gel column chromatography (pure EtOAc) to give the title compound asWhite solid (1.30 g, 83%).

The synthetic route of 911461-47-7 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Guangdong Dongyangguang Pharmaceutical Co., Ltd.; Jiatuo Sciences Corporation; Xi Ning; Wang Liang; Wu Zuping; Feng Xuejin; Wu Yanjun; (154 pag.)CN104513235; (2017); B;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Adding a certain compound to certain chemical reactions, such as: 7254-29-7, 2-Amino-5-nitropyrimidin-4(1H)-one, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Quality Control of 2-Amino-5-nitropyrimidin-4(1H)-one, blongs to pyrimidines compound. Quality Control of 2-Amino-5-nitropyrimidin-4(1H)-one

Step 2-Synthesis of 6-chloro-5-nitro-1,6-dihydropyrimidin-2-amine A suspension mixture of 2-amino-5-nitro-3,4-dihydropyrimidin-4-one (1.5 g, 9.61 mmol) and phosphorus oxychloride (27 mL, 0.29 mol) was heated under reflux (100 C.) for 18 hr. The reaction mixture turned into a yellow solution. The mixture was cooled to RT before being concentrated in vacuo. DCM (10 mL) was added and concentrated in vacuo was repeated. Ice (ca 5 g) was added, resulted in a sticky solid. DCM (20 mL) was added and the mixture was quenched by addition to an ice-cold saturated aqueous NaHCO3 solution (150 mL). The pH of mixture was adjusted to basic by final addition of 2M aq K2CO3. Attempt to extract product with DCM resulted in emulsion formation. Emulsion was removed by suction filtration. The aqueous layer was extracted with EtOAc (3*50 mL). The EtOAc extracts were combined with the DCM extract, dried over Na2SO4, filtered and concentrated in vacuo to afford the title compound as a yellow powder: 1H NMR (500 MHz, DMSO) delta 8.40-8.48 (2H, m), 9.02 (1H, s). LC-MS: m/z=+174.9 (M+H)+.

The synthetic route of 7254-29-7 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Genentech, Inc.; US2012/214762; (2012); A1;,
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Pyrimidine – Wikipedia

Related Products of 32998-03-1 , The common heterocyclic compound, 32998-03-1, name is 2,6-Dichloro-N-methylpyrimidin-4-amine, molecular formula is C5H5Cl2N3, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

EXAMPLE 5 2,6-bis-(2–Hydroxyethyl)methylamino-4-methylaminopyrimidine (V) A mixture of 2,6-dichloro-4-methylamino-pyrimidine (III, EXAMPLE 1, 1.78 g) and 2-(methylamino)ethanol (IV, 25 ml) is heated under reflux for about 18 hours, then is allowed to cool and is diluted with ethyl acetate (100 ml). The mixture is washed with aqueous potassium bicarbonate (0.5N), water (4*25 ml) and with saline (50 ml). The aqueous phases are backwashed with ethyl acetate. The organic extracts are combined, dried and concentrated to give the title compound, NMR (CDCl3) 4.82, 3.8, 3.68, 3.11, 3.00 and 2.84delta; CMR (CDCl3) 164.0, 161.76, 71.16, 63.08, 62.47, 52.64, 36.91, 36.49 and 28.35delta.

The synthetic route of 32998-03-1 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; The Upjohn Company; US5502187; (1996); A;,
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Pyrimidine – Wikipedia

Related Products of 87253-62-1, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 87253-62-1, name is 5,7-Dimethyl-[1,2,4]triazolo[1,5-a]pyrimidine-2-carboxylic acid, molecular formula is C8H8N4O2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

General procedure: In 25ml RB flask to a solution of Compound 9 (200 mg) in dry DMF (5ml), EDCI (250 mg, 1.25eq) and DMAP (130 mg,1eq) were added followed by addition of Sulfonamide (1eq). RM was stirred at RT for 4hrs. Solvent from the reaction mixture was evaporated. To the residue water was added and acidified with 6N HCl, solid precipitated out. Solid was filtered and dried. Crude solid was purified by flash chromatography eluating with 4-8% MeOH/DCM as solvent system to give pure product.

According to the analysis of related databases, 87253-62-1, the application of this compound in the production field has become more and more popular.

Reference:
Article; Patil, Vikas; Kale, Manoj; Raichurkar, Anandkumar; Bhaskar, Brahatheeswaran; Prahlad, Dwarakanath; Balganesh, Meenakshi; Nandan, Santosh; Shahul Hameed; Bioorganic and Medicinal Chemistry Letters; vol. 24; 9; (2014); p. 2222 – 2225;,
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Pyrimidine – Wikipedia

With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.36314-98-4, name is 2-Amino-4-cyanopyrimidine, molecular formula is C5H4N4, molecular weight is 120.11, as common compound, the synthetic route is as follows.SDS of cas: 36314-98-4

Intermediate 1-11-4To a solution of 2-aminopyrimidine-4-carbonitrile (1 g, 8.3 mmol) in 7M NH3 in MeOH (25.5 mL) was added Raney-Nickel (50% wet, 1.955 g, 33 mmol) and stirred at RT under an H2 atmosphere (32.5 bar) for 22h. The reaction was filtered and concentrated to give the intermediate 1-11-4 (954 mg, 92%) which was used without further purification.1H-NMR (400 MHz ,DMSO-d6), Shift [ppm]= 3.55 (2H), 6.34-6.54 (2H), 6.63 (1H), 8.09- 8.21 (1H).

At the same time, in my other blogs, there are other synthetic methods of this type of compound,36314-98-4, 2-Amino-4-cyanopyrimidine, and friends who are interested can also refer to it.

Reference:
Patent; BAYER PHARMA AKTIENGESELLSCHAFT; GRAHAM, Keith; KLAR, Ulrich; BRIEM, Hans; HITCHCOCK, Marion; BAeRFACKER, Lars; EIS, Knut; SCHULZE, Volker; SIEMEISTER, Gerhard; BONE, Wilhelm; SCHROeDER, Jens; HOLTON, Simon; LIENAU, Philip; TEMPEL, Rene; SONNENSCHEIN, Helmut; BALINT, Jozsef; GRAUBAUM, Heinz; (577 pag.)WO2015/193339; (2015); A1;,
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Pyrimidine – Wikipedia

Reference of 16097-60-2 ,Some common heterocyclic compound, 16097-60-2, molecular formula is C5H3ClF3N3, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

Example 21 4-(4-{[2-Amino-6-(trifluoromethyl)pyrimidin-4-yl]amino}-2-fluorobenzyl)-1H-pyrrolo[2,3-b]pyridine-3-carbonitrile 82 mg (0.31 mmol) of 4-(4-amino-2-fluorobenzyl)-1H-pyrrolo[2,3-b]pyridine-3-carbonitrile and 67 mg (0.34 mmol) of 4-chloro-6-trifluoromethylpyrimidine-2-amine are suspended in 3 ml of water, 1.5 ml of ethanol and 0.15 ml of 4N hydrochloric acid. The reaction mixture is heated at reflux for 2 hours. After cooling, the mixture is made alkaline using dilute aqueous sodium hydroxide solution, a little methanol is added, the mixture is extracted with ethyl acetate and the solvent is removed under reduced pressure. The residue is purified by preparative HPLC. This gives crystals. Yield: 111 mg (65% of theory) LC-MS (Method 3): Rt=2.34 min. MS (ESI pos.): m/z=428 [M+H]+. 1H-NMR (DMSO-d, 300 MHz): delta=4.41 (s, 2H), 6.35 (s, 1H), 6.90 (d, 1H), 6.96 (br. s, 2H), 7.14 (t, 1H), 7.32 (dd, 1H), 7.93 (dd, 1H), 8.29 (d, 1H), 8.46 (s, 1H), 9.77 (s, 1H), 12.86 (br. s, 1H).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,16097-60-2, its application will become more common.

Reference:
Patent; Bayer HealthCare AG; US2008/269268; (2008); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 40497-30-1, name is 2-Methylpyrimidine-4,6(1H,5H)-dione. This compound has unique chemical properties. The synthetic route is as follows. Product Details of 40497-30-1

FOX-7 was synthesized according to the method using the procedure of Fu [9]. 2-methylpyrimidine-4,6-dione (2.53 g,0.02 mol) was dissolved in 12mL concentrated H2SO4 (98%), and then 4mL Nitric acid fuming (98%) was dripped in the mixture. The reaction mixture was kept under 15C. After 3 h, the mixture was poured into ice water. The yellow precipitate formed, which was filtered and dried 5 h under vacuum at 50C, yielding 2.40 g (81.1%).The yellow crystal was obtained from C2H5OH solvent. IR (KBr,nu /cm-1): 3407, 3321, 3294, 3216, 1622, 1501, 1473, 1388, 1328, 1201,1161, 1133, 1020, 620, 453 cm-1.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 40497-30-1, 2-Methylpyrimidine-4,6(1H,5H)-dione.

Reference:
Article; Li, Keyao; Ren, Xiangwen; Fu, Shuqin; Zhu, Jiaping; Journal of Molecular Structure; vol. 1173; (2018); p. 26 – 32;,
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Pyrimidine – Wikipedia