Tag: M.W:100-200

Related Products of 69385-85-9, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 69385-85-9, name is N-(Piperidin-4-yl)pyrimidin-2-amine, molecular formula is C9H14N4, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

EXAMPLE 14 A mixture of 7.9 g of 3,4-dihydro-2H-1-benzopyran-2-methanol 4-methylbenzenesulfonate(ester), 4.5 g N-(4-piperidinyl)-2-pyrimidinamine, 5.3 g of sodium carbonate and 100 ml of 4-methyl-2-pentanone was stirred overnight at reflux temperature. The reaction mixture was evaporated and the residue was diluted with water. The product was extracted with dichloromethane and the extract was dried, filtered and evaporated. The residue was purified by column chromatography (silica gel; CH2 Cl2 100%). The eluent of the desired fraction was evaporated and the residue was crystallized from acetonitrile. The product was filtered off and dried, yielding 28 g (98.8%) of (+-)-N-[1-[(3,4-dihydro-2H-1-benzopyran-2-yl)methyl]-4-piperidinyl]-2-pyrimidinamine; mp. 141.9 C. (comp. 128).

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 69385-85-9, N-(Piperidin-4-yl)pyrimidin-2-amine.

Reference:
Patent; Janssen Pharmaceutica N.V.; US5541180; (1996); A;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Adding a certain compound to certain chemical reactions, such as: 34415-10-6, 2-Methyl-6-oxo-1,6-dihydropyrimidine-4-carboxylic acid, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Quality Control of 2-Methyl-6-oxo-1,6-dihydropyrimidine-4-carboxylic acid, blongs to pyrimidines compound. Quality Control of 2-Methyl-6-oxo-1,6-dihydropyrimidine-4-carboxylic acid

Preparation of 6-chloro-2-methylpyrimidine-4-carbonyl chloride:To 920 mg (5.97 mmol) of 6-hydroxy-2-methylpyrimidine-4-carboxylic acid was added 13 mL of POCl3. The mixture was heated at reflux for 1 h, then concentrated in vacuo to a brown oil. This was suspended in 25 mL of pentane and extracted with water (2 x 10 mL). The combined water layers were back extracted with pentane (1 x 25 mL), then the combined pentane layers were washed again with water (2 x 10 mL), dried over MgSO4, filtered, and concentrated to 494 mg (43%) of a colorless oil.

The synthetic route of 34415-10-6 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; SIRTRIS PHARMACEUTICALS, INC.; WO2009/61453; (2009); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Synthetic Route of 914916-98-6, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 914916-98-6, name is 6-Amino-5-chloro-4-pyrimidinecarboxylic acid. This compound has unique chemical properties. The synthetic route is as follows.

In a 100 mL round-bottom flask, 23.2 (1.21 g, 0.00697 mole), methyl 2-(1-aminoethyl)thiazole-5-carboxylate (1.30 g, 0.00697 mole), and TBTU (2.69 g, 0.00837 mole) were dissolved in N,N-dimethylformamide (25.0 mL, 0.323 mole) to which was added N,N-diisopropylethylamine (3.64 mL, 0.0209 mole). The resulting yellow brown solution was allowed to stir at RT for 3 hr. The reaction mixture was diluted with 250 mL EtOAc, washed with 75 mL satd. NaHCO3 (2×), 75 mL of water, and 50 mL brine. The organic layer was dried over Na2SO4 and concentrated to a brown oil. The residue was purified by flash column chromatography (50% EtOAc/Hexanes gradient to 100% EtOAc) to yield 1.12 g (0.0070 47%) of desired product 23.3. LCMS m/z 342 [M+1]+.

According to the analysis of related databases, 914916-98-6, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Sunesis Pharmaceuticals, Inc.; US2009/36419; (2009); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Related Products of 216309-28-3, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 216309-28-3, name is 5-((Trimethylsilyl)ethynyl)pyrimidine, molecular formula is C9H12N2Si, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

S8b) 3,-Dideoxy-3-i4-(l,3-pyrimidin-5-yl)-lH-l,2,3-triazol-l-yll-3,-i4-(3,4,5- trifluorophenyl)-lH-l,2,3-triazol-l-yll-l.,l ‘-sulfanediyl-di-B-D-galactopyranosideIntermediate 1 (92 mg) and 5-[2-(trimethylsilyl)ethynyl]-pyridine (65 mg) was dissolved in MeCN (5 mL, dry) and stirred at r.t. Copper(I) iodide (24 mg) was added followed by Hunig’s base (65 mu) and the mixture was heated to 50 C. After 18 h cesium fluoride (5 mg) was added and the temperature increased to 70 C. After 24 h the mixture was filtered and concentrated. The residue was purified by HPLC (Xterra/MeCN:H20:25 mM NH3). Freezedrying afforded the title compound as a white solid (73 mg). H NMR (400 MHz, Methanol-i4) delta 9.24 (s, 2H), 9.13 (s, 1H), 8.76 (s, 1H), 8.58 (s, 1H), 7.65 – 7.56 (m, 2H), 5.01 – 4.88 (m, 4H), 4.75 (q, J= 10.3 Hz, 2H), 4.17 (dd, J = 8.7, 2.4 Hz, 2H), 3.95 – 3.78 (m, 4H), 3.73 (dd, J= 11.3, 3.5 Hz, 2H). ESI-MS m/z calcd for [C26H28F3N808S]+(M+H)+: 669.16; found: 669.15.

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 216309-28-3, 5-((Trimethylsilyl)ethynyl)pyrimidine.

Reference:
Patent; GALECTO BIOTECH AB; ZETTERBERG, Fredrik; NILSSON, Ulf; LEFFLER, Hakon; BRIMERT, Thomas; JOHNSSON, Richard; VERMA, Priya; (71 pag.)WO2016/113335; (2016); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.71149-52-5, name is 4-Chloro-2-methyl-7H-pyrrolo[2,3-d]pyrimidine, molecular formula is C7H6ClN3, molecular weight is 167.6, as common compound, the synthetic route is as follows.Recommanded Product: 71149-52-5

To a solution of 4-chloro-2-methyl-7H-pyrrolo[2,3-d]pyrimidine (400 mg, 2.4 mmol) in dichloromethane (10 mL) was added N-iodosuccinimide (537 mg, 2.39 mmol).The mixture was stirred at room temperature for 2 hours, then washed with aqueous sodium sulfite solution, dried over sodium sulfate, filtered, and concentrated in vacuo to provide the product as a brown solid. Yield: 330 mg, 1.12 mmol, 47%. LCMS m/z 293.8 [M+H].

At the same time, in my other blogs, there are other synthetic methods of this type of compound,71149-52-5, 4-Chloro-2-methyl-7H-pyrrolo[2,3-d]pyrimidine, and friends who are interested can also refer to it.

Reference:
Patent; PFIZER INC.; GALATSIS, Paul; HAYWARD, Matthew Merrill; HENDERSON, Jaclyn; KORMOS, Bethany Lyn; KURUMBAIL, Ravi G; STEPAN, Antonia Friederike; VERHOEST, Patrick Robert; WAGER, Travis T.; ZHANG, Lei; WO2014/1973; (2014); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Reference of 23945-50-8 ,Some common heterocyclic compound, 23945-50-8, molecular formula is C5H4N2O3S, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

Example 2 Under an atmosphere of nitrogen, an acetonitrile solution (30 ml) of methacryloyl chloride (20.9 g, 0.2 mol) was slowly added dropwise at room temperature, using a dropping funnel, to 1,6-hexanediol (47.3 g, 0.40 mol), molecular sieve 3A powder (40 g) and acetonitrile (470 ml) in a 1-L three-necked flask. After the completion of the dropwise addition, the mixture was refluxed with heating for 5 hours. The mixture was then left alone to cool to room temperature, the molecular sieve 3A powder was filtered out from the reaction mixture, and acetonitrile was distilled off under reduced pressure from the filtrate. Methylene chloride (300 ml) was added to the residue, and the resultant methylene chloride solution was washed with water. The methylene chloride layer was dried over anhydrous sodium sulfate, and the solvent was distilled off under reduced pressure. 6-Hydroxyhexyl methacrylate (33.3 g) was separated and purified as a colorless transparent liquid from this residue by silica gel column chromatography. 6-Hydroxyhexyl methacrylate (5.59 g, 30 mmol), N,N’-di cyclohexylca rbodii mide (2.27 g, 11 mmol), 5-carboxy-2-thiouracil (1.72 g, 10 mmol) and tetrahydrofuran (50 ml) were put in a 200-ml three-necked flask to make a solution, and the solution was continuously stirred at room temperature for 3 days. A white precipitate was formed as the reaction progressed, and after the completion of the reaction, the white precipitate was filtered out. Then the same separation and purification operations were carried out as in Example 1 to give 6-methacryloyloxyhexyl 2-thiouracil-5-carboxylate [B] (1.13 g, 3.3 mmol) repre- sented by the following formula. The results of NMR (d6DMSO), MASS and elementary analysis are shown below. MASS (M+1)+=341

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 23945-50-8, 4-Oxo-2-thioxo-1,2,3,4-tetrahydropyrimidine-5-carboxylic acid, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; TOKUYAMA CORPORATION; EP802194; (1997); A3;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Electric Literature of 38275-42-2, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 38275-42-2, name is 5-Chloro-2-(methylthio)pyrimidine. A new synthetic method of this compound is introduced below.

EXAMPLE 7 2-(Chloromethyl)thio-5-chloropyrimidine 2-Methylthio-5-chloropyrimidine (75 mmol) and sulfuryl chloride (104 mmol) were heated together in refluxing dichloromethane (100 ml) for 3 h. Evaporation of the mixture left a solid which was recrystallized from ethanol; yield 82%, m.p. 78 C. 1 H NMR (CDCl3): 5.20 (SCH2), 8.54 (H-4, H-6).

At the same time, in my other blogs, there are other synthetic methods of this type of compound,38275-42-2, 5-Chloro-2-(methylthio)pyrimidine, and friends who are interested can also refer to it.

Reference:
Patent; Nyegaard & Co. A/S; US4423047; (1983); A;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 1513-69-5, name is 2-Amino-4-hydroxy-6-(trifluoromethyl)pyrimidine, the common compound, a new synthetic route is introduced below. category: pyrimidines

33.4 g (0.186 mol) of 4-hydroxy-6-trifluoromethylpyrimidin-2-ylamine are added in portions (in each case ca. 5 g) to a mixture of 85 ml of phosphorus oxychloride and 47.5 ml of dimethylaniline and the mixture is heated at reflux until the added solid has dissolved. The mixture is then heated at reflux for a further 90 minutes. After cooling, the reaction mixture is added to ice water while observing the safety precautions for phosphorus oxychloride. The aqueous phase is extracted with methylene chloride, the organic phase is separated off and dried with sodium sulfate, and the drying agent is filtered off. Following concentration by evaporation, 47.8 g of a crude mixture are obtained. Following column chromatographic separation with ethyl acetate/heptane as eluent, 8.5 g of 4-chloro-6-trifluoromethylpyrimidin-2-ylamine were obtained (solid, 22% yield, purity 95%).

The synthetic route of 1513-69-5 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; BAYER CROPSCIENCE AG; US2010/167935; (2010); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Adding a certain compound to certain chemical reactions, such as: 29458-38-6, 6-Methoxypyrimidine-2,4(1H,3H)-dione, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Recommanded Product: 6-Methoxypyrimidine-2,4(1H,3H)-dione, blongs to pyrimidines compound. Recommanded Product: 6-Methoxypyrimidine-2,4(1H,3H)-dione

A mixture of 2,4-dihydroxy-6-methoxypyrimidine (15g, 0.106mol) in phosphorus (III) oxychloride (400ml) was heated under reflux for 4 hours to give solution. Excess is phosphorus (III) oxychloride was removed by evaporation, the residue treated with ice/water and extracted with EtOAc. The combined extracts were washed with water, dried (Na2SO4) and the solvent removed by evaporation to give 2,4-dichloro-6-methoxypyrimidine (5.5g, 30%) as an oil. NMR.3.96 (3H, s), 6.63 (IH, s); m/z.179 [MH]+.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,29458-38-6, 6-Methoxypyrimidine-2,4(1H,3H)-dione, and friends who are interested can also refer to it.

Reference:
Patent; ASTRAZENECA AB; ASTRAZENECA UK LIMITED; WO2008/117051; (2008); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Electric Literature of 42839-08-7, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.42839-08-7, name is Ethyl pyrimidine-2-carboxylate, molecular formula is C7H8N2O2, molecular weight is 152.15, as common compound, the synthetic route is as follows.

A mixture of ethyl pyrimidin-2-carboxylate (100 gm) and hydrazine hydrate (50 ml in ethanol (500 ml) was stirred at 30 C over a period of 14 h. The suspension was filtered at suction and the wet cake washed with small quantity of ethanol (25 ml) followed by diethyl ether (50 ml) to provide title compound in 80 gm quantity (88%) as a white solid.Mass: m/z: 139.0 (M+l)IH NMR: (400 Mhz, DMSO d6): 4.60 (br s, 2H, exchangeable), 7.64 (t, IH), 8.91 (d, 2H),10.00 (br s, IH, exchangeable)

The chemical industry reduces the impact on the environment during synthesis 42839-08-7, I believe this compound will play a more active role in future production and life.

Reference:
Patent; WOCKHARDT RESEARCH CENTRE; TRIVEDI, Bharat Kalidas; PATEL, Mahesh Vithalbhai; WO2010/136971; (2010); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia