Tag: M.W:100-200

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 206564-00-3, name is 4-(2-Furyl)pyrimidin-2-amine. This compound has unique chemical properties. The synthetic route is as follows. SDS of cas: 206564-00-3

General procedure: 4-p-Tolylpyrimidin-2-amine (3a) (1.0 equiv), N-chlorosuccinimide (1.1 equiv) and benzoyl peroxide (0.2 equiv) were dissolved in acetonitrile and stirred at 80 C for 6 h. The reaction mixture was cooled to room temperature, then the solvent was removed in vacuo. The crude product was purified by silica gel column with acetone/petroleum ether (v/v, 1:5) as eluent to obtain 4a. Using the same procedure described above for the other compounds exception of 6a-6c under a lower reaction temperature (40 C).

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 206564-00-3, 4-(2-Furyl)pyrimidin-2-amine.

Reference:
Article; Chen, Wei; Li, Yuxin; Zhou, Yunyun; Ma, Yi; Li, Zhengming; Chinese Chemical Letters; vol. 30; 12; (2019); p. 2160 – 2162;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Reference of 4271-96-9, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 4271-96-9, name is 1,2-Dimethyl-1,4,5,6-tetrahydropyrimidine. A new synthetic method of this compound is introduced below.

General procedure: A solution of 55% aqueous hydroiodic acid (1 mL, ca. 7.3 mmol) was added dropwise over 1 min to a stirred mixture of amidine (1a-e, 4 mmol) or amine (1f-j, 4 mmol) in dioxane (8 mL) at 0 C. After the mixture was stirred at room temperature for 12 h, the mixture was evaporated in vacuo. The residue was washed with ether/THF (1:1 or 1:0), and the precipitate was dried in vacuo for 12 h at 50 C (1i?HI and 1j?HI were dried for 6 h at 30 C) to give corresponding hydroiodides (1a-j?HI).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,4271-96-9, its application will become more common.

Reference:
Article; Aoyagi, Naoto; Furusho, Yoshio; Endo, Takeshi; Tetrahedron; vol. 75; 52; (2019);,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Application of 120977-94-8, Adding some certain compound to certain chemical reactions, such as: 120977-94-8, name is 2,6-Dichloro-3H-pyrimidin-4-one,molecular formula is C4H2Cl2N2O, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 120977-94-8.

Step A 6-((1′-tert-Butoxycarbonyl-4,4′-bipiperidin)-1-yl)-2-chloro-3H-pyrimid-4-one A solution of 100 mg (0.61 mmol) of 2,6-dichloropyrimid-4-one (Helv. Chim. Acta 1989, 72, 738) and 246 mg (0.92 mmol) of 1-tert-butoxycarbonyl-4,4′-bipiperidine in 6 mL of EtOH was refluxed for 2.25 hours. After cooling the reaction with an ice bath, the resulting solid was filtered and dried to yield 126 mg (52%) of the title compound: Rf: 0.77 (90:10:1 v/v/v CH2Cl2/MeOH/NH4OH); 1H NMR (500 MHz, CD3OD) delta 1.12-1.85 (m, 19H), 2.62-2.67 (m, 2H), 2.87-2.92 (m, 2H), 4.13-4.15 (m, 2H), 4.53-4.55 (m, 2H), 5.74 (s, 1H).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 120977-94-8, 2,6-Dichloro-3H-pyrimidin-4-one, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Merck & Co., Inc.; US6498161; (2002); B1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Application of 57473-33-3, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.57473-33-3, name is 7-Chloroimidazo[1,2-a]pyrimidin-5(1H)-one, molecular formula is C6H4ClN3O, molecular weight is 169.57, as common compound, the synthetic route is as follows.

Example 67-Chloro-l-(methylmvalate)imidazo[l,2-aJpyrimidin-5-one:To a suspension of 7-chloroimidazo[l,2-alpha]pyrimidin-5-one [for preparation see Annals of the New York Academy of Sciences. 1975, 255, 166-176] (600 mg, 3.54 mmol) in dry dimethylformarnide (20 mL) was added sodium hydride (60% in oil, 168 mg, 4.2 mmoles) at 20C and stirred for one hour. Chloromethyl pivalate (612 muL) was added and stirred at 20C for 16 hours. The reaction mixture was evaporated to dryness. The residue was purified on silica gel using dichloromethane/methanol (99/1) as eluant to give the title compound (710 mg) as a white powder.1H NMR (DMSO-d6) delta ppm: 1.15 (s, 9H, CH3), 6.04 (s, 2H, CH2), 6.11 (s, IH), 7.75 (syst AB, 2H, CH);Mass spectrum : m/z (FAB>0) 284 (M+H)+, 567 (2M+H)+.

The chemical industry reduces the impact on the environment during synthesis 57473-33-3, I believe this compound will play a more active role in future production and life.

Reference:
Patent; IDENIX (CAYMAN) LIMITED; CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE; UNIVERSITA DEGLI STUDI DI CAGLIARI; UNIVERSTITAT OSNABRUCK LABORATORIUM FUR ORGANIC AND BIORGANIC CHEMIE; WO2006/922; (2006); A2;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Electric Literature of 7399-93-1, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 7399-93-1, name is Methyl 6-oxo-3,6-dihydropyrimidine-4-carboxylate, molecular formula is C6H6N2O3, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

Step 1: Methyl 1-(1-(tert-butoxycarbonyl)-2,6-dioxopiperidin-3-yl)-6-oxo-1,6- dihydropyrimidine-4-carboxylate. (1511) tert-Butyl 3-bromo-2,6-dioxopiperidine-1-carboxylate (1.0 equiv.) and methyl 6-oxo-1,6- dihydropyrimidine-4-carboxylate (1.0 equiv.) are mixed in DMF (0.2M) and cesium carbonate is added (2.0 equiv.). The reaction mixture is stirred at 60 oC for 16 hours. The reaction mixture is partitioned between brine and ethyl acetate. The organic layer is dried with sodium sulfate, filtered and evaporated under reduced pressure. The crude residue is purified by silica gel column chromatography to afford methyl 1-(1-(tert-butoxycarbonyl)-2,6-dioxopiperidin-3-yl)-6-oxo-1,6- dihydropyrimidine-4-carboxylate.

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 7399-93-1, Methyl 6-oxo-3,6-dihydropyrimidine-4-carboxylate.

Reference:
Patent; C4 THERAPEUTICS, INC.; PHILLIPS, Andrew, J.; NASVESCHUK, Chris, G.; HENDERSON, James, A.; LIANG, Yanke; CHEN, Chi-li; DUPLESSIS, Martin; HE, Minsheng; LAZARSKI, Kiel; (980 pag.)WO2017/197051; (2017); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Reference of 304646-29-5 , The common heterocyclic compound, 304646-29-5, name is 2-Methoxy-5-nitropyrimidin-4-amine, molecular formula is C5H6N4O3, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

A mixture of compound 6 (560 mg, 3.29 mmol) in MeOH (30 mL) was added 10% Pd on carbon (56.4 mg). After the mixture was stirred at 20 C under H2 (15 psi) for 1 h, it wasfiltered and the filtrate was concentrated to give compound 7 (310 mg, 2.21 mmol, 67.2% yield) as a brown solid.

The synthetic route of 304646-29-5 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; GENENTECH, INC.; DRAGOVICH, Peter; PEI, Zhonghua; PILLOW, Thomas; SADOWSKY, Jack; CHEN, Jinhua; WAI, John; (237 pag.)WO2017/64675; (2017); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Adding a certain compound to certain chemical reactions, such as: 25902-86-7, 2-Methoxypyrimidin-4(1H)-one, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 25902-86-7, blongs to pyrimidines compound. Safety of 2-Methoxypyrimidin-4(1H)-one

A mixture of 18 g (0.0779 m) of the 2-methoxypyrimidinone, 12.23 g (0.0779 m) of alpha-furylmethylthioethylamine and 50 ml of toluene was heated at reflux for 12 hours. Toluene (100 ml) was added to the cooled reaction mixture. The separated solid was washed with ethyl acetate and dried to give 20.69 g (74%) of 2-[[2-[(2-furylmethyl)thio]ethyl]amino]-5-[(6-methyl-3-pyridinyl)methyl]-4-(1H)-pyrimidinone. Recrystallization from isopropanol-water gave 14.51 g (52%), m.p. 147-152, of purified compound. Anal. Calcd. for C18 H20 N4 O2 S: C, 60.25; H, 5.65; N, 15.71; S, 8.99. Found: C, 60.29; H, 5.33; N, 15.43; S, 8.50.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,25902-86-7, its application will become more common.

Reference:
Patent; Smithkline Beckman Corporation; US4352933; (1982); A;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Reference of 38275-42-2, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 38275-42-2, name is 5-Chloro-2-(methylthio)pyrimidine. This compound has unique chemical properties. The synthetic route is as follows.

EXAMPLE 39 2-Methylsulfinyl-5-chloropyrimidine A solution of 2-methylthio-5-chloropyrimidine (13 mmol) in chloroform (85 ml) was cooled to -20 C. and m-chloroperbenzoic acid (17 mmol) added with stirring. The mixture was stirred for 40 min at -20 C. and for 4 h at 0 C. and left at this temperature overnight. The chloroform solution was then washed with 1 M potassium carbonate (3*10 ml) and the dried (MgSO4) solution evaporated. The residual oily material crystallized on standing; yield 80% m.p. 48 C. (n-heptane). 1 H NMR (CDCl3): delta2.93 (Me), 8.83 (2H-4,6).

According to the analysis of related databases, 38275-42-2, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Nyegaard & Co. A/S; US4423047; (1983); A;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 32998-03-1, name is 2,6-Dichloro-N-methylpyrimidin-4-amine. A new synthetic method of this compound is introduced below., COA of Formula: C5H5Cl2N3

EXAMPLE 3 4-Methylamino-2,6-di-1-pyrrolidinopyrimidine (V) Pyrrolidine (IV, 25 ml) is added (exothermic) to 2,6-dichloro-4-methylaminopyrimidine (III, EXAMPLE 1, 1.81 g). The mixture is stirred and heated under reflux for 23 hours, then is allowed to cool and concentrated under reduced pressure. The residue is partitioned between ethyl acetate and aqueous potassium bicarbonate, the phases separated and organic phase is concentrated to give a solid. The solid is crystallized from hexane to give the title compound, mp 100.5-103; NMR (CDCl3) 4.74, 3.51, 3.43, 2.81 and 1.9delta; CMR (CDCl3) 164.50, 161.92, 160.18, 70.78, 46.06, 45.85, 28.47, 25.44, 25.19delta. Alternatively, the title compound can be obtained by the reaction of 4-chloro-2,6-di-1-pyrrolidinylpyrimidine and methylamine (II) in pyridine in a pressure tube at 100, MS (M+) 247.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 32998-03-1, 2,6-Dichloro-N-methylpyrimidin-4-amine.

Reference:
Patent; The Upjohn Company; US5502187; (1996); A;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Synthetic Route of 175277-33-5, Adding some certain compound to certain chemical reactions, such as: 175277-33-5, name is 4-(Dimethoxymethyl)-2-methylpyrimidine,molecular formula is C8H12N2O2, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 175277-33-5.

3N HClaq (30 mL, 90.00 mmol) was added to 4-(dimethoxymethyl)-2-methylpyrimidine (3 g, 17.84 mmol) at room teperature. The resulting solution was stirred at 50 C for 4 hours. The solvent was removed under reduced pressure to afford 2-methylpyrimidine-4- carbaldehyde (2.50 g, 88 %) as a red oil. ?H NMR (DMSO, 24 C, 400Hz) 2.81 (3H, s), 7.71(1H, d), 9.02 (1H, d), 9.93 (1H, s). mlz (ES+), [M+H]+ = 123.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 175277-33-5, 4-(Dimethoxymethyl)-2-methylpyrimidine, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; ASTRAZENECA AB; WARD, Richard, Andrew; GRAHAM, Mark, Andrew; SWALLOW, Steven; JONES, Clifford, David; (282 pag.)WO2016/162325; (2016); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia