Tag: M.W:100-200

Name: 5-(hydroxymethyl)-2,4-dimethylpyridin-3-ol hydrochloride. The reaction of aromatic heterocyclic molecules with protons is called protonation. Aromatic heterocycles are more basic than benzene due to the participation of heteroatoms. Compound: 5-(hydroxymethyl)-2,4-dimethylpyridin-3-ol hydrochloride, is researched, Molecular C8H12ClNO2, CAS is 148-51-6, about Inhibition of colitis by ring-modified analogues of 6-acetamido-2,4,5-trimethylpyridin-3-ol. Author is Chaudhary, Chhabi Lal; Chaudhary, Prakash; Dahal, Sadan; Bae, Dawon; Nam, Tae-gyu; Kim, Jung-Ae; Jeong, Byeong-Seon.

6-Aminopyridin-3-ol scaffold has shown an excellent anti-inflammatory bowel disease activity. Various analogs with the scaffold were synthesized in pursuit of the diversity of side chains tethering on the C(6)-position. SAR among the analogs was investigated to understand the effects of the side chains and their linkers on their anti-inflammatory activities. In this study, structural modification moved beyond side chains on the C(6)-position and reached to pyridine ring itself. It expedited to synthesize diverse ring-modified analogs of a representative pyridine-3-ol, 6-acetamido-2,4,5-trimethylpyridin-3-ol. In the evaluation of compounds on their inhibitory actions against TNF-α-induced adhesion of monocytic cells to colonic epithelial cells, an in vitro model mimicking colon inflammation, the effects of compounds I , II, and III were greater than tofacitinib, an orally available anti-colitis drug, and compound dehydroxylated analog II exhibit the greatest activity. In addition, TNF-α-induced angiogenesis, which permits more inflammatory cell migration into inflamed tissues, was significantly blocked by compounds I and II in a concentration-dependent manner. In the comparison of in vivo therapeutic effects of compounds I , II, and III on dextran sulfate sodium (DSS)-induced colitis in mice, compound dehydroxylated analog II was the most potent and efficacious, and compound demethylated analog III was better than compound I which exhibited a similar degree of inhibitory effect to tofacitinib.

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Reference:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Wendt, Gerhard; Bernhart, F. W. published the article 《The structure of a sulfur-containing compound with vitamin B6 activity》. Keywords: VITAMIN B 6/chemistry.They researched the compound: 5-(hydroxymethyl)-2,4-dimethylpyridin-3-ol hydrochloride( cas:148-51-6 ).COA of Formula: C8H12ClNO2. Aromatic heterocyclic compounds can be divided into two categories: single heterocyclic and fused heterocyclic. In addition, there is a lot of other information about this compound (cas:148-51-6) here.

Pyridoxal-HCl (0.001 mole) was added to a warm solution of 0.001 mole 2,4-dinitrophenylhydrazine in 40 ml. of 95% EtOH, the mixture gently heated 5 min., after cooling the orange-yellow crystals collected and suspended 3 times in water with stirring (30 min.) (the crystal color changed to red), filtered off, dried, and recrystallized from iso-BuOH to give yellow crystals of 2,4-dinitrophenylhydrazone, m. 256-7°. To 500 mg. diacetate of bis-4-pyridoxyl disulfide (IV) (500 mg.) in 5 ml. 0.1N HCl was added acetone to a slight turbidity. After standing in the cold, 360 mg. crystals of di-HCl salt separated, m. 222°. IV.2HCl (441 mg.) dissolved in 220 ml. H2O, neutralized with 168 mg. NaHCO3, shaken with 2.0 g. Raney Ni catalyst and 3 atm. H 4 hrs. at 25°, the catalyst removed, the combined filtrates concentrated in vacuo in 10 ml., solid NaHCO3 added to pH 8.6, the solution extracted with CHCl3 30 hrs., the extract concentrated to a sirup which was dissolved in EtOH, and alc. HCl added yielded 250 mg. crystals, m. 264-5°. IV.2HCl (500 mg.), 600 mg. Sn foil, and 6 ml. 4N HCl was shaken 20 hrs. at room temperature; after diluting with H2O the Sn removed as sulfide by filtration, the filtrate dried in vacuo, and recrystallized from EtOH gave 250-300 mg. 4-pyridoxyl mercaptan (VI). VI (100 mg. in 25 ml. H2O) was adjusted to pH 8.5 with 2N NH4OH and air passed through the solution until the nitroprusside test was neg. Oxidation was accompanied by the precipitation of the free base of IV in 66% yield, m. 222°. A mixed sample of SB8.2HCl (Berhart, et al., CA 54, 19993c) and IV.2HCl did not depress the m.p. The identity of both compounds was proved by paper chromatography.

Although many compounds look similar to this compound(148-51-6)COA of Formula: C8H12ClNO2, numerous studies have shown that this compound(SMILES:OC1=C(C)C(CO)=CN=C1C.[H]Cl), has unique advantages. If you want to know more about similar compounds, you can read my other articles.

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Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Name: 5-(hydroxymethyl)-2,4-dimethylpyridin-3-ol hydrochloride. Aromatic heterocyclic compounds can also be classified according to the number of heteroatoms contained in the heterocycle: single heteroatom, two heteroatoms, three heteroatoms and four heteroatoms. Compound: 5-(hydroxymethyl)-2,4-dimethylpyridin-3-ol hydrochloride, is researched, Molecular C8H12ClNO2, CAS is 148-51-6, about Gas electron diffraction and quantum chemical study of the structure of a 2-nitrobenzenesulfonyl chloride molecule. Author is Petrov, V. M.; Giricheva, N. I.; Girichev, G. V.; Bardina, A. V.; Petrova, V. N.; Ivanov, S. N..

A combined gas electron diffraction and quantum chem. (B3LYP/6-311+G**, B3LYP/cc-pVTZ, B3LYP/cc-pVTZ, midix (Cl), and MP2/cc-pVTZ) study of the structure of a 2-NO2-C6H4-SO2Cl mol. is performed. It is found exptl. that at a temperature of 345(5) K the gas phase contains two conformers of the C 1 symmetry. Conformer I with a nearly perpendicular arrangement of the S-Cl bond with respect to the benzene ring plane (the C(NO2)-C-S-Cl torsion angle is 84(3)°) is contained predominantly (69(12)%). In conformer II, the S-Cl bond is located near the benzene ring plane (the C(NO2)-C-S-Cl angle is 172(3)°). The following exptl. internuclear distances (Å) are obtained for conformer I: rh1(C-H) = 1.064(15), rh1(C-C)av = 1.397(3), rh1(C-S) = 1.761(6), rh1(S-O)av = 1.426(4), rh1(S-Cl) = 2.043(5), rh1(N-O)av = 1.222(4), rh1(C-N) = 1.485(16). In both conformers, the NO2 group is turned by more than 30° relative to the benzene ring plane.

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Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

In organic chemistry, atoms other than carbon and hydrogen are generally referred to as heteroatoms. The most common heteroatoms are nitrogen, oxygen and sulfur. Now I present to you an article called Solvent-free N-Boc deprotection by ex situ generation of hydrogen chloride gas, published in 2021, which mentions a compound: 35621-01-3, mainly applied to amine hydrochloride salt preparation green chem; tertbutyl carbamate deprotection, Reference of Piperidin-4-amine dihydrochloride.

An efficient, scalable and sustainable method for the quant. deprotection of the tert-Bu carbamate (N-Boc) protecting group is described, using down to near-stoichiometric amounts of hydrogen chloride gas in solvent-free conditions. The ex situ generation of hydrogen chloride gas from sodium chloride and sulfuric acid in a two-chamber reactor, introducing a straightforward method for controlled and stoichiometric release of HCl gas were demonstrated. The solvent-free conditions allow deprotection of a wide variety of N-Boc derivatives e.g., N-Boc benzylamine to obtain the hydrochloride salts in e.g., benzylamine hydrochloride quant. yields. The procedure obviates the need for any work-up or purification steps providing an uncomplicated green alternative to standard methods. Due to the solvent-free, anhydrous conditions, this method shows high tolerance towards acid sensitive functional groups and furnishes expanded functional group orthogonality.

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Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

The chemical properties of alicyclic heterocycles are similar to those of the corresponding chain compounds. Compound: 5-(hydroxymethyl)-2,4-dimethylpyridin-3-ol hydrochloride, is researched, Molecular C8H12ClNO2, CAS is 148-51-6, about [N,N-Bis(2-chloroethyl)-1,2-ethanediamine-N,N’]bis(3-methyl-2,4-pentanedionato-O,O’)cobalt(III) perchlorate: a potential hypoxia selective anticancer agent, the main research direction is mol structure cobalt chloroethylethanediamine methylpentanedionato.Safety of 5-(hydroxymethyl)-2,4-dimethylpyridin-3-ol hydrochloride.

Crystals of the title compound are monoclinic, space group P21/c, with a 17.229(3), b 10.817(5), c 14.851(6) Å, and β 110.78(3)°; Z = 4, dc = 1.462; R(F2) = 0.050, Rw(F2) = 0.160 for 4049 reflections. The coordination geometry about Co is typical of an octahedral trischelate complex. The Co-N bond length involving the tertiary N atom of the bis(chloroethyl)ethanediamine ligand [2.092(4) Å] is significantly longer than that to the primary N atom [1.931(4) Å].

Although many compounds look similar to this compound(148-51-6)Safety of 5-(hydroxymethyl)-2,4-dimethylpyridin-3-ol hydrochloride, numerous studies have shown that this compound(SMILES:OC1=C(C)C(CO)=CN=C1C.[H]Cl), has unique advantages. If you want to know more about similar compounds, you can read my other articles.

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Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic.Morisawa, Yasuhiro; Kataoka, Mitsuru; Sakamoto, Toshiaki; Saito, Fumiko researched the compound: 5-(hydroxymethyl)-2,4-dimethylpyridin-3-ol hydrochloride( cas:148-51-6 ).Name: 5-(hydroxymethyl)-2,4-dimethylpyridin-3-ol hydrochloride.They published the article 《Studies on anticoccidial agents. Part VI. Modification at the 2-position of 4-deoxypyridoxol and α4-norpyridoxol》 about this compound( cas:148-51-6 ) in Agricultural and Biological Chemistry. Keywords: pyridoxol derivative anticoccidial; norpyridoxol derivative anticoccidial; coccidiostat pyridoxol norpyridoxol. We’ll tell you more about this compound (cas:148-51-6).

The title derivatives I (R = Me, R1 = Et; R = R1 = H; R = H, R1 = HOCH2; R = H, R1 = MeO) were prepared Thus, I (R = H, R1 = Me) was treated with PhCH2Cl and the product oxidized and treated with Ac2O to give 2-(acetoxymethyl)-3-(benzyloxy)-5-(benzyloxymethyl)pyridine, which was hydrolyzed and hydrogenated to give I (R = H, R1 = HOCH2). At 200 ppm I (R = H, R1 = MeO) had anticoccidial activity against Eimeria acervulina.

Although many compounds look similar to this compound(148-51-6)Name: 5-(hydroxymethyl)-2,4-dimethylpyridin-3-ol hydrochloride, numerous studies have shown that this compound(SMILES:OC1=C(C)C(CO)=CN=C1C.[H]Cl), has unique advantages. If you want to know more about similar compounds, you can read my other articles.

Reference:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Chen, Junli; Campbell, Adrian P.; Urmi, Kaniz F.; Wakelin, Laurence P. G.; Denny, William A.; Griffith, Renate; Finch, Angela M. published an article about the compound: 4-Chloro-8-methylquinoline( cas:18436-73-2,SMILESS:CC1=C2N=CC=C(Cl)C2=CC=C1 ).Application of 18436-73-2. Aromatic heterocyclic compounds can be classified according to the number of heteroatoms or the size of the ring. The authors also want to convey more information about this compound (cas:18436-73-2) through the article.

A series of ring-substituted ethyl- and heptyl-linked 4-aminoquinoline dimers were synthesized and evaluated for their affinities at the 3 human α1-adrenoceptor (α1-AR) subtypes and the human serotonin 5-HT1A-receptor (5-HT1A-R). We find that the structure-specificity profiles are different for the two series at the α1-AR subtypes, which suggests that homobivalent 4-aminoquinolines can be developed with α1-AR subtype selectivity. The 8-Me ethyl-linked analog has the highest affinity for the α1A-AR, 7 nM, and the greatest capacity for discriminating between α1A-AR and α1B-AR (6-fold), α1D-AR (68-fold), and the 5-HT1A-R (168-fold). α1B-AR selectivity was observed with the 6-Me derivative of the ethyl- and heptyl-linked 4-aminoquinoline dimers and the 7-methoxy (7-OMe) derivative of the heptyl-linked analog. These substitutions result in 4- to 80-fold selectivity for α1B-AR over α1A-AR, α1D-AR, and 5-HT1A-R. In contrast, 4-aminoquinoline dimers with selectivity for α1D-AR are more elusive, since none studied to date has greater affinity for the α1D-AR over the other two α1-ARs. The selectivity of the 8-Me ethyl-linked 4-aminoquinoline dimer for the α1A-AR, and 6-Me ethyl-linked, and the 6-Me and 7-OMe heptyl-linked 4-aminoquinoline dimers for the α1B-AR, makes them promising leads for drug development of α1A-AR or α1B-AR subtype selective ligands with reduced 5-HT1A-R affinity.

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Reference:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

COA of Formula: C8H12ClNO2. The reaction of aromatic heterocyclic molecules with protons is called protonation. Aromatic heterocycles are more basic than benzene due to the participation of heteroatoms. Compound: 5-(hydroxymethyl)-2,4-dimethylpyridin-3-ol hydrochloride, is researched, Molecular C8H12ClNO2, CAS is 148-51-6, about Amino derivatives of pyridoxine and its analogs. Author is Yakovleva, N. L.; Balyakina, M. V.; Gunar, V. L..

I [(R = OH, R1 = Me, R2 = CH2OH (II); RR1 = OCMe2CH2O, R2 = CHOH; R = OH, R1 = CH2OH, R2 = Me] with OP(NMe2)3 gave III [R = OH, R1 = Me, R2 = CH2NMe2 (IV); R = OH, R1 = CH2OH, R2 = CH2NMe2; R = OH, R1 = CH2 NMe2, R2 = Me]. Heating II with SOCl2 gave I (R = OH, R1 = Me, R2 = CH2Cl), which was transformed to IV by reaction with Me2NH. Reaction of V (R3 = Cl) with HNMe2 gave V (R3 = NMe2).

Although many compounds look similar to this compound(148-51-6)COA of Formula: C8H12ClNO2, numerous studies have shown that this compound(SMILES:OC1=C(C)C(CO)=CN=C1C.[H]Cl), has unique advantages. If you want to know more about similar compounds, you can read my other articles.

Reference:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Most of the compounds have physiologically active properties, and their biological properties are often attributed to the heteroatoms contained in their molecules, and most of these heteroatoms also appear in cyclic structures. A Journal, Comparative Study, Article, Biochemical Pharmacology called Putrescine or spermidine binding site of aminopropyltransferases and competitive inhibitors, Author is Shirahata, Akira; Morohohi, Toru; Fukai, Masayo; Akatsu, Sakae; Samejima, Keijiro, which mentions a compound: 35621-01-3, SMILESS is NC1CCNCC1.[H]Cl.[H]Cl, Molecular C5H14Cl2N2, Related Products of 35621-01-3.

A model of the active site of aminopropyltransferases was proposed based on the study of a number of monoamino and diamino compounds as potential inhibitors and substrates, resp., of spermidine synthase purified from pig liver. The active site seems to have a relatively large hydrophobic cavity adjacent to a neg. charged site, to which a protonated amino group of putrescine binds, with another amino group of putrescine being situated in the hydrophobic cavity as a free form to be aminopropylated by decarboxylated S-adenosylmethionine. On the basis of the above-mentioned model, another modified one was proposed for spermine synthase, and several compounds designed according to the modified model were found to potently inhibit spermine synthase, purified from rat brain, in competition with spermidine. The newly developed inhibitors were about two orders of magnitude more potent in vitro than a known inhibitor of spermine synthase, dimethyl(5′-adenosyl)sulfonium perchlorate.

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Reference:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Safety of 5-(hydroxymethyl)-2,4-dimethylpyridin-3-ol hydrochloride. The mechanism of aromatic electrophilic substitution of aromatic heterocycles is consistent with that of benzene. Compound: 5-(hydroxymethyl)-2,4-dimethylpyridin-3-ol hydrochloride, is researched, Molecular C8H12ClNO2, CAS is 148-51-6, about Phosphorescence characteristics of several antimetabolites. Author is Sanders, L. B.; Cetorelli, J. J.; Winefordner, James D..

Phosphorescence excitation and emission wavelength peaks, lifetimes, limits of detection, and concentration ranges of anal. usefulness of 37 antimetabolites in rigid (77°K.) ethanolic solution were determined Seventeen of the metabolites produced anal. useful phosphorescence, whereas the remaining 20 were of limited or no anal. use.

Although many compounds look similar to this compound(148-51-6)Safety of 5-(hydroxymethyl)-2,4-dimethylpyridin-3-ol hydrochloride, numerous studies have shown that this compound(SMILES:OC1=C(C)C(CO)=CN=C1C.[H]Cl), has unique advantages. If you want to know more about similar compounds, you can read my other articles.

Reference:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia